No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
667 |
4. Check minimum number of eventsNone |
667 |
5. Include endpointsNone |
667 |
6. Filter based on genotype QC (FinnGen only) |
667 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M43
- Name in latin
- Torticollis
Similar endpoints
↥List of similar endpoints to
Torticollis
based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9116 | 4207 | 4879 |
| Only index persons | 7518 | 3531 | 3987 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.12 | 0.14 |
| Only index persons | 0.14 | 0.13 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 10.56 | 12.33 | 8.83 |
| Only index persons | 12.61 | 14.72 | 10.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 667 | 392 | 275 |
| Unadjusted period prevalence (%) | 0.13 | 0.13 | 0.12 |
| Median age at first event (years) | 24.38 | 25.78 | 22.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 608
- Matched controls
- 6078
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M43.6
ICD-10 Finland
Torticollis
844.0
323.0
382
12
71720
ICD-8 Finland
Other nonarticular rheumatism, Torticollis not specified as congential, pyschogenic or traumatic
+∞
183.9
167
*
7235A
ICD-9 Finland
Other disorders of cervical region, Torticollis, unspecified
+∞
72.4
68
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
22.9
44.1
64
31
N03AX16
ATC
pregabalin; oral
4.7
38.4
148
391
G24.3
ICD-10 Finland
Spasmodic torticollis
53.8
38.1
45
9
M03BX02
ATC
tizanidine; oral
2.9
33.0
395
2393
M03BC01
ATC
orphenadrine (citrate); systemic
3.6
32.2
172
601
N03AX12
ATC
gabapentin; oral
5.5
30.3
95
197
N02AX02
ATC
tramadol; systemic, rectal
2.9
28.7
233
1079
M54.5
ICD-10 Finland
Low back pain
3.0
26.3
182
753
N03AE01
ATC
clonazepam; systemic
6.9
25.7
66
105
M48.0
ICD-10 Finland
Spinal stenosis
26.4
25.5
35
14
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
26.7
24.2
33
13
M54.9
ICD-10 Finland
Dorsalgia, unspecified
5.5
22.7
70
141
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
20.3
21.0
31
16
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
8.1
19.5
44
58
M54.2
ICD-10 Finland
Cervicalgia
6.4
19.4
52
88
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
11.2
19.2
36
34
M54.4
ICD-10 Finland
Lumbago with sciatica
4.1
18.8
76
203
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.0
17.9
59
128
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
29.8
17.5
23
8
M01AE02
ATC
naproxen; oral, rectal
2.1
16.9
358
2479
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
10.2
16.9
33
34
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
13.7
14.8
25
19
N06AA09
ATC
amitriptyline; systemic
4.5
14.6
52
123
R51.80
ICD-10 Finland
Headache
2.6
13.6
106
454
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
13.5
241
1511
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.5
13.5
64
196
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
143.0
13.5
14
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
143.0
13.5
14
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.5
13.1
113
510
M47.82
ICD-10 Finland
Other spondylosis, cervical region
51.1
12.9
15
*
N06AX21
ATC
duloxetine; oral
3.3
12.9
66
215
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
24.9
12.5
17
7
L01
ICPC
Neck symptom/complaint
2.7
12.0
87
356
N02AJ06
ATC
codeine and paracetamol; systemic
2.0
11.6
198
1204
M54.3
ICD-10 Finland
Sciatica
6.6
11.5
29
46
L03
ICPC
Low back symptom/complaint
2.3
11.5
123
614
A02BC02
ATC
pantoprazole; systemic
1.8
11.4
323
2341
H02AB06
ATC
prednisolone; systemic
1.9
11.4
239
1566
M25.5
ICD-10 Finland
Pain in joint
2.1
11.4
153
847
A02BC01
ATC
omeprazole; systemic
2.1
11.2
141
760
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
11.0
207
1299
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
11.0
138
742
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
61.1
10.7
12
*
M79.6
ICD-10 Finland
Pain in limb
1.9
10.5
176
1060
M50.3
ICD-10 Finland
Other cervical disc degeneration
33.1
10.4
13
*
R03AC02
ATC
salbutamol; inhalant
1.8
10.3
303
2192
M01AB05
ATC
diclofenac; systemic, rectal
1.8
10.3
349
2636
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
10.2
123
649
M01AH05
ATC
etoricoxib; oral
1.8
10.1
296
2135
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.4
10.0
48
149
N05BA01
ATC
diazepam; systemic, rectal
2.6
10.0
78
330
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
9.6
94
451
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
15.3
9.6
15
10
M47.9
ICD-10 Finland
Spondylosis, unspecified
22.1
9.4
13
6
S80.0
ICD-10 Finland
Contusion of knee
3.2
9.0
47
156
M03BC51
ATC
orphenadrine, combinations; systemic
1.9
9.0
146
861
N02BE01
ATC
paracetamol; systemic, rectal
1.8
9.0
458
3840
M01AC06
ATC
meloxicam; systemic, rectal
1.9
9.0
163
1001
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
8.8
178
1128
M79.1
ICD-10 Finland
Myalgia
2.5
8.7
71
310
R52.1
ICD-10 Finland
Chronic intractable pain
50.7
8.7
10
*
NF1AA
NOMESCO Finland
Hip X-ray examination
3.6
8.6
38
112
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
27.9
8.5
11
*
R07.3
ICD-10 Finland
Other chest pain
2.9
8.4
52
193
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
8.3
8
*
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
8.3
8
*
N06AB04
ATC
citalopram; systemic
2.0
8.3
111
605
C07AA05
ATC
propranolol; systemic
2.0
8.2
114
630
G44.2
ICD-10 Finland
Tension-type headache
2.3
8.2
76
355
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.7
8.2
34
95
J01DA01
ATC
[U] cefalexin; systemic
1.6
8.2
338
2631
R52.2
ICD-10 Finland
Other chronic pain
7.0
8.1
19
28
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.5
8.1
36
107
A02BC05
ATC
esomeprazole; systemic
1.7
8.0
183
1203
R52.9
ICD-10 Finland
Pain, unspecified
2.9
7.9
47
171
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
8.6
7.8
16
19
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
45.6
7.7
9
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
7.7
109
609
M54.1
ICD-10 Finland
Radiculopathy
9.0
7.6
15
17
N06AX11
ATC
mirtazapine; oral
1.8
7.6
159
1017
L14
ICPC
Leg/thigh symptom/complaint
3.1
7.5
39
131
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
81.0
7.4
8
*
3338X
ICD-9 Finland
Other extrapyramidal disease and abnormal movement disorders, Fragments of torsion dystonia
81.0
7.4
8
*
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
13.6
7.4
12
9
UJF32
NOMESCO Finland
Coloscopy
1.9
7.4
108
608
AA1AD
NOMESCO Finland
CT of head and brain
2.0
7.4
99
540
N06AX16
ATC
venlafaxine; oral
2.2
7.2
78
389
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.2
193
1322
XA402
NOMESCO Finland
ENMG
6.7
7.2
17
26
3AX01
NOMESCO Finland
NA
20.3
7.1
10
5
N05CF01
ATC
zopiclone; oral
1.8
7.1
139
866
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.1
7.1
18
30
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
7.0
100
556
N02AA05
ATC
oxycodone; systemic
2.5
7.0
52
217
J01FF01
ATC
clindamycin; systemic
1.8
6.8
139
874
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.8
6.8
43
161
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
6.8
131
812
N05AH04
ATC
quetiapine; oral
1.9
6.7
99
560
R03BA05
ATC
fluticasone; inhalant
1.9
6.6
106
618
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
6.6
69
340
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.7
6.5
42
161
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
6.4
71
359
M45
ICD-10 Finland
Ankylosing spondylitis
70.6
6.4
7
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
6.4
131
823
G43.9
ICD-10 Finland
Migraine, unspecified
2.6
6.4
45
183
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
6.3
234
1735
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
6.3
6
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
6.3
6
*
D07AD01
ATC
clobetasol; topical
2.1
6.2
71
361
SPAT1229
SPAT
Assessment of need for aid
3.0
6.2
33
113
N02AC04
ATC
dextropropoxyphene; oral
6.4
6.2
15
24
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
3.4
6.1
27
81
A01
ICPC
Pain general/multiple sites
2.7
6.1
39
148
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
10.2
6.0
11
11
G43.3
ICD-10 Finland
Complicated migraine
6.1
6.0
15
25
Mortality – FinRegistry
↥Association
Association between endpoint M13_TORTICOLLIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TORTICOLLIS | 1.139 [0.93, 1.4] | 0.219 |
| Birth year | 0.997 [0.99, 1.01] | 0.44 |
During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 2594 females with M13_TORTICOLLIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TORTICOLLIS | 1.233 [1.0, 1.51] | 0.045 |
| Birth year | 0.983 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 3021 males with M13_TORTICOLLIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_TORTICOLLIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.207% |
| 5 | 0.744% | 1.233% |
| 10 | 1.772% | 3.16% |
| 15 | 3.443% | 5.849% |
| 20 | 6.289% | 9.76% |
Relationships between endpoints
↥Index endpoint: M13_TORTICOLLIS – Torticollis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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