phimosis: A condition in which there is constriction in the tip of the foreskin resulting in inability to fully retract the foreskin over the glans penis. Causes include balanoposthitis, balanitis xerotica obliterans, and untreated diabetes.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
470 |
4. Check minimum number of eventsNone |
470 |
5. Include endpointsNone |
470 |
6. Filter based on genotype QC (FinnGen only) |
470 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Kyphosis
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4018 | 2016 | 1983 |
| Only index persons | 3629 | 1845 | 1784 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 57.70 | 66.00 | 49.13 |
| Only index persons | 53.54 | 64.43 | 42.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 470 | 280 | 190 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.08 |
| Median age at first event (years) | 63.17 | 63.58 | 62.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 411
- Matched controls
- 4108
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M40.1
ICD-10 Finland
Other secondary kyphosis
+∞
196.0
172
*
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
1192.7
167.1
152
*
M40.2
ICD-10 Finland
Other and unspecified kyphosis
+∞
166.2
148
*
M48.0
ICD-10 Finland
Spinal stenosis
98.9
133.7
143
22
M40.0
ICD-10 Finland
Postural kyphosis
+∞
111.7
102
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
28.3
96.0
134
69
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
86.4
95.0
104
16
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
57.4
88.9
104
24
N03AX12
ATC
gabapentin; oral
13.0
81.2
158
188
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
13.0
76.8
148
170
N03AX16
ATC
pregabalin; oral
9.1
73.1
181
327
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
77.6
63.7
71
11
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
57.9
61.7
72
15
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
57.7
54
*
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
164.8
55.4
57
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
202.1
52.2
53
*
M54.5
ICD-10 Finland
Low back pain
5.8
50.4
178
479
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
50.0
47
*
N02AX02
ATC
tramadol; systemic, rectal
4.8
47.6
234
889
M54.9
ICD-10 Finland
Dorsalgia, unspecified
12.6
47.6
89
88
M43.1
ICD-10 Finland
Spondylolisthesis
129.0
43.7
46
*
N06AX21
ATC
duloxetine; oral
9.0
40.7
92
128
M54.4
ICD-10 Finland
Lumbago with sciatica
8.1
37.6
91
140
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
88.5
36.5
40
5
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
64.8
35.9
41
7
L03
ICPC
Low back symptom/complaint
4.7
35.9
147
435
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
29.3
35.0
47
18
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
+∞
34.9
33
*
M47.82
ICD-10 Finland
Other spondylosis, cervical region
33.5
34.7
45
15
NAK30
NOMESCO Finland
Osteotomy of spine
365.7
34.4
34
*
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
35.0
34.3
44
14
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
33.8
32
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.9
33.3
179
674
M47.9
ICD-10 Finland
Spondylosis, unspecified
178.8
32.2
33
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.5
31.9
231
1096
M41.9
ICD-10 Finland
Scoliosis, unspecified
111.4
29.1
31
*
L86
ICPC
Back syndrome with radiating pain
11.8
28.7
54
52
M54.6
ICD-10 Finland
Pain in thoracic spine
10.7
26.4
52
55
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
19.4
25.8
39
22
WX725
NOMESCO Finland
Noninvasive ventilation
8.6
25.6
57
75
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
25.3
24
*
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
26.5
23.4
32
13
NAU20
NOMESCO Finland
Removal of internal fixation device from spine or neck
+∞
23.1
22
*
WX704
NOMESCO Finland
Intubation
6.0
22.9
66
126
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
13.3
22.8
40
33
SPAT1301
SPAT
No procedures
3.0
22.5
180
852
N02BE01
ATC
paracetamol; systemic, rectal
4.2
22.4
372
2846
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
+∞
22.1
21
*
TPH07
NOMESCO Finland
Cathetrisation of artery
4.6
22.0
82
209
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
21.8
218
1180
N02AA05
ATC
oxycodone; systemic
4.0
21.7
97
294
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
6.0
21.3
61
115
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
15.2
21.2
35
25
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
25.9
21.1
29
12
N06AA09
ATC
amitriptyline; systemic
5.1
20.9
70
159
M42.0
ICD-10 Finland
Juvenile osteochondrosis of spine
115.9
20.8
22
*
M43.0
ICD-10 Finland
Spondylolysis
220.6
20.8
21
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.1
20.7
146
626
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
9.8
20.7
42
47
N02AJ06
ATC
codeine and paracetamol; systemic
2.8
20.4
172
829
M79.6
ICD-10 Finland
Pain in limb
2.9
20.3
165
775
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.5
20.2
108
378
L28
ICPC
Limited function/disability (L)
3.6
19.5
99
332
M54.1
ICD-10 Finland
Radiculopathy
27.6
19.4
26
10
N03AE01
ATC
clonazepam; systemic
7.5
19.1
46
68
SPAT1263
SPAT
Sampling
2.6
18.9
213
1201
NAG65
NOMESCO Finland
Anterior and posterior fusion of lumbar spine
+∞
18.9
18
*
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
73.4
18.9
21
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
18.5
148
680
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.6
18.5
94
315
A02BC03
ATC
lansoprazole; oral
2.8
18.4
147
673
NA2AD
NOMESCO Finland
Thoracic spine CT examination
46.3
18.4
22
5
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
15.5
17.9
29
20
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
+∞
17.8
17
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
17.6
118
482
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
17.4
178
938
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.1
17.1
71
199
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
23.1
17.1
24
11
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
16.8
116
478
N06AX11
ATC
mirtazapine; oral
2.7
16.7
143
677
A06AD11
ATC
lactulose; oral
3.5
16.7
87
295
M01AH02
ATC
rofecoxib; oral
3.8
16.6
75
226
ZZH31
NOMESCO Finland
Bone allograft, small pieces
21.1
16.6
24
12
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.5
16.3
85
288
L02
ICPC
Back symptom/complaint
4.8
16.3
56
130
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.0
16.2
53
117
SPAT1153
SPAT
Removal of sutures
2.5
15.9
163
848
ZZH40
NOMESCO Finland
Substitute of bone
34.9
15.9
20
6
NAG66
NOMESCO Finland
Posterior interbody fusion of lumbar spine, 2 vertebrae
+∞
15.7
15
*
N05BA01
ATC
diazepam; systemic, rectal
3.5
15.3
78
259
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.5
15.2
55
135
A02BC01
ATC
omeprazole; systemic
2.6
15.1
138
669
N06AX16
ATC
venlafaxine; oral
3.7
15.1
71
221
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
15.1
94
359
M01AH05
ATC
etoricoxib; oral
2.3
14.8
238
1536
M05BX04
ATC
denosumab; parenteral
5.9
14.8
42
78
M03BC01
ATC
orphenadrine (citrate); systemic
3.0
14.7
97
386
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
11.5
14.7
27
25
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
14.7
14
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.9
14.5
63
183
A02BC02
ATC
pantoprazole; systemic
2.3
14.3
272
1890
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
14.2
150
782
A28
ICPC
Limited function/disability NOS
3.0
14.2
88
337
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.3
14.1
54
140
M03BX02
ATC
tizanidine; oral
2.3
14.0
244
1617
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
14.0
81
293
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
20.9
13.9
20
10
R52.2
ICD-10 Finland
Other chronic pain
9.3
13.7
28
32
AA1AD
NOMESCO Finland
CT of head and brain
2.6
13.7
117
541
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
13.6
13
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
13.6
13
*
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
13.6
13
*
M01AH01
ATC
celecoxib; oral (coxibs)
3.0
13.5
87
339
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
26.8
13.5
18
7
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.2
13.4
198
1207
B01AB05
ATC
enoxaparin; parenteral
2.4
13.4
147
776
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
13.6
13.1
22
17
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.1
13.0
52
140
M54.2
ICD-10 Finland
Cervicalgia
6.4
13.0
34
57
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.4
13.0
48
120
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
51.7
12.9
15
*
UJF32
NOMESCO Finland
Coloscopy
2.5
12.9
121
588
SPAT1229
SPAT
Assessment of need for aid
3.8
12.8
56
164
NF1AA
NOMESCO Finland
Hip X-ray examination
4.0
12.6
52
144
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
12.6
183
1099
M41.5
ICD-10 Finland
Other secondary scoliosis
133.9
12.5
13
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.3
12.5
150
824
SPAT1262
SPAT
Handing over of treatment supplies
2.6
12.4
99
441
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.5
12.3
36
70
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
38.8
12.3
15
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.8
12.2
53
154
N05BA04
ATC
oxazepam; oral
2.5
12.2
111
530
SPAT1310
SPAT
Counselling related to known health issue
2.2
12.1
152
851
L95
ICPC
Osteoporosis
7.2
12.1
29
43
C03CA01
ATC
furosemide; systemic
2.3
12.1
141
760
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
4.0
12.1
49
134
N04BC05
ATC
pramipexole; oral
3.9
12.0
50
140
M01AE03
ATC
ketoprofen; systemic, rectal
2.2
12.0
160
920
WW502
NOMESCO Finland
Autotransfusion
48.1
11.9
14
*
N05AH04
ATC
quetiapine; oral
2.9
11.8
77
300
R06.0
ICD-10 Finland
Dyspnoea
2.4
11.7
119
599
M50.3
ICD-10 Finland
Other cervical disc degeneration
31.0
11.7
15
5
ZXE20
NOMESCO Finland
More than three and less than five hours
2.9
11.7
74
285
S18
ICPC
Laceration/cut
2.1
11.5
186
1157
M41.1
ICD-10 Finland
Juvenile idiopathic scoliosis
+∞
11.5
11
*
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
11.5
11
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
6.9
11.5
28
43
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
6.1
11.3
30
52
H05AA02
ATC
teriparatide; parenteral
25.8
11.2
15
6
318
Kela drug reimbursment
Teriparatide
25.8
11.2
15
6
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
11.2
80
330
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
7.0
11.2
27
41
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
7.0
11.2
27
41
SPAT1216
SPAT
Assessment of functional ability
2.7
11.1
83
351
L84
ICPC
Back syndrome without radiat pain
6.6
11.1
28
45
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
11.1
86
373
E0000UV
ATC
NA
2.1
11.1
172
1046
WX720
NOMESCO Finland
Own respiration
5.7
11.0
31
58
X59
ICD-10 Finland
Exposure to unspecified factor
2.6
10.9
87
381
A02BA02
ATC
ranitidine; systemic
2.5
10.9
93
427
SPAT1097
SPAT
Recording of ECG
2.7
10.9
77
318
WX610
NOMESCO Finland
Patient controlled analgesia
28.9
10.8
14
5
M41.8
ICD-10 Finland
Other forms of scoliosis
61.6
10.7
12
*
M96.0
ICD-10 Finland
Pseudarthrosis after fusion or arthrodesis
61.6
10.7
12
*
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
5.7
10.6
30
56
G20
ICD-10 Finland
Parkinson disease
5.9
10.6
29
52
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
10.6
137
766
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.3
10.6
56
190
M25.5
ICD-10 Finland
Pain in joint
2.3
10.6
112
572
NG1DA
NOMESCO Finland
X-ray of knees
14.7
10.6
17
12
M01AC06
ATC
meloxicam; systemic, rectal
2.1
10.5
149
868
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
112.7
10.5
11
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.0
10.4
33
71
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.9
10.4
25
38
RF210
NOMESCO Finland
NA
6.5
10.3
26
42
F34.1
ICD-10 Finland
Dysthymia
7.8
10.3
23
31
M54.8
ICD-10 Finland
Other dorsalgia
7.8
10.3
23
31
UKC02
NOMESCO Finland
Cystoscopy
2.7
10.3
78
331
ZXE40
NOMESCO Finland
More than seven and less than nine hours
7.5
10.1
23
32
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
10.1
111
576
R02
ICPC
Shortness of breath/dyspnoea
2.9
10.0
62
235
R52.1
ICD-10 Finland
Chronic intractable pain
26.7
9.9
13
5
SPAT1249
SPAT
Treatment-related counselling outside office
2.0
9.8
173
1095
M54
ICD-10 Finland
Dorsalgia
3.4
9.8
47
149
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
56.3
9.7
11
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
6.0
9.7
26
46
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
8.7
9.7
20
24
L17
ICPC
Foot/toe symptom/complaint
2.2
9.7
110
579
A02BC05
ATC
esomeprazole; systemic
2.0
9.6
164
1024
N04BD01
ATC
selegiline; oral
9.4
9.6
19
21
C07AA05
ATC
propranolol; systemic
2.5
9.6
82
374
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
9.5
58
217
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
102.2
9.5
10
*
M01AB05
ATC
diclofenac; systemic, rectal
1.9
9.4
251
1844
NA7FA
NOMESCO Finland
Other X-ray examination of spine with load
+∞
9.4
9
*
NAG52
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, 2-3 vertebraea
+∞
9.4
9
*
SPAT1312
SPAT
General health counselling
2.0
9.4
145
868
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
9.2
121
674
L13
ICPC
Hip symptom/complaint
2.5
9.1
75
335
N06AB04
ATC
citalopram; systemic
2.2
9.1
99
508
J01MA02
ATC
ciprofloxacin; systemic
2.0
9.1
156
971
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.9
9.0
55
205
H02AB06
ATC
prednisolone; systemic
1.9
9.0
187
1245
SAA02
NOMESCO Finland
Basic examination of mouth
1.9
9.0
255
1899
K59.09
ICD-10 Finland
Constipation, unspecified
3.8
8.9
37
104
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.7
8.9
38
110
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
4.4
8.8
31
75
N05CD07
ATC
temazepam; oral
2.8
8.7
57
221
WX402
NOMESCO Finland
General anaesthesia
2.4
8.7
77
356
NA7AD
NOMESCO Finland
Spine CT
51.1
8.7
10
*
N06AB03
ATC
fluoxetine; oral
2.8
8.7
57
222
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.8
8.7
58
230
M02AA07
ATC
piroxicam; topical
2.0
8.7
147
904
R60.0
ICD-10 Finland
Localized oedema
2.9
8.7
54
205
A01
ICPC
Pain general/multiple sites
3.6
8.6
38
113
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
28.2
8.5
11
*
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.8
8.5
35
98
J01FF01
ATC
clindamycin; systemic
2.1
8.5
116
654
M54.3
ICD-10 Finland
Sciatica
6.9
8.5
20
30
S97
ICPC
Chronic ulcer skin
4.0
8.5
33
88
M79.7
ICD-10 Finland
Fibromyalgia
8.1
8.4
18
23
ABC53
NOMESCO Finland
Decompression of thoracic spinal canal and nerve roots
91.8
8.4
9
*
M47.81
ICD-10 Finland
Other spondylosis, occipito-atlanto-axial region
91.8
8.4
9
*
N06AX03
ATC
mianserin; oral
5.0
8.4
26
55
SPAT1260
SPAT
Consultation of another employee
2.3
8.4
86
428
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.6
8.4
37
110
7371A
ICD-9 Finland
Curvature of spine, Kyphosis (acquired)
+∞
8.4
8
*
NA7LT
NOMESCO Finland
Percutaneous vertebroplasty
+∞
8.4
8
*
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
8.4
8
*
NAK40
NOMESCO Finland
Vertebroplasty
+∞
8.4
8
*
9211
FHL
Exploration or removal of diskusprolapse
+∞
8.4
8
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
8.4
60
249
SPAT1325
SPAT
Vaccination
1.9
8.3
160
1028
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
8.3
108
596
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.7
8.3
20
31
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.6
8.3
37
111
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.3
8.2
29
71
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.8
8.2
54
212
E000001
ATC
NA
2.2
8.1
89
457
WX110
NOMESCO Finland
Local anesthesy
1.9
8.1
272
2110
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.6
8.1
27
62
J01DA01
ATC
[U] cefalexin; systemic
1.8
8.1
241
1794
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
13.4
7.9
13
10
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
7.9
47
174
M01AB55
ATC
diclofenac, combinations; oral
3.5
7.9
35
105
G54.0
ICD-10 Finland
Brachial plexus disorders
9.7
7.8
15
16
M45
ICD-10 Finland
Ankylosing spondylitis
45.8
7.7
9
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.6
7.7
34
101
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
7.7
39
129
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.4
7.7
69
322
N03AF01
ATC
carbamazepine; oral, rectal
4.5
7.7
26
61
N02AC04
ATC
dextropropoxyphene; oral
5.3
7.7
22
43
R03AC02
ATC
salbutamol; inhalant
1.8
7.6
200
1417
N03AX09
ATC
lamotrigine; oral
4.8
7.6
24
52
M79.1
ICD-10 Finland
Myalgia
2.7
7.6
54
219
L01
ICPC
Neck symptom/complaint
2.5
7.6
60
260
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.9
7.6
47
176
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.9
7.5
44
162
W19
ICD-10 Finland
Unspecified fall
2.8
7.4
47
180
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.0
7.4
42
149
XA404
NOMESCO Finland
SEP
81.5
7.4
8
*
T84.2
ICD-10 Finland
Mechanical complication of internal fixation device of other bones
81.5
7.4
8
*
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
81.5
7.4
8
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.2
7.4
27
68
XKC03
NOMESCO Finland
Water cystometry
5.1
7.4
22
45
SAA03
NOMESCO Finland
Extended examination of mouth
1.8
7.4
154
1011
D07AC01
ATC
betamethasone; topical
1.9
7.3
133
833
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
7.3
54
228
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
+∞
7.3
7
*
7370A
ICD-9 Finland
Curvature of spine, Adolescent postural kyphosis
+∞
7.3
7
*
M48.1
ICD-10 Finland
Ankylosing hyperostosis [Forestier]
+∞
7.3
7
*
NA3BA
NOMESCO Finland
Lumbar spine extensive X-ray examination without contrast
+∞
7.3
7
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
7.3
7
*
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
6.2
7.2
18
30
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.3
7.1
35
114
G04BD12
ATC
mirabegron; oral
2.7
7.1
48
191
SPAT1240
SPAT
Therapeutic discussion
2.7
7.1
48
192
SPAT1254
SPAT
Administration of medicine
2.2
7.0
73
362
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.3
7.0
20
39
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.1
7.0
85
454
M05BA07
ATC
risedronic acid; oral
4.1
7.0
26
67
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
7.0
173
1194
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.5
7.0
23
53
R5140
NOMESCO Finland
Monitoring the use of the aid
2.8
6.9
44
169
J01DB01
ATC
cefalexin; oral
1.9
6.9
322
2702
N05CF01
ATC
zopiclone; oral
1.9
6.9
125
780
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.0
6.8
39
140
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
6.8
61
285
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.9
6.8
39
141
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
40.7
6.8
8
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
17.0
6.8
10
6
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.7
6.7
43
168
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
6.6
136
881
N04BD02
ATC
rasagiline; oral
12.5
6.6
11
9
NH3EA
NOMESCO Finland
Feet X-ray examination with load
7.0
6.6
15
22
X58
ICD-10 Finland
Exposure to other specified factors
2.4
6.5
54
241
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.0
6.5
87
480
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.8
6.5
41
155
ZXA10
NOMESCO Finland
Bilateral
2.1
6.5
82
445
M01AX17
ATC
nimesulide; oral
2.0
6.5
97
561
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.2
6.5
32
105
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.5
6.5
28
83
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.7
6.5
42
165
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
70.9
6.4
7
*
P04
ICPC
Feeling/behaving irritable/angry
70.9
6.4
7
*
RS230
NOMESCO Finland
NA
70.9
6.4
7
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.9
6.4
37
134
R13
ICD-10 Finland
Dysphagia
3.3
6.4
31
100
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
14.6
6.4
10
7
A07AA02
ATC
nystatin; oral
3.3
6.4
30
95
N06AA10
ATC
nortriptyline; systemic
8.3
6.4
13
16
SPAT1058
SPAT
PEF monitoring instruction
2.8
6.4
40
151
G04BD07
ATC
tolterodine; oral
3.2
6.4
31
101
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.4
6.3
29
90
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.2
6.3
32
107
R42
ICD-10 Finland
Dizziness and giddiness
2.0
6.3
84
465
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
11.3
6.3
11
10
N87
ICPC
Parkinsonism
7.2
6.3
14
20
R51.80
ICD-10 Finland
Headache
2.3
6.3
55
254
NAG67
NOMESCO Finland
Posterior interbody fusion of lumbar spine, more than 2 vertebrae
+∞
6.3
6
*
ABC30
NOMESCO Finland
Decompression of cervical nerve roots
+∞
6.3
6
*
S22.1
ICD-10 Finland
Multiple fractures of thoracic spine
+∞
6.3
6
*
Z56.5
ICD-10 Finland
Uncongenial work
+∞
6.3
6
*
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
27.1
6.2
8
*
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
27.1
6.2
8
*
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
27.1
6.2
8
*
WX702
NOMESCO Finland
Supraglottic ventilation device
3.7
6.2
25
70
N05CF02
ATC
zolpidem; oral
2.1
6.2
72
378
N06AG02
ATC
moclobemide; oral
4.2
6.2
22
55
J02AC01
ATC
fluconazole; systemic
1.8
6.2
142
951
M03BX01
ATC
baclofen; systemic
7.9
6.2
13
17
N06AB10
ATC
escitalopram; oral
2.1
6.1
71
369
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.9
6.1
36
133
K02.1
ICD-10 Finland
Caries of dentine
1.7
6.1
209
1566
RF220
NOMESCO Finland
NA
8.8
6.1
12
14
N06AX12
ATC
bupropion; oral
3.9
6.1
23
61
WX200
NOMESCO Finland
Interscalenous plexus blockade
6.2
6.0
15
25
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.5
6.0
48
210
JN3AD
NOMESCO Finland
Abdominal CT examination
2.9
6.0
35
128
D12
ICPC
Constipation
4.4
6.0
20
47
Mortality – FinRegistry
↥Association
Association between endpoint M13_KYPHOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_KYPHOSIS | 1.762 [1.47, 2.11] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.67 |
During the follow-up period (1.1.1998 — 31.12.2019), 324 out of 1582 females with M13_KYPHOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_KYPHOSIS | 1.699 [1.37, 2.1] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 334 out of 1602 males with M13_KYPHOSIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_KYPHOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.219% | 0.331% |
| 5 | 1.156% | 2.032% |
| 10 | 2.702% | 4.863% |
| 15 | 5.535% | 8.989% |
| 20 | 9.47% | 14.798% |
Relationships between endpoints
↥Index endpoint: M13_KYPHOSIS – Kyphosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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