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Unspecific neurodegenerative disorder

Endpoint Browser PheWeb

G6_NEURODEGENERATIVE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F00*, G30
  • Hospital discharge: ICD-9 — 3310
  • Hospital discharge: ICD-8 — 29010
  • Cause of death: ICD-10 — F00*, G30
  • Cause of death: ICD-9 — 3310
  • Cause of death: ICD-8 — 29010
  • KELA reimbursements: KELA codes — 307
  • KELA reimbursements: ICD-10 — F00*, G30
  • Medicine purchases: ATC — N06D

4 out of 7 registries used, show all original rules.

21102

4. Check minimum number of events

Min. number of events 3
21102

5. Include endpoints

21102

6. Filter based on genotype QC (FinnGen only)

21102

Control definitions (FinnGen only)

Control exclude
G6_ALZHEIMER

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 21102 9873 11229
Unadjusted period prevalence (%) 4.21 3.37 4.95
Median age at first event (years) 79.23 79.47 79.02

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

Mortality – FinRegistry

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This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

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Index endpoint: G6_NEURODEGENERATIVE – Unspecific neurodegenerative disorder

GWS hits: 47

This endpoint is excluded (different definition than used in FinnGen).