Risteys · M13_SPONDYLOPATHYNAS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M48.8, M48.9 Cause of death: ICD-10 — M48.8, M48.9 2 out of 7 registries used, show all original rules.	944
4. Check minimum number of events None	944
5. Include endpoints None	944
6. Filter based on genotype QC (FinnGen only)	944

	All	Female	Male
Number of individuals
Whole population	6865	3859	2962
Only index persons	6209	3561	2648
Unadjusted period prevalence (%)
Whole population	0.10	0.11	0.08
Only index persons	0.12	0.13	0.10
Median age at first event (years)
Whole population	68.14	70.49	65.01
Only index persons	67.04	69.66	63.51

	All	Female	Male
Number of individuals	944	509	435
Unadjusted period prevalence (%)	0.18	0.17	0.19
Median age at first event (years)	64.93	63.21	66.95

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
847: Matched controls
8469

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M48.0

ICD-10 Finland

Spinal stenosis

420.0

323.0

533

M48.9

ICD-10 Finland

Spondylopathy, unspecified

+∞

323.0

601

M48.8

ICD-10 Finland

Other specified spondylopathies

3579.8

293.3

266

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

96.8

272.1

293

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

558.2

257.1

243

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

83.1

209.1

231

N03AX16

ATC

pregabalin; oral

11.5

195.7

439

725

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

23.2

157.3

234

137

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

98.0

147.4

160

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

218.2

143.7

145

M54.5

ICD-10 Finland

Low back pain

7.7

140.6

408

914

M54.4

ICD-10 Finland

Lumbago with sciatica

14.1

139.8

256

252

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

10.6

136.8

296

407

N03AX12

ATC

gabapentin; oral

11.0

131.5

276

355

N02AX02

ATC

tramadol; systemic, rectal

6.1

129.2

553

2002

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

59.2

104.2

122

M47.9

ICD-10 Finland

Spondylosis, unspecified

70.0

96.5

110

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

218.6

95.5

M54.9

ICD-10 Finland

Dorsalgia, unspecified

14.3

94.1

167

143

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

4.3

86.0

505

2169

M43.1

ICD-10 Finland

Spondylolisthesis

159.2

82.7

NAG62

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, 2-3 vertebraea

437.6

81.4

L03

ICPC

Low back symptom/complaint

5.3

79.5

293

774

N06AX21

ATC

duloxetine; oral

8.6

73.3

171

242

N06AA09

ATC

amitriptyline; systemic

7.1

66.2

177

305

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

181.6

65.0

M54.3

ICD-10 Finland

Sciatica

19.4

64.7

100

M47.82

ICD-10 Finland

Other spondylosis, cervical region

31.6

62.4

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

22.4

60.7

M03BX02

ATC

tizanidine; oral

3.3

59.3

548

3012

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

608.0

58.4

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

34.1

57.5

N02BE01

ATC

paracetamol; systemic, rectal

5.3

55.0

782

5869

NAG40

NOMESCO Finland

Anterior fusion of cervical spine without fixation

+∞

52.6

M79.6

ICD-10 Finland

Pain in limb

3.2

51.5

367

1618

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

271.0

50.7

L86

ICPC

Back syndrome with radiating pain

11.5

50.5

M01AH05

ATC

etoricoxib; oral

3.0

50.2

527

3003

N02AA05

ATC

oxycodone; systemic

4.1

48.8

220

665

ABC26

NOMESCO Finland

Open discectomy of lumbar spine

+∞

46.3

M54.1

ICD-10 Finland

Radiculopathy

26.1

45.2

ABC16

NOMESCO Finland

Microsurgical excision of lumbar intervertebral disc displacement

+∞

45.2

7227C

ICD-9 Finland

Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]

+∞

43.1

M01AX17

ATC

nimesulide; oral

3.2

42.6

291

1204

M47.80

ICD-10 Finland

Other spondylosis, multiple sites in spine

42.5

42.1

M01AH01

ATC

celecoxib; oral (coxibs)

3.6

41.5

219

746

N02AJ06

ATC

codeine and paracetamol; systemic

2.9

41.3

338

1574

G55.2*M47.9

ICD-10 Finland

Nerve root and plexus compressions in spondylosis

220.6

41.2

A02BC02

ATC

pantoprazole; systemic

2.8

41.0

601

3968

M75.1

ICD-10 Finland

Rotator cuff syndrome

3.3

41.0

252

962

M01AH02

ATC

rofecoxib; oral

4.1

40.9

178

513

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.5

39.9

218

760

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.9

39.8

332

1555

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.9

38.5

309

1408

M01AB05

ATC

diclofenac; systemic, rectal

2.6

36.3

566

3730

WX408

NOMESCO Finland

General anesthesy, balanced

2.8

35.6

285

1283

ZZH21

NOMESCO Finland

Graft of patients own bone, small pieces

18.3

35.4

R07.4

ICD-10 Finland

Chest pain, unspecified

2.8

34.8

283

1285

M03BC51

ATC

orphenadrine, combinations; systemic

2.9

34.3

256

1098

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

43.0

33.4

M53.1

ICD-10 Finland

Cervicobrachial syndrome

5.3

33.1

107

225

M51.9

ICD-10 Finland

Intervertebral disc disorder, unspecified

93.9

33.0

M01AC06

ATC

meloxicam; systemic, rectal

2.5

32.6

349

1840

M19.0

ICD-10 Finland

Primary arthrosis of other joints

4.5

32.5

125

316

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

7.5

32.3

115

NAG63

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, more than 3 vertebraea

328.8

32.1

M50.3

ICD-10 Finland

Other cervical disc degeneration

49.6

31.8

M96.1

ICD-10 Finland

Postlaminectomy syndrome, not elsewhere classified

+∞

31.4

M47.1

ICD-10 Finland

Other spondylosis with myelopathy

+∞

31.4

A02BC03

ATC

lansoprazole; oral

2.6

31.3

298

1462

G56.0

ICD-10 Finland

Carpal tunnel syndrome

3.7

31.3

150

463

N06AX11

ATC

mirtazapine; oral

2.5

30.7

312

1588

H02AB06

ATC

prednisolone; systemic

2.3

30.6

440

2671

72510

ICD-8 Finland

Displacement of intervertebral disk, Lumbalis cum prolapsu disci

+∞

30.4

J01DB01

ATC

cefalexin; oral

2.6

29.9

691

5300

M54.2

ICD-10 Finland

Cervicalgia

7.4

29.7

107

R06.0

ICD-10 Finland

Dyspnoea

2.6

29.5

265

1252

C03CA01

ATC

furosemide; systemic

2.4

29.5

352

1940

M03BC01

ATC

orphenadrine (citrate); systemic

3.0

29.4

194

755

M25.5

ICD-10 Finland

Pain in joint

2.7

29.4

247

1122

9211

FHL

Exploration or removal of diskusprolapse

+∞

29.3

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.9

28.4

196

787

M51.8

ICD-10 Finland

Other specified intervertebral disc disorders

+∞

28.3

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.3

27.6

349

1958

L28

ICPC

Limited function/disability (L)

2.9

27.6

192

772

M01AE03

ATC

ketoprofen; systemic, rectal

2.3

27.4

360

2056

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.4

27.4

288

1473

R52.2

ICD-10 Finland

Other chronic pain

10.4

27.3

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

10.6

27.1

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

6.0

27.0

139

R51.80

ICD-10 Finland

Headache

3.5

26.7

135

432

G55.1*M51.1

ICD-10 Finland

Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions

47.4

26.6

M01AE01

ATC

ibuprofen; systemic, rectal

2.7

26.3

721

5786

AA1AD

NOMESCO Finland

CT of head and brain

2.5

26.2

255

1243

M01AE02

ATC

naproxen; oral, rectal

2.2

25.9

462

3014

ABC60

NOMESCO Finland

Decompression of cervical spinal cord

268.4

25.8

M43.0

ICD-10 Finland

Spondylolysis

268.4

25.8

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

4.2

25.8

104

273

N05CF01

ATC

zopiclone; oral

2.3

25.8

333

1871

S18

ICPC

Laceration/cut

2.2

25.6

394

2403

NF1AA

NOMESCO Finland

Hip X-ray examination

3.6

25.2

123

382

R03AC02

ATC

salbutamol; inhalant

2.2

25.1

442

2851

L13

ICPC

Hip symptom/complaint

2.9

25.0

171

675

X59

ICD-10 Finland

Exposure to unspecified factor

2.8

25.0

183

754

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.2

24.9

343

1981

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

28.5

24.6

A02BC05

ATC

esomeprazole; systemic

2.2

24.6

352

2067

N06AX16

ATC

venlafaxine; oral

3.4

24.3

127

415

M17.1

ICD-10 Finland

Other primary gonarthrosis

2.5

24.3

225

1062

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.9

24.3

170

681

J01FF01

ATC

clindamycin; systemic

2.4

24.2

263

1351

UJF32

NOMESCO Finland

Coloscopy

2.4

24.2

251

1257

TAB20

NOMESCO Finland

Epidural puncture

57.8

24.2

9212

FHL

Other posterior root decompression surgery (eg laminectomy, Gill)

+∞

24.1

M48

ICD-10 Finland

Other spondylopathies

89.4

23.8

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

3.0

23.6

156

599

G44.2

ICD-10 Finland

Tension-type headache

3.4

23.6

124

407

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

3.4

23.4

122

398

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.1

23.2

412

2636

M16.1

ICD-10 Finland

Other primary coxarthrosis

3.1

23.1

143

528

WX308

NOMESCO Finland

Sacral anesthesy

+∞

23.0

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

3.2

23.0

132

461

M45

ICD-10 Finland

Ankylosing spondylitis

85.8

22.8

Z01.8

ICD-10 Finland

Other specified special examinations

2.5

22.7

204

941

ZXE20

NOMESCO Finland

More than three and less than five hours

2.8

22.5

164

671

F32.9

ICD-10 Finland

Depressive episode, unspecified

3.6

22.4

108

331

J01MA02

ATC

ciprofloxacin; systemic

2.1

22.4

361

2207

M01AB51

ATC

indometacin, combinations; oral, rectal

10.7

22.3

N06CA01

ATC

amitriptyline and psycholeptics; systemic

3.5

22.3

111

349

N03AE01

ATC

clonazepam; systemic

4.9

22.1

161

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

3.9

22.1

275

A02BC01

ATC

omeprazole; systemic

2.3

22.0

265

1419

G99.2*M47.9

ICD-10 Finland

Myelopathy in spondylosis

+∞

22.0

NAG65

NOMESCO Finland

Anterior and posterior fusion of lumbar spine

+∞

22.0

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

6.6

21.4

M70.6

ICD-10 Finland

Trochanteric bursitis

3.1

21.4

125

442

ACC51

NOMESCO Finland

Release of median nerve

4.1

21.3

231

A06AD11

ATC

lactulose; oral

2.6

21.2

181

809

NA3SA

NOMESCO Finland

Lumbar spine X-ray examination in standing position

51.4

21.2

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.0

21.0

390

2504

M54.0

ICD-10 Finland

Panniculitis affecting regions of neck and back

61.6

21.0

M54.6

ICD-10 Finland

Pain in thoracic spine

6.0

20.9

105

7240B

ICD-9 Finland

Other and unspecified disorders of back, Spinal stenosis, other than cervical[STENOSIS CANALIS SPINALIS LUMBOSACRALIS]

+∞

20.9

72880

ICD-8 Finland

Vertebrogenic pain syndrome, Radicula syndrome of lower limbs

+∞

20.9

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

4.0

20.9

230

NE1AA

NOMESCO Finland

Pelvis X-ray examination

3.9

20.9

256

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

2.7

20.8

158

662

AB5BT

NOMESCO Finland

Blockage of nerv root with X-ray guidance

112.8

20.7

B01AB05

ATC

enoxaparin; parenteral

2.1

20.6

299

1731

M54

ICD-10 Finland

Dorsalgia

3.4

20.5

104

331

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

2.1

20.4

294

1692

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

2.5

20.4

191

899

R52.1

ICD-10 Finland

Chronic intractable pain

49.3

20.2

A02BA02

ATC

ranitidine; systemic

2.3

20.0

210

1044

M02AA07

ATC

piroxicam; topical

2.0

20.0

342

2111

M79.0

ICD-10 Finland

Rheumatism, unspecified

9.7

19.8

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

4.1

19.7

211

N30.0

ICD-10 Finland

Acute cystitis

2.7

19.6

148

616

ZZH40

NOMESCO Finland

Substitute of bone

22.2

19.6

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.9

19.4

124

466

J01AA02

ATC

doxycycline; systemic

2.1

19.3

653

5214

ZXE10

NOMESCO Finland

More than one and less than three hours

2.0

19.3

333

2056

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.4

19.2

183

864

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

20.6

19.2

SPAT1263

SPAT

Sampling

2.0

18.9

370

2396

Z3226

NOMESCO Finland

Physiotherapist

2.4

18.8

176

822

A06AC01

ATC

ispaghula (psylla seeds); oral

2.2

18.7

229

1222

NA3DG

NOMESCO Finland

Lumbar spine very extensive MRI examination with high intensity magnet

102.3

18.6

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.4

18.4

175

825

SPAT1153

SPAT

Removal of sutures

2.0

18.3

297

1782

J01FA10

ATC

azithromycin; systemic

1.9

18.1

424

2918

M01AX05

ATC

glucosamine; oral

2.2

18.0

219

1159

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.9

18.0

371

2434

P01BA02

ATC

hydroxychloroquine; oral

3.5

18.0

267

J01DA01

ATC

[U] cefalexin; systemic

1.9

17.9

522

3876

M01AB55

ATC

diclofenac, combinations; oral

3.6

17.9

251

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

5.4

17.9

105

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.5

17.8

274

SPAT1149

SPAT

Suture or treatment of traumatic wound

2.6

17.8

138

581

NA3CF

NOMESCO Finland

Lumbar spine extensive MRI examination with median intensity magnet

+∞

17.8

ABC30

NOMESCO Finland

Decompression of cervical nerve roots

+∞

17.8

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

8.3

17.7

UKC02

NOMESCO Finland

Cystoscopy

2.4

17.6

170

807

M79.1

ICD-10 Finland

Myalgia

3.0

17.5

106

383

N04BC05

ATC

pramipexole; oral

3.5

17.5

262

R60.0

ICD-10 Finland

Localized oedema

2.8

17.4

125

501

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.6

17.3

141

611

N05AH04

ATC

quetiapine; oral

2.6

17.3

141

611

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

2.9

17.2

110

410

SAA02

NOMESCO Finland

Basic examination of mouth

1.9

17.2

468

3373

SAA01

NOMESCO Finland

Simple examination of mouth

1.9

17.1

524

3928

R52.9

ICD-10 Finland

Pain, unspecified

3.6

17.1

239

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.8

17.1

120

474

N05BA01

ATC

diazepam; systemic, rectal

2.6

16.9

135

577

J45.9

ICD-10 Finland

Asthma, unspecified

2.4

16.9

167

799

N02AC04

ATC

dextropropoxyphene; oral

5.0

16.8

113

M79.7

ICD-10 Finland

Fibromyalgia

10.1

16.8

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

3.4

16.7

260

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

2.0

16.6

274

1639

L17

ICPC

Foot/toe symptom/complaint

2.1

16.5

222

1223

R53

ICD-10 Finland

Malaise and fatigue

2.2

16.5

194

1008

N05BA04

ATC

oxazepam; oral

2.1

16.5

226

1253

SPAT1229

SPAT

Assessment of need for aid

3.0

16.3

352

SPAT1249

SPAT

Treatment-related counselling outside office

1.9

16.3

336

2179

A01

ICPC

Pain general/multiple sites

3.4

16.3

254

A07EC01

ATC

sulfasalazine; oral, rectal

3.5

16.2

244

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

2.0

16.1

239

1366

NE1BG

NOMESCO Finland

Pelvic, hip and femur MRI examination with high intensity magnet

9.7

16.0

NBG15

NOMESCO Finland

Acromioplastia, arthroscopic

3.9

15.9

183

ZXD05

NOMESCO Finland

Urgent procedure

2.0

15.8

268

1616

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

2.4

15.7

146

676

K59.09

ICD-10 Finland

Constipation, unspecified

3.6

15.7

217

Z01.2

ICD-10 Finland

Dental examination

1.9

15.7

308

1957

M15.9

ICD-10 Finland

Polyarthrosis, unspecified

3.6

15.6

218

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

4.0

15.5

167

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

4.0

15.4

168

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.9

15.4

277

1704

XKD06

NOMESCO Finland

Physiologic investigation of micturition

5.7

15.3

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

2.4

15.2

145

678

Z50.1

ICD-10 Finland

Other physical therapy

3.8

15.2

180

WX110

NOMESCO Finland

Local anesthesy

1.8

15.2

520

3964

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.3

15.2

150

716

M01AB08

ATC

etodolac; oral

3.4

15.0

236

L08

ICPC

Shoulder symptom/complaint

2.2

15.0

162

806

K59.0

ICD-10 Finland

Constipation

3.7

14.8

184

J01CA04

ATC

amoxicillin; systemic

1.9

14.8

627

5108

R02

ICPC

Shortness of breath/dyspnoea

2.6

14.8

115

484

R07.3

ICD-10 Finland

Other chest pain

3.0

14.8

326

M41.9

ICD-10 Finland

Scoliosis, unspecified

21.5

14.7

G99.2*M47.1

ICD-10 Finland

Spondylogenic compression of spinal cord

+∞

14.6

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

+∞

14.6

SPAT1211

SPAT

Application of soft bandage

2.8

14.6

100

390

M15.0

ICD-10 Finland

Primary generalized (osteo)arthrosis

5.3

14.6

Z02.7

ICD-10 Finland

Issue of medical certificate

3.5

14.6

214

XA402

NOMESCO Finland

ENMG

7.8

14.5

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.8

14.4

410

2927

N06AX03

ATC

mianserin; oral

4.1

14.4

143

N06AB10

ATC

escitalopram; oral

2.3

14.3

151

741

R42

ICD-10 Finland

Dizziness and giddiness

2.1

14.3

199

1101

M54.8

ICD-10 Finland

Other dorsalgia

6.2

14.2

WZB00

NOMESCO Finland

Telephone receipt or other advice

2.0

14.2

207

1169

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.8

14.2

394

2786

G04CA02

ATC

tamsulosin; oral

2.0

14.1

210

1195

I50.9

ICD-10 Finland

Heart failure, unspecified

2.2

14.1

162

826

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

2.9

14.0

313

ZXA00

NOMESCO Finland

Right side

1.9

14.0

252

1538

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

4.9

14.0

M70.7

ICD-10 Finland

Other bursitis of hip

6.4

13.9

ABD30

NOMESCO Finland

Implantation of spinal stimulation device

30.6

13.9

N05CD07

ATC

temazepam; oral

2.3

13.9

137

651

K02.1

ICD-10 Finland

Caries of dentine

1.8

13.9

407

2922

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.0

13.9

201

1131

M53.0

ICD-10 Finland

Cervicocranial syndrome

3.5

13.8

201

X58

ICD-10 Finland

Exposure to other specified factors

2.6

13.7

108

456

B01AF01

ATC

rivaroxaban; oral

2.4

13.7

121

544

N06AB04

ATC

citalopram; systemic

2.1

13.6

182

992

C07AB07

ATC

bisoprolol; oral

1.7

13.6

433

3182

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.8

13.6

377

2655

7245A

ICD-9 Finland

Other and unspecified disorders of back, Backache, unspecified

+∞

13.6

G99.2

ICD-10 Finland

Myelopathy in diseases classified elsewhere

+∞

13.6

ABC66

NOMESCO Finland

Decompression of lumbal spinal channel

+∞

13.6

NAG66

NOMESCO Finland

Posterior interbody fusion of lumbar spine, 2 vertebrae

+∞

13.6

NAG61

NOMESCO Finland

Posterior fusion of lumbar spine without fixation

+∞

13.6

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

4.2

13.6

131

N39.4

ICD-10 Finland

Other specified urinary incontinence

2.8

13.5

344

M02AA10

ATC

ketoprofen; topical

2.2

13.4

149

746

I10

ICD-10 Finland

Essential (primary) hypertension

1.7

13.4

535

4197

H02AB04

ATC

methylprednisolone; systemic

2.3

13.2

130

615

G55.2

ICD-10 Finland

Nerve root and plexus compressions in spondylosis

40.7

13.2

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

15.3

13.1

P01AB01

ATC

metronidazole; oral, rectal

1.8

13.1

307

2041

R4110

NOMESCO Finland

Physiotherapy

1.9

13.1

223

1331

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

2.2

13.0

140

693

L02

ICPC

Back symptom/complaint

3.3

12.8

213

S46.0

ICD-10 Finland

Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder

2.9

12.7

290

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

3.4

12.6

193

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

3.4

12.6

194

G83.4

ICD-10 Finland

Cauda equina syndrome

131.9

12.5

NFB30

NOMESCO Finland

Primary total prosthetic replacement of hip joint not using cement

3.0

12.4

268

SPAT1260

SPAT

Consultation of another employee

2.1

12.4

162

871

XKD00

NOMESCO Finland

Uroflowmetry

2.1

12.3

154

812

R50.9

ICD-10 Finland

Fever, unspecified

2.3

12.3

125

601

NA1AD

NOMESCO Finland

Cervical spine CT examination

4.4

12.3

104

WX002

NOMESCO Finland

Sedation and analgesia

2.0

12.3

179

1002

S97

ICPC

Chronic ulcer skin

3.3

12.3

203

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

2.4

12.2

107

478

P03

ICPC

Feeling depressed

3.3

12.2

193

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.2

12.2

132

653

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.7

12.1

402

2951

R03AK06

ATC

salmeterol and fluticasone; inhalant

2.2

12.1

127

619

J01FA09

ATC

clarithromycin; systemic

1.8

12.1

231

1432

R03BB04

ATC

tiotropium bromide; inhalant

2.4

12.1

104

462

L15

ICPC

Knee symptom/complaint

2.0

12.0

173

965

G47.3

ICD-10 Finland

Sleep apnoea

2.0

12.0

168

929

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

2.6

11.9

358

M17.9

ICD-10 Finland

Gonarthrosis, unspecified

2.4

11.9

107

483

N05CF02

ATC

zolpidem; oral

2.1

11.9

143

742

WZA90

NOMESCO Finland

Other doctors statement

2.0

11.8

171

956

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

3.8

11.8

138

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

2.9

11.8

267

E66.01

ICD-10 Finland

Obesity due to excess calories

3.3

11.8

187

C10AA04

ATC

fluvastatin; oral

2.4

11.8

101

445

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.9

11.7

275

SPAT1254

SPAT

Administration of medicine

2.1

11.7

146

769

7890A

ICD-9 Finland

Other symptoms involving abdomen and pelvis, Abdominal pain

3.6

11.7

150

TAC99

NOMESCO Finland

Other blockade for chronic pain

30.5

11.7

K30

ICD-10 Finland

Functional dyspepsia

2.6

11.6

377

G55.1*M51.9

ICD-10 Finland

Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)

65.9

11.6

NAU20

NOMESCO Finland

Removal of internal fixation device from spine or neck

65.9

11.6

M09AX01

ATC

hyaluronic acid; parenteral

3.1

11.6

221

M19.8

ICD-10 Finland

Other specified arthrosis

4.9

11.6

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.7

11.6

298

2021

R03DC03

ATC

montelukast; oral

2.2

11.6

122

597

C01DA14

ATC

isosorbide mononitrate; oral

2.0

11.6

167

933

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.9

11.5

205

1237

M03BX01

ATC

baclofen; systemic

7.6

11.5

TAD08

NOMESCO Finland

Sympathetic block on sacral Level

+∞

11.5

M35.3

ICD-10 Finland

Polymyalgia rheumatica

3.7

11.5

142

XKC03

NOMESCO Finland

Water cystometry

4.6

11.5

M53.2

ICD-10 Finland

Spinal instabilities

121.6

11.5

ZXM20

NOMESCO Finland

Intraoperative use of computerised tomography

121.6

11.5

C10AA05

ATC

atorvastatin; oral

1.7

11.4

340

2404

SPAT1220

SPAT

Assessment of need for rehabilitation and/or rehabilitation plan

2.8

11.4

292

M01AB01

ATC

indometacin; systemic, rectal

2.5

11.4

375

J01.0

ICD-10 Finland

Acute maxillary sinusitis

2.1

11.4

145

768

SPAT1222

SPAT

Counselling/guidance promoting independent living

2.1

11.4

145

769

J01EA01

ATC

trimethoprim; systemic

1.8

11.4

225

1405

N06AA10

ATC

nortriptyline; systemic

6.7

11.3

SPAT1167

SPAT

Insertion of urinary catheter

3.9

11.3

123

SPAT1295

SPAT

Other function in accordance with physical therapy nomenclature

3.5

11.3

160

ABD32

NOMESCO Finland

Implantation of temporary spinal stimulation device

35.5

11.3

D07AC01

ATC

betamethasone; topical

1.7

11.3

278

1860

K29.3

ICD-10 Finland

Chronic superficial gastritis

4.4

11.2

I25.9

ICD-10 Finland

Chronic ischaemic heart disease, unspecified

2.2

11.2

115

556

J01MA06

ATC

norfloxacin; oral

2.1

11.2

128

650

G55.1

ICD-10 Finland

Nerve root and plexus compressions in intervertebral disc disorders

25.4

11.2

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

3.2

11.2

195

SPAT1203

SPAT

Injection therapy, other than intramuscular or subcutaneous

3.9

11.1

120

A46

ICD-10 Finland

Erysipelas

2.1

11.1

132

681

XKD03

NOMESCO Finland

Urethral pressure profilometry

4.7

10.9

R01BA52

ATC

pseudoephedrine, combinations; oral

1.8

10.9

233

1490

W19

ICD-10 Finland

Unspecified fall

2.5

10.9

388

NA1EA

NOMESCO Finland

Cervical spine X-ray examination with flexion

10.7

10.8

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.2

10.8

112

542

R05DA20

ATC

opium alkaloids and derivatives - combinations

1.8

10.8

205

1259

AN1

Coronary angiography

2.1

10.8

125

637

Z3231

NOMESCO Finland

Registered nurse

1.8

10.8

226

1435

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

1.8

10.8

202

1237

A03FA02

ATC

cisapride; oral, rectal

2.6

10.7

315

J02AC01

ATC

fluconazole; systemic

1.7

10.7

276

1866

R60.9

ICD-10 Finland

Oedema, unspecified

3.4

10.7

156

J01FA06

ATC

roxithromycin; oral

1.7

10.7

312

2183

SPAT1301

SPAT

No procedures

1.7

10.7

265

1771

B01AC04

ATC

clopidogrel; oral

2.0

10.7

153

849

M04AA01

ATC

allopurinol; systemic

2.1

10.6

134

707

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

3.0

10.5

215

72870

ICD-8 Finland

Vertebrogenic pain syndrome, Lumbalgia

+∞

10.4

NAG41

NOMESCO Finland

Anterior fusion of cervical spine with fixation

+∞

10.4

M46.4

ICD-10 Finland

Discitis, unspecified

+∞

10.4

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.6

10.4

343

2480

G04BD04

ATC

oxybutynin; oral, transdermal

2.9

10.4

234

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.9

10.3

166

959

H02.3

ICD-10 Finland

Blepharochalasis

2.9

10.3

235

G62.8

ICD-10 Finland

Other specified polyneuropathies

19.1

10.3

A01AB09

ATC

miconazole; local oral

2.5

10.3

362

JN3BD

NOMESCO Finland

Extensive abdominal CT

2.3

10.2

428

M13.9

ICD-10 Finland

Arthritis, unspecified

2.8

10.2

237

SPAT1083

SPAT

Initiation and monitoring of IV fluid therapy

3.2

10.2

179

I25.1

ICD-10 Finland

Atherosclerotic heart disease

1.8

10.2

217

1381

N03AX09

ATC

lamotrigine; oral

4.4

10.2

N04BA02

ATC

levodopa and decarboxylase inhibitor; oral

3.4

10.2

146

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.8

10.2

221

1416

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

3.7

10.2

125

-1

NOMESCO Finland

1.7

10.1

232

1507

TPH04

NOMESCO Finland

Cathetrisation of vein

1.9

10.1

168

985

F41.2

ICD-10 Finland

Mixed anxiety and depressive disorder

3.3

10.1

158

A07AA02

ATC

nystatin; oral

2.8

10.0

240

R05FB02

ATC

cough suppressants and expectorants

1.6

10.0

322

2306

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

2.2

10.0

105

512

SDA02

NOMESCO Finland

Parodonthologic therapy

1.7

10.0

234

1533

N39.3

ICD-10 Finland

Stress incontinence

2.7

10.0

259

R06AE07

ATC

cetirizine; oral

1.6

10.0

309

2190

SPAT1216

SPAT

Assessment of functional ability

2.0

10.0

146

817

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

1.8

9.9

190

1168

R33

ICD-10 Finland

Retention of urine

2.4

9.9

357

N31.2

ICD-10 Finland

Flaccid neuropathic bladder, not elsewhere classified

12.4

9.9

EBA05

NOMESCO Finland

Complicated extraction of tooth

2.0

9.9

145

810

I20.99

ICD-10 Finland

Angina pectoris, unspecified

2.5

9.9

318

I48

ICD-10 Finland

Atrial fibrillation and flutter

1.7

9.8

227

1479

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

3.1

9.8

184

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.6

9.8

304

2151

NBL00

NOMESCO Finland

Suture or reinsertation of rotator cuff of shoulder

3.2

9.8

167

Angiography of the heart and coronary arteries

2.6

9.7

286

E66.8

ICD-10 Finland

Other obesity

3.5

9.7

130

H04.10

ICD-10 Finland

Dry eye syndrome

2.5

9.7

345

NA3CM

NOMESCO Finland

Lumbar spine extensive MRI examination with 3 Tesla magnet

55.6

9.7

J01MA12

ATC

levofloxacin; systemic

1.8

9.7

169

1006

F51.0

ICD-10 Finland

Nonorganic insomnia

2.3

9.6

423

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.7

9.6

246

A04

ICPC

Weakness/tiredness general

2.1

9.6

117

609

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

2.8

9.6

222

R01AD08

ATC

fluticasone; nasal

1.8

9.6

201

1267

N06AX12

ATC

bupropion; oral

3.7

9.5

111

B01AA03

ATC

warfarin; systemic

1.8

9.5

205

1304

D64.9

ICD-10 Finland

Anaemia, unspecified

2.2

9.5

104

517

N06AB06

ATC

sertraline; oral

2.5

9.5

323

R05FA02

ATC

opium derivatives and expectorants; systemic

1.6

9.5

312

2239

L01

ICPC

Neck symptom/complaint

2.2

9.4

461

R03BA01

ATC

beclometasone; inhalant

2.1

9.4

113

582

J01CA08

ATC

pivmecillinam; oral

1.6

9.4

306

2187

G99.2*M47.0

ICD-10 Finland

Anterior spinal and vertebral artery compression syndromes

+∞

9.4

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

2.1

9.4

115

598

K44.9

ICD-10 Finland

Diaphragmatic hernia without obstruction or gangrene

2.6

9.4

280

NA1BA

NOMESCO Finland

Cervical spine extensive X-ray examination without contrast

10.8

9.3

N03AF01

ATC

carbamazepine; oral, rectal

3.1

9.3

174

FN1BC

NOMESCO Finland

Extensive angiography of hear and/or coronary arteries

2.8

9.3

214

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

13.9

9.2

G04BD08

ATC

solifenacin; oral

2.5

9.2

296

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.8

9.2

162

968

A11

ICPC

Chest pain NOS

2.5

9.2

297

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

2.5

9.1

286

SPAT1262

SPAT

Handing over of treatment supplies

1.8

9.1

163

974

M06.8

ICD-10 Finland

Other specified rheumatoid arthritis

11.6

9.1

M01AE11

ATC

tiaprofenic acid; oral, rectal

3.1

9.1

160

E66.00

ICD-10 Finland

Metabolic syndrome

3.2

9.0

149

NA7BG

NOMESCO Finland

Spine and spinal cord MRI examination with high intensity magnet

37.1

9.0

RF210

NOMESCO Finland

4.1

9.0

SPAT1215

SPAT

Assessment of need for medical rehabilitation

3.2

9.0

155

M77.1

ICD-10 Finland

Lateral epicondylitis

3.0

9.0

183

J45.0

ICD-10 Finland

Predominantly allergic asthma

2.6

9.0

256

R05

ICD-10 Finland

Cough

1.8

9.0

155

916

78719

ICD-8 Finland

Symptoms referable to limbs and joints, Dolor extremitatis aliud sive NUD

18.8

8.9

WX200

NOMESCO Finland

Interscalenous plexus blockade

5.8

8.9

R13

ICD-10 Finland

Dysphagia

2.7

8.9

232

M96.0

ICD-10 Finland

Pseudarthrosis after fusion or arthrodesis

24.3

8.9

SPAT1255

SPAT

Intravenous administration of medicine

2.5

8.9

284

S30.0

ICD-10 Finland

Contusion of lower back and pelvis

4.0

8.9

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.7

8.9

242

1646

G04BD12

ATC

mirabegron; oral

2.1

8.9

494

1220

FHL

Arthroscopy

3.6

8.9

113

E0000UV

ATC

1.6

8.9

302

2178

N40

ICD-10 Finland

Hyperplasia of prostate

1.8

8.9

183

1149

C01DA02

ATC

glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal

1.7

8.9

199

1278

SPAT1099

SPAT

Measurement of blood pressure with Doppler ultrasound device

3.6

8.8

108

H02AB07

ATC

prednisone; oral

2.0

8.8

121

658

M09AA72

ATC

quinine, combinations with psycholeptics; systemic

3.4

8.8

124

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

2.1

8.8

497

M80.9

ICD-10 Finland

Unspecified osteoporosis with pathological fracture

6.0

8.8

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

2.4

8.7

313

M75.8

ICD-10 Finland

Other shoulder lesions

4.6

8.7

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

2.1

8.7

102

519

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

2.9

8.7

188

7151F

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]

3.9

8.7

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

2.9

8.7

197

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.0

8.7

112

595

C07AB02

ATC

metoprolol; systemic

1.7

8.7

196

1263

R11

ICD-10 Finland

Nausea and vomiting

2.5

8.7

295

R1250

NOMESCO Finland

Evaluation of functional capability

4.9

8.6

R51

ICD-10 Finland

Headache

3.5

8.6

116

KMAK

NOMESCO Finland

1.6

8.6

352

2651

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

2.6

8.6

251

R35

ICD-10 Finland

Polyuria

2.6

8.6

243

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

4.2

8.5

NGD05

NOMESCO Finland

Partial excision of meniscus of knee, arthroscopic

2.1

8.5

462

G04CA01

ATC

alfuzosin; oral

2.1

8.5

504

L84

ICPC

Back syndrome without radiat pain

3.8

8.5

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

2.6

8.5

245

R51.81

ICD-10 Finland

Facial pain NOS

5.7

8.5

R20.2

ICD-10 Finland

Paraesthesia of skin

3.0

8.5

166

F29

ICPC

Eye symptom/complaint other

2.4

8.4

306

L04AA13

ATC

leflunomide; oral

4.7

8.4

72898

ICD-8 Finland

Vertebrogenic pain syndrome, Alia definita

+∞

8.3

7221A

ICD-9 Finland

Intervertebral disk disorders, Displacement of thoracic or lumbar intervertebral disk without myelopathy

+∞

8.3

NA7BT

NOMESCO Finland

Injection to spinal facet joint with radiological guidance

+∞

8.3

ZXD10

NOMESCO Finland

Scheduled procedure

1.6

8.3

309

2266

NFC20

NOMESCO Finland

Secondary implantation of hip prosthesis

5.9

8.3

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

5.9

8.3

C08CA01

ATC

amlodipine; oral

1.6

8.3

321

2379

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

1.6

8.3

304

2223

Z03.80

ICD-10 Finland

Observation for other suspected diseases and conditions

4.5

8.3

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

2.7

8.3

207

L88

ICPC

Rheumatoid/seropositive arthritis

3.6

8.2

NF1BA

NOMESCO Finland

Hip extensive X-ray examination

3.4

8.2

115

M05BA04

ATC

alendronic acid; oral

2.2

8.2

433

SAA03

NOMESCO Finland

Extended examination of mouth

1.6

8.2

255

1791

R55

ICD-10 Finland

Syncope and collapse

2.0

8.2

514

SPAT1292

SPAT

Other function in accordance with SHToL (Finnish classification of nursing interventions)

2.2

8.2

385

NB1BA

NOMESCO Finland

Shoulder extensive X-ray examination without contrast

3.7

8.1

J01MA14

ATC

moxifloxacin; systemic

2.2

8.1

366

L16

ICPC

Ankle symptom/complaint

2.3

8.1

332

Z87.1

ICD-10 Finland

Personal history of diseases of the digestive system

1.6

8.1

306

2254

G54.0

ICD-10 Finland

Brachial plexus disorders

6.4

8.0

M53.3

ICD-10 Finland

Sacrococcygeal disorders, not elsewhere classified

22.3

8.0

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.5

8.0

272

Z01.1

ICD-10 Finland

Examination of ears and hearing

1.9

8.0

114

629

TPH07

NOMESCO Finland

Cathetrisation of artery

2.1

7.9

448

R01AD09

ATC

mometasone; nasal

1.6

7.9

300

2208

M72.2

ICD-10 Finland

Plantar fascial fibromatosis

2.6

7.8

213

R4120

NOMESCO Finland

Occupational therapy

2.7

7.8

205

SPAT1310

SPAT

Counselling related to known health issue

1.6

7.8

239

1667

XJH00

NOMESCO Finland

Transanal ultrasonography

2.5

7.8

252

E000001

ATC

1.8

7.8

155

960

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

2.1

7.8

436

G04BD07

ATC

tolterodine; oral

2.6

7.8

215

S49.9

ICD-10 Finland

Unspecified injury of shoulder and upper arm

6.5

7.7

S13.4

ICD-10 Finland

Sprain and strain of cervical spine

4.7

7.7

Y88.3

ICD-10 Finland

Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

4.2

7.7

Z03.5

ICD-10 Finland

Observation for other suspected cardiovascular diseases

2.4

7.7

273

ZSN00

NOMESCO Finland

Procedure related to previous procedure classified in chapter N

12.0

7.6

S01GX01

ATC

cromoglicic acid; ophthalmic

1.8

7.6

132

779

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

2.3

7.6

323

R10.2

ICD-10 Finland

Pelvic and perineal pain

5.8

7.6

Z2446

NOMESCO Finland

Social worker

2.7

7.6

194

ZZH31

NOMESCO Finland

Bone allograft, small pieces

10.1

7.5

H81.3

ICD-10 Finland

Other peripheral vertigo

3.7

7.5

A02BX02

ATC

sucralfate; oral

2.8

7.5

164

B01AX06

ATC

[U] rivaroxaban; oral

4.0

7.5

-48

ICPC

Clarification/discussion RFE/demand

4.0

7.5

SPAT1240

SPAT

Therapeutic discussion

2.4

7.5

271

T36

ICD-10 Finland

Poisoning by systemic antibiotics

3.4

7.5

102

M19.9

ICD-10 Finland

Arthrosis, unspecified

3.1

7.5

130

NG1BA

NOMESCO Finland

Knee extensive X-ray examination

5.1

7.4

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

2.4

7.4

265

C08CA02

ATC

felodipine; oral

2.0

7.4

488

M50.9

ICD-10 Finland

Cervical disc disorder, unspecified

80.8

7.4

NGB40

NOMESCO Finland

Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis

3.4

7.4

103

L03.0

ICD-10 Finland

Cellulitis of finger and toe

2.5

7.4

227

1225

FHL

Arthroscopy and other therapeutic procedure

6.0

7.4

G45.1

ICD-10 Finland

Carotid artery syndrome (hemispheric)

2.8

7.4

160

WX306

NOMESCO Finland

Lumbar epidural anesthesy

3.0

7.4

137

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

3.5

7.4

F32.1

ICD-10 Finland

Moderate depressive episode

3.6

7.3

C10AC01

ATC

colestyramine; oral

4.1

7.3

SPAT1281

SPAT

Other administrative function

2.3

7.3

292

NDM40

NOMESCO Finland

Discission of sheath of tendon of wrist or hand

4.5

7.3

M17

ICD-10 Finland

Gonarthrosis [arthrosis of knee]

2.0

7.3

484

G99.2*M51.0

ICD-10 Finland

Lumbar and other intervertebral disc disorders with myelopathy

+∞

7.3

G99.2*M50.0

ICD-10 Finland

Cervical disc disorder with myelopathy

+∞

7.3

ABC50

NOMESCO Finland

Decopression of cervical spinal canal and nerve roots

+∞

7.3

7225A

ICD-9 Finland

Intervertebral disk disorders, Degeneration of thoracic or lumbar intervertebral disk[DEGENERATIO DISCI INTERVERTEBRALIS THORAC SEU LUMB]

+∞

7.3

M01AE52

ATC

naproxen and esomeprazole; oral

3.4

7.3

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.2

7.3

364

T81.0

ICD-10 Finland

Haemorrhage and haematoma complicating a procedure, not elsewhere classified

2.4

7.2

243

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

4.7

7.2

Z71.9

ICD-10 Finland

Counselling, unspecified

2.7

7.2

187

R03AC03

ATC

terbutaline; inhalant

1.9

7.2

103

570

K58.0

ICD-10 Finland

Irritable bowel syndrome with diarrhoea

2.8

7.2

157

R03AK07

ATC

formoterol and budesonide; inhalant

1.8

7.2

132

795

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.0

7.2

437

NA6BG

NOMESCO Finland

Sacro-iliac joint MRI examination with high intensity magnet

30.3

7.2

AEA24

NOMESCO Finland

Removal of spinal stimulation elecrode

30.3

7.2

I87.2

ICD-10 Finland

Venous insufficiency (chronic)(peripheral)

2.1

7.1

424

NJ3NA

NOMESCO Finland

Measurement of difference in extremity lengty with X-ray

4.1

7.1

S89.9

ICD-10 Finland

Unspecified injury of lower leg

3.9

7.1

M21.4

ICD-10 Finland

Flat foot [pes planus] (acquired)

3.8

7.1

Z09.0

ICD-10 Finland

Follow-up examination after surgery for other conditions

2.3

7.1

291

NB1AD

NOMESCO Finland

Shoulder CT examination

5.4

7.1

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

2.3

7.1

292

D07AC13

ATC

mometasone; topical

1.6

7.1

212

1467

SPAT1053

SPAT

Memory test

1.7

7.1

149

937

H43.8

ICD-10 Finland

Other disorders of vitreous body

2.2

7.1

339

L03.1

ICD-10 Finland

Cellulitis of other parts of limb

4.4

7.1

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

2.3

7.0

273

G25.9

ICD-10 Finland

Extrapyramidal and movement disorder, unspecified

7.1

7.0

KED22

NOMESCO Finland

Transurethral resection of prostate

2.5

7.0

233

NBA30

NOMESCO Finland

Exploration of joint of shoulder or upper arm, arthroscopic

3.9

7.0

ZXA05

NOMESCO Finland

Left side

1.6

7.0

211

1460

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.6

7.0

179

1190

Z76.9

ICD-10 Finland

Person encountering health services in unspecified circumstances

2.4

7.0

255

UDH02

NOMESCO Finland

Rhinopharyngoscopy

2.5

6.9

216

NB1CG

NOMESCO Finland

Shoulder and humerus extensive MRI examination with high intensity magnet

5.5

6.9

C10AA03

ATC

pravastatin; oral

2.2

6.9

323

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.6

6.9

194

1320

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

2.0

6.9

442

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

2.2

6.9

337

R75

ICPC

Sinusitis acute/chronic

3.1

6.9

115

S40.0

ICD-10 Finland

Contusion of shoulder and upper arm

3.3

6.9

104

A03FA01

ATC

metoclopramide; systemic, rectal

1.7

6.9

159

1025

C10AX09

ATC

ezetimibe; oral

2.0

6.9

445

R15

ICD-10 Finland

Faecal incontinence

3.6

6.8

QX2XE

NOMESCO Finland

Ultrsound examination of soft tissue not elsewhere classified

4.1

6.8

J37.0

ICD-10 Finland

Chronic laryngitis

3.8

6.8

M77.9

ICD-10 Finland

Enthesopathy, unspecified

3.9

6.8

R25.2

ICD-10 Finland

Cramp and spasm

4.6

6.8

ZXA10

NOMESCO Finland

Bilateral

1.7

6.8

154

988

R03BA05

ATC

fluticasone; inhalant

1.8

6.8

129

785

M76.0

ICD-10 Finland

Gluteal tendinitis

9.4

6.8

Z00.0

ICD-10 Finland

General medical examination

1.7

6.8

146

921

M01CB01

ATC

sodium aurothiomalate; parenteral

5.7

6.8

L12

ICPC

Hand/finger symptom/complaint

1.9

6.8

545

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

3.6

6.7

B01AC07

ATC

dipyridamole; systemic

2.4

6.7

234

EBA00

NOMESCO Finland

Extraction of tooth

1.5

6.7

233

1670

9242

FHL

Other reconstruction or plastic surgery of shoulder joint (including ac joint)

5.0

6.7

D07CA01

ATC

hydrocortisone and antibiotics; topical

1.9

6.6

542

A08

ICPC

Swelling

2.8

6.6

141

N05BB01

ATC

hydroxyzine; systemic

2.4

6.6

228

L99

ICPC

Musculoskeletal disease other

4.1

6.6

ZXE30

NOMESCO Finland

More than five and less than seven hours

2.6

6.6

172

M35.7

ICD-10 Finland

Hypermobility syndrome

12.4

6.6

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.1

6.6

344

351

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

1.8

6.6

117

696

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

3.3

6.6

E66.9

ICD-10 Finland

Obesity, unspecified

3.5

6.5

M05BX04

ATC

denosumab; parenteral

2.5

6.5

192

H02AB09

ATC

hydrocortisone; systemic

4.2

6.5

N81.6

ICD-10 Finland

Rectocele

2.3

6.5

251

I25.0

ICD-10 Finland

Atherosclerotic cardiovascular disease, so described

2.3

6.5

251

78559

ICD-8 Finland

Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD

3.2

6.5

103

-54

ICPC

Repair/fix-suture/cast/prosth device

3.3

6.5

R10.0

ICD-10 Finland

Acute abdomen

3.7

6.5

G56.2

ICD-10 Finland

Lesion of ulnar nerve

3.9

6.5

C08CA13

ATC

lercanidipine; oral

1.8

6.5

118

706

M01AX01

ATC

nabumetone; oral

2.9

6.5

130

A02BA04

ATC

nizatidine; systemic

2.1

6.5

338

JN3AD

NOMESCO Finland

Abdominal CT examination

2.2

6.5

278

U02

ICPC

Urinary frequency/urgency

1.9

6.5

546

WX402

NOMESCO Finland

General anaesthesia

1.8

6.4

109

637

M99.3

ICD-10 Finland

Osseous stenosis of neural canal

70.3

6.4

NAG42

NOMESCO Finland

Posterior fusion of cervical spine with or without fixation

70.3

6.4

M48.1

ICD-10 Finland

Ankylosing hyperostosis [Forestier]

70.3

6.4

NA6CG

NOMESCO Finland

Sacro-iliac joint extensive MRI examination with high intensity magnet

70.3

6.4

M41.5

ICD-10 Finland

Other secondary scoliosis

70.3

6.4

I20.09

ICD-10 Finland

Unstable angina

2.3

6.4

246

D11

ICPC

Diarrhoea

2.1

6.4

354

NBB20

NOMESCO Finland

Primary total prosthetic replacement of humero-scapular joint

7.5

6.4

L09

ICPC

Arm symptom/complaint

3.1

6.4

110

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

3.8

6.4

M16

ICD-10 Finland

Coxarthrosis [arthrosis of hip]

2.8

6.4

145

D07AB02

ATC

hydrocortisone butyrate; topical

1.6

6.4

206

1447

R03BA02

ATC

budesonide; inhalant

1.7

6.4

122

743

ZXC95

NOMESCO Finland

Use of surgical navigator

8.2

6.3

M01AC01

ATC

piroxicam; systemic, rectal

1.8

6.3

105

612

N01

ICPC

Headache

2.3

6.3

241

WX203

NOMESCO Finland

Infraclavicular plexus blockade

3.9

6.3

N06AA12

ATC

doxepin; systemic

2.5

6.3

190

L29

ICPC

Musculoskeletal sympt/complt other

2.2

6.3

287

I20.90

ICD-10 Finland

Angina pectoris, unspecified

2.8

6.3

134

G72.9

ICD-10 Finland

Myopathy, unspecified

9.3

6.3

J01CE02

ATC

phenoxymethylpenicillin; oral

1.4

6.3

481

4039

SPAT1097

SPAT

Recording of ECG

1.7

6.3

132

826

S06.0

ICD-10 Finland

Concussion

2.0

6.3

404

J01FA15

ATC

telithromycin; oral

2.1

6.3

352

7214A

ICD-9 Finland

Spondylosis and allied disorders, Thoracic or lumbar spondylosis with myelopathy

+∞

6.3

ABC99

NOMESCO Finland

Other decompressive operation on spinal cord or nerve root

+∞

6.3

7225B

ICD-9 Finland

Intervertebral disk disorders, Degeneration of thoracic or lumbar intervertebral disk[DEGEN DISCI INTERVERT THORAC SEU LUMBOSACR CUM INST]

+∞

6.3

ABC10

NOMESCO Finland

Microsurgical excision of cervical intervertebral disc displacement

+∞

6.3

Z96.6

ICD-10 Finland

Presence of orthopaedic joint implants

2.8

6.2

135

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

3.1

6.2

101

N07BC02

ATC

methadone; systemic

26.9

6.2

M46.1

ICD-10 Finland

Sacroiliitis, not elsewhere classified

26.9

6.2

F43.20

ICD-10 Finland

Adaptation disorder with short-term depression

7.1

6.2

R03AC13

ATC

formoterol; inhalant

2.6

6.2

177

M01AH03

ATC

valdecoxib; oral

2.4

6.2

215

M15

ICD-10 Finland

Polyarthrosis

2.5

6.2

185

K59.00

ICD-10 Finland

Constipation caused by slow bowel passage (SCT)

4.0

6.2

C01CA24

ATC

epinephrine; parenteral

2.8

6.2

142

P25

ICPC

Phase of life problem adult

3.8

6.2

G25.0

ICD-10 Finland

Essential tremor

3.4

6.2

J20

ICD-10 Finland

Acute bronchitis

2.1

6.2

355

N30.9

ICD-10 Finland

Cystitis, unspecified

2.3

6.2

237

L30.9

ICD-10 Finland

Dermatitis, unspecified

1.7

6.2

125

776

L90

ICPC

Osteoarthrosis of knee

2.2

6.2

271

I50.0

ICD-10 Finland

Congestive heart failure

2.0

6.2

399

ECB00

NOMESCO Finland

Suture of gingiva

3.0

6.1

108

I25.2

ICD-10 Finland

Old myocardial infarction

2.1

6.1

347

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

4.7

6.1

H02.4

ICD-10 Finland

Ptosis of eyelid

3.2

6.1

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.5

6.1

229

1661

Z51.88

ICD-10 Finland

Other specified medical care

3.8

6.1

JN3CD

NOMESCO Finland

Abdominal CT examination both without and with contrast

2.8

6.1

131

290

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

1.7

6.1

132

832

N02CC01

ATC

sumatriptan; nasal, systemic, rectal

2.1

6.1

308

SPAT1104

SPAT

Monitoring of emergency patient

2.2

6.1

299

R32

ICD-10 Finland

Unspecified urinary incontinence

3.1

6.1

103

WX204

NOMESCO Finland

Axillary plexus blockaced

3.4

6.1

I25

ICD-10 Finland

Chronic ischaemic heart disease

2.4

6.1

200

M65.4

ICD-10 Finland

Radial styloid tenosynovitis [de Quervain]

4.4

6.1

S22.3

ICD-10 Finland

Fracture of rib

2.3

6.1

232

XF400

NOMESCO Finland

ECG with 12 standard connections

1.7

6.1

132

837

-50

ICPC

Medication/prescr/renewal

2.5

6.1

174

K10.3

ICD-10 Finland

Alveolitis of jaws

3.1

6.0

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

1.5

6.0

197

1386

NB6AA

NOMESCO Finland

Humerus X-ray examination

4.2

6.0

N06AX05

ATC

trazodone; oral

4.0

6.0

B01AF02

ATC

apixaban; oral

1.8

6.0

542

SPAT1296

SPAT

Other function in accordance with occupational therapy nomenclature

6.1

6.0

D07CC01

ATC

betamethasone and antibiotics; topical

1.8

6.0

560

NAME	M13_SPONDYLOPATHYNAS
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M48[8-9]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M48[8-9]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
M13_SPONDYLOPATHYNAS	1.386 [1.25, 1.54]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.376

Parameter	HR [95% CI]	p-value
M13_SPONDYLOPATHYNAS	1.517 [1.34, 1.72]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.075

N-year risk	Females	Males
1	0.13%	0.262%
5	0.832%	1.793%
10	2.113%	4.895%
15	4.274%	9.13%
20	7.471%	16.101%

Other specified/unspecified spondylopathies

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints