No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
986 |
4. Check minimum number of eventsNone |
986 |
5. Include endpointsNone |
986 |
6. Filter based on genotype QC (FinnGen only) |
986 |
Control definitions (FinnGen only)
- Control exclude
- M13_OSTEOCHONDRO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M80-M85
- Name in latin
- Aliae perturbationes densitatis et structurae ossium
Similar endpoints
↥List of similar endpoints to
Other disorders of bone density and structure
based on the number of shared cases.
Similar with more cases:
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8060 | 4419 | 3617 |
| Only index persons | 7643 | 4236 | 3407 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.10 |
| Only index persons | 0.14 | 0.16 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 39.96 | 45.13 | 33.56 |
| Only index persons | 39.69 | 44.77 | 33.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 986 | 636 | 350 |
| Unadjusted period prevalence (%) | 0.19 | 0.22 | 0.15 |
| Median age at first event (years) | 45.13 | 44.80 | 45.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 887
- Matched controls
- 8870
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M85.8
ICD-10 Finland
Other specified disorders of bone density and structure
4281.0
323.0
304
*
M85.4
ICD-10 Finland
Solitary bone cyst
+∞
183.9
170
*
M85.9
ICD-10 Finland
Disorder of bone density and structure, unspecified
1303.6
119.7
114
*
M85.6
ICD-10 Finland
Other cyst of bone
+∞
96.6
91
*
M85.0
ICD-10 Finland
Fibrous dysplasia (monostotic)
+∞
78.3
74
*
M85.5
ICD-10 Finland
Aneurysmal bone cyst
+∞
47.3
45
*
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
19.5
47.0
72
40
M85.3
ICD-10 Finland
Osteitis condensans
+∞
42.0
40
*
7332X
ICD-9 Finland
Other disorders of bone and cartilage, Cyst of bone[CYSTA OSSIS ALIA]
+∞
34.6
33
*
9102
FHL
Trepanation or removal of the local bone process
26.2
32.6
45
18
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
15.0
32.3
54
38
7332A
ICD-9 Finland
Other disorders of bone and cartilage, Cyst of bone[CYSTA SOLITARIA OSSIS]
+∞
31.4
30
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
13.3
26.9
47
37
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
10.8
26.8
52
51
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
96.2
25.8
28
*
N02AX02
ATC
tramadol; systemic, rectal
2.1
23.8
388
2384
M25.5
ICD-10 Finland
Pain in joint
2.2
22.2
293
1628
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
16.8
19.7
31
19
M05BA04
ATC
alendronic acid; oral
4.0
18.7
77
205
N03AX12
ATC
gabapentin; oral
2.4
16.8
151
687
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
+∞
16.7
16
*
N03AX16
ATC
pregabalin; oral
2.1
16.6
216
1170
M01AC06
ATC
meloxicam; systemic, rectal
1.9
15.9
317
2018
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.9
15.7
100
372
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
7.3
15.2
36
51
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
14.9
238
1390
NGK05
NOMESCO Finland
Partial or total excision of bone of lower leg
57.6
14.8
17
*
NDK99
NOMESCO Finland
Other operation on bone of hand or wrist
57.6
14.8
17
*
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
14.4
315
2053
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
22.7
14.3
20
9
318
Kela drug reimbursment
Teriparatide
+∞
13.6
13
*
M54.5
ICD-10 Finland
Low back pain
1.8
13.5
298
1940
SPAT1153
SPAT
Removal of sutures
1.8
13.2
263
1652
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
12.8
401
2893
NFK10
NOMESCO Finland
Fenestration or partial or total excision of bone of femur
70.8
12.6
14
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.4
12.6
62
193
H05AA02
ATC
teriparatide; parenteral
+∞
12.5
12
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
12.2
321
2193
J01MA02
ATC
ciprofloxacin; systemic
1.7
12.1
303
2038
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
12.0
101
443
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
47.3
11.9
14
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
11.9
248
1574
J01DB01
ATC
cefalexin; oral
1.8
11.9
709
6097
M01AB05
ATC
diclofenac; systemic, rectal
1.7
11.8
560
4494
N02BE01
ATC
paracetamol; systemic, rectal
1.9
11.8
734
6392
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
11.7
88
362
M05BX04
ATC
denosumab; parenteral
4.5
11.7
41
95
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
11.7
320
2202
M80, M85
ICD-10 Finland
NA
+∞
11.5
11
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
11.2
91
390
ZXA00
NOMESCO Finland
Right side
1.8
10.8
217
1353
M05BA07
ATC
risedronic acid; oral
4.5
10.8
37
84
M01AH05
ATC
etoricoxib; oral
1.6
10.8
497
3913
B01AB05
ATC
enoxaparin; parenteral
1.8
10.7
229
1460
A02BC02
ATC
pantoprazole; systemic
1.6
10.5
511
4068
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.1
10.5
119
596
M79.6
ICD-10 Finland
Pain in limb
1.7
10.5
295
2031
M84.0
ICD-10 Finland
Malunion of fracture
+∞
10.4
10
*
M01AE01
ATC
ibuprofen; systemic, rectal
2.0
10.4
791
7140
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
10.3
186
1116
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
5.9
10.0
27
47
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
9.7
143
800
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
9.6
220
1421
ZXA05
NOMESCO Finland
Left side
1.8
9.5
198
1244
M80.5
ICD-10 Finland
Idiopathic osteoporosis with pathological fracture
101.0
9.4
10
*
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
+∞
9.4
9
*
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
+∞
9.4
9
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
5.0
9.3
29
60
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.1
9.3
50
168
M03BC01
ATC
orphenadrine (citrate); systemic
1.7
9.3
211
1360
A02BC03
ATC
lansoprazole; oral
1.7
9.2
230
1522
M81.8
ICD-10 Finland
Other osteoporosis
37.1
9.0
11
*
M80
ICD-10 Finland
Osteoporosis with pathological fracture
24.3
8.9
12
5
M03BX02
ATC
tizanidine; oral
1.5
8.9
524
4289
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
8.9
76
336
X58
ICD-10 Finland
Exposure to other specified factors
2.0
8.8
121
657
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.3
8.8
81
372
M01AH02
ATC
rofecoxib; oral
2.0
8.7
109
573
M01AE02
ATC
naproxen; oral, rectal
1.5
8.6
484
3907
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.5
8.6
65
269
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.5
8.6
38
111
NHR99
NOMESCO Finland
Other operation for tumour of ankle or foot
90.8
8.4
9
*
J01AA02
ATC
doxycycline; systemic
1.6
8.4
630
5411
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
12.9
8.4
14
11
M85.1
ICD-10 Finland
Skeletal fluorosis
+∞
8.3
8
*
M92.6
ICD-10 Finland
Juvenile osteochondrosis of tarsus
+∞
8.3
8
*
Q78.1
ICD-10 Finland
Polyostotic fibrous dysplasia
+∞
8.3
8
*
M85.2
ICD-10 Finland
Hyperostosis of skull
+∞
8.3
8
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.6
8.3
57
224
S18
ICPC
Laceration/cut
1.6
8.3
312
2288
NF1AA
NOMESCO Finland
Hip X-ray examination
2.5
8.2
63
264
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.7
8.1
183
1170
T82
ICPC
Obesity
3.3
8.0
38
117
H02AB06
ATC
prednisolone; systemic
1.5
8.0
355
2700
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.1
8.0
97
500
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.5
7.9
63
267
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
4.1
7.8
29
73
M02AA07
ATC
piroxicam; topical
1.6
7.7
269
1929
J01FF01
ATC
clindamycin; systemic
1.6
7.7
220
1502
P01BA02
ATC
hydroxychloroquine; oral
2.3
7.5
67
302
R01AD09
ATC
mometasone; nasal
1.5
7.5
374
2908
L03
ICPC
Low back symptom/complaint
1.6
7.4
201
1351
M89.0
ICD-10 Finland
Algoneurodystrophy
80.7
7.4
8
*
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.0
7.4
19
32
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.1
7.3
80
397
UJF32
NOMESCO Finland
Coloscopy
1.6
7.3
191
1270
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
7.3
86
441
M79.7
ICD-10 Finland
Fibromyalgia
3.1
7.3
38
127
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.1
7.1
37
123
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.8
7.1
45
168
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.8
7.1
125
743
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
4.2
7.0
25
61
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
7.0
213
1476
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
7.0
90
479
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
3.3
6.8
32
99
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
6.8
6.8
16
24
WX320
NOMESCO Finland
Spinalanesthesy
1.6
6.7
167
1095
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
6.7
155
994
EDA10
NOMESCO Finland
Biopsy of mandible
22.7
6.7
9
*
NF3AA
NOMESCO Finland
Femur X-ray examination
4.6
6.6
21
46
L11
ICPC
Wrist symptom/complaint
2.1
6.5
68
333
P01AB01
ATC
metronidazole; oral, rectal
1.5
6.5
315
2415
WX110
NOMESCO Finland
Local anesthesy
1.5
6.5
584
5049
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
6.5
317
2437
M25.8
ICD-10 Finland
Other specified joint disorders
14.4
6.4
10
7
D16.0
ICD-10 Finland
Benign neoplasm: Scapula and long bones of upper limb
14.4
6.4
10
7
J01DA01
ATC
[U] cefalexin; systemic
1.4
6.3
507
4278
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
5.2
6.3
18
35
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.5
6.3
48
201
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.5
6.3
48
201
NHG22
NOMESCO Finland
Fusion of subtalar joint
11.1
6.3
11
10
NHA30
NOMESCO Finland
Exploration of joint of ankle or foot, arthroscopic
9.3
6.3
12
13
NBK10
NOMESCO Finland
Partial or total excision of bone of shoulder or upper arm, humerus
+∞
6.3
6
*
M93.2
ICD-10 Finland
Osteochondritis dissecans
+∞
6.3
6
*
M87.0
ICD-10 Finland
Idiopathic aseptic necrosis of bone
+∞
6.3
6
*
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.9
6.2
93
523
L88
ICPC
Rheumatoid/seropositive arthritis
2.9
6.2
35
122
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
4.3
6.1
21
50
WX212
NOMESCO Finland
Femoral plexus blockade
4.7
6.1
19
41
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
4.1
6.1
22
55
J01FA10
ATC
azithromycin; systemic
1.4
6.1
497
4191
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.7
6.1
143
922
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.1
399
3234
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.0
6.1
79
422
R51.80
ICD-10 Finland
Headache
1.7
6.1
129
811
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.2
6.1
55
253
A07AA02
ATC
nystatin; oral
2.3
6.0
50
221
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.8
6.0
23
61
Mortality – FinRegistry
↥Association
Association between endpoint M13_BONEDENSOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDENSOTH | 1.323 [1.12, 1.56] | < 0.001 |
| Birth year | 0.995 [0.99, 1.01] | 0.332 |
During the follow-up period (1.1.1998 — 31.12.2019), 397 out of 3559 females with M13_BONEDENSOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDENSOTH | 1.259 [1.08, 1.47] | 0.004 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 307 out of 2959 males with M13_BONEDENSOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_BONEDENSOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.162% | 0.24% |
| 5 | 0.766% | 1.641% |
| 10 | 1.882% | 3.791% |
| 15 | 3.928% | 7.102% |
| 20 | 6.893% | 11.974% |
Relationships between endpoints
↥Index endpoint: M13_BONEDENSOTH – Other disorders of bone density and structure
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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