No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
107 |
4. Check minimum number of eventsNone |
107 |
5. Include endpointsNone |
107 |
6. Filter based on genotype QC (FinnGen only) |
107 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Myositis ossificans
based on the number of shared cases.
Similar with more cases:
- Disorders of muscles
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 910 | 446 | 457 |
| Only index persons | 779 | 393 | 386 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.97 | 59.89 | 54.01 |
| Only index persons | 54.29 | 56.07 | 52.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 107 | 48 | 59 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 51.11 | 48.80 | 52.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 96
- Matched controls
- 960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M61.1
ICD-10 Finland
Myositis ossificans progressiva
+∞
51.8
45
*
M61.0
ICD-10 Finland
Myositis ossificans traumatica
+∞
46.7
41
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
13.5
22.3
42
52
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
12.0
12.0
22
23
M79.6
ICD-10 Finland
Pain in limb
5.2
11.8
45
139
7281A
ICD-9 Finland
Disorders of muscle, ligament and fascia, Muscular calcification and ossification[MYOSITIS PROGRESSIVA OSSIFICANS]
+∞
10.6
10
*
WX002
NOMESCO Finland
Sedation and analgesia
5.1
9.9
35
97
NF1AA
NOMESCO Finland
Hip X-ray examination
8.4
9.5
21
31
ZXA00
NOMESCO Finland
Right side
4.5
9.3
38
121
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
21.2
9.2
13
7
B01AB05
ATC
enoxaparin; parenteral
4.2
9.0
41
144
N03AX16
ATC
pregabalin; oral
4.6
9.0
35
106
NFB50
NOMESCO Finland
Primary total prosthetic replacement of hip joint using cement
16.9
7.9
12
8
N02BE01
ATC
paracetamol; systemic, rectal
5.2
7.4
87
625
M48.0
ICD-10 Finland
Spinal stenosis
5.3
7.4
23
54
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.5
7.2
21
46
N02AX02
ATC
tramadol; systemic, rectal
3.3
7.1
51
247
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
13.6
6.8
11
9
M01AC06
ATC
meloxicam; systemic, rectal
3.3
6.7
43
189
L13
ICPC
Hip symptom/complaint
4.6
6.5
23
62
M01AX05
ATC
glucosamine; oral
4.1
6.3
25
75
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.0
6.3
48
238
M01AE03
ATC
ketoprofen; systemic, rectal
3.0
6.2
47
230
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.3
6.1
23
66
Mortality – FinRegistry
↥Association
Association between endpoint M13_MYOSITISOSSIF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MYOSITISOSSIF | 1.458 [1.13, 1.89] | 0.004 |
| Birth year | 0.992 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 381 females with M13_MYOSITISOSSIF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MYOSITISOSSIF | 1.557 [1.22, 1.98] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 111 out of 355 males with M13_MYOSITISOSSIF died.
Mortality risk
Mortality risk for people of age
years, who have M13_MYOSITISOSSIF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | 0.386% |
| 5 | 0.821% | 2.098% |
| 10 | 1.829% | 5.174% |
| 15 | 3.638% | 9.824% |
| 20 | 6.346% | 16.21% |
Relationships between endpoints
↥Index endpoint: M13_MYOSITISOSSIF – Myositis ossificans
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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