Iliotibial band syndrome

M13_ILIOTIBBAND

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M76.3
  • Hospital discharge: ICD-9 7265B|7266G
  • Cause of death: ICD-10 M76.3
  • Cause of death: ICD-9 7265B|7266G

2 out of 7 registries used, show all original rules.

430

4. Check minimum number of events

None

430

5. Include endpoints

None

430

6. Filter based on genotype QC (FinnGen only)

430

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M76
Name in latin
Syndroma tractus iliotibialis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2417 1492 918
Only index persons 2369 1469 900
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.03
Only index persons 0.05 0.05 0.03
Median age at first event (years)
Whole population 43.28 50.72 31.26
Only index persons 43.28 50.64 31.26

-FinnGen-

Key figures

All Female Male
Number of individuals 430 322 108
Unadjusted period prevalence (%) 0.09 0.11 0.05
Median age at first event (years) 50.97 52.71 45.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
398
Matched controls
3980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M76.3
ICD-10 Finland
Iliotibial band syndrome
16384.0
323.0
376
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
38.5
65.4
83
27
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
31.2
52.5
70
27
M54.5
ICD-10 Finland
Low back pain
5.4
46.2
173
493
M48.0
ICD-10 Finland
Spinal stenosis
60.9
45.9
53
10
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
47.9
44.8
54
13
N03AX16
ATC
pregabalin; oral
6.2
43.5
136
308
M54.4
ICD-10 Finland
Lumbago with sciatica
8.9
43.1
99
143
M01AH05
ATC
etoricoxib; oral
4.8
42.7
306
1638
M70.6
ICD-10 Finland
Trochanteric bursitis
7.2
38.0
100
176
N03AX12
ATC
gabapentin; oral
7.6
34.3
86
139
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
191.3
34.3
35
*
M25.5
ICD-10 Finland
Pain in joint
4.1
34.1
173
626
M79.6
ICD-10 Finland
Pain in limb
3.8
32.0
191
784
N02AX02
ATC
tramadol; systemic, rectal
3.7
31.9
198
838
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
313.7
29.2
29
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.1
27.1
124
394
M53.3
ICD-10 Finland
Sacrococcygeal disorders, not elsewhere classified
150.2
27.0
28
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
47.9
25.9
31
7
M01AB05
ATC
diclofenac; systemic, rectal
3.4
25.7
304
1951
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.1
25.4
213
1074
M53.1
ICD-10 Finland
Cervicobrachial syndrome
5.7
24.2
74
153
M03BX02
ATC
tizanidine; oral
3.1
23.8
287
1812
M03BC01
ATC
orphenadrine (citrate); systemic
3.5
22.7
128
475
M54.3
ICD-10 Finland
Sciatica
15.7
22.1
36
25
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
10.1
21.4
43
47
M76.0
ICD-10 Finland
Gluteal tendinitis
17.3
20.5
32
20
7266G
ICD-9 Finland
Peripheral enthesopathies and allied syndromes, Enthesopathy of knee[SDR TRACTUS ILIOTIBIALE]
+∞
20.0
19
*
M47.9
ICD-10 Finland
Spondylosis, unspecified
110.6
19.8
21
*
M47.82
ICD-10 Finland
Other spondylosis, cervical region
19.4
19.4
29
16
N06AX21
ATC
duloxetine; oral
5.4
19.3
61
130
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
36.3
19.1
24
7
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
10.6
19.1
37
38
M54.6
ICD-10 Finland
Pain in thoracic spine
7.2
18.3
45
69
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
6.8
18.2
47
77
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
17.6
18.1
28
17
M54.1
ICD-10 Finland
Radiculopathy
24.1
18.0
25
11
L86
ICPC
Back syndrome with radiating pain
9.0
17.9
38
46
M54.9
ICD-10 Finland
Dorsalgia, unspecified
6.0
17.3
49
91
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.3
17.1
67
178
M76.8
ICD-10 Finland
Other enthesopathies of lower limb, excluding foot
27.0
17.1
23
9
M79.1
ICD-10 Finland
Myalgia
4.0
17.0
74
217
NFM10
NOMESCO Finland
Fasciotomy of thigh
+∞
16.8
16
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
16.8
16
*
S33.6
ICD-10 Finland
Sprain and strain of sacroiliac joint
+∞
16.8
16
*
L03
ICPC
Low back symptom/complaint
3.1
16.7
104
404
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
12.9
16.6
29
24
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
16.5
155
777
M02AA07
ATC
piroxicam; topical
2.6
16.3
163
847
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
4.5
16.1
60
152
A02BC03
ATC
lansoprazole; oral
2.7
16.0
130
597
L13
ICPC
Hip symptom/complaint
3.5
15.9
83
282
M01AC06
ATC
meloxicam; systemic, rectal
2.5
15.9
169
902
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
4.3
15.8
62
165
M01AH01
ATC
celecoxib; oral (coxibs)
3.3
15.5
85
300
N02AJ06
ATC
codeine and paracetamol; systemic
2.5
15.0
159
839
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
+∞
14.7
14
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.0
14.4
92
360
M19.0
ICD-10 Finland
Primary arthrosis of other joints
4.8
14.3
49
114
N02BE01
ATC
paracetamol; systemic, rectal
2.9
14.0
345
2759
M23.8
ICD-10 Finland
Other internal derangements of knee
7.0
13.9
34
52
L15
ICPC
Knee symptom/complaint
2.8
13.8
100
422
Z3226
NOMESCO Finland
Physiotherapist
3.0
13.6
86
331
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
5.5
13.5
40
79
M01AX05
ATC
glucosamine; oral
3.0
13.3
87
344
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
15.8
13.2
21
14
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
12.9
119
574
M53.0
ICD-10 Finland
Cervicocranial syndrome
4.6
12.9
46
111
M22.4
ICD-10 Finland
Chondromalacia patellae
7.1
12.8
31
47
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
12.6
12
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
3.6
12.5
58
178
A02BC02
ATC
pantoprazole; systemic
2.2
12.3
252
1761
G44.2
ICD-10 Finland
Tension-type headache
3.2
12.2
68
240
R03AC02
ATC
salbutamol; inhalant
2.1
11.9
213
1401
9476
FHL
Splitting of fascia or aponeurosis
31.1
11.7
15
5
M43.1
ICD-10 Finland
Spondylolisthesis
23.7
11.7
16
7
M01AE02
ATC
naproxen; oral, rectal
2.1
11.7
237
1636
M01AH02
ATC
rofecoxib; oral
3.5
11.5
55
174
J01AA02
ATC
doxycycline; systemic
2.3
11.4
314
2461
ZXA00
NOMESCO Finland
Right side
2.4
11.2
112
560
M54.2
ICD-10 Finland
Cervicalgia
5.4
11.2
33
65
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.8
11.1
47
134
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.5
11.1
104
501
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
5.9
11.0
30
54
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
18.5
10.8
16
9
N02AA05
ATC
oxycodone; systemic
3.4
10.8
53
171
A02BC05
ATC
esomeprazole; systemic
2.1
10.7
163
983
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
61.7
10.7
12
*
X59
ICD-10 Finland
Exposure to unspecified factor
2.6
10.3
81
353
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.1
10.1
39
102
M03BC51
ATC
orphenadrine, combinations; systemic
2.2
10.1
127
703
M01AX17
ATC
nimesulide; oral
2.4
10.1
101
503
R06.0
ICD-10 Finland
Dyspnoea
2.5
10.0
91
429
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.0
9.9
58
212
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
8.1
9.7
21
27
R51.80
ICD-10 Finland
Headache
2.8
9.7
67
272
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
6.3
9.7
25
42
J01DB01
ATC
cefalexin; oral
2.2
9.7
328
2690
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
4.3
9.6
35
87
H02AB06
ATC
prednisolone; systemic
2.0
9.6
175
1122
SPAT1153
SPAT
Removal of sutures
2.1
9.5
123
687
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
9.3
107
566
J01FA10
ATC
azithromycin; systemic
1.9
9.3
246
1808
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.9
9.2
37
101
S80.0
ICD-10 Finland
Contusion of knee
3.7
9.2
39
112
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
8.6
9.2
19
23
M01AE01
ATC
ibuprofen; systemic, rectal
2.7
9.1
363
3154
ZXA05
NOMESCO Finland
Left side
2.3
9.1
100
516
N06AA09
ATC
amitriptyline; systemic
3.6
9.0
40
119
XQ800
NOMESCO Finland
Prick test
3.4
9.0
43
136
M54.8
ICD-10 Finland
Other dorsalgia
7.1
9.0
21
31
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
7.9
8.7
19
25
XA402
NOMESCO Finland
ENMG
11.9
8.6
15
13
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
8.4
152
960
M02AA10
ATC
ketoprofen; topical
2.6
8.4
65
280
RF210
NOMESCO Finland
NA
6.5
8.4
21
34
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
8.4
8
*
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
8.4
8
*
R42
ICD-10 Finland
Dizziness and giddiness
2.3
8.3
81
393
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
8.3
95
497
AA1AD
NOMESCO Finland
CT of head and brain
2.3
8.3
83
410
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
8.2
95
503
M16.1
ICD-10 Finland
Other primary coxarthrosis
3.0
8.1
46
164
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
8.1
88
451
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.2
8.1
94
498
L01
ICPC
Neck symptom/complaint
2.7
8.1
55
222
M75.9
ICD-10 Finland
Shoulder lesion, unspecified
5.6
8.0
22
41
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.8
7.9
217
1577
R01AD12
ATC
fluticasone furoate; nasal
1.9
7.8
130
793
R01BA52
ATC
pseudoephedrine, combinations; oral
1.9
7.7
135
838
J01FA15
ATC
telithromycin; oral
2.8
7.7
48
183
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
7.6
176
1201
NF1AA
NOMESCO Finland
Hip X-ray examination
3.6
7.6
33
97
A02BC01
ATC
omeprazole; systemic
2.1
7.6
98
541
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.2
7.5
27
67
S18
ICPC
Laceration/cut
1.9
7.5
148
956
M70.7
ICD-10 Finland
Other bursitis of hip
7.9
7.5
16
21
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
13.7
7.4
12
9
L08
ICPC
Shoulder symptom/complaint
2.2
7.4
76
379
SPAT1212
SPAT
Extensive examination of musculoskeletal system
3.3
7.4
36
116
J01FA06
ATC
roxithromycin; oral
1.8
7.4
163
1094
R5599
NOMESCO Finland
Other rehabilitation service
8.6
7.4
15
18
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
7.4
53
220
M35.7
ICD-10 Finland
Hypermobility syndrome
9.6
7.3
14
15
00000
ICD-8 Finland
NA
9.6
7.3
14
15
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
9.6
7.3
14
15
M79.7
ICD-10 Finland
Fibromyalgia
6.4
7.3
18
29
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
2.8
7.3
46
176
SAA01
NOMESCO Finland
Simple examination of mouth
1.8
7.3
278
2223
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
16.1
7.3
11
7
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
7.2
140
898
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
7.2
102
583
R4110
NOMESCO Finland
Physiotherapy
2.0
7.2
100
565
Z2221
NOMESCO Finland
Medical doctor
1.9
7.0
115
691
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.6
7.0
30
88
R03AC03
ATC
terbutaline; inhalant
2.4
7.0
62
289
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
6.9
135
864
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.3
6.9
34
111
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.6
6.9
50
207
Z3231
NOMESCO Finland
Registered nurse
2.0
6.9
100
576
R06AE07
ATC
cetirizine; oral
1.8
6.9
175
1222
J02AC01
ATC
fluconazole; systemic
1.8
6.9
175
1222
R07.3
ICD-10 Finland
Other chest pain
3.2
6.8
35
118
M24.8
ICD-10 Finland
Other specific joint derangements, not elsewhere classified
40.8
6.8
8
*
J01CA04
ATC
amoxicillin; systemic
1.9
6.7
319
2700
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
5.7
6.7
18
33
ZXE00
NOMESCO Finland
One hour or less
1.8
6.6
149
995
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
6.6
134
867
S06.0
ICD-10 Finland
Concussion
2.7
6.6
43
169
R52.9
ICD-10 Finland
Pain, unspecified
3.0
6.6
37
131
R53
ICD-10 Finland
Malaise and fatigue
2.2
6.5
72
370
N06AX11
ATC
mirtazapine; oral
1.9
6.5
117
727
G57.1
ICD-10 Finland
Meralgia paraesthetica
14.6
6.4
10
7
R01AD09
ATC
mometasone; nasal
1.7
6.4
176
1248
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.3
6.4
18
35
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
3.1
6.4
34
118
UJF32
NOMESCO Finland
Coloscopy
2.0
6.3
87
490
M50.3
ICD-10 Finland
Other cervical disc degeneration
18.4
6.3
9
5
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
+∞
6.3
6
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
6.3
6
*
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
+∞
6.3
6
*
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
27.1
6.2
8
*
M01AX01
ATC
nabumetone; oral
4.5
6.1
20
46
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
5.3
6.1
17
33
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.7
6.1
40
159
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
10.2
6.1
11
11
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.5
6.1
46
198
R05FA02
ATC
opium derivatives and expectorants; systemic
1.7
6.0
162
1137
B01AB05
ATC
enoxaparin; parenteral
1.8
6.0
112
702

Mortality – FinRegistry

Association

Association between endpoint M13_ILIOTIBBAND and mortality.

Females

Parameter HR [95% CI] p-value
M13_ILIOTIBBAND 0.714 [0.55, 0.93] 0.012
Birth year 0.993 [0.98, 1.0] 0.137

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 1175 females with M13_ILIOTIBBAND died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_ILIOTIBBAND.

N-year risk Females Males
1 0.072% No data
5 0.395% No data
10 0.934% No data
15 1.941% No data
20 3.434% No data

Relationships between endpoints

Index endpoint: M13_ILIOTIBBAND – Iliotibial band syndrome

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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