No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- G6_AD_WIDE, F5_DEMENTIA, F5_DEMENTIA_U, F5_PSYCH, NEURODIS, MEMLOSS, TRAUMBRAIN_NONCONCUS
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Alzheimer’s disease (undefined), excluding more controls
based on the number of shared cases.
Similar with more cases:
- Alzheimer’s disease (undefined)
- Dementia in Alzheimer disease
- Alzheimer disease
- Alzheimer disease, excluding more controls
- Degenerative diseases of the nervous system
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12062 | 7792 | 4086 |
| Only index persons | 8572 | 5763 | 2809 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.22 | 0.11 |
| Only index persons | 0.18 | 0.21 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 82.15 | 82.98 | 80.69 |
| Only index persons | 82.66 | 83.38 | 81.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 516 | 228 | 288 |
| Unadjusted period prevalence (%) | 0.11 | 0.08 | 0.13 |
| Median age at first event (years) | 80.30 | 82.05 | 78.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 470
- Matched controls
- 4592
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F009, G309
ICD-10 Finland
NA
+∞
323.0
465
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
3429.6
323.0
283
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
323.0
363
*
N06DX01
ATC
memantine; oral
983.0
277.3
247
5
G30.1
ICD-10 Finland
Alzheimer disease with late onset
514.3
273.8
250
10
N06DA02
ATC
donepezil; oral
398.2
233.8
219
10
N05AX08
ATC
risperidone; systemic
62.2
156.7
182
46
N06DA03
ATC
rivastigmine; oral, transdermal
632.7
146.9
139
*
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
338.5
130.2
127
5
F03
ICD-10 Finland
Unspecified dementia
74.2
117.0
132
24
F0019, G301
ICD-10 Finland
NA
+∞
97.6
91
*
N05AH04
ATC
quetiapine; oral
26.4
85.8
122
60
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
732.0
67.1
65
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
244.8
64.3
65
*
N06DA04
ATC
galantamine; oral
154.7
53.6
56
*
G30.0
ICD-10 Finland
Alzheimer disease with early onset
566.7
53.1
52
*
G30.8
ICD-10 Finland
Other Alzheimer disease
123.8
52.5
56
5
F0009, G300
ICD-10 Finland
NA
+∞
51.6
49
*
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
542.1
51.0
50
*
N06AB04
ATC
citalopram; systemic
6.6
49.7
145
289
P70
ICPC
Dementia
51.7
43.4
52
11
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
82.9
41.3
46
6
S06.0
ICD-10 Finland
Concussion
53.7
37.9
45
9
N05BA04
ATC
oxazepam; oral
4.5
37.3
159
469
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
138.1
36.9
39
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
103.6
35.9
39
*
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
+∞
35.6
34
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
+∞
35.6
34
*
N03AG01
ATC
valproic acid; systemic, rectal
365.0
35.1
35
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
9.7
34.5
73
85
N05AD03
ATC
melperone; systemic
24.2
31.6
45
20
R53
ICD-10 Finland
Malaise and fatigue
3.9
28.7
142
463
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.2
27.8
193
814
N06AB10
ATC
escitalopram; oral
7.4
25.1
62
92
N06AX11
ATC
mirtazapine; oral
3.6
25.1
131
440
G30
ICD-10 Finland
Alzheimer disease
257.2
24.7
25
*
Z75.5
ICD-10 Finland
Holiday relief care
23.0
23.0
33
15
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
22.0
213
1074
N05AH03
ATC
olanzapine; systemic
64.3
21.8
25
*
P20
ICPC
Memory disturbance
4.2
20.0
83
225
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
8.0
20.0
46
61
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
19.8
19
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
+∞
19.8
19
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
19.8
19
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
8.9
19.5
42
50
A06AD11
ATC
lactulose; oral
2.8
19.4
152
662
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
23.2
19.0
27
12
G20
ICD-10 Finland
Parkinson disease
+∞
18.7
18
*
AA1AD
NOMESCO Finland
CT of head and brain
3.5
18.6
94
302
F05.9
ICD-10 Finland
Delirium, unspecified
101.8
18.5
20
*
WYA20
NOMESCO Finland
Home visit
16.7
18.3
29
18
N05BA06
ATC
lorazepam; systemic, sublingual
7.0
18.3
46
70
G40.9
ICD-10 Finland
Epilepsy, unspecified
+∞
17.7
17
*
F0029, G308
ICD-10 Finland
NA
+∞
17.7
17
*
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
17.7
17
*
N05AD01
ATC
haloperidol; systemic
6.8
17.6
45
70
R41.0
ICD-10 Finland
Disorientation, unspecified
8.6
17.0
37
45
Z02.4
ICD-10 Finland
Examination for driving licence
0.1
16.3
5
519
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
+∞
15.6
15
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
19.6
15.5
23
12
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
14.8
113
477
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
+∞
14.5
14
*
SPAT1251
SPAT
Organisation of medication
5.4
14.5
44
86
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
8.4
13.8
30
37
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
+∞
13.5
13
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.7
13.4
103
434
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.7
13.2
99
410
F06.7
ICD-10 Finland
Mild cognitive disorder
19.3
12.8
19
10
F05.1
ICD-10 Finland
Delirium superimposed on dementia
+∞
12.4
12
*
R41.3
ICD-10 Finland
Other amnesia
24.5
12.4
17
7
G47.3
ICD-10 Finland
Sleep apnoea
18.2
12.0
18
10
R56.8
ICD-10 Finland
Other and unspecified convulsions
11.2
12.0
22
20
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
7.2
11.8
28
40
F01.9
ICD-10 Finland
Vascular dementia, unspecified
30.2
11.6
15
5
SPAT1245
SPAT
Provision of support and information to patient’s family members
4.7
11.5
39
87
F00.00
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
+∞
11.4
11
*
N05AA02
ATC
levomepromazine; systemic
7.1
11.3
27
39
J01DB01
ATC
cefalexin; oral
2.0
11.2
268
1857
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
4.2
11.1
42
104
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.1
10.9
62
214
B01AC07
ATC
dipyridamole; systemic
3.1
10.8
61
210
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
60.0
10.6
12
*
3310A
ICD-9 Finland
Other cerebral degenerations, Alzheimer's disease
+∞
10.4
10
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
10.0
310
2312
N05CD07
ATC
temazepam; oral
2.2
10.0
109
544
R55
ICD-10 Finland
Syncope and collapse
2.7
9.7
67
262
F22.0
ICD-10 Finland
Delusional disorder
54.9
9.6
11
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
6.9
9.5
23
34
S18
ICPC
Laceration/cut
0.4
9.5
35
832
130
Kela drug reimbursment
Malignant tumour
0.1
9.4
6
367
F00.19
ICD-10 Finland
Dementia in Alzheimer's disease with late onset without information about additional symptoms
99.6
9.4
10
*
2900A
ICD-9 Finland
Senile and presenile organic psychotic conditions, Senile dementia, uncomplicated
+∞
9.3
9
*
N07AA05
ATC
NA
+∞
9.3
9
*
S72.0
ICD-10 Finland
Fracture of neck of femur
3.0
9.1
52
180
W19
ICD-10 Finland
Unspecified fall
3.3
9.1
45
141
A98
ICPC
Health maint/preventive medicine
0.5
9.1
129
1922
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.1
9.0
111
583
H81
ICPC
Excessive ear wax
0.2
9.0
10
432
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
8.4
65
270
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
89.5
8.4
9
*
J01CA08
ATC
pivmecillinam; oral
1.8
8.3
172
1096
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
+∞
8.3
8
*
F0014, G301
ICD-10 Finland
NA
+∞
8.3
8
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
8.3
8
*
I64
ICD-10 Finland
Stroke, not specified as haemorrhage or infarction
+∞
8.3
8
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
+∞
8.3
8
*
N02AJ06
ATC
codeine and paracetamol; systemic
0.2
8.1
12
442
N06AB06
ATC
sertraline; oral
5.6
7.9
22
40
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
3.7
7.9
33
91
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.3
7.9
13
453
N03AF01
ATC
carbamazepine; oral, rectal
4.8
7.9
25
53
N05AB03
ATC
perphenazine; systemic, rectal
10.8
7.7
14
13
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
44.7
7.7
9
*
C04AE01
ATC
ergoloid mesylates; systemic
6.0
7.6
20
34
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
7.5
157
994
G56.0
ICD-10 Finland
Carpal tunnel syndrome
8.4
7.2
15
18
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
7.2
7
*
G72.8
ICD-10 Finland
Other specified myopathies
+∞
7.2
7
*
J01MA02
ATC
ciprofloxacin; systemic
1.8
7.2
175
1159
H02AA02
ATC
fludrocortisone; oral
9.3
6.7
13
14
N06AA12
ATC
doxepin; systemic
3.4
6.7
30
89
SPAT1153
SPAT
Removal of sutures
0.4
6.6
24
577
N30.9
ICD-10 Finland
Cystitis, unspecified
3.0
6.5
35
118
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.2
6.5
5
274
A10AE04
ATC
insulin glargine; parenteral
2.8
6.4
41
154
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.2
6.4
6
289
R42
ICD-10 Finland
Dizziness and giddiness
2.0
6.3
90
495
E86
ICD-10 Finland
Volume depletion
4.1
6.3
23
57
B01AF02
ATC
apixaban; oral
0.2
6.2
6
283
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
4.6
6.2
20
44
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
6.2
6
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
+∞
6.2
6
*
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
+∞
6.2
6
*
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
+∞
6.2
6
*
F10.73
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol dementia
+∞
6.2
6
*
30041
ICD-8 Finland
Neuroses, Depressiva
+∞
6.2
6
*
F009, G308
ICD-10 Finland
NA
+∞
6.2
6
*
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
+∞
6.2
6
*
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
6.2
6
*
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
6.2
6
*
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
+∞
6.2
6
*
30320
ICD-8 Finland
Alcoholism, Alcoholic addiction
+∞
6.2
6
*
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
+∞
6.2
6
*
K90
ICPC
Stroke/cerebrovascular accident
17.9
6.2
9
5
I95.1
ICD-10 Finland
Orthostatic hypotension
3.8
6.1
24
64
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
3.5
6.0
26
75
Mortality – FinRegistry
↥Association
Association between endpoint AD_U_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AD_U_EXMORE | 2.456 [2.2, 2.74] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.109 |
During the follow-up period (1.1.1998 — 31.12.2019), 6337 out of 7115 females with AD_U_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AD_U_EXMORE | 3.053 [2.55, 3.65] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 3338 out of 3652 males with AD_U_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have AD_U_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.289% | 0.508% |
| 5 | 1.414% | 3.453% |
| 10 | 3.811% | 8.089% |
| 15 | 7.001% | 15.732% |
| 20 | 11.882% | 25.234% |
Relationships between endpoints
↥Index endpoint: AD_U_EXMORE – Alzheimer’s disease (undefined), excluding more controls
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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