Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
267 |
4. Check minimum number of eventsNone |
267 |
5. Include endpointsNone |
267 |
6. Filter based on genotype QC (FinnGen only) |
267 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K73
Similar endpoints
↥List of similar endpoints to
Nonalcoholic steatohepatitis
based on the number of shared cases.
Similar with more cases:
- Chronic hepatitis, not elsewhere classified
- Diseases of liver
- Gastrointestinal diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1036 | 555 | 476 |
| Only index persons | 1025 | 553 | 472 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.00 | 59.82 | 51.78 |
| Only index persons | 56.32 | 60.05 | 51.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 267 | 154 | 113 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 59.28 | 59.34 | 59.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 231
- Matched controls
- 2310
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
+∞
323.0
231
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
65.3
88.7
101
27
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
46.4
68.9
84
28
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
11.1
39.9
83
111
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
95.8
37.2
40
5
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
6.2
33.2
113
308
215
Kela drug reimbursment
Diabetes, non-insulin-treated
5.4
29.5
116
363
103
Kela drug reimbursment
Diabetes, insulin-treated
5.2
28.2
116
377
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
12.3
27.8
52
53
A10BA02
ATC
metformin; oral
4.9
26.5
115
389
A10BG03
ATC
pioglitazone; oral
21.8
25.3
37
20
T90
ICPC
Diabetes non-insulin dependent
4.8
24.0
100
316
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
11.5
22.5
43
45
E66.01
ICD-10 Finland
Obesity due to excess calories
7.5
21.6
54
90
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.2
21.3
108
402
E66.00
ICD-10 Finland
Metabolic syndrome
8.9
20.8
46
63
A10AE04
ATC
insulin glargine; parenteral
6.7
20.8
57
108
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
23.5
20.5
29
14
C03DA01
ATC
spironolactone; oral
8.1
19.6
46
69
A10BH01
ATC
sitagliptin; oral
5.9
19.2
58
124
E66.8
ICD-10 Finland
Other obesity
8.7
18.2
40
54
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
6.8
17.5
46
81
K76.9
ICD-10 Finland
Liver disease, unspecified
17.8
17.5
27
17
A10BJ06
ATC
semaglutide; parenteral
11.1
17.3
33
34
160
Kela drug reimbursment
exenatide
16.8
17.1
27
18
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
64.7
16.0
18
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.4
15.1
61
175
I10
ICD-10 Finland
Essential (primary) hypertension
3.1
15.0
157
931
A10BH05
ATC
linagliptin; oral
9.3
14.0
29
35
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
57.0
14.0
16
*
SPAT1262
SPAT
Handing over of treatment supplies
3.6
13.2
69
246
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
34.2
12.7
16
5
A10BX04
ATC
[U] exenatide; parenteral
26.1
12.7
17
7
R18
ICD-10 Finland
Ascites
17.1
12.4
19
12
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
11.4
12.1
22
21
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.4
11.0
59
211
A10BK03
ATC
empagliflozin; oral
5.3
11.0
34
73
E66.9
ICD-10 Finland
Obesity, unspecified
9.2
10.8
22
26
C03CA01
ATC
furosemide; systemic
3.1
10.8
69
280
G47.3
ICD-10 Finland
Sleep apnoea
3.0
10.7
74
317
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.8
10.6
83
381
K74.0
ICD-10 Finland
Hepatic fibrosis
115.0
10.5
11
*
A10BJ02
ATC
liraglutide; parenteral
11.4
10.5
19
18
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
57.5
9.7
11
*
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
9.4
9
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
9.7
9.2
18
20
205
Kela drug reimbursment
Chronic hypertension
2.7
8.9
72
332
N02AX02
ATC
tramadol; systemic, rectal
2.3
8.8
117
704
A10BX07
ATC
[U] liraglutide; parenteral
14.8
8.8
14
10
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
+∞
8.4
8
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.9
8.3
53
212
J01MA02
ATC
ciprofloxacin; systemic
2.3
7.8
101
591
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
12.4
7.7
13
11
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
12.4
7.7
13
11
R03AC02
ATC
salbutamol; inhalant
2.2
7.5
134
900
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
7.5
93
530
162
Kela drug reimbursment
liraglutide
14.0
7.5
12
9
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.7
7.4
32
96
N06AX11
ATC
mirtazapine; oral
2.3
7.4
88
493
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
7.3
7
*
E66
ICD-10 Finland
Obesity
5.1
7.2
22
47
E83.1
ICD-10 Finland
Disorders of iron metabolism
31.1
7.2
9
*
D97
ICPC
Liver disease NOS
31.1
7.2
9
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.8
7.1
29
83
D07AC01
ATC
betamethasone; topical
2.2
7.0
92
535
R94.5
ICD-10 Finland
Abnormal results of liver function studies
14.4
7.0
11
8
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
6.9
51
220
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
6.9
61
294
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
41.3
6.8
8
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
6.7
28
82
WX892
NOMESCO Finland
Monitored bed care
3.8
6.7
27
77
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
12.8
6.7
11
9
177
Kela drug reimbursment
Insulin glargine 300 U / ml
9.1
6.6
13
15
T82
ICPC
Obesity
4.9
6.5
20
44
K70.0
ICD-10 Finland
Alcoholic fatty liver
71.8
6.5
7
*
A10BJ05
ATC
dulaglutide; parenteral
14.9
6.5
10
7
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
5.8
6.4
17
31
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
7.4
6.3
14
20
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.9
6.3
39
151
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.5
6.3
55
260
UJF92
NOMESCO Finland
Capsular endoscopy
6.6
6.3
15
24
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
+∞
6.3
6
*
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
6.3
6
*
K72.9
ICD-10 Finland
Hepatic failure, unspecified
+∞
6.3
6
*
K29.7
ICD-10 Finland
Gastritis, unspecified
6.1
6.3
16
28
A07AA11
ATC
rifaximin; oral
27.5
6.3
8
*
A10BD07
ATC
metformin and sitagliptin; systemic
4.4
6.2
21
51
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
4.4
6.2
21
51
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.1
6.2
34
121
R4190
NOMESCO Finland
Nutritional therapy
5.5
6.1
17
33
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
6.0
60
305
Mortality – FinRegistry
↥Association
Association between endpoint NASH and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have NASH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: NASH – Nonalcoholic steatohepatitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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