Risteys · K11

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K73 Hospital discharge: ICD-9 — 5714A\|5714X Hospital discharge: ICD-8 — 57001 Cause of death: ICD-10 — K73 Cause of death: ICD-9 — 5714A\|5714X Cause of death: ICD-8 — 57001 2 out of 7 registries used, show all original rules.	1256
4. Check minimum number of events None	1256
5. Include endpoints None	1256
6. Filter based on genotype QC (FinnGen only)	1256

	All	Female	Male
Number of individuals
Whole population	7890	4726	3100
Only index persons	6673	4123	2550
Unadjusted period prevalence (%)
Whole population	0.12	0.14	0.09
Only index persons	0.13	0.15	0.10
Median age at first event (years)
Whole population	55.74	57.47	53.03
Only index persons	54.41	56.19	51.54

	All	Female	Male
Number of individuals	1256	812	444
Unadjusted period prevalence (%)	0.25	0.28	0.20
Median age at first event (years)	54.57	54.18	55.27

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1128: Matched controls
11277

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K73.2

ICD-10 Finland

Chronic active hepatitis, not elsewhere classified

+∞

323.0

505

K73.9

ICD-10 Finland

Chronic hepatitis, unspecified

+∞

323.0

397

JJ2AT

NOMESCO Finland

Biopsy of liver with ultrasound guidance

142.4

323.0

438

L04AX01

ATC

azathioprine; systemic

34.6

308.9

411

184

K73.80

ICD-10 Finland

Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)

575.0

241.0

231

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

13.9

218.8

413

451

K75.9

ICD-10 Finland

Inflammatory liver disease, unspecified

+∞

210.1

195

K76.9

ICD-10 Finland

Liver disease, unspecified

588.0

203.6

196

A05AA02

ATC

ursodeoxycholic acid; oral

64.0

195.5

226

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

9.6

182.3

426

670

K75.4

ICD-10 Finland

Autoimmune hepatitis

+∞

171.3

160

A07EA06

ATC

budesonide; oral, local oral

21.6

163.1

247

144

K76.0

ICD-10 Finland

Fatty (change of) liver, not elsewhere classified

63.6

157.1

182

K74.6

ICD-10 Finland

Other and unspecified cirrhosis of liver

+∞

136.3

128

K74.3

ICD-10 Finland

Primary biliary cirrhosis

+∞

135.2

127

K73.0

ICD-10 Finland

Chronic persistent hepatitis, not elsewhere classified

+∞

122.1

115

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

4.7

118.8

566

2006

R74.0

ICD-10 Finland

Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]

34.1

101.4

133

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

5.6

95.4

324

763

K83.0

ICD-10 Finland

Cholangitis

30.9

83.5

112

JJ1LE

NOMESCO Finland

Ultrasound elastography of liver

59.4

79.4

H02AB06

ATC

prednisolone; systemic

3.3

78.2

699

3732

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.4

78.1

555

2499

I85.9

ICD-10 Finland

Oesophageal varices without bleeding

109.0

75.0

Z94.4

ICD-10 Finland

Liver transplant status

363.6

69.4

TJJ00

NOMESCO Finland

Percutaneous needle biopsy of liver

240.9

67.0

JN1CG

NOMESCO Finland

Extensive MRI examination of upper part of abdomen with high intensity magnet

15.1

65.3

111

R17

ICD-10 Finland

Hyperbilirubinaemia, with or without jaundice, not elsewhere classified

26.0

63.5

K70.3

ICD-10 Finland

Alcoholic cirrhosis of liver

169.4

61.6

JJC00

NOMESCO Finland

Allogenic transplantation of liver

608.7

59.3

L01BB02

ATC

mercaptopurine; oral

29.8

57.8

L04AA06

ATC

mycophenolic acid; systemic

16.4

55.6

UJF30

NOMESCO Finland

Ileoscopy through colon

4.7

54.3

206

516

JKE98

NOMESCO Finland

Other transduodenal endoscopic operation on bile duct or ampulla of Vater

19.0

51.8

C03DA01

ATC

spironolactone; oral

4.5

50.1

195

499

5714X

ICD-9 Finland

Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]

+∞

49.3

UJF32

NOMESCO Finland

Coloscopy

2.8

46.6

390

1794

JN3DE

NOMESCO Finland

Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation

66.6

44.5

K51.5

ICD-10 Finland

Left sided colitis

9.5

43.9

106

L04AD01

ATC

ciclosporin; systemic

11.3

43.1

JL5BG

NOMESCO Finland

MRI examinaiton of bile and pancreas ducts with high intesity magnet

11.3

43.1

K72.0

ICD-10 Finland

Acute and subacute hepatic failure

422.3

41.4

K73.89

ICD-10 Finland

Other long-term hepatitis, not classified differently

+∞

40.9

208

Kela drug reimbursment

Ulcerative colitis and Crohn's disease

6.0

40.6

118

216

H02AB07

ATC

prednisone; oral

3.3

40.5

240

864

JJ9AE

NOMESCO Finland

Ultrasound examination of liver transplant

411.5

40.4

A02BC02

ATC

pantoprazole; systemic

2.4

39.7

802

5712

A07EC02

ATC

mesalazine; oral, rectal

5.1

39.3

132

286

JCA22

NOMESCO Finland

Endoscopic ligature of oesophageal varices

207.1

39.1

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.3

39.0

543

3215

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

4.4

38.9

151

381

127

Kela drug reimbursment

Transplant complication

13.3

38.5

R94.5

ICD-10 Finland

Abnormal results of liver function studies

20.6

38.2

R18

ICD-10 Finland

Ascites

14.8

37.3

K72.9

ICD-10 Finland

Hepatic failure, unspecified

196.4

37.0

ZX120

NOMESCO Finland

Intravenous

3.6

36.0

178

555

C03CA01

ATC

furosemide; systemic

2.6

35.6

334

1594

N02AX02

ATC

tramadol; systemic, rectal

2.2

35.4

540

3284

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

19.8

35.1

JL5AG

NOMESCO Finland

Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet

22.7

34.6

K74.0

ICD-10 Finland

Hepatic fibrosis

+∞

33.5

K51.9

ICD-10 Finland

Ulcerative colitis, unspecified

6.5

33.3

149

JJA20

NOMESCO Finland

Open biopsy of liver

90.3

31.9

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

2.5

30.7

291

1381

J01MA02

ATC

ciprofloxacin; systemic

2.1

30.5

480

2899

D97

ICPC

Liver disease NOS

39.3

30.4

TPH04

NOMESCO Finland

Cathetrisation of vein

2.5

30.3

286

1351

JN1DG

NOMESCO Finland

Very extensive MRI examination of upper part of abdomen with high intensity magnet

10.0

29.7

I85.0

ICD-10 Finland

Oesophageal varices with bleeding

106.2

28.8

C22.0

ICD-10 Finland

Malignant neoplasm: Liver cell carcinoma

153.9

28.8

103

Kela drug reimbursment

Diabetes, insulin-treated

2.3

28.7

320

1641

215

Kela drug reimbursment

Diabetes, non-insulin-treated

2.4

28.7

306

1535

JJ5AT

NOMESCO Finland

288.3

27.9

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

3.9

27.6

122

344

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.1

27.6

445

2687

UJK02

NOMESCO Finland

ERCP

8.6

26.3

JL5SB

NOMESCO Finland

Endoscopic retrograd cholangiopancreaticography

11.6

26.3

K73.8

ICD-10 Finland

Other chronic hepatitis, not elsewhere classified

+∞

26.1

A10AE04

ATC

insulin glargine; parenteral

3.3

26.1

140

461

C10AC01

ATC

colestyramine; oral

6.6

25.5

107

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

3.7

25.4

118

347

A06AD11

ATC

lactulose; oral

2.7

25.2

189

777

K80.2

ICD-10 Finland

Calculus of gallbladder without cholecystitis

2.9

24.8

169

652

JA3AT

NOMESCO Finland

Cathetrisation of abdominal cavity with ultrasound guidance

9.6

23.4

T90

ICPC

Diabetes non-insulin dependent

2.2

23.3

276

1434

A07AA11

ATC

rifaximin; oral

+∞

23.0

K72.1

ICD-10 Finland

Chronic hepatic failure

+∞

23.0

H02AB04

ATC

methylprednisolone; systemic

2.4

21.2

207

977

R50.9

ICD-10 Finland

Fever, unspecified

2.5

20.8

182

811

JX1XE

NOMESCO Finland

Other ultrasound examinaton of alimentary organs

78.3

20.7

JN3BD

NOMESCO Finland

Extensive abdominal CT

2.6

20.3

157

652

JJ3AT

NOMESCO Finland

Cytology of liver with ultrasound guidance

48.9

20.2

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.5

19.9

171

753

5714B

ICD-9 Finland

Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ACTIVA (HBSAG-)]

+∞

19.8

8170/3-C22.0

ICD-O-3

Hepatocellular carcinoma, NOS, of liver

106.9

19.6

K50.8

ICD-10 Finland

Other Crohn disease

7.6

19.3

K51.1

ICD-10 Finland

Ulcerative (chronic) ileocolitis

10.6

19.2

Z01.8

ICD-10 Finland

Other specified special examinations

2.1

19.0

268

1486

JN3CD

NOMESCO Finland

Abdominal CT examination both without and with contrast

4.7

19.0

148

A10BA02

ATC

metformin; oral

2.0

19.0

301

1746

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.2

18.9

207

1027

J01MA12

ATC

levofloxacin; systemic

2.2

18.8

223

1147

K70.1

ICD-10 Finland

Alcoholic hepatitis

+∞

18.8

UJK12

NOMESCO Finland

Peroral cholangioscopy

28.4

18.8

JKA21

NOMESCO Finland

Laparoscopic cholecystectomy

2.6

18.7

150

634

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.3

18.3

177

828

K50.1

ICD-10 Finland

Crohn disease of large intestine

10.6

18.2

JN3AD

NOMESCO Finland

Abdominal CT examination

3.2

18.2

102

344

K70.9

ICD-10 Finland

Alcoholic liver disease, unspecified

+∞

17.7

K76.89

ICD-10 Finland

Other specified diseases of liver

96.6

17.6

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

3.3

17.4

293

L04AA01

ATC

[U] ciclosporin; systemic

7.1

17.3

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

5.2

17.2

105

A10BH01

ATC

sitagliptin; oral

2.7

17.1

122

482

B18.2

ICD-10 Finland

Chronic viral hepatitis C

10.9

17.0

R74.8

ICD-10 Finland

Abnormal levels of other serum enzymes

3.9

17.0

186

K92.0

ICD-10 Finland

Haematemesis

6.3

16.9

285

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

3.6

16.9

228

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.6

16.8

133

556

UJD02

NOMESCO Finland

Gastroscopy

3.6

16.8

229

K75.2

ICD-10 Finland

Nonspecific reactive hepatitis

+∞

16.7

D64.9

ICD-10 Finland

Anaemia, unspecified

2.7

16.6

123

496

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

4.6

15.9

124

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

2.7

15.8

115

459

K70.4

ICD-10 Finland

Alcoholic hepatic failure

+∞

15.7

K70.0

ICD-10 Finland

Alcoholic fatty liver

162.1

15.5

JKE02

NOMESCO Finland

Transduodenal endoscopic incision of common bile duct orifice

7.8

15.4

M35.9

ICD-10 Finland

Systemic involvement of connective tissue, unspecified

7.5

15.0

JN1BG

NOMESCO Finland

MRI examination of upper part of abodmen with high intensity magnet

10.2

15.0

K51.0

ICD-10 Finland

Ulcerative (chronic) pancolitis

12.6

14.9

Z2221

NOMESCO Finland

Medical doctor

1.8

14.7

328

2116

5719X

ICD-9 Finland

Chronic liver disease and cirrhosis, Unspecified chronic liver disease without mention of alcohol

+∞

14.6

K75.8

ICD-10 Finland

Other specified inflammatory liver diseases

+∞

14.6

K73.1

ICD-10 Finland

Chronic lobular hepatitis, not elsewhere classified

+∞

14.6

K74.5

ICD-10 Finland

Biliary cirrhosis, unspecified

+∞

14.6

B19.9

ICD-10 Finland

Unspecified viral hepatitis without hepatic coma

151.9

14.5

K51.8

ICD-10 Finland

Other ulcerative colitis

7.0

14.5

D69.6

ICD-10 Finland

Thrombocytopenia, unspecified

7.0

14.5

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

3.1

14.4

280

E66.00

ICD-10 Finland

Metabolic syndrome

3.2

14.4

247

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.0

14.4

192

1030

A02BC03

ATC

lansoprazole; oral

1.8

14.3

330

2148

WX408

NOMESCO Finland

General anesthesy, balanced

1.8

14.2

305

1942

A02BC01

ATC

omeprazole; systemic

1.8

14.1

301

1911

C07AA05

ATC

propranolol; systemic

1.9

14.1

236

1382

SPAT1262

SPAT

Handing over of treatment supplies

2.0

14.0

208

1164

I10

ICD-10 Finland

Essential (primary) hypertension

1.6

13.7

578

4439

P01BA02

ATC

hydroxychloroquine; oral

2.5

13.7

111

470

JA2AT

NOMESCO Finland

Abdominal puncture with ultrasound guidance

10.6

13.3

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

2.7

13.2

358

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.0

13.1

188

1035

H02AB09

ATC

hydrocortisone; systemic

4.7

13.1

TK800

NOMESCO Finland

Hemodialysis

5.0

13.0

A10BG03

ATC

pioglitazone; oral

4.6

13.0

102

K50.0

ICD-10 Finland

Crohn disease of small intestine

6.7

12.8

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

2.3

12.7

119

546

346

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

3.3

12.7

208

K83.1

ICD-10 Finland

Obstruction of bile duct

7.9

12.6

JL5CG

NOMESCO Finland

Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet

9.4

12.5

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

2.3

12.5

123

577

XW000

NOMESCO Finland

Bone marrow biopsy

3.4

12.4

184

K50.9

ICD-10 Finland

Crohn disease, unspecified

6.3

12.3

160

Kela drug reimbursment

exenatide

4.8

12.3

E66.8

ICD-10 Finland

Other obesity

2.9

12.3

282

E66.01

ICD-10 Finland

Obesity due to excess calories

2.4

12.3

111

499

K51.3

ICD-10 Finland

Ulcerative (chronic) rectosigmoiditis

5.0

12.1

JKE32

NOMESCO Finland

Endoscopic dilatation of bile duct

27.0

12.1

K83.9

ICD-10 Finland

Disease of biliary tract, unspecified

13.5

12.0

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.8

12.0

247

1540

P01AB01

ATC

metronidazole; oral, rectal

1.6

11.8

440

3232

WX402

NOMESCO Finland

General anaesthesia

1.9

11.7

195

1129

K76.7

ICD-10 Finland

Hepatorenal syndrome

+∞

11.5

57300

ICD-8 Finland

Other diseases of liver, Hepatitis NUD

+∞

11.5

5739X

ICD-9 Finland

Other disorders of liver, Unspecified disorder of liver

121.2

11.4

E14.9

ICD-10 Finland

Unspecified diabetes mellitus, without complications

5.5

11.4

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

3.1

11.4

208

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

2.1

11.3

141

733

K29.3

ICD-10 Finland

Chronic superficial gastritis

3.6

11.3

148

E13.9

ICD-10 Finland

Other specified diabetes mellitus, without complications

9.0

11.3

ZXE40

NOMESCO Finland

More than seven and less than nine hours

4.4

11.2

JJA21

NOMESCO Finland

Laparoscopic biopsy of liver

25.3

11.2

K83.8

ICD-10 Finland

Other specified diseases of biliary tract

25.3

11.2

Z2446

NOMESCO Finland

Social worker

2.5

11.1

351

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.7

11.1

282

1865

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

2.6

11.1

318

XF400

NOMESCO Finland

ECG with 12 standard connections

1.9

10.9

170

961

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

3.0

10.9

213

WW500

NOMESCO Finland

Blood transfusion

3.3

10.9

175

326

Kela drug reimbursment

Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)

12.1

10.9

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.8

10.8

225

1401

O99.6

ICD-10 Finland

Diseases of the digestive system complicating pregnancy, childbirth and the puerperium

10.7

10.8

UJF92

NOMESCO Finland

Capsular endoscopy

4.2

10.5

57309

ICD-8 Finland

Other diseases of liver, Unspecified

+∞

10.4

A10AE05

ATC

insulin detemir; parenteral

2.8

10.4

251

D37.6

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts

7.0

10.1

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.4

10.1

395

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.8

10.1

190

1144

H26.3

ICD-10 Finland

Drug-induced cataract

8.5

10.1

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

2.9

9.9

204

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

2.3

9.9

400

A10BH05

ATC

linagliptin; oral

3.1

9.9

182

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.9

9.8

143

786

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.0

9.8

136

737

H03AA01

ATC

levothyroxine sodium; systemic

1.6

9.8

260

1734

A10BJ06

ATC

semaglutide; parenteral

3.3

9.7

151

A02BA02

ATC

ranitidine; systemic

1.7

9.7

204

1274

K29.6

ICD-10 Finland

Other gastritis

6.4

9.6

M05BA04

ATC

alendronic acid; oral

2.2

9.6

455

K29.5

ICD-10 Finland

Chronic gastritis, unspecified

3.8

9.5

106

N02AA05

ATC

oxycodone; systemic

1.9

9.4

149

845

JKE12

NOMESCO Finland

Endoscopic extraction of calculus from bile duct

7.6

9.4

5761C

ICD-9 Finland

Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]

100.8

9.4

K75.3

ICD-10 Finland

Granulomatous hepatitis, not elsewhere classified

+∞

9.4

K70.2

ICD-10 Finland

Alcoholic fibrosis and sclerosis of liver

+∞

9.4

K74.2

ICD-10 Finland

Hepatic fibrosis with hepatic sclerosis

+∞

9.4

K71.2

ICD-10 Finland

Toxic liver disease with acute hepatitis

+∞

9.4

E0000UV

ATC

1.5

9.4

420

3178

K42.9

ICD-10 Finland

Umbilical hernia without obstruction or gangrene

2.8

9.2

203

WX892

NOMESCO Finland

Monitored bed care

2.3

9.2

371

A07EA02

ATC

hydrocortisone; rectal

3.9

9.2

ZXE50

NOMESCO Finland

More than nine and less than 12 hours

6.0

9.1

F32.9

ICD-10 Finland

Depressive episode, unspecified

1.9

9.1

128

699

N06AB04

ATC

citalopram; systemic

1.7

9.0

228

1499

C08CA01

ATC

amlodipine; oral

1.5

9.0

338

2452

ZXD05

NOMESCO Finland

Urgent procedure

1.5

8.8

313

2240

C07AB07

ATC

bisoprolol; oral

1.5

8.7

444

3436

R16.1

ICD-10 Finland

Splenomegaly, not elsewhere classified

50.4

8.7

PC2DE

NOMESCO Finland

Ultrasound examination of liver vasculature with Doppler method

50.4

8.7

K92.1

ICD-10 Finland

Melaena

2.6

8.7

246

Z3231

NOMESCO Finland

Registered nurse

1.6

8.6

294

2078

AA1AD

NOMESCO Finland

CT of head and brain

1.6

8.6

224

1478

K80.5

ICD-10 Finland

Calculus of bile duct without cholangitis or cholecystitis

3.8

8.6

JKD20

NOMESCO Finland

Anastomosis of bile duct to jejunum

27.7

8.5

7904A

ICD-9 Finland

Nonspecific findings on examination of blood, Nonspecific elevation oflevels of transaminase or lactic acid dehydrogenase [LDH]

90.7

8.4

E66.9

ICD-10 Finland

Obesity, unspecified

2.9

8.4

173

JDW98

NOMESCO Finland

Other transluminal endoscopic operation on stomach or duodenum

4.9

8.4

WX872

NOMESCO Finland

Intensive care

2.7

8.4

221

5714A

ICD-9 Finland

Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA PERSISTENS]

+∞

8.3

K71.9

ICD-10 Finland

Toxic liver disease, unspecified

+∞

8.3

K29.7

ICD-10 Finland

Gastritis, unspecified

2.9

8.3

169

WX002

NOMESCO Finland

Sedation and analgesia

1.6

8.2

210

1377

J01FF01

ATC

clindamycin; systemic

1.5

8.1

282

1999

E83.1

ICD-10 Finland

Disorders of iron metabolism

11.8

8.1

3AC01

NOMESCO Finland

6.9

8.1

C22.9

ICD-10 Finland

Malignant neoplasm: Liver, unspecified

22.2

8.0

Z3226

NOMESCO Finland

Physiotherapist

1.7

8.0

196

1271

S97

ICPC

Chronic ulcer skin

2.5

8.0

241

N17.9

ICD-10 Finland

Acute renal failure, unspecified

3.1

8.0

134

ZXE00

NOMESCO Finland

One hour or less

1.5

8.0

412

3186

C07AG02

ATC

carvedilol; oral

2.5

8.0

252

D69.3

ICD-10 Finland

Idiopathic thrombocytopenic purpura

7.3

8.0

N05CF01

ATC

zopiclone; oral

1.5

7.9

317

2322

JN1CD

NOMESCO Finland

Very extensive CT examination of upper part of abdomen

7.8

7.9

N03AX16

ATC

pregabalin; oral

1.6

7.9

239

1640

N30.0

ICD-10 Finland

Acute cystitis

1.8

7.9

150

907

WX000

NOMESCO Finland

Monitoring vital functions without anesthesy

2.8

7.9

170

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.4

7.8

532

4335

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

1.8

7.8

127

728

UJF45

NOMESCO Finland

Flexible sigmoidoscopy with biopsy

2.1

7.8

453

K51

ICD-10 Finland

Ulcerative colitis

7.0

7.8

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

2.5

7.7

251

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.5

7.7

349

2621

A10BJ02

ATC

liraglutide; parenteral

3.5

7.6

100

RS120

NOMESCO Finland

18.5

7.6

M35.1

ICD-10 Finland

Other overlap syndromes

11.9

7.6

TPH07

NOMESCO Finland

Cathetrisation of artery

1.9

7.5

105

571

C03EA01

ATC

hydrochlorothiazide and potassium-sparing agents; oral

1.7

7.5

158

982

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.5

7.5

289

2094

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.5

7.5

293

2133

ZXD10

NOMESCO Finland

Scheduled procedure

1.4

7.5

394

3049

A46

ICD-10 Finland

Erysipelas

1.8

7.4

132

779

JN4BD

NOMESCO Finland

Extensive body CT

1.9

7.4

111

621

J01DB01

ATC

cefalexin; oral

1.5

7.4

878

7918

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

2.4

7.3

257

K75.0

ICD-10 Finland

Abscess of liver

+∞

7.3

K76.6

ICD-10 Finland

Portal hypertension

+∞

7.3

M80.4

ICD-10 Finland

Drug-induced osteoporosis with pathological fracture

9.4

7.3

K81.9

ICD-10 Finland

Cholecystitis, unspecified

5.2

7.3

TKC20

NOMESCO Finland

Catheterisation of bladder

2.2

7.3

348

Z94.0

ICD-10 Finland

Kidney transplant status

5.8

7.2

K85.9

ICD-10 Finland

Acute pancreatitis, unspecified

4.7

7.2

L04AB04

ATC

adalimumab; parenteral

3.7

7.2

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

2.1

7.2

391

A10BX04

ATC

[U] exenatide; parenteral

5.1

7.1

M81.9

ICD-10 Finland

Osteoporosis, unspecified

2.7

7.1

182

R4110

NOMESCO Finland

Physiotherapy

1.5

7.1

274

1986

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

4.2

7.0

177

Kela drug reimbursment

Insulin glargine 300 U / ml

3.9

7.0

K90.0

ICD-10 Finland

Coeliac disease

2.9

7.0

140

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

2.4

7.0

253

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

2.0

6.9

475

K80.0

ICD-10 Finland

Calculus of gallbladder with acute cholecystitis

2.6

6.9

197

K52.9

ICD-10 Finland

Noninfective gastroenteritis and colitis, unspecified

2.6

6.9

179

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

6.7

6.8

K52.88

ICD-10 Finland

Other specified noninfective gastroenteritis and colitis

3.6

6.8

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

1.7

6.8

134

818

L04AA05

ATC

[U] tacrolimus; systemic

40.3

6.8

JCA32

NOMESCO Finland

Endoscopic injection in oesophagus

40.3

6.8

JKE22

NOMESCO Finland

Endoscopic extraction of foreign body from bile duct

16.8

6.7

E11.6

ICD-10 Finland

Type 2 diabetes mellitus, with other specified complications

4.1

6.7

RS220

NOMESCO Finland

4.1

6.7

R53

ICD-10 Finland

Malaise and fatigue

1.6

6.7

199

1357

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.5

6.7

245

1750

JN4CD

NOMESCO Finland

Very extensive body CT

2.7

6.7

163

205

Kela drug reimbursment

Chronic hypertension

1.5

6.6

239

1700

JKE18

NOMESCO Finland

Endoscopic internal drainage of bile duct

6.5

6.6

JN3CG

NOMESCO Finland

Extensive MRI examination of abdomen with high intensity magnet

12.3

6.6

A41.8

ICD-10 Finland

Other specified sepsis

4.4

6.6

D50.0

ICD-10 Finland

Iron deficiency anaemia secondary to blood loss (chronic)

2.9

6.5

136

B99

ICD-10 Finland

Other and unspecified infectious diseases

3.7

6.5

SPAT1083

SPAT

Initiation and monitoring of IV fluid therapy

2.5

6.5

185

K80.3

ICD-10 Finland

Calculus of bile duct with cholangitis

6.2

6.5

SPAT1148

SPAT

Treatment of chronic ulcer or burn

1.7

6.5

126

767

R03AC02

ATC

salbutamol; inhalant

1.4

6.5

535

4459

N17.8

ICD-10 Finland

Other acute renal failure

5.4

6.5

A07AA09

ATC

vancomycin; oral

4.3

6.4

R06.0

ICD-10 Finland

Dyspnoea

1.5

6.4

234

1669

SPAT1255

SPAT

Intravenous administration of medicine

2.1

6.4

324

198

Kela drug reimbursment

Sorafenib

70.2

6.4

0705A

ICD-9 Finland

Viral hepatitis, Other specified viral hepatitis without mention of hepatic coma

70.2

6.4

N06AX11

ATC

mirtazapine; oral

1.4

6.4

310

2344

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

2.0

6.4

418

A10BK03

ATC

empagliflozin; oral

2.0

6.4

363

A06AC01

ATC

ispaghula (psylla seeds); oral

1.5

6.4

241

1732

J01DA01

ATC

[U] cefalexin; systemic

1.4

6.3

645

5559

K44.9

ICD-10 Finland

Diaphragmatic hernia without obstruction or gangrene

2.0

6.3

426

E11

ICD-10 Finland

Type 2 diabetes mellitus

1.7

6.3

140

882

WX882

NOMESCO Finland

High dependency care

3.2

6.3

100

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

1.9

6.3

458

JDA42

NOMESCO Finland

Other endoscopic haemostatic procedure in stomach or pylorus

18.1

6.3

57308

ICD-8 Finland

Other diseases of liver, Alii definiti

+∞

6.3

57001

ICD-8 Finland

Acute and subacute necrosis of liver, Hepatitis subacuta degenerativa

+∞

6.3

UKC02

NOMESCO Finland

Cystoscopy

1.7

6.2

138

870

6611

FHL

Needle biopsy in the operating room

26.8

6.2

1280

FHL

Endoscopic retrograde cholangiography and pancreaticography

26.8

6.2

M81.8

ICD-10 Finland

Other osteoporosis

7.1

6.2

A10BX07

ATC

[U] liraglutide; parenteral

4.1

6.2

M10.9

ICD-10 Finland

Gout, unspecified

2.3

6.2

234

J05AB11

ATC

valaciclovir; oral

1.7

6.2

136

854

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

1.9

6.2

498

A10AB06

ATC

insulin glulisine; parenteral

5.4

6.2

R11

ICD-10 Finland

Nausea and vomiting

2.0

6.1

396

L28

ICPC

Limited function/disability (L)

1.6

6.1

143

913

A10BK01

ATC

dapagliflozin; oral

2.5

6.1

191

NAME	K11_CHRONHEP
CONTROL_EXCLUDE	K11_LIVER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K73
HD_ICD_9	5714A\|5714X
HD_ICD_8	57001
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K73
COD_ICD_9	5714A\|5714X
COD_ICD_8	57001
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
K11_CHRONHEP	2.604 [2.3, 2.95]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.142

Parameter	HR [95% CI]	p-value
K11_CHRONHEP	3.327 [2.86, 3.87]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.022

N-year risk	Females	Males
1	0.215%	0.576%
5	1.371%	4.121%
10	3.587%	9.979%
15	6.769%	19.304%
20	12.043%	30.726%

Chronic hepatitis, not elsewhere classified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints