This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Alzheimer’s disease (undefined)
AD_U
Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
516 |
4. Check minimum number of eventsNone |
516 |
5. Include endpointsNone |
516 |
6. Filter based on genotype QC (FinnGen only) |
516 |
Control definitions (FinnGen only)
- Control exclude
- G6_ALZHEIMER
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Alzheimer’s disease (undefined)
based on the number of shared cases.
Similar with more cases:
- Alzheimer’s disease (undefined), excluding more controls
- Dementia in Alzheimer disease
- Alzheimer disease
- Alzheimer disease, excluding more controls
- Degenerative diseases of the nervous system
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 516 | 228 | 288 |
| Unadjusted period prevalence (%) | 0.11 | 0.08 | 0.13 |
| Median age at first event (years) | 80.30 | 82.05 | 78.91 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 473
- Matched controls
- 4730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
206.3
323.0
364
75
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
1217.8
323.0
285
6
F009, G309
ICD-10 Finland
NA
+∞
323.0
468
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
142.0
247.3
250
37
N06DX01
ATC
memantine; oral
41.1
191.4
247
122
N06DA02
ATC
donepezil; oral
36.4
166.3
220
110
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
69.7
113.1
128
25
N06DA03
ATC
rivastigmine; oral, transdermal
34.1
105.3
139
57
F0019, G301
ICD-10 Finland
NA
+∞
99.6
92
*
N05AX08
ATC
risperidone; systemic
11.3
86.4
182
248
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
107.4
60.6
65
7
G30.0
ICD-10 Finland
Alzheimer disease with early onset
579.8
53.6
52
*
F0009, G300
ICD-10 Finland
NA
+∞
52.0
49
*
G30.8
ICD-10 Finland
Other Alzheimer disease
42.1
45.2
56
15
N05AH04
ATC
quetiapine; oral
6.7
43.2
122
234
F03
ICD-10 Finland
Unspecified dementia
5.1
37.0
134
342
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
26.5
36.2
50
21
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
+∞
35.9
34
*
N06DA04
ATC
galantamine; oral
16.6
34.6
56
38
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
22.0
31.6
46
23
P70
ICPC
Dementia
11.5
27.5
52
50
N06AB04
ATC
citalopram; systemic
3.0
20.4
145
613
F0029, G308
ICD-10 Finland
NA
+∞
17.8
17
*
N05BA04
ATC
oxazepam; oral
2.6
17.5
160
776
G30
ICD-10 Finland
Alzheimer disease
21.9
17.5
25
12
N05AD03
ATC
melperone; systemic
6.3
16.8
45
77
Z02.4
ICD-10 Finland
Examination for driving licence
0.1
15.5
5
512
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.4
14.1
73
243
R53
ICD-10 Finland
Malaise and fatigue
2.2
12.1
144
775
Z75.5
ICD-10 Finland
Holiday relief care
5.7
12.0
34
63
WYA20
NOMESCO Finland
Home visit
6.8
11.7
29
45
N03AG01
ATC
valproic acid; systemic, rectal
5.2
11.5
35
71
F00.00
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
+∞
11.5
11
*
N05AH03
ATC
olanzapine; systemic
8.2
11.5
25
32
S18
ICPC
Laceration/cut
0.3
10.8
35
891
3310A
ICD-9 Finland
Other cerebral degenerations, Alzheimer's disease
+∞
10.5
10
*
F00.19
ICD-10 Finland
Dementia in Alzheimer's disease with late onset without information about additional symptoms
+∞
10.5
10
*
N05AD01
ATC
haloperidol; systemic
3.7
10.3
45
131
H81
ICPC
Excessive ear wax
0.2
10.1
10
475
A98
ICPC
Health maint/preventive medicine
0.5
10.1
129
2006
N05BA06
ATC
lorazepam; systemic, sublingual
3.5
9.9
46
141
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
9.7
214
1444
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.2
9.4
13
513
N02AJ06
ATC
codeine and paracetamol; systemic
0.2
9.3
12
488
SPAT1251
SPAT
Organisation of medication
3.4
9.0
44
140
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.2
9.0
46
152
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
8.6
194
1305
F0014, G301
ICD-10 Finland
NA
+∞
8.4
8
*
N06AX11
ATC
mirtazapine; oral
1.9
8.3
131
777
A06AD11
ATC
lactulose; oral
1.9
8.2
153
963
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.7
8.1
34
96
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.1
8.1
5
324
N06AB10
ATC
escitalopram; oral
2.5
7.9
62
267
N07AA05
ATC
NA
45.7
7.7
9
*
R41.0
ICD-10 Finland
Disorientation, unspecified
3.3
7.6
37
119
H13
ICPC
Plugged feeling ear
0.3
7.4
14
467
B01AF02
ATC
apixaban; oral
0.2
7.3
6
323
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
5.8
7.1
19
34
SPAT1153
SPAT
Removal of sutures
0.4
7.0
24
604
P20
ICPC
Memory disturbance
2.1
6.8
83
441
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.2
6.5
23
57
F009, G308
ICD-10 Finland
NA
+∞
6.3
6
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.3
6.1
16
453
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
0.3
6.1
16
456
H02
ICPC
Hearing complaint
0.2
6.1
8
322
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
0.4
6.0
21
526
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.2
6.0
6
288
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: AD_U – Alzheimer’s disease (undefined)
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).