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Nonalcoholic steatohepatitis

DOID EFO Endpoint Browser PheWeb

NASH

Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K73.80
  • Cause of death: ICD-10 — K73.80

2 out of 7 registries used, show all original rules.

267

4. Check minimum number of events

None

267

5. Include endpoints

None

267

6. Filter based on genotype QC (FinnGen only)

267

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K73

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1036 555 476
Only index persons 1025 553 472
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 56.00 59.82 51.78
Only index persons 56.32 60.05 51.94

-FinnGen-

Key figures

All Female Male
Number of individuals 267 154 113
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 59.28 59.34 59.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
231
Matched controls
2310
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
+∞
323.0
231
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
65.3
88.7
101
27
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
46.4
68.9
84
28
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
11.1
39.9
83
111
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
95.8
37.2
40
5
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
6.2
33.2
113
308
215
Kela drug reimbursment
Diabetes, non-insulin-treated
5.4
29.5
116
363
103
Kela drug reimbursment
Diabetes, insulin-treated
5.2
28.2
116
377
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
12.3
27.8
52
53
A10BA02
ATC
metformin; oral
4.9
26.5
115
389
A10BG03
ATC
pioglitazone; oral
21.8
25.3
37
20
T90
ICPC
Diabetes non-insulin dependent
4.8
24.0
100
316
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
11.5
22.5
43
45
E66.01
ICD-10 Finland
Obesity due to excess calories
7.5
21.6
54
90
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.2
21.3
108
402
E66.00
ICD-10 Finland
Metabolic syndrome
8.9
20.8
46
63
A10AE04
ATC
insulin glargine; parenteral
6.7
20.8
57
108
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
23.5
20.5
29
14
C03DA01
ATC
spironolactone; oral
8.1
19.6
46
69
A10BH01
ATC
sitagliptin; oral
5.9
19.2
58
124
E66.8
ICD-10 Finland
Other obesity
8.7
18.2
40
54
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
6.8
17.5
46
81
K76.9
ICD-10 Finland
Liver disease, unspecified
17.8
17.5
27
17
A10BJ06
ATC
semaglutide; parenteral
11.1
17.3
33
34
160
Kela drug reimbursment
exenatide
16.8
17.1
27
18
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
64.7
16.0
18
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.4
15.1
61
175
I10
ICD-10 Finland
Essential (primary) hypertension
3.1
15.0
157
931
A10BH05
ATC
linagliptin; oral
9.3
14.0
29
35
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
57.0
14.0
16
*
SPAT1262
SPAT
Handing over of treatment supplies
3.6
13.2
69
246
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
34.2
12.7
16
5
A10BX04
ATC
[U] exenatide; parenteral
26.1
12.7
17
7
R18
ICD-10 Finland
Ascites
17.1
12.4
19
12
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
11.4
12.1
22
21
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.4
11.0
59
211
A10BK03
ATC
empagliflozin; oral
5.3
11.0
34
73
E66.9
ICD-10 Finland
Obesity, unspecified
9.2
10.8
22
26
C03CA01
ATC
furosemide; systemic
3.1
10.8
69
280
G47.3
ICD-10 Finland
Sleep apnoea
3.0
10.7
74
317
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.8
10.6
83
381
K74.0
ICD-10 Finland
Hepatic fibrosis
115.0
10.5
11
*
A10BJ02
ATC
liraglutide; parenteral
11.4
10.5
19
18
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
57.5
9.7
11
*
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
9.4
9
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
9.7
9.2
18
20
205
Kela drug reimbursment
Chronic hypertension
2.7
8.9
72
332
N02AX02
ATC
tramadol; systemic, rectal
2.3
8.8
117
704
A10BX07
ATC
[U] liraglutide; parenteral
14.8
8.8
14
10
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
+∞
8.4
8
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.9
8.3
53
212
J01MA02
ATC
ciprofloxacin; systemic
2.3
7.8
101
591
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
12.4
7.7
13
11
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
12.4
7.7
13
11
R03AC02
ATC
salbutamol; inhalant
2.2
7.5
134
900
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
7.5
93
530
162
Kela drug reimbursment
liraglutide
14.0
7.5
12
9
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.7
7.4
32
96
N06AX11
ATC
mirtazapine; oral
2.3
7.4
88
493
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
7.3
7
*
E66
ICD-10 Finland
Obesity
5.1
7.2
22
47
D97
ICPC
Liver disease NOS
31.1
7.2
9
*
E83.1
ICD-10 Finland
Disorders of iron metabolism
31.1
7.2
9
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.8
7.1
29
83
D07AC01
ATC
betamethasone; topical
2.2
7.0
92
535
R94.5
ICD-10 Finland
Abnormal results of liver function studies
14.4
7.0
11
8
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
6.9
51
220
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
6.9
61
294
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
41.3
6.8
8
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
6.7
28
82
WX892
NOMESCO Finland
Monitored bed care
3.8
6.7
27
77
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
12.8
6.7
11
9
177
Kela drug reimbursment
Insulin glargine 300 U / ml
9.1
6.6
13
15
T82
ICPC
Obesity
4.9
6.5
20
44
K70.0
ICD-10 Finland
Alcoholic fatty liver
71.8
6.5
7
*
A10BJ05
ATC
dulaglutide; parenteral
14.9
6.5
10
7
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
5.8
6.4
17
31
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
7.4
6.3
14
20
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.9
6.3
39
151
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.5
6.3
55
260
UJF92
NOMESCO Finland
Capsular endoscopy
6.6
6.3
15
24
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
6.3
6
*
K72.9
ICD-10 Finland
Hepatic failure, unspecified
+∞
6.3
6
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
+∞
6.3
6
*
K29.7
ICD-10 Finland
Gastritis, unspecified
6.1
6.3
16
28
A07AA11
ATC
rifaximin; oral
27.5
6.3
8
*
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
4.4
6.2
21
51
A10BD07
ATC
metformin and sitagliptin; systemic
4.4
6.2
21
51
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.1
6.2
34
121
R4190
NOMESCO Finland
Nutritional therapy
5.5
6.1
17
33
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
6.0
60
305

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
141
58
50.40
213.81
1.3
1.2
213.6
48.6
titre
—
14
7
143
150
19.37
135.22
1.5
1.6
1.3
1.6
g/l
0.62
129
136
149
184
17.06
125.87
2.2
2.5
11.1
10.2
g/l
1.55
134
169
149
201
15.51
117.50
3.9
2.4
0.2
0.2
g/l
0.09
139
186
169
273
15.14
116.68
2.7
2.3
2.5
2.4
g/l
1.63
162
251
63
13
63.12
111.13
1.7
1.0
—
—
—
0
0
160
257
14.04
110.02
2.7
2.3
24.7
24.8
%
0.03
131
226
160
269
13.35
105.58
1.6
1.5
—
—
—
0
0
166
302
12.89
102.40
2.7
2.3
14.2
14.6
umol/l
0.25
160
276
156
315
10.51
85.75
1.6
1.3
526.2
542.2
titre
0.04
26
74
155
318
10.24
83.71
1.6
1.6
—
—
—
0
0
128
259
8.57
67.99
4.9
2.6
9.4
6.9
umol/l
0.64
120
226
234
879
14.45
67.89
11.2
4.9
36.3
35.9
g/l
0.44
224
822
54
32
20.90
67.02
1.1
1.0
—
—
—
0
0
57
39
18.31
65.91
1.1
1.1
—
—
—
0
0
148
471
5.81
46.02
1.9
1.4
3.2
2.3
g/l
4.42
116
287
197
821
6.34
43.94
11.0
6.3
1.1
1.1
inr
0.31
52
228
207
925
6.51
41.76
4.4
2.5
223.5
111.5
ug/l
4.67
196
859
135
453
5.01
37.91
2.7
2.0
3.1
3.1
mg/l
0.09
118
387
157
598
4.95
37.37
4.3
3.3
40.4
270.2
mg/l
0.86
114
390
47
57
9.79
37.15
1.4
1.1
—
—
—
0
0
160
636
4.78
35.58
5.1
3.9
6.7
8.6
mg/mmol
0.33
117
391
161
660
4.63
33.94
4.4
3.0
7.5
7.9
mmol/l
0.58
143
557
166
720
4.45
31.82
7.9
5.7
—
—
—
0
0
134
507
4.30
30.84
1.4
1.3
1.0
2.2
u/ml
0.69
26
134
156
696
3.99
27.60
5.4
2.5
51.2
54.9
u/l
0.92
148
655
67
164
5.12
26.70
1.3
1.5
—
—
—
0
0
202
1105
4.40
25.89
7.7
5.6
0.6
0.6
e9/l
0.18
174
945
202
1111
4.36
25.54
7.7
5.6
0.0
0.0
e9/l
2.22
174
949
204
1143
4.33
24.79
8.1
6.1
0.2
0.2
e9/l
1.07
178
1005
248
1635
8.26
23.76
10.4
3.0
141.8
47.3
u/l
9.57
239
1548
201
1135
4.12
23.65
7.8
5.6
1.8
2.0
e9/l
0.63
176
996
189
1045
3.77
22.49
9.4
6.0
8.6
8.5
%
0.14
182
985
188
1040
3.73
22.26
8.8
5.7
3.0
2.8
%
0.78
181
970
184
1005
3.67
22.21
8.5
5.7
0.8
0.7
%
1.33
177
938
189
1055
3.71
21.93
8.9
5.6
56.4
56.7
%
0.13
181
992
159
798
3.45
21.91
2.5
1.8
96.2
96.8
pmol/l
0.04
91
383
185
1025
3.62
21.59
10.6
7.4
1.2
1.2
mmol/l
1.24
165
889
27
8
37.32
21.57
1.1
1.1
—
—
—
0
0
190
1073
3.67
21.45
8.9
5.8
28.4
28.6
%
0.12
180
1005
213
1296
4.18
21.40
11.1
9.5
4.0
4.0
e9/l
0.01
183
1125
25
6
45.77
20.84
1.1
1.0
—
—
—
0
0
27
37
8.01
19.01
1.2
1.1
—
—
—
0
0
19
16
12.71
18.89
1.2
1.1
—
—
—
0
0
172
964
3.20
18.61
7.5
6.1
1.2
1.2
mmol/l
1.22
162
883
198
1236
3.33
17.18
7.0
5.0
8.1
6.6
mmol/l
7.71
193
1149
88
351
3.25
16.97
3.4
3.7
0.8
0.8
mmol/l
1.22
81
331
62
200
3.74
16.67
1.3
1.3
—
—
—
0
0
52
149
4.09
16.52
3.1
3.3
86.7
72.1
e9/l
1.34
43
115
59
190
3.70
15.85
1.3
1.2
—
—
—
0
0
118
587
2.81
15.00
3.8
2.5
380.3
4872.4
umol/l
1.89
105
510
34
76
4.98
14.71
2.7
2.2
1.2
1.5
g/l
1.15
28
64
123
661
2.60
12.97
3.7
2.3
—
—
—
0
0
162
996
2.59
12.82
6.8
4.1
—
—
—
0
0
62
235
3.13
12.69
12.9
17.7
1.2
1.4
inr
—
6
34
34
87
4.33
12.43
6.2
3.5
—
—
—
0
0
100
501
2.59
12.02
3.4
2.3
—
—
—
0
0
63
249
3.00
11.94
1.8
1.7
—
—
—
0
0
115
620
2.50
11.80
2.7
2.1
202.5
329.4
u/l
0.50
109
586
260
2226
7.41
11.70
7.8
4.2
6.9
5.9
mmol/l
11.79
247
2065
30
73
4.50
11.67
1.2
1.3
—
—
—
0
0
80
366
2.69
11.49
1.6
1.6
188406220.8
23397892.0
pmol/l
0.63
69
312
71
306
2.80
11.44
1.4
1.2
—
—
—
0
0
73
320
2.76
11.38
2.2
1.6
1058.3
1203.9
nmol/l
0.59
58
238
22
43
5.49
10.99
1.2
1.2
347.9
245.9
u/ml
0.54
12
24
91
454
2.52
10.87
1.7
1.4
19.7
22.3
nmol/l
0.93
83
378
116
648
2.40
10.79
4.1
3.6
7.4
7.4
ph
—
9
110
23
48
5.15
10.70
1.2
1.4
—
—
—
0
0
99
520
2.44
10.52
6.1
4.5
—
—
—
0
0
14
6
24.51
10.35
3.3
1.3
—
—
—
0
0
226
1729
3.00
10.09
4.7
3.9
14.5
14.7
pmol/l
0.66
210
1581
68
309
2.61
9.74
3.4
2.1
—
—
—
0
0
44
158
3.14
9.74
1.7
2.9
68.4
67.6
g/l
0.28
39
148
111
630
2.30
9.74
2.0
1.7
1.9
1.4
mmol/l
3.07
96
541
217
1640
2.73
9.66
7.1
3.9
16.3
10.4
mm/h
6.16
201
1509
99
538
2.34
9.59
4.8
2.6
—
—
—
0
0
252
2083
4.73
9.35
6.3
4.6
1.9
2.4
mu/l
0.42
238
1923
43
159
3.03
9.03
3.5
4.2
1.7
2.0
mmol/l
0.24
37
131
44
166
2.98
8.92
4.2
4.4
—
—
—
0
0
74
372
2.37
8.42
3.4
2.6
512.0
571.9
mosm/kgh2o
1.64
62
315
198
1482
2.30
8.20
7.5
3.7
—
—
—
0
0
37
133
3.07
8.14
1.7
2.3
—
—
—
0
0
259
2297
5.26
8.06
6.5
4.3
4.4
4.8
mmol/l
9.74
246
2152
12
8
15.62
7.79
3.6
3.3
—
—
—
0
0
57
265
2.46
7.65
1.4
1.3
—
—
—
0
0
60
287
2.41
7.57
2.9
2.1
158.9
117.1
ug/g
0.49
51
226
13
22
6.16
7.45
2.6
2.6
—
—
—
0
0
28
90
3.36
7.38
2.9
3.4
37.7
1624.1
u/ml
0.53
23
78
153
1062
2.03
7.37
6.1
4.3
0.0
0.0
estimate
0.00
23
199
152
1058
2.01
7.21
4.5
3.1
0.0
0.0
estimate
0.00
22
195
44
187
2.62
7.09
9.3
4.5
—
—
—
0
0
153
1075
1.99
6.98
4.6
3.2
0.0
0.0
estimate
0.28
20
190
255
2213
4.39
6.89
5.6
3.8
1.8
1.3
mmol/l
7.63
242
2052
141
988
1.91
6.23
11.1
8.9
0.0
0.0
e9/l
0.55
109
798
84
497
2.01
6.12
4.8
3.2
—
—
—
0
0
22
70
3.34
5.89
5.6
4.1
0.2
0.1
g/l
0.09
11
26
55
281
2.21
5.87
1.9
1.5
—
—
—
0
0
70
397
2.03
5.69
1.7
1.8
—
—
—
0
0
257
2289
4.28
5.65
6.5
4.2
1.2
1.5
mmol/l
28.13
245
2129
39
175
2.44
5.59
3.3
4.4
0.4
1.4
%
2.30
11
57
35
152
2.50
5.38
3.3
4.6
0.0
0.2
%
—
9
42
89
562
1.88
5.23
3.9
2.8
—
—
—
0
0
22
77
3.02
5.06
9.4
12.1
1.1
1.0
%
0.34
22
70
124
875
1.78
5.02
2.0
2.0
—
—
—
0
0
95
621
1.82
4.96
4.3
2.9
53.9
59.7
e6/l
0.07
75
462
89
571
1.84
4.93
4.0
2.9
0.3
0.4
e6/l
0.09
68
416
12
28
4.44
4.88
2.3
2.6
—
—
—
0
0
8
7
11.73
4.81
3.8
1.7
—
—
—
0
0
13
33
4.09
4.77
3.2
2.1
—
—
—
0
0
34
155
2.37
4.71
3.4
4.5
0.3
0.7
%
—
9
38
68
407
1.90
4.65
3.1
2.4
6.1
5.1
e6/l
0.26
60
357
11
25
4.55
4.60
1.3
1.1
—
—
—
0
0
11
25
4.55
4.60
1.2
1.4
—
—
—
0
0
259
2398
3.67
4.58
31.6
11.2
—
—
—
0
0
91
604
1.77
4.43
4.7
3.2
—
—
—
0
0
106
735
1.73
4.43
5.1
3.3
64.5
54.7
e6/l
0.11
76
496
104
718
1.73
4.41
3.3
3.5
2.4
2.4
mmol/l
0.21
86
632
21
78
2.84
4.37
9.5
11.9
1.9
1.6
%
0.72
21
70
19
67
2.98
4.32
2.4
2.7
—
—
—
0
0
17
56
3.17
4.32
1.8
2.5
100.4
95.6
ug/min
0.03
11
31
267
2563
+∞
4.31
45.2
18.2
6.9
6.6
e9/l
1.52
262
2501
267
2563
+∞
4.31
45.0
18.1
4.6
4.6
e12/l
0.17
262
2499
43
225
2.09
4.28
7.0
10.7
0.6
1.3
mmol/l
0.76
29
177
33
155
2.29
4.27
2.8
2.5
3.5
4.2
e9/l
0.96
23
122
43
226
2.08
4.23
7.1
10.6
11.4
12.4
kpa
0.68
43
215
43
226
2.08
4.23
7.1
10.6
5.1
5.2
kpa
0.37
43
214
9
13
7.12
4.19
1.7
2.1
—
—
—
0
0
33
157
2.26
4.15
6.4
8.9
—
—
—
0
0
19
69
2.89
4.11
1.2
1.3
327.3
310.8
ug/g
—
8
41
7
7
10.22
4.03
1.0
1.0
—
—
—
0
0
7
7
10.22
4.03
1.0
1.3
—
—
—
0
0
27
119
2.41
4.03
8.1
13.2
—
—
—
0
0
11
28
4.05
4.02
1.5
1.5
15.1
11.4
mmol/l
—
6
8
10
24
4.29
3.92
1.4
1.1
—
—
—
0
0
85
573
1.71
3.84
8.2
6.9
—
—
—
0
0
6
5
12.23
3.78
1.0
1.0
—
—
—
0
0
42
232
1.96
3.60
1.4
1.4
—
—
—
0
0
13
41
3.28
3.54
1.5
2.0
—
—
—
0
0
9
17
5.44
3.54
1.0
1.2
—
—
—
0
0
71
473
1.68
3.30
5.0
3.4
1.0
1.0
kg/l
0.78
15
64
25
117
2.25
3.28
1.4
1.2
—
—
—
0
0
104
764
1.59
3.27
4.5
3.2
21.0
29.5
ng/l
0.86
82
497
31
160
2.06
3.20
3.4
4.6
0.1
0.3
%
—
10
49
8
16
5.12
3.07
1.1
1.3
—
—
—
0
0
15
58
2.68
2.93
2.0
3.7
25.1
27.0
mg/l
0.16
15
48
15
58
2.68
2.93
1.9
3.7
35.2
39.8
mg/l
0.22
15
49
62
412
1.66
2.88
1.3
1.3
26.6
31.9
iu/ml
0.18
20
145
14
53
2.73
2.84
8.7
15.4
11.6
11.1
mmol/l
0.20
14
46
14
53
2.73
2.84
8.7
15.4
104.6
105.8
mmol/l
0.43
14
46
8
18
4.55
2.81
1.3
1.1
—
—
—
0
0
10
31
3.31
2.80
1.1
1.2
—
—
—
0
0
70
483
1.61
2.80
2.3
1.7
0.9
1.1
mg/l
0.28
61
381
21
98
2.24
2.79
3.1
1.5
—
—
—
0
0
17
72
2.45
2.79
1.7
1.6
—
—
—
0
0
25
126
2.09
2.76
5.7
8.8
—
—
—
0
0
9
24
3.84
2.69
1.7
1.7
—
—
—
0
0
12
43
2.87
2.68
2.2
4.4
—
—
—
0
0
83
605
1.54
2.60
1.5
1.4
—
—
—
0
0
8
20
4.09
2.59
1.8
4.9
—
—
—
0
0
60
406
1.62
2.58
4.0
3.6
63.0
198.6
ng/l
0.87
44
299
30
166
1.91
2.58
1.4
1.2
145.3
181.5
iu/ml
0.24
12
65
184
1588
1.51
2.48
4.0
3.5
—
—
—
0
0
15
64
2.42
2.43
5.0
2.6
—
—
—
0
0
70
501
1.54
2.36
4.9
4.8
—
—
—
0
0
233
2135
1.72
2.29
33.5
13.3
40.4
40.7
%
0.22
174
1643
12
48
2.57
2.22
1.9
1.1
—
—
—
0
0
11
42
2.69
2.21
2.4
3.2
—
—
—
0
0
28
160
1.84
2.20
5.4
3.5
—
—
—
0
0
7
19
3.75
2.16
1.3
1.1
—
—
—
0
0
9
31
2.97
2.09
1.0
1.5
—
—
—
0
0
6
15
4.07
2.05
1.0
1.3
119.8
176.1
nmol/l
—
6
15
6
15
4.07
2.05
1.7
3.7
1467.5
650.5
u/ml
—
6
15
75
565
1.46
1.95
5.0
3.4
0.0
0.0
estimate
0.00
23
194
30
184
1.71
1.88
2.9
2.2
12.3
14.1
nmol/l
0.65
25
171
22
123
1.86
1.86
1.0
1.1
—
—
—
0
0
9
35
2.62
1.82
2.0
2.7
—
—
—
0
0
19
102
1.93
1.81
1.0
1.1
—
—
—
0
0
10
41
2.50
1.77
1.1
1.9
—
—
—
0
0
10
41
2.50
1.77
1.3
1.3
—
—
—
0
0
26
160
1.69
1.63
1.3
1.3
114.7
315.8
u/ml
0.68
26
144
13
63
2.12
1.62
1.5
1.1
—
—
—
0
0
55
404
1.46
1.62
1.3
1.3
1.2
9.8
u/ml
2.94
15
154
40
275
1.53
1.62
1.4
1.2
—
—
—
0
0
15
78
1.98
1.57
1.7
1.5
198.5
306.3
mu/l
1.62
15
70
16
86
1.92
1.54
5.5
3.0
—
—
—
0
0
7
27
2.63
1.52
1.1
1.1
—
—
—
0
0
18
102
1.82
1.49
2.8
2.3
0.1
0.1
e6/l
0.06
18
95
74
586
1.36
1.42
3.4
2.8
—
—
—
0
0
9
40
2.29
1.41
4.2
4.3
—
—
—
0
0
7
29
2.45
1.40
1.0
1.3
—
—
—
0
0
6
23
2.64
1.37
3.3
3.4
—
—
—
0
0
17
279
0.58
1.35
1.2
1.4
—
—
—
0
0
20
121
1.71
1.35
6.7
8.3
23.3
25.3
mmol/l
1.71
20
121
80
647
1.34
1.34
4.6
4.3
1.6
2.3
ug/l
0.49
72
586
19
114
1.72
1.32
1.1
1.1
—
106.0
—
0
5
10
48
2.13
1.29
1.9
2.9
9.4
8.2
kpa
—
10
42
35
250
1.46
1.20
1.6
1.7
—
—
—
0
0
6
26
2.34
1.19
1.2
1.0
—
—
—
0
0
17
103
1.69
1.16
2.9
2.3
—
—
—
0
0
7
30
2.37
1.13
2.0
1.3
—
—
—
0
0
8
40
2.03
1.13
1.5
6.7
—
—
—
0
0
7
32
2.22
1.09
1.1
1.3
—
—
—
0
0
73
873
0.77
1.07
3.7
2.6
—
—
—
0
0
5
22
2.30
1.04
1.4
1.0
—
—
—
0
0
24
165
1.50
1.01
1.4
1.4
—
—
—
0
0
47
367
1.34
0.99
2.8
3.1
2.4
2.5
mmol/l
0.04
37
316
5
23
2.20
0.98
1.8
1.5
2.4
2.7
mg/l
—
5
23
5
23
2.20
0.98
1.0
1.4
—
—
—
0
0
10
170
0.57
0.93
2.0
1.5
—
—
—
0
0
6
28
2.17
0.92
1.7
1.4
—
—
—
0
0
6
29
2.09
0.90
7.0
2.6
13.2
7.9
mmol/l
—
6
29
8
42
1.93
0.89
4.3
3.6
9.2
8.9
kpa
—
8
42
8
42
1.93
0.89
4.3
3.6
4.4
5.3
kpa
—
8
42
6
31
1.96
0.85
10.7
2.5
1.8
1.4
mmol/l
—
6
31
21
150
1.43
0.76
1.3
1.3
—
—
—
0
0
29
223
1.34
0.70
1.2
1.4
—
—
—
0
0
12
77
1.58
0.70
1.0
1.2
—
—
—
0
0
20
145
1.41
0.68
4.5
2.2
—
—
—
0
0
5
28
1.80
0.66
1.4
1.1
—
—
—
0
0
5
28
1.80
0.66
1.8
1.4
0.5
0.4
g/l
—
5
19
8
50
1.62
0.62
4.3
3.4
7.4
7.4
ph
—
8
42
209
1999
1.21
0.61
38.2
16.0
332.6
333.4
g/l
0.53
209
1991
11
73
1.53
0.57
3.9
4.6
—
—
—
0
0
6
40
1.51
0.52
1.2
1.3
—
—
—
0
0
46
394
1.20
0.49
2.5
2.7
0.6
0.7
ug/l
1.23
28
247
18
137
1.34
0.48
3.1
2.7
26.1
55.5
u/ml
0.86
18
131
7
48
1.47
0.47
6.1
1.8
—
—
—
0
0
5
32
1.57
0.42
5.6
3.1
—
—
—
0
0
5
34
1.48
0.40
1.6
1.6
—
—
—
0
0
5
34
1.48
0.40
3.2
2.3
—
—
—
0
0
5
34
1.48
0.40
1.6
1.6
—
—
—
0
0
5
34
1.48
0.40
1.6
1.6
—
—
—
0
0
5
34
1.48
0.40
1.6
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
9
67
1.36
0.38
1.0
1.2
—
—
—
0
0
11
147
0.74
0.38
1.3
1.6
—
—
—
0
0
18
145
1.26
0.34
3.3
3.9
1.2
1.2
mmol/l
0.05
18
129
7
95
0.73
0.22
2.0
1.4
—
—
—
0
0
5
41
1.22
0.22
1.2
2.7
—
—
—
0
0
8
101
0.79
0.21
1.9
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
39.0
—
0
7
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
10
80
1.26
0.21
5.8
11.0
—
—
—
0
0
5
66
0.75
0.17
1.2
1.3
—
—
—
0
0
8
68
1.18
0.17
1.0
1.1
—
—
—
0
0
19
168
1.14
0.16
4.3
3.5
—
—
—
0
0
6
79
0.75
0.15
2.2
1.3
—
—
—
0
0
8
99
0.80
0.14
1.9
1.4
—
—
—
0
0
8
100
0.79
0.14
1.9
1.4
—
—
—
0
0
8
100
0.79
0.14
1.9
1.4
—
—
—
0
0
17
155
1.10
0.09
1.2
1.3
—
38.0
—
0
9
6
54
1.11
0.09
1.3
1.5
—
—
—
0
0
5
60
0.83
0.08
2.4
1.6
—
—
—
0
0
19
184
1.04
0.00
1.7
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
10.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
5.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
82.4
—
0
5
0
6
0.00
0.00
0.0
10.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint NASH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have NASH.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: NASH – Nonalcoholic steatohepatitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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