Risteys · M13_OVERUSENAS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M70.8, M70.9 Hospital discharge: ICD-9 — 7266A Cause of death: ICD-10 — M70.8, M70.9 Cause of death: ICD-9 — 7266A 2 out of 7 registries used, show all original rules.	1143
4. Check minimum number of events None	1143
5. Include endpoints None	1143
6. Filter based on genotype QC (FinnGen only)	1143

	All	Female	Male
Number of individuals
Whole population	7457	4293	3132
Only index persons	7151	4134	3017
Unadjusted period prevalence (%)
Whole population	0.11	0.12	0.09
Only index persons	0.14	0.15	0.12
Median age at first event (years)
Whole population	44.30	46.78	40.94
Only index persons	43.99	46.43	40.63

	All	Female	Male
Number of individuals	1143	766	377
Unadjusted period prevalence (%)	0.23	0.26	0.17
Median age at first event (years)	51.04	49.82	53.52

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1019: Matched controls
10188

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M70.9

ICD-10 Finland

Unspecified soft tissue disorder related to use, overuse and pressure

470.8

323.0

344

M70.8

ICD-10 Finland

Other soft tissue disorders related to use, overuse and pressure

2277.0

323.0

660

M79.6

ICD-10 Finland

Pain in limb

4.3

91.1

447

1564

M01AH05

ATC

etoricoxib; oral

3.4

71.4

717

4191

M70.6

ICD-10 Finland

Trochanteric bursitis

6.3

70.9

208

400

N03AX16

ATC

pregabalin; oral

4.1

69.3

325

1038

M75.1

ICD-10 Finland

Rotator cuff syndrome

4.7

69.0

272

734

M25.5

ICD-10 Finland

Pain in joint

3.4

60.9

381

1517

N02AX02

ATC

tramadol; systemic, rectal

3.1

60.5

487

2322

N03AX12

ATC

gabapentin; oral

4.5

56.1

224

599

M54.5

ICD-10 Finland

Low back pain

3.0

54.0

413

1863

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

5.9

53.2

160

311

NBG15

NOMESCO Finland

Acromioplastia, arthroscopic

17.0

49.1

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

12.8

47.8

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.7

47.2

525

2914

M54.4

ICD-10 Finland

Lumbago with sciatica

3.8

47.0

232

741

M01AB05

ATC

diclofenac; systemic, rectal

2.6

42.7

733

5052

Z50.1

ICD-10 Finland

Other physical therapy

6.7

41.4

110

180

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

5.1

41.0

139

307

M03BX02

ATC

tizanidine; oral

2.5

40.7

693

4685

M01AE02

ATC

naproxen; oral, rectal

2.4

39.9

630

4076

M79.0

ICD-10 Finland

Rheumatism, unspecified

34.2

37.9

M79.1

ICD-10 Finland

Myalgia

4.0

37.1

161

453

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

3.6

36.6

185

592

M02AA07

ATC

piroxicam; topical

2.5

36.2

395

2077

M03BC01

ATC

orphenadrine (citrate); systemic

2.7

36.1

307

1401

NDM40

NOMESCO Finland

Discission of sheath of tendon of wrist or hand

101.3

36.0

NE1BG

NOMESCO Finland

Pelvic, hip and femur MRI examination with high intensity magnet

12.5

35.8

NBG10

NOMESCO Finland

Acromioplastia

98.6

35.0

N06AX21

ATC

duloxetine; oral

3.9

33.7

152

441

R4110

NOMESCO Finland

Physiotherapy

2.6

33.2

311

1490

M01AE03

ATC

ketoprofen; systemic, rectal

2.3

32.8

409

2273

N02AJ06

ATC

codeine and paracetamol; systemic

2.3

32.3

403

2235

N06AA09

ATC

amitriptyline; systemic

4.1

31.4

130

348

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.3

31.2

383

2097

A02BC02

ATC

pantoprazole; systemic

2.2

31.0

665

4697

M01AH02

ATC

rofecoxib; oral

3.4

30.9

164

542

M19.0

ICD-10 Finland

Primary arthrosis of other joints

4.6

30.4

112

268

M67.4

ICD-10 Finland

Ganglion

7.4

30.0

105

ZXA00

NOMESCO Finland

Right side

2.5

29.9

286

1373

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

19.6

29.8

Z3226

NOMESCO Finland

Physiotherapist

2.8

29.4

219

907

A02BC05

ATC

esomeprazole; systemic

2.2

28.9

428

2536

G56.0

ICD-10 Finland

Carpal tunnel syndrome

3.3

28.0

155

526

NH1BG

NOMESCO Finland

Ankle and foot MRI examination with high intensity magnet

15.0

27.7

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

4.5

27.5

103

250

L13

ICPC

Hip symptom/complaint

2.9

27.4

186

726

7266A

ICD-9 Finland

Peripheral enthesopathies and allied syndromes, Enthesopathy of knee[BURSITIS PEDIS ANSERINI]

+∞

27.2

M54.9

ICD-10 Finland

Dorsalgia, unspecified

3.6

27.2

134

416

M75.0

ICD-10 Finland

Adhesive capsulitis of shoulder

7.0

27.0

103

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

5.2

26.9

176

M01AC06

ATC

meloxicam; systemic, rectal

2.2

26.7

386

2242

J01AA02

ATC

doxycycline; systemic

2.2

26.7

797

6272

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

10.9

26.5

M01AH01

ATC

celecoxib; oral (coxibs)

2.7

26.0

206

880

J01DB01

ATC

cefalexin; oral

2.3

26.0

842

6829

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

2.1

25.7

466

2966

A02BC01

ATC

omeprazole; systemic

2.3

25.1

287

1487

M48.0

ICD-10 Finland

Spinal stenosis

3.5

25.1

126

396

M79.7

ICD-10 Finland

Fibromyalgia

10.9

25.0

X59

ICD-10 Finland

Exposure to unspecified factor

2.6

24.5

210

936

M17.1

ICD-10 Finland

Other primary gonarthrosis

2.6

24.2

193

826

N02BE01

ATC

paracetamol; systemic, rectal

2.3

23.9

862

7146

NHL16

NOMESCO Finland

Tenolysis or tenosynovectomy of achilles tendon

245.5

23.7

M77.1

ICD-10 Finland

Lateral epicondylitis

4.3

23.7

226

R07.4

ICD-10 Finland

Chest pain, unspecified

2.3

23.4

259

1317

M01AX17

ATC

nimesulide; oral

2.3

23.1

255

1292

M01AE01

ATC

ibuprofen; systemic, rectal

2.8

23.0

936

8146

G54.0

ICD-10 Finland

Brachial plexus disorders

9.6

23.0

R51.80

ICD-10 Finland

Headache

2.8

22.6

164

662

L08

ICPC

Shoulder symptom/complaint

2.6

22.6

186

807

R5599

NOMESCO Finland

Other rehabilitation service

7.9

22.6

H02AB06

ATC

prednisolone; systemic

2.0

22.5

454

2963

M65.3

ICD-10 Finland

Trigger finger

9.1

22.3

R52.2

ICD-10 Finland

Other chronic pain

7.6

22.0

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.2

21.7

278

1500

J01.0

ICD-10 Finland

Acute maxillary sinusitis

2.2

21.3

242

1239

M01AB55

ATC

diclofenac, combinations; oral

4.1

20.9

218

NCM10

NOMESCO Finland

Fasciotomy of forearm

112.3

20.6

NDM20

NOMESCO Finland

Excision of synovial ganglion of wrist or hand

42.6

20.5

Z46.9

ICD-10 Finland

Fitting and adjustment of unspecified device

13.4

20.3

NHM20

NOMESCO Finland

Excision of synovial ganglion of ankle or foot

33.3

20.3

A06AC01

ATC

ispaghula (psylla seeds); oral

2.2

20.1

247

1305

NB1CG

NOMESCO Finland

Shoulder and humerus extensive MRI examination with high intensity magnet

19.3

20.0

L03

ICPC

Low back symptom/complaint

2.2

19.9

248

1320

SPAT1236

SPAT

Informing family of child’s disability

7.2

19.8

M76.6

ICD-10 Finland

Achilles tendinitis

5.6

19.8

108

ZXA05

NOMESCO Finland

Left side

2.2

19.7

243

1282

R01AD09

ATC

mometasone; nasal

1.9

19.5

469

3205

ZXD10

NOMESCO Finland

Scheduled procedure

1.9

19.4

386

2465

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

2.2

19.1

235

1236

Z71.9

ICD-10 Finland

Counselling, unspecified

3.6

18.9

265

M47.80

ICD-10 Finland

Other spondylosis, multiple sites in spine

7.3

18.8

J01FA10

ATC

azithromycin; systemic

1.8

18.7

600

4488

L17

ICPC

Foot/toe symptom/complaint

2.1

18.6

243

1315

S46.0

ICD-10 Finland

Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder

3.9

18.5

212

ZXE10

NOMESCO Finland

More than one and less than three hours

1.9

18.3

355

2237

NGM10

NOMESCO Finland

Fasciotomy of of knee or lower leg

25.6

18.3

Z01.8

ICD-10 Finland

Other specified special examinations

2.2

18.3

218

1131

M53.1

ICD-10 Finland

Cervicobrachial syndrome

2.9

18.2

121

459

M02AA10

ATC

ketoprofen; topical

2.4

18.1

168

773

Z01.7

ICD-10 Finland

Laboratory examination

2.7

17.9

131

529

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.2

17.8

332

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

2.8

17.7

119

456

M77.4

ICD-10 Finland

Metatarsalgia

4.3

17.7

160

NBL00

NOMESCO Finland

Suture or reinsertation of rotator cuff of shoulder

5.9

17.6

R03AC02

ATC

salbutamol; inhalant

1.8

17.5

508

3648

M76.8

ICD-10 Finland

Other enthesopathies of lower limb, excluding foot

10.3

17.5

A02BC03

ATC

lansoprazole; oral

2.0

17.3

271

1570

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.3

17.2

184

904

J01MA02

ATC

ciprofloxacin; systemic

1.8

17.2

370

2407

J01FF01

ATC

clindamycin; systemic

2.0

17.1

272

1585

J01FA09

ATC

clarithromycin; systemic

1.9

17.0

326

2034

A02BA02

ATC

ranitidine; systemic

2.2

16.8

188

941

9473

FHL

Local soft tissue removal or exploration (eg Bursa)

+∞

16.7

M47.82

ICD-10 Finland

Other spondylosis, cervical region

5.5

16.7

Z12.3

ICD-10 Finland

Special screening examination for neoplasm of breast

11.9

16.6

X58

ICD-10 Finland

Exposure to other specified factors

2.5

16.6

145

644

Z13.5

ICD-10 Finland

Special screening examination for eye and ear disorders

13.7

16.5

M47.9

ICD-10 Finland

Spondylosis, unspecified

6.6

16.4

NGD05

NOMESCO Finland

Partial excision of meniscus of knee, arthroscopic

2.6

16.3

122

498

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

5.7

16.3

R05FB02

ATC

cough suppressants and expectorants

1.8

16.2

369

2430

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

4.2

15.9

152

J01DA01

ATC

[U] cefalexin; systemic

1.7

15.8

621

4830

J45.9

ICD-10 Finland

Asthma, unspecified

2.2

15.7

168

825

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.2

15.7

168

826

M67.8

ICD-10 Finland

Other specified disorders of synovium and tendon

26.7

15.6

NBG00

NOMESCO Finland

Plastic operation on acromioclavicular joint

26.7

15.6

A01

ICPC

Pain general/multiple sites

3.2

15.6

272

R42

ICD-10 Finland

Dizziness and giddiness

2.1

15.6

194

1019

G44.2

ICD-10 Finland

Tension-type headache

2.4

15.6

144

658

M65.8

ICD-10 Finland

Other synovitis and tenosynovitis

9.1

15.5

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

6.0

15.2

Z48.0

ICD-10 Finland

Attention to surgical dressings and sutures

4.2

15.2

144

N06AX16

ATC

venlafaxine; oral

2.3

15.2

149

702

M03BC51

ATC

orphenadrine, combinations; systemic

1.9

15.1

289

1785

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

4.5

15.0

122

N06CA01

ATC

amitriptyline and psycholeptics; systemic

2.7

15.0

109

435

M72.2

ICD-10 Finland

Plantar fascial fibromatosis

3.2

14.9

264

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.2

14.9

173

881

WX002

NOMESCO Finland

Sedation and analgesia

2.1

14.7

188

996

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.8

14.6

360

WX408

NOMESCO Finland

General anesthesy, balanced

1.9

14.6

259

1556

M54.6

ICD-10 Finland

Pain in thoracic spine

3.2

14.6

257

N03AE01

ATC

clonazepam; systemic

3.5

14.5

208

Z71.8

ICD-10 Finland

Other specified counselling

1.9

14.3

244

1443

M54.3

ICD-10 Finland

Sciatica

3.5

14.0

192

L28

ICPC

Limited function/disability (L)

2.3

13.9

131

602

S83.2

ICD-10 Finland

Tear of meniscus, current

3.0

13.9

283

M76.9

ICD-10 Finland

Enthesopathy of lower limb, unspecified

11.6

13.8

M75.8

ICD-10 Finland

Other shoulder lesions

5.5

13.7

ZXE00

NOMESCO Finland

One hour or less

1.7

13.7

378

2612

WX320

NOMESCO Finland

Spinalanesthesy

2.0

13.7

211

1201

M70.7

ICD-10 Finland

Other bursitis of hip

7.1

13.4

R06.0

ICD-10 Finland

Dyspnoea

1.9

13.4

207

1178

M79.9

ICD-10 Finland

Soft tissue disorder, unspecified

26.1

13.4

R52.9

ICD-10 Finland

Pain, unspecified

2.7

13.4

352

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

3.7

13.3

168

XF402

NOMESCO Finland

ECG with work load test

2.5

13.3

107

455

M76.0

ICD-10 Finland

Gluteal tendinitis

8.7

13.3

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.8

13.3

250

1525

M79.2

ICD-10 Finland

Neuralgia and neuritis, unspecified

10.6

13.3

ZXA10

NOMESCO Finland

Bilateral

2.0

13.2

173

925

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.9

13.1

217

1266

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.3

13.1

124

573

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.5

13.1

102

426

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

4.2

13.0

121

M77.0

ICD-10 Finland

Medial epicondylitis

6.5

13.0

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

4.3

12.9

117

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

3.1

12.8

235

R03AC03

ATC

terbutaline; inhalant

2.2

12.8

146

734

NE1AA

NOMESCO Finland

Pelvis X-ray examination

3.3

12.6

209

UJF32

NOMESCO Finland

Coloscopy

1.8

12.5

227

1367

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

3.5

12.5

178

G57.1

ICD-10 Finland

Meralgia paraesthetica

8.1

12.4

Z2221

NOMESCO Finland

Medical doctor

1.7

12.2

280

1815

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.7

12.2

328

J31.0

ICD-10 Finland

Chronic rhinitis

2.6

12.1

367

NBF25

NOMESCO Finland

Operation for humeroscapular osteochondritis, arthroscopic

11.2

12.1

S18

ICPC

Laceration/cut

1.7

12.0

359

2511

NBL22

NOMESCO Finland

Myotomy, tenotomy or excision of tendon of upper arm

21.6

12.0

NA6BG

NOMESCO Finland

Sacro-iliac joint MRI examination with high intensity magnet

9.4

12.0

N06AX11

ATC

mirtazapine; oral

1.7

11.9

294

1947

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.6

11.9

494

3772

K07.60

ICD-10 Finland

Snapping jaw

3.6

11.8

148

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

3.8

11.8

133

NG1CG

NOMESCO Finland

Knee and lower leg extensive MRI examination with high intensity magnet

5.9

11.7

R01AD08

ATC

fluticasone; nasal

1.7

11.7

285

1880

J01FA06

ATC

roxithromycin; oral

1.6

11.7

377

2691

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.2

11.7

123

595

R52.1

ICD-10 Finland

Chronic intractable pain

23.2

11.6

J02AC01

ATC

fluconazole; systemic

1.6

11.6

410

2994

NB1BG

NOMESCO Finland

Shoulder and humerus MRI examination with high intensity magnet

11.3

11.6

S83.6

ICD-10 Finland

Sprain and strain of other and unspecified parts of knee

3.3

11.5

178

H04.10

ICD-10 Finland

Dry eye syndrome

2.4

11.5

416

R03DC03

ATC

montelukast; oral

2.0

11.5

159

865

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

3.1

11.5

222

L29

ICPC

Musculoskeletal sympt/complt other

2.8

11.5

283

NB1BA

NOMESCO Finland

Shoulder extensive X-ray examination without contrast

5.3

11.4

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

2.6

11.4

353

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

2.4

11.4

425

D06

ICPC

Abdominal pain localized other

2.6

11.3

340

M65.4

ICD-10 Finland

Radial styloid tenosynovitis [de Quervain]

6.3

11.3

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.6

11.3

364

2590

M54

ICD-10 Finland

Dorsalgia

2.3

11.2

109

510

J01CA04

ATC

amoxicillin; systemic

1.7

11.1

797

6933

M01AX05

ATC

glucosamine; oral

2.0

11.1

156

855

R07.3

ICD-10 Finland

Other chest pain

2.5

11.1

358

XA402

NOMESCO Finland

ENMG

5.2

11.0

M54.2

ICD-10 Finland

Cervicalgia

2.7

10.9

289

M71.2

ICD-10 Finland

Synovial cyst of popliteal space [Baker]

6.1

10.9

B01AB05

ATC

enoxaparin; parenteral

1.7

10.9

254

1644

M13.9

ICD-10 Finland

Arthritis, unspecified

2.9

10.9

249

Z00.8

ICD-10 Finland

Other general examinations

2.7

10.9

298

Z71.2

ICD-10 Finland

Person consulting for explanation of investigation findings

1.8

10.9

216

1332

M15.9

ICD-10 Finland

Polyarthrosis, unspecified

3.5

10.9

143

Z3231

NOMESCO Finland

Registered nurse

1.7

10.8

249

1608

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

2.4

10.8

416

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

2.5

10.8

376

R06AX27

ATC

desloratadine; oral

1.7

10.8

270

1787

R4120

NOMESCO Finland

Occupational therapy

2.9

10.8

245

NBA30

NOMESCO Finland

Exploration of joint of shoulder or upper arm, arthroscopic

9.7

10.8

N02AA05

ATC

oxycodone; systemic

2.2

10.8

108

511

M01AB08

ATC

etodolac; oral

2.6

10.7

321

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

2.9

10.7

240

ACC51

NOMESCO Finland

Release of median nerve

2.8

10.6

265

1220

FHL

Arthroscopy

3.8

10.6

120

ND1CG

NOMESCO Finland

Wrist and hand extensive MRI examination with high intensity magnet

11.4

10.6

WX110

NOMESCO Finland

Local anesthesy

1.6

10.5

659

5485

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

2.5

10.5

349

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

2.3

10.4

101

473

NBE45

NOMESCO Finland

Plastic repair of ligament of shoulder not using prosthetic material, arthroscopic

8.9

10.3

A03FA02

ATC

cisapride; oral, rectal

2.8

10.3

258

ZXD20

NOMESCO Finland

Day surgery

2.1

10.3

123

631

XX9CW

NOMESCO Finland

Submitting image material and/or investigation material to patient

9.7

10.3

M77.9

ICD-10 Finland

Enthesopathy, unspecified

4.4

10.3

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

4.4

10.3

R05

ICD-10 Finland

Cough

1.9

10.2

174

1019

XF400

NOMESCO Finland

ECG with 12 standard connections

2.0

10.2

136

726

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

3.4

10.1

147

NB2AT

NOMESCO Finland

Intra artrial injection of shoulder with ultrasound guidance

14.7

10.0

R06AE07

ATC

cetirizine; oral

1.6

10.0

413

3102

M70.0

ICD-10 Finland

Chronic crepitant synovitis of hand and wrist

40.5

10.0

R10.2

ICD-10 Finland

Pelvic and perineal pain

5.0

10.0

M65.9

ICD-10 Finland

Synovitis and tenosynovitis, unspecified

5.7

9.9

NBT60

NOMESCO Finland

Forcible manipulation of humeroscapular joint

26.3

9.8

NDM10

NOMESCO Finland

Palmar fasciotomy of hand

26.3

9.8

L11

ICPC

Wrist symptom/complaint

2.5

9.7

311

NAG40

NOMESCO Finland

Anterior fusion of cervical spine without fixation

5.2

9.7

L12

ICPC

Hand/finger symptom/complaint

2.0

9.7

127

675

M54.1

ICD-10 Finland

Radiculopathy

3.7

9.7

114

A04

ICPC

Weakness/tiredness general

2.1

9.7

106

524

L01

ICPC

Neck symptom/complaint

2.0

9.6

126

669

N02CC01

ATC

sumatriptan; nasal, systemic, rectal

1.9

9.6

143

799

Z03.5

ICD-10 Finland

Observation for other suspected cardiovascular diseases

2.4

9.6

335

N06AA10

ATC

nortriptyline; systemic

5.5

9.6

M75.2

ICD-10 Finland

Bicipital tendinitis

5.5

9.6

P01AB01

ATC

metronidazole; oral, rectal

1.6

9.5

375

2775

M75.3

ICD-10 Finland

Calcific tendinitis of shoulder

9.2

9.5

R01AD12

ATC

fluticasone furoate; nasal

1.6

9.5

289

2007

K58.0

ICD-10 Finland

Irritable bowel syndrome with diarrhoea

2.8

9.5

223

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.7

9.5

241

1597

Z51.88

ICD-10 Finland

Other specified medical care

5.0

9.5

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

2.6

9.5

284

M66.4

ICD-10 Finland

Spontaneous rupture of other tendons

+∞

9.4

NHM10

NOMESCO Finland

Fasciotomy of ankle or foot

+∞

9.4

NHM99

NOMESCO Finland

Other operation on fascia, ganglion, synovial sheath or bursa of ankle or foot

12.5

9.4

NG1BG

NOMESCO Finland

Knee and lower leg MRI examination with high intensity magnet

3.5

9.4

123

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.5

9.3

451

3498

L14

ICPC

Leg/thigh symptom/complaint

2.6

9.2

271

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.8

9.2

164

974

R03AK07

ATC

formoterol and budesonide; inhalant

1.8

9.2

175

1062

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

2.4

9.2

334

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.6

9.1

266

M50.3

ICD-10 Finland

Other cervical disc degeneration

4.9

9.0

G56.4

ICD-10 Finland

Causalgia

37.0

9.0

NB1AT

NOMESCO Finland

Puncture of shoulder with ultrasound guidance

37.0

9.0

J45.0

ICD-10 Finland

Predominantly allergic asthma

2.3

9.0

352

SPAT1212

SPAT

Extensive examination of musculoskeletal system

2.4

9.0

340

Z01.1

ICD-10 Finland

Examination of ears and hearing

2.0

8.9

115

607

R60.0

ICD-10 Finland

Localized oedema

2.2

8.9

422

C07AB07

ATC

bisoprolol; oral

1.5

8.9

361

2680

ND1AA

NOMESCO Finland

Wrist X-ray examination

2.8

8.9

214

S43.4

ICD-10 Finland

Sprain and strain of shoulder joint

4.0

8.9

R74

ICPC

Upper respiratory infection acute

1.6

8.9

264

1820

R02

ICPC

Shortness of breath/dyspnoea

2.1

8.8

488

M17.9

ICD-10 Finland

Gonarthrosis, unspecified

2.3

8.8

382

F01

ICPC

Eye pain

4.0

8.8

Z26.9

ICD-10 Finland

Need for immunization against unspecified infectious disease

4.8

8.8

M02AA15

ATC

diclofenac; topical (antiinflammatory prep., non-steroids for topical use)

2.4

8.8

318

M16.1

ICD-10 Finland

Other primary coxarthrosis

2.2

8.8

432

L15

ICPC

Knee symptom/complaint

1.8

8.7

171

1046

WX308

NOMESCO Finland

Sacral anesthesy

50.4

8.7

R20.2

ICD-10 Finland

Paraesthesia of skin

2.6

8.7

255

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

3.0

8.7

168

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.1

8.7

463

R13

ICD-10 Finland

Dysphagia

2.7

8.7

230

R03AC12

ATC

salmeterol; inhalant

3.3

8.6

126

M01AX01

ATC

nabumetone; oral

3.3

8.6

126

JN3BD

NOMESCO Finland

Extensive abdominal CT

2.1

8.6

478

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

2.6

8.6

249

X50

ICD-10 Finland

Overexertion and strenuous or repetitive movements

4.8

8.6

SAA01

NOMESCO Finland

Simple examination of mouth

1.5

8.4

659

5619

73398

ICD-8 Finland

Other diseases of muscle, tendon and fascia, Alii definiti

+∞

8.3

R06.4

ICD-10 Finland

Hyperventilation

5.3

8.3

E0000UV

ATC

1.5

8.3

357

2677

XF404

NOMESCO Finland

Ambulatory ECG

2.2

8.3

395

G43.1

ICD-10 Finland

Migraine with aura [classical migraine]

2.4

8.2

289

M01AG02

ATC

tolfenamic acid; oral, rectal

1.8

8.2

155

934

D01

ICPC

Abdominal pain/cramps general

2.0

8.2

105

552

J01MA12

ATC

levofloxacin; systemic

1.8

8.2

147

875

Z01.3

ICD-10 Finland

Examination of blood pressure

7.6

8.2

N01

ICPC

Headache

2.1

8.1

483

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.7

8.1

202

N41.1

ICD-10 Finland

Chronic prostatitis

4.5

8.1

K30

ICD-10 Finland

Functional dyspepsia

2.1

8.1

476

D02

ICPC

Abdominal pain epigastric

2.5

8.1

240

D07AD01

ATC

clobetasol; topical

1.8

8.1

144

854

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

2.0

8.0

102

536

N05CF01

ATC

zopiclone; oral

1.6

8.0

262

1843

NH1CG

NOMESCO Finland

Ankle and foot extensive MRI examination with high intensity magnet

5.9

8.0

L05

ICPC

Flank/axilla symptom/complaint

2.8

8.0

191

L86

ICPC

Back syndrome with radiating pain

2.8

8.0

191

M21.4

ICD-10 Finland

Flat foot [pes planus] (acquired)

3.8

8.0

M35.7

ICD-10 Finland

Hypermobility syndrome

7.3

8.0

N81.6

ICD-10 Finland

Rectocele

2.5

8.0

261

SHB00

NOMESCO Finland

Prepation and fitting of bite rail to mouth

2.1

8.0

456

L16

ICPC

Ankle symptom/complaint

2.1

8.0

443

UKC02

NOMESCO Finland

Cystoscopy

1.9

8.0

115

633

K02.1

ICD-10 Finland

Caries of dentine

1.5

8.0

527

4312

N03AF01

ATC

carbamazepine; oral, rectal

2.8

8.0

184

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.5

8.0

337

2512

A02BA04

ATC

nizatidine; systemic

2.3

8.0

301

M01AC01

ATC

piroxicam; systemic, rectal

1.9

7.9

113

621

AA1AD

NOMESCO Finland

CT of head and brain

1.7

7.9

185

1190

WX120

NOMESCO Finland

Intravenous local anesthesy of arm

7.8

7.9

WZC30

SPAT

4.4

7.9

M43.1

ICD-10 Finland

Spondylolisthesis

3.1

7.8

136

G43.9

ICD-10 Finland

Migraine, unspecified

2.5

7.8

248

M01AB01

ATC

indometacin; systemic, rectal

2.5

7.8

257

R96

ICPC

Asthma

2.2

7.8

364

R03BA05

ATC

fluticasone; inhalant

1.7

7.8

158

975

ZXE06

NOMESCO Finland

Procedure duration 50 to 59 minutes

2.6

7.8

214

TAB00

NOMESCO Finland

Lumbar puncture

2.9

7.7

166

R35

ICD-10 Finland

Polyuria

2.6

7.7

207

WYA10

NOMESCO Finland

First aid or other corresponding healthcare contact

2.2

7.7

373

XFE00

NOMESCO Finland

Epicardial ultrasonography

4.2

7.6

SPAT1263

SPAT

Sampling

1.5

7.6

363

2771

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

2.0

7.6

496

M17

ICD-10 Finland

Gonarthrosis [arthrosis of knee]

2.1

7.6

403

M71.9

ICD-10 Finland

Bursopathy, unspecified

11.9

7.6

NHL50

NOMESCO Finland

Tenolysis or tenosynovectomy of foot

25.2

7.6

NC1CG

NOMESCO Finland

Elbow and forearm extensive MRI examination with high intensity magnet

25.2

7.6

R06AX22

ATC

ebastine; oral

1.7

7.6

170

1081

NB1AE

NOMESCO Finland

Shoulder ultrasound examination

6.2

7.6

R21

ICPC

Throat symptom/complaint

1.7

7.5

179

1158

R01BA52

ATC

pseudoephedrine, combinations; oral

1.5

7.5

286

2082

M22.4

ICD-10 Finland

Chondromalacia patellae

3.4

7.5

102

XX9AW

NOMESCO Finland

Production of copy from X-ray picture

3.4

7.5

102

M19.1

ICD-10 Finland

Post-traumatic arthrosis of other joints

4.5

7.5

XKD06

NOMESCO Finland

Physiologic investigation of micturition

3.7

7.4

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

1.8

7.3

123

716

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

1.6

7.3

200

1340

ND1BG

NOMESCO Finland

Wrist and hand MRI examination with high intensity magnet

8.4

7.3

J45.1

ICD-10 Finland

Nonallergic asthma

2.3

7.3

279

LC2BE

NOMESCO Finland

Transvaginal ultrasound examination of uterus, parametria and lower abdomen

1.5

7.3

266

1909

M19.8

ICD-10 Finland

Other specified arthrosis

3.6

7.3

M75.9

ICD-10 Finland

Shoulder lesion, unspecified

3.3

7.3

104

M76.7

ICD-10 Finland

Peroneal tendinitis

11.0

7.3

M24.8

ICD-10 Finland

Other specific joint derangements, not elsewhere classified

11.0

7.3

Q66.7

ICD-10 Finland

Pes cavus

+∞

7.3

7261X

ICD-9 Finland

Peripheral enthesopathies and allied syndromes, Rotator cuff syndrome of shoulder and allied disorders[MUU TAI TARKEMMIN MÄÄRITTELEM KIERTÄJÄKALVOSINSDR]

+∞

7.3

NCL22

NOMESCO Finland

Myotomy or tenotomy of elbow or forearm

+∞

7.3

K58.9

ICD-10 Finland

Irritable bowel syndrome without diarrhoea

3.1

7.3

121

A07EC01

ATC

sulfasalazine; oral, rectal

2.2

7.2

327

S13.4

ICD-10 Finland

Sprain and strain of cervical spine

3.0

7.2

142

WX203

NOMESCO Finland

Infraclavicular plexus blockade

4.0

7.2

L04

ICPC

Chest symptom/complaint

2.5

7.2

224

E66.00

ICD-10 Finland

Metabolic syndrome

2.6

7.2

206

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.4

7.1

502

4124

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

2.5

7.1

218

R07.0

ICD-10 Finland

Pain in throat

2.4

7.1

245

I80.3

ICD-10 Finland

Phlebitis and thrombophlebitis of lower extremities, unspecified

3.6

7.1

Z01.6

ICD-10 Finland

Radiological examination, not elsewhere classified

2.0

7.1

436

N04BC05

ATC

pramipexole; oral

2.4

7.1

238

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.1

7.1

374

NBE35

NOMESCO Finland

Transposition of ligament of shoulder, arthroscopic

10.1

7.0

M75

ICD-10 Finland

Shoulder lesions

3.0

7.0

139

Z04.9

ICD-10 Finland

Examination and observation for unspecified reason

3.0

7.0

139

F33.11

ICD-10 Finland

Recurrent depression, moderate episode of somatic syndrome

3.8

7.0

ND2DA

NOMESCO Finland

Bilateral hand X-ray examination

5.0

7.0

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

2.2

7.0

341

NHK99

NOMESCO Finland

Other operation on bone of ankle or foot

5.2

7.0

M53.3

ICD-10 Finland

Sacrococcygeal disorders, not elsewhere classified

6.4

7.0

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.6

6.9

226

1580

R51.81

ICD-10 Finland

Facial pain NOS

4.1

6.9

SPAT1215

SPAT

Assessment of need for medical rehabilitation

2.8

6.9

155

R22.9

ICD-10 Finland

Localized swelling, mass and lump, unspecified

2.2

6.9

322

S01GX01

ATC

cromoglicic acid; ophthalmic

1.6

6.9

187

1251

N05BA01

ATC

diazepam; systemic, rectal

1.8

6.9

112

645

SPAT1153

SPAT

Removal of sutures

1.5

6.9

248

1778

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.5

6.8

349

2686

M54.8

ICD-10 Finland

Other dorsalgia

2.9

6.8

136

LEF03

NOMESCO Finland

Posterior colporrpahy with sutures for primary rectocele

2.9

6.8

136

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

4.2

6.8

KMAK

NOMESCO Finland

1.4

6.8

483

3959

Z09.0

ICD-10 Finland

Follow-up examination after surgery for other conditions

2.1

6.8

388

M70.5

ICD-10 Finland

Other bursitis of knee

11.0

6.8

SPAT1285

SPAT

Provision of consultation response

2.5

6.8

211

H02BX01

ATC

methylprednisolone, combinations; systemic

2.9

6.8

137

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

1.8

6.8

111

638

AB5BT

NOMESCO Finland

Blockage of nerv root with X-ray guidance

9.4

6.8

D10

ICPC

Vomiting

2.4

6.8

231

S06.0

ICD-10 Finland

Concussion

2.0

6.8

433

N06AB10

ATC

escitalopram; oral

1.6

6.7

174

1149

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.5

6.7

258

1871

9736

FHL

Subcutaneous tumor removal in operating room or anesthesia

7.2

6.7

L30.9

ICD-10 Finland

Dermatitis, unspecified

1.7

6.7

148

936

G04BD12

ATC

mirabegron; oral

2.1

6.7

384

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

5.0

6.7

M71.5

ICD-10 Finland

Other bursitis, not elsewhere classified

22.7

6.7

OAB50

SPAT

6.5

6.6

G56.2

ICD-10 Finland

Lesion of ulnar nerve

3.5

6.6

A07AA02

ATC

nystatin; oral

2.3

6.6

259

JAH01

NOMESCO Finland

Laparoscopy

2.5

6.6

190

N02AC04

ATC

dextropropoxyphene; oral

3.4

6.6

A29

ICPC

General symptom/complaint other

1.9

6.6

481

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

3.3

6.5

ABD30

NOMESCO Finland

Implantation of spinal stimulation device

10.1

6.5

M09AA72

ATC

quinine, combinations with psycholeptics; systemic

4.2

6.5

I80.29

ICD-10 Finland

Phlebitis and thrombophlebitis of other deep vessels of lower extremities

3.6

6.5

G57.6

ICD-10 Finland

Lesion of plantar nerve

4.0

6.5

NGF35

NOMESCO Finland

Plastic operation of joint cartilage of knee

3.3

6.5

R05

ICPC

Cough

1.6

6.5

183

1235

R00.2

ICD-10 Finland

Palpitations

2.1

6.5

346

G55.2*M47.9

ICD-10 Finland

Nerve root and plexus compressions in spondylosis

5.4

6.5

K44.9

ICD-10 Finland

Diaphragmatic hernia without obstruction or gangrene

2.3

6.5

264

WX204

NOMESCO Finland

Axillary plexus blockaced

3.4

6.5

K80

ICPC

Cardiac arrhythmia NOS

2.2

6.5

298

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

4.3

6.4

N39.4

ICD-10 Finland

Other specified urinary incontinence

2.2

6.4

312

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

2.0

6.4

390

M72.0

ICD-10 Finland

Palmar fascial fibromatosis [Dupuytren]

7.5

6.4

K59.0

ICD-10 Finland

Constipation

2.6

6.4

179

M48.9

ICD-10 Finland

Spondylopathy, unspecified

14.4

6.4

K11.2

ICD-10 Finland

Sialoadenitis

3.2

6.4

U07.2

ICD-10 Finland

COVID-19, virus not identified

1.6

6.4

160

1047

N06AA12

ATC

doxepin; systemic

2.5

6.4

188

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

8.2

6.3

G55.1*M51.9

ICD-10 Finland

Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)

8.2

6.3

C09CA06

ATC

candesartan; oral

1.6

6.3

181

1224

G50.1

ICD-10 Finland

Atypical facial pain

4.0

6.3

G56.3

ICD-10 Finland

Lesion of radial nerve

11.1

6.3

P01BA02

ATC

hydroxychloroquine; oral

2.1

6.3

334

Z01.2

ICD-10 Finland

Dental examination

1.4

6.3

363

2856

R05FA02

ATC

opium derivatives and expectorants; systemic

1.4

6.3

349

2725

M66.0

ICD-10 Finland

Rupture of popliteal cyst

18.1

6.3

N02AJ13

ATC

tramadol and paracetamol; systemic

4.4

6.3

Z3229

NOMESCO Finland

Other healthcare associate professional

2.1

6.2

337

H02AB04

ATC

methylprednisolone; systemic

1.7

6.2

118

712

NF1AA

NOMESCO Finland

Hip X-ray examination

2.1

6.2

303

R03AC13

ATC

formoterol; inhalant

2.5

6.2

185

C03CA01

ATC

furosemide; systemic

1.6

6.2

161

1062

ZXE20

NOMESCO Finland

More than three and less than five hours

1.8

6.2

111

660

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

3.2

6.1

ZXE05

NOMESCO Finland

Procedure duration 40 to 49 minutes

2.3

6.1

225

J01AA07

ATC

tetracycline; systemic

1.7

6.1

141

900

J01MA01

ATC

ofloxacin; systemic

2.1

6.1

346

H66.9

ICD-10 Finland

Otitis media, unspecified

2.4

6.1

206

I87.2

ICD-10 Finland

Venous insufficiency (chronic)(peripheral)

1.9

6.1

443

K12.10

ICD-10 Finland

Stomatitis NOS

12.6

6.1

WX105

NOMESCO Finland

Surface analgesia on skin or mucosa

1.9

6.0

421

SBB10

NOMESCO Finland

Teeth copy

2.2

6.0

253

R01AD11

ATC

triamcinolone; nasal

2.0

6.0

407

M84.3

ICD-10 Finland

Stress fracture, not elsewhere classified

6.1

6.0

NAME	M13_OVERUSENAS
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M70[8-9]
HD_ICD_9	7266A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M70[8-9]
COD_ICD_9	7266A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
M13_OVERUSENAS	1.099 [0.95, 1.27]	0.192
Birth year	1.001 [0.99, 1.01]	0.813

Parameter	HR [95% CI]	p-value
M13_OVERUSENAS	1.009 [0.86, 1.19]	0.91
Birth year	0.988 [0.98, 1.0]	0.011

N-year risk	Females	Males
1	0.119%	0.23%
5	0.688%	1.344%
10	1.744%	3.272%
15	3.526%	6.085%
20	6.667%	10.218%

Other/unspecified soft tissue disorders related to use, overuse and pressure

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints