Risteys · OSTEON

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M87.1# 1 out of 7 registries used, show all original rules.	403
4. Check minimum number of events None	403
5. Include endpoints None	403
6. Filter based on genotype QC (FinnGen only)	403

	All	Female	Male
Number of individuals
Whole population	1822	909	908
Only index persons	1748	891	857
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	67.96	67.79	68.14
Only index persons	68.30	68.00	68.61

	All	Female	Male
Number of individuals	403	198	205
Unadjusted period prevalence (%)	0.08	0.07	0.09
Median age at first event (years)	69.87	69.61	70.12

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
370: Matched controls
3701

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M87.1

ICD-10 Finland

Osteonecrosis due to drugs

+∞

323.0

370

M05BX04

ATC

denosumab; parenteral

48.0

167.0

208

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

13.6

105.7

299

873

H02AB02

ATC

dexamethasone; systemic

17.1

105.6

188

210

C79.5

ICD-10 Finland

Secondary malignant neoplasm of bone and bone marrow

50.9

91.0

109

ECB20

NOMESCO Finland

Oral alveoplasty

76.0

82.5

SAA03

NOMESCO Finland

Extended examination of mouth

8.7

78.4

271

887

WF049

NOMESCO Finland

Radiotherapy of metastasis

27.2

76.9

108

WD105

NOMESCO Finland

Cystostatic therapy of methastized malignancy

22.7

76.9

115

A03FA01

ATC

metoclopramide; systemic, rectal

8.1

70.2

203

480

N02AA05

ATC

oxycodone; systemic

8.8

68.7

178

352

EB1BI

NOMESCO Finland

Cone beam imaging of teeth and jaws (1–2 quarters)

67.9

66.9

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

7.0

65.4

250

849

163

Kela drug reimbursment

Abiraterone and enzalutamide

78.0

62.9

C79.8

ICD-10 Finland

Secondary malignant neoplasm of other specified sites

17.9

50.5

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

5.4

49.8

254

1070

WD305

NOMESCO Finland

Simple therapy of methastized malignancy with biomodifiers

37.6

49.6

A04AA02

ATC

granisetron; systemic, transdermal

10.6

47.6

123

JN4BD

NOMESCO Finland

Extensive body CT

7.2

47.5

133

268

L02BB04

ATC

enzalutamide; oral

62.9

47.0

ZX120

NOMESCO Finland

Intravenous

7.6

44.1

115

206

ZX112

NOMESCO Finland

Subcutaneous

20.5

43.0

WD205

NOMESCO Finland

Therapy of methastized malignancy with hormones

57.5

42.9

116

Kela drug reimbursment

Prostate cancer

9.7

42.3

122

352

Kela drug reimbursment

Abiraterone and enzalutamide

74.7

41.1

L02BX03

ATC

abiraterone; oral

65.3

40.3

L02BB03

ATC

bicalutamide; oral

16.6

39.1

L03AA02

ATC

filgrastim; parenteral

16.0

37.4

WD225

NOMESCO Finland

Demanding therapy of methastized malignancy with hormones

34.2

37.1

Z51.5

ICD-10 Finland

Palliative care

8.4

37.1

133

Y77

ICPC

Malignant neoplasm prostate

15.6

37.1

A04AA01

ATC

ondansetron; systemic, rectal

7.9

36.4

145

A49.9

ICD-10 Finland

Bacterial infection, unspecified

6.0

35.8

112

249

L02BA03

ATC

fulvestrant; parenteral

105.5

35.4

192

Kela drug reimbursment

Fulvestrant

136.5

35.4

JN4AD

NOMESCO Finland

Body CT examination

7.1

35.2

169

R50.9

ICD-10 Finland

Fever, unspecified

5.5

34.9

119

293

L02BX02

ATC

degarelix; parenteral

33.9

34.8

NK6AN

NOMESCO Finland

Total body bone isotope imaging

13.8

34.6

EB1AI

NOMESCO Finland

Cone beam imaging of teeth and jaws (one quarter)

24.8

34.1

153

Kela drug reimbursment

Lenalidomid

62.0

34.0

L04AX04

ATC

lenalidomide; oral

70.2

33.7

C90.0

ICD-10 Finland

Multiple myeloma

28.3

33.2

K10.20

ICD-10 Finland

Osteomyelitis (neonatal) of jaw (acute)(chronic)(suppurative)

+∞

32.8

K10.25

ICD-10 Finland

Sequences of jawbones

352.5

32.4

EDW99

NOMESCO Finland

Other operation on mandible

340.0

31.3

8140/3-C61.9

ICD-O-3

Adenocarcinoma, NOS, of prostate gland

5.8

30.4

212

H02AB06

ATC

prednisolone; systemic

3.7

30.3

248

1322

EB1CI

NOMESCO Finland

Cone beam imaging of teeth and jaws (3-4 quarters)

62.1

29.7

C61

ICD-10 Finland

Malignant neoplasm of prostate

5.5

29.6

223

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

8.5

29.2

A79

ICPC

Malignancy NOS

24.7

28.5

K10.21

ICD-10 Finland

Osteoradionecrosis of jaw (acute)(chronic)(suppurative)

+∞

28.5

WZB00

NOMESCO Finland

Telephone receipt or other advice

3.8

28.5

159

613

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.5

28.1

244

1326

L02AE02

ATC

leuprorelin; implant, parenteral

8.9

28.0

1501

Kela drug reimbursment

Palbociclib

104.6

27.1

WW500

NOMESCO Finland

Blood transfusion

9.7

26.7

XW000

NOMESCO Finland

Bone marrow biopsy

7.5

26.6

104

329

Kela drug reimbursment

Lenalidomide

100.7

26.0

5BA08

NOMESCO Finland

36.0

26.0

WD125

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

8.8

25.7

TPH04

NOMESCO Finland

Cathetrisation of vein

3.7

25.4

142

536

XX3DW

NOMESCO Finland

Time consuming IT work

5.1

25.3

213

M87.0

ICD-10 Finland

Idiopathic aseptic necrosis of bone

75.3

25.2

SXB00

NOMESCO Finland

Removeal of sutres from oral mucosa

7.0

25.1

109

394

Kela drug reimbursment

Palbociclib

96.8

25.0

L01XE33

ATC

[U] palbociclib; oral

267.2

25.0

A02BC02

ATC

pantoprazole; systemic

3.6

24.9

295

1934

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

8.8

24.6

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

6.7

23.4

107

WD505

NOMESCO Finland

Simple enzyme inhibitor or similar therapy of methastized malignancy

43.1

23.0

EBA10

NOMESCO Finland

Surgical removal of tooth

5.0

22.6

191

L02BG06

ATC

exemestane; oral

16.5

22.5

X76

ICPC

Malignant neoplasm breast female

13.5

22.4

9732/3-C42.1

ICD-O-3

Plasma cell myeloma of bone marrow

31.3

22.2

L03AA13

ATC

pegfilgrastim; parenteral

8.7

21.8

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

6.7

21.8

100

115

Kela drug reimbursment

Breast cancer

5.2

21.8

163

C03CA01

ATC

furosemide; systemic

3.1

21.6

163

751

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

6.0

21.5

119

WF004

NOMESCO Finland

Palliative radiotherapy

13.6

21.4

L02BA01

ATC

tamoxifen; oral

8.3

20.7

M87.9

ICD-10 Finland

Osteonecrosis, unspecified

51.1

20.4

L02BG04

ATC

letrozole; oral

5.8

20.1

120

EDB00

NOMESCO Finland

Partial excision of mandible

+∞

20.0

Z94.8

ICD-10 Finland

Other transplanted organ and tissue status

77.5

19.9

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

4.4

19.6

203

EDA10

NOMESCO Finland

Biopsy of mandible

73.8

18.9

NE1AA

NOMESCO Finland

Pelvis X-ray examination

5.4

18.7

126

SPAT1256

SPAT

Intramuscular and subcutaneous injection

2.7

18.6

212

1230

NF1AA

NOMESCO Finland

Hip X-ray examination

4.4

18.3

189

AA3AI

NOMESCO Finland

Cone beam CT of facial bones

34.9

18.2

SAA02

NOMESCO Finland

Basic examination of mouth

2.7

18.0

262

1736

D70.82

ICD-10 Finland

Drug-induced neutropenia

13.4

18.0

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.6

17.8

315

K08.1

ICD-10 Finland

Loss of teeth due to accident, extraction or local periodontal disease

3.9

17.4

242

B01AB05

ATC

enoxaparin; parenteral

2.7

17.2

159

804

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

5.4

17.2

110

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

2.6

17.1

219

1327

A28

ICPC

Limited function/disability NOS

3.3

17.0

356

WZC30

NOMESCO Finland

Teaching

3.5

17.0

311

N02BE01

ATC

paracetamol; systemic, rectal

4.4

16.9

345

2797

YN7AD

NOMESCO Finland

CT examination of spine for dose design of radiotherapy

66.5

16.9

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

6.0

16.6

N03AX16

ATC

pregabalin; oral

2.9

16.5

124

549

M05BA06

ATC

ibandronic acid; systemic

16.3

16.4

L95

ICPC

Osteoporosis

7.4

16.2

SXC05

NOMESCO Finland

Other oral or dental procedure

6.6

16.2

WX110

NOMESCO Finland

Local anesthesy

2.7

16.0

275

1929

ZX090

NOMESCO Finland

Other technic of radiotherapy

7.4

15.9

SAA01

NOMESCO Finland

Simple examination of mouth

2.7

15.9

279

1980

L04AA06

ATC

mycophenolic acid; systemic

12.5

15.8

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

5.2

15.6

108

N02AJ06

ATC

codeine and paracetamol; systemic

2.5

15.5

169

923

127

Kela drug reimbursment

Transplant complication

13.9

15.4

K04.5

ICD-10 Finland

Chronic apical periodontitis

2.7

15.4

129

605

YL1BD

NOMESCO Finland

Extensive CT examination of pelvis for dose design of radiotherapy

9.1

15.3

WW300

NOMESCO Finland

Transfer of autologic stem cells

47.1

15.2

1CD02

NOMESCO Finland

17.4

15.0

WD515

NOMESCO Finland

Demanding therapy of malignancy with enzyme inhibitors and similar treatments

83.5

14.7

5BX04

NOMESCO Finland

83.5

14.7

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

3.5

14.6

240

M05BA04

ATC

alendronic acid; oral

3.9

14.6

183

NE1BG

NOMESCO Finland

Pelvic, hip and femur MRI examination with high intensity magnet

7.8

14.4

WX2DD

NOMESCO Finland

Low-dose CT of skeleton in whole body

55.5

13.9

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

7.3

13.8

HAC20

NOMESCO Finland

Total mastectomy

5.8

13.8

WD115

NOMESCO Finland

Multiple cystostatic therapy of methastized malignancy

11.6

13.7

1XX32

NOMESCO Finland

78.1

13.7

EFA20

NOMESCO Finland

Decortication of jaws

+∞

13.6

K10.28

ICD-10 Finland

Other inflammatory condition of the jaws

145.0

13.5

J05AB11

ATC

valaciclovir; oral

3.4

13.5

243

L01CA04

ATC

vinorelbine; systemic

15.8

13.3

NJ3DA

NOMESCO Finland

Long bones of extremities X-ray examination

23.5

13.0

EBA00

NOMESCO Finland

Extraction of tooth

2.4

13.0

151

829

K08.3

ICD-10 Finland

Retained dental root

4.1

12.8

143

WX290

NOMESCO Finland

Other blockade of nerve

2.3

12.8

167

974

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

9.8

12.7

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

3.8

12.6

161

WW409

NOMESCO Finland

Other aferesis

134.3

12.5

M87.3

ICD-10 Finland

Other secondary osteonecrosis

134.3

12.5

393

Kela drug reimbursment

Pomalidomide

134.3

12.5

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.6

12.4

180

AA1AA

NOMESCO Finland

Head X-ray examination

16.6

12.3

SXC03

NOMESCO Finland

Other oral or dental procedure

16.6

12.3

J01DB01

ATC

cefalexin; oral

2.7

12.2

313

2491

M05BB03

ATC

alendronic acid and colecalciferol; oral

7.2

12.2

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

6.8

12.1

L04AD01

ATC

ciclosporin; systemic

8.9

12.0

PJD52

NOMESCO Finland

Block dissection of axillary lymph nodes

5.2

12.0

YN7BD

NOMESCO Finland

Extensive CT examination of spine for dose design of radiotherapy

48.3

12.0

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

5.0

11.9

JN4CD

NOMESCO Finland

Very extensive body CT

5.7

11.8

L01BC06

ATC

capecitabine; oral

5.8

11.8

SAA04

NOMESCO Finland

Special inverstigation of mouth

4.7

11.7

L01EF01

ATC

palbociclib; oral

67.1

11.7

H02AB07

ATC

prednisone; oral

2.9

11.5

321

1507

Kela drug reimbursment

Pomalidomide

123.6

11.5

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

3.8

11.4

142

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

7.2

11.4

L04AX01

ATC

azathioprine; systemic

5.3

11.3

A06AD11

ATC

lactulose; oral

2.8

11.2

332

TNE25

NOMESCO Finland

Drill biopsy of bone marrow, pelvis

11.7

11.2

SPF00

NOMESCO Finland

Repatation of teeth prosthesis

6.6

11.2

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.4

11.1

118

613

ZYC01

NOMESCO Finland

Remote contact by phone

5.2

11.0

N03AX12

ATC

gabapentin; oral

2.8

11.0

330

ZXA00

NOMESCO Finland

Right side

2.3

11.0

133

735

J05AB01

ATC

aciclovir; systemic

2.6

11.0

435

J01FF01

ATC

clindamycin; systemic

2.3

10.9

126

680

K05.31

ICD-10 Finland

Periodontitis pronounced

3.1

10.8

235

WD135

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

13.4

10.8

WD325

NOMESCO Finland

Demanding therapy of methastized malignancy with biomodifiers

13.4

10.8

YX9AD

NOMESCO Finland

Other CT eamination for dose design of radiotherapy

7.4

10.8

EBA15

NOMESCO Finland

Extraction of large number of teeth

4.8

10.7

XX7FT

NOMESCO Finland

Radioyttrium therapy with connected antibody

61.8

10.7

L03AA14

ATC

lipegfilgrastim; parenteral

10.5

10.6

A06AH03

ATC

naloxegol; oral

10.5

10.6

TEW99

NOMESCO Finland

Other minor procedure in surgery of teeth, jaws, mouth and pharynx

4.9

10.5

L04AX06

ATC

pomalidomide; oral

113.0

10.5

N02AX02

ATC

tramadol; systemic, rectal

2.1

10.5

184

1191

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.1

10.3

187

1223

SPF20

NOMESCO Finland

Temporary soling for filling

13.6

10.3

NFB30

NOMESCO Finland

Primary total prosthetic replacement of hip joint not using cement

3.8

10.2

128

WW200

NOMESCO Finland

Immunization

6.4

10.2

EB1AA

NOMESCO Finland

Tooth X-ray examination

2.1

10.2

213

1471

L04AA01

ATC

[U] ciclosporin; systemic

10.5

10.1

SPAT1254

SPAT

Administration of medicine

2.6

10.1

340

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.5

10.0

397

EBA12

NOMESCO Finland

Complicated surgical removal of tooth

8.5

10.0

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

4.2

10.0

ZXE20

NOMESCO Finland

More than three and less than five hours

2.7

10.0

328

L02AE03

ATC

goserelin; implant

17.3

9.9

318

Kela drug reimbursment

Teriparatide

12.7

9.9

C50.99

ICD-10 Finland

Breast, unspecified

5.7

9.7

J01MA12

ATC

levofloxacin; systemic

2.4

9.7

477

ZXD05

NOMESCO Finland

Urgent procedure

2.2

9.7

131

751

B03XA02

ATC

darbepoetin alfa; parenteral

7.5

9.6

R4110

NOMESCO Finland

Physiotherapy

2.2

9.6

121

672

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

3.1

9.5

200

Z01.2

ICD-10 Finland

Dental examination

2.1

9.5

156

969

ECA99

NOMESCO Finland

Other incision or excision of gingiva and alveolus

102.5

9.5

XX7AT

NOMESCO Finland

Radiation therapy with Radium-223

102.5

9.5

M81.9

ICD-10 Finland

Osteoporosis, unspecified

4.5

9.5

3054

Kela drug reimbursment

30.9

9.5

GA5AA

NOMESCO Finland

Rib X-ray examination

30.9

9.5

1523

Kela drug reimbursment

30.9

9.5

WW402

NOMESCO Finland

Leucoferesis

+∞

9.4

A07AA02

ATC

nystatin; oral

3.5

9.4

137

M05BA02

ATC

clodronic acid; systemic

22.4

9.4

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.5

9.4

365

C78.7

ICD-10 Finland

Secondary malignant neoplasm of liver and intrahepatic bile duct

6.6

9.2

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

11.9

9.1

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

11.9

9.1

M80.0

ICD-10 Finland

Postmenopausal osteoporosis with pathological fracture

6.8

9.1

Z3226

NOMESCO Finland

Physiotherapist

2.4

9.1

407

ECW99

NOMESCO Finland

Other operation on gingiva or alveoli

37.7

9.1

-50

ICPC

Medication/prescr/renewal

4.5

9.0

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

3.6

9.0

125

M05BA07

ATC

risedronic acid; oral

5.2

9.0

SPAT1255

SPAT

Intravenous administration of medicine

3.4

8.9

137

B03XA01

ATC

erythropoietin; parenteral

13.0

8.9

B01AB10

ATC

tinzaparin; parenteral

3.2

8.9

155

TPX10

NOMESCO Finland

Implantation of vascular injection port

5.1

8.9

WX199

NOMESCO Finland

Other local analgesia

5.4

8.6

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

2.6

8.6

272

SBB00

NOMESCO Finland

Fotograf of mouth and teeth

5.6

8.6

C50.4

ICD-10 Finland

Malignant neoplasm: Upper-outer quadrant of breast

20.6

8.5

H02AB09

ATC

hydrocortisone; systemic

5.5

8.5

M87.8

ICD-10 Finland

Other osteonecrosis

92.0

8.4

N05CF01

ATC

zopiclone; oral

2.0

8.3

133

808

WX892

NOMESCO Finland

Monitored bed care

3.1

8.3

160

Z2221

NOMESCO Finland

Medical doctor

2.1

8.3

117

673

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

3.4

8.2

124

ZX013

NOMESCO Finland

Radiotherapy with large shaped fields - SSD therapy

12.1

8.1

H05AA02

ATC

teriparatide; parenteral

12.1

8.1

R06AE07

ATC

cetirizine; oral

1.9

8.1

163

1077

EDA00

NOMESCO Finland

Incision of mandible

17.7

8.1

NK6AQ

NOMESCO Finland

Whole body bone SPET with low dose CT

34.1

8.1

C91.0

ICD-10 Finland

Acute lymphoblastic leukaemia [ALL]

22.6

8.1

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.9

8.0

191

KE1AT

NOMESCO Finland

Biopsy of prostata with ultrasoudnguidance

3.3

8.0

126

N05BA04

ATC

oxazepam; oral

2.1

7.9

535

ZXE30

NOMESCO Finland

More than five and less than seven hours

3.8

7.9

Z3231

NOMESCO Finland

Registered nurse

2.0

7.9

122

728

NF3AA

NOMESCO Finland

Femur X-ray examination

7.2

7.9

166

Kela drug reimbursment

Dalteparin and tinzaparin (treatment for more than 6 months)

9.7

7.8

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.3

7.8

377

K12.2

ICD-10 Finland

Cellulitis and abscess of mouth

15.4

7.8

J01MA14

ATC

moxifloxacin; systemic

2.8

7.8

189

EEW99

NOMESCO Finland

Other operation on maxilla

45.9

7.7

1CX01

NOMESCO Finland

45.9

7.7

L02BG03

ATC

anastrozole; oral

6.9

7.7

WX408

NOMESCO Finland

General anesthesy, balanced

2.0

7.7

116

687

ZX108

NOMESCO Finland

Inhalation

12.2

7.6

J01MA02

ATC

ciprofloxacin; systemic

1.9

7.6

158

1050

D64.9

ICD-10 Finland

Anaemia, unspecified

2.6

7.6

243

Z2446

NOMESCO Finland

Social worker

3.3

7.6

120

AA1BD

NOMESCO Finland

Extensive CT of head and brain

5.2

7.5

SPAT1217

SPAT

Assessment of need for services (elderly/care support)

3.2

7.5

132

P01AB01

ATC

metronidazole; oral, rectal

1.9

7.5

153

1009

TPH90

NOMESCO Finland

Removal of fixed intravenous catheter

7.9

7.5

T86.0

ICD-10 Finland

Bone-marrow transplant rejection

81.6

7.4

SPAT1222

SPAT

Counselling/guidance promoting independent living

2.3

7.4

329

G03HA01

ATC

cyproterone; systemic

13.7

7.4

M80.4

ICD-10 Finland

Drug-induced osteoporosis with pathological fracture

13.7

7.4

X59

ICD-10 Finland

Exposure to unspecified factor

2.3

7.4

386

EN1BD

NOMESCO Finland

Very extensive CT examination of mouth and soft tissues of neck

8.6

7.4

C50.81

ICD-10 Finland

Overall malignant tumor of the mammary gland, ductal tumor

8.6

7.4

Z51.1

ICD-10 Finland

Chemotherapy session for neoplasm

8.6

7.4

WD405

NOMESCO Finland

Simple antiboidy therapy of methastized malignancy

5.4

7.4

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

3.1

7.4

144

EDB99

NOMESCO Finland

Other excision on mandible

+∞

7.3

M87

ICD-10 Finland

Osteonecrosis

+∞

7.3

K10.26

ICD-10 Finland

Periostitis of jaw (acute)(chronic)(suppurative)

+∞

7.3

L01AA03

ATC

melphalan; systemic

+∞

7.3

C77.8

ICD-10 Finland

Secondary and unspecified malignant neoplasm: Lymph nodes of multiple regions

16.1

7.3

JN3KE

NOMESCO Finland

Abdominal ultrasound with added contrast

16.1

7.3

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

4.2

7.2

C77.5

ICD-10 Finland

Secondary and unspecified malignant neoplasm: Intrapelvic lymph nodes

30.6

7.2

EEA10

NOMESCO Finland

Biopsy of maxilla

30.6

7.2

NEA10

NOMESCO Finland

Exploration of soft tissue of pelvis, percutaneous

30.6

7.2

AA1AD

NOMESCO Finland

CT of head and brain

2.0

7.1

107

628

YX9BD

NOMESCO Finland

Other extensive CT eamination for dose design of radiotherapy

10.3

7.1

ZXM00

NOMESCO Finland

Intraoperative use of ultrasonographic imaging

10.3

7.1

YL1AD

NOMESCO Finland

CT examination of pelvis for dose design of radiotherapy

7.2

7.1

J01CA04

ATC

amoxicillin; systemic

2.0

7.0

294

2451

PH1AE

NOMESCO Finland

Ultrasound examination of upper extremity veins

8.5

6.9

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

2.7

6.8

173

ZXC40

NOMESCO Finland

Use of ultrasound

40.8

6.8

J01CE02

ATC

phenoxymethylpenicillin; oral

1.8

6.7

246

1934

SPA00

NOMESCO Finland

Changing form of teeth in prepation for prothetic work

3.5

6.7

L28

ICPC

Limited function/disability (L)

2.2

6.7

360

R60.0

ICD-10 Finland

Localized oedema

2.5

6.6

240

TPH07

NOMESCO Finland

Cathetrisation of artery

2.5

6.6

228

A29

ICPC

General symptom/complaint other

2.5

6.6

228

Z08.7

ICD-10 Finland

Follow-up examination after combined treatment for malignant neoplasm

12.5

6.6

M19.2

ICD-10 Finland

Other secondary arthrosis

8.9

6.6

C50.91

ICD-10 Finland

Malignant tumor in another specified localization in ductal mammary gland

8.9

6.6

SPE90

NOMESCO Finland

Other fitting and preparation of partial tooth prosthesis

5.2

6.6

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.0

6.5

508

K02.1

ICD-10 Finland

Caries of dentine

1.8

6.5

197

1453

C50.90

ICD-10 Finland

Malignant tumor in other or unspecified location in mammary gland without histology

6.4

6.5

XX9AW

NOMESCO Finland

Production of copy from X-ray picture

4.2

6.5

ZXA05

NOMESCO Finland

Left side

1.9

6.4

110

673

NA2CG

NOMESCO Finland

Thoracal spine extensive MRI examination with high intensity magnet

14.6

6.4

ECA20

NOMESCO Finland

Biopsy of gingiva

8.4

6.4

NA3DG

NOMESCO Finland

Lumbar spine very extensive MRI examination with high intensity magnet

9.5

6.3

NK6CT

NOMESCO Finland

Bone biopsy with CT guidance

18.4

6.3

SPAT1088

SPAT

Blood transfusion

18.4

6.3

8520/3-C50.9

ICD-O-3

Lobular carcinoma, NOS, of breast, NOS

7.2

6.3

WZA90

NOMESCO Finland

Other doctors statement

2.0

6.3

540

Z52.89

ICD-10 Finland

Donor of other organ or tissue

+∞

6.3

WD215

NOMESCO Finland

Multiple therapy of methastized malignancy with hormones

+∞

6.3

EDC99

NOMESCO Finland

Other reconstructive operations on mandible

+∞

6.3

K05.30

ICD-10 Finland

Periodontitis complex

2.3

6.3

269

WX002

NOMESCO Finland

Sedation and analgesia

2.0

6.3

501

YNB10

NOMESCO Finland

Collection of stem cells for transplant

27.2

6.2

HA1AA

NOMESCO Finland

X-ray mammography

2.8

6.2

156

A01

ICPC

Pain general/multiple sites

2.9

6.2

132

A05AA02

ATC

ursodeoxycholic acid; oral

7.9

6.2

TKC20

NOMESCO Finland

Catheterisation of bladder

2.8

6.2

150

SPAT1137

SPAT

Taking care of patient’s/customer’s hygiene

3.1

6.1

110

WX725

NOMESCO Finland

Noninvasive ventilation

3.7

6.1

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.6

6.1

188

B02.9

ICD-10 Finland

Zoster without complication

3.2

6.1

XF600

NOMESCO Finland

Bloodpressure measurement

2.9

6.1

128

ZX080

NOMESCO Finland

Image guided radiotherapy

6.2

6.1

WX402

NOMESCO Finland

General anaesthesia

2.2

6.0

322

A46

ICD-10 Finland

Erysipelas

2.2

6.0

323

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

2.9

6.0

129

NAME	OSTEON_DRUGS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M871
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
OSTEON_DRUGS	6.288 [4.04, 9.8]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.139

Parameter	HR [95% CI]	p-value
OSTEON_DRUGS	7.082 [4.47, 11.23]	< 0.001
Birth year	0.985 [0.97, 1.0]	0.005

N-year risk	Females	Males
1	0.545%	1.567%
5	3.374%	8.081%
10	8.458%	18.232%
15	15.072%	31.532%
20	25.297%	48.531%

Osteonecrosis due to drugs

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints