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Dementia in Alzheimer disease

F5_ALZHDEMENT

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F00*
Hospital discharge: ICD-8 29010
Cause of death: ICD-10 F00*
Cause of death: ICD-8 29010

2 out of 7 registries used, show all original rules.

6344

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Check minimum number of events None

6344

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Include endpoints None

6344

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Remove individuals based on genotype QC

6145

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F5_ALZHDEMENT

Control definitions

Control exclude F5_ORGANIC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 6145 2733 3412
Unadjusted prevalence (%) 1.49 1.19 1.88
Mean age at first event (years) 79.66 79.78 79.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.20 10.23 [9.19, 11.37] <1e-100 3770
15 years 0.02 2.94 [2.63, 3.28] 4.7e-80 1006
5 years 0.01 7.44 [6.68, 8.28] <1e-100 1857
1 year 0.00 13.12 [11.69, 14.72] <1e-100 895

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: F5_ALZHDEMENT – Dementia in Alzheimer disease
GWS hits: 8

Survival analyses between endpoints

Plot

before Dementia in Alzheimer disease
after Dementia in Alzheimer disease

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Drugs most likely to be purchased after Dementia in Alzheimer disease

Endpoint not on priority list, no data to show.