No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
139 |
4. Check minimum number of eventsNone |
139 |
5. Include endpointsNone |
139 |
6. Filter based on genotype QC (FinnGen only) |
139 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other fibroblastic disorders
based on the number of shared cases.
Similar with more cases:
- Fibroblastic disorders
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1061 | 528 | 526 |
| Only index persons | 957 | 489 | 468 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 51.89 | 50.70 | 52.89 |
| Only index persons | 50.79 | 49.57 | 52.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 139 | 72 | 67 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 51.04 | 47.99 | 54.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 128
- Matched controls
- 1281
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M72.9
ICD-10 Finland
Fibroblastic disorder, unspecified
+∞
69.1
60
*
M72.8
ICD-10 Finland
Other fibroblastic disorders
+∞
39.6
36
*
7287X
ICD-9 Finland
Disorders of muscle, ligament and fascia, Other fibromatoses[FIBROMATOSIS ALIA MUSCULI,LIGAMENTI ET FASCIAE]
+∞
38.5
35
*
M72.0
ICD-10 Finland
Palmar fascial fibromatosis [Dupuytren]
+∞
36.1
33
*
NDM10
NOMESCO Finland
Palmar fasciotomy of hand
+∞
30.4
28
*
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
9.5
13.0
27
35
M79.6
ICD-10 Finland
Pain in limb
3.7
9.9
52
198
G72.9
ICD-10 Finland
Myopathy, unspecified
107.5
9.5
10
*
NHM10
NOMESCO Finland
Fasciotomy of ankle or foot
+∞
9.5
9
*
9476
FHL
Splitting of fascia or aponeurosis
96.0
8.5
9
*
N03AX12
ATC
gabapentin; oral
4.6
8.3
30
80
N02AX02
ATC
tramadol; systemic, rectal
2.9
7.3
61
309
M01AX17
ATC
nimesulide; oral
3.2
7.2
42
167
WX204
NOMESCO Finland
Axillary plexus blockaced
24.0
6.8
9
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
6.4
66
369
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.5
6.3
30
102
Mortality – FinRegistry
↥Association
Association between endpoint M13_FIBROBLASTNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FIBROBLASTNAS | 1.513 [1.07, 2.14] | 0.019 |
| Birth year | 0.992 [0.98, 1.0] | 0.059 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 333 females with M13_FIBROBLASTNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FIBROBLASTNAS | 1.146 [0.9, 1.45] | 0.263 |
| Birth year | 0.993 [0.98, 1.0] | 0.158 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 384 males with M13_FIBROBLASTNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_FIBROBLASTNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.163% | 0.247% |
| 5 | 0.856% | 1.611% |
| 10 | 2.199% | 3.758% |
| 15 | 3.941% | 7.482% |
| 20 | 6.81% | 12.945% |
Relationships between endpoints
↥Index endpoint: M13_FIBROBLASTNAS – Other fibroblastic disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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