Fatigue fracture of vertebra

M13_FATIGFRACT

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M48.4 Cause of death: ICD-10 — M48.4 2 out of 7 registries used, show all original rules.	165
4. Check minimum number of events None	165
5. Include endpoints None	165
6. Filter based on genotype QC (FinnGen only)	165

Control definitions (FinnGen only)

Control exclude: M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M48
Name in latin: Fractura vertebrae ex fatigatione

NAME	M13_FATIGFRACT
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M484
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M484
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Fatigue fracture of vertebra based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1686	892	789
Only index persons	1561	823	738
Unadjusted period prevalence (%)
Whole population	0.02	0.03	0.02
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	40.97	61.05	18.09
Only index persons	40.52	60.94	17.75

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	165	103	62
Unadjusted period prevalence (%)	0.03	0.04	0.03
Median age at first event (years)	62.68	62.70	62.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
143: Matched controls
1430

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M48.4

ICD-10 Finland

Fatigue fracture of vertebra

4503599627370496.0

201.3

142

M48.0

ICD-10 Finland

Spinal stenosis

177.0

38.9

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

42.3

27.0

M54.5

ICD-10 Finland

Low back pain

7.7

25.8

174

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

90.3

21.4

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

57.1

20.9

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

22.4

20.1

M54.4

ICD-10 Finland

Lumbago with sciatica

11.1

19.3

N03AX16

ATC

pregabalin; oral

7.0

18.8

107

M54.9

ICD-10 Finland

Dorsalgia, unspecified

14.9

18.4

N03AX12

ATC

gabapentin; oral

9.0

17.9

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

72.4

17.2

N02AA05

ATC

oxycodone; systemic

6.2

15.1

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

6.9

15.0

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

18.5

12.0

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

130.0

11.6

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

130.0

11.6

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.7

11.3

258

L03

ICPC

Low back symptom/complaint

4.0

10.3

150

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

43.4

10.1

M05BA04

ATC

alendronic acid; oral

5.0

10.1

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

10.2

9.9

N02AX02

ATC

tramadol; systemic, rectal

3.3

9.8

303

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.3

9.8

304

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

106.8

9.5

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

106.8

9.5

M54.3

ICD-10 Finland

Sciatica

29.5

8.6

M43.1

ICD-10 Finland

Spondylolisthesis

95.4

8.5

M25.5

ICD-10 Finland

Pain in joint

3.3

8.3

196

N02AJ06

ATC

codeine and paracetamol; systemic

3.1

8.3

258

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

35.6

8.2

M81.9

ICD-10 Finland

Osteoporosis, unspecified

8.2

7.9

M84.3

ICD-10 Finland

Stress fracture, not elsewhere classified

47.6

7.8

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

19.7

7.7

A02BC05

ATC

esomeprazole; systemic

2.8

7.5

337

TAC99

NOMESCO Finland

Other blockade for chronic pain

+∞

7.3

M43.0

ICD-10 Finland

Spondylolysis

+∞

7.3

M05BX04

ATC

denosumab; parenteral

7.7

7.2

N06AA09

ATC

amitriptyline; systemic

5.4

7.2

M54

ICD-10 Finland

Dorsalgia

4.9

7.1

Z01.8

ICD-10 Finland

Other specified special examinations

3.4

7.1

139

L02

ICPC

Back symptom/complaint

5.3

6.5

NAG40

NOMESCO Finland

Anterior fusion of cervical spine without fixation

+∞

6.3

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

+∞

6.3

NAG62

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, 2-3 vertebraea

+∞

6.3

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

10.7

6.1

J01DA01

ATC

[U] cefalexin; systemic

2.4

6.1

521

M05BB03

ATC

alendronic acid and colecalciferol; oral

7.8

6.1

K08.1

ICD-10 Finland

Loss of teeth due to accident, extraction or local periodontal disease

4.4

6.0

Mortality – FinRegistry

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Association

Association between endpoint M13_FATIGFRACT and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_FATIGFRACT	1.518 [1.15, 2.0]	0.003
Birth year	0.996 [0.99, 1.0]	0.403

During the follow-up period (1.1.1998 — 31.12.2019), 179 out of 579 females with M13_FATIGFRACT died.

Males

Parameter	HR [95% CI]	p-value
M13_FATIGFRACT	1.865 [1.31, 2.66]	< 0.001
Birth year	0.984 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 387 males with M13_FATIGFRACT died.

Mortality risk

Mortality risk for people of age

years, who have M13_FATIGFRACT.

N-year risk	Females	Males
1	0.183%	0.329%
5	0.973%	1.964%
10	2.401%	4.885%
15	4.479%	8.956%
20	7.785%	15.13%

Relationships between endpoints

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Index endpoint: M13_FATIGFRACT – Fatigue fracture of vertebra

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fatigue fracture of vertebra

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints