hepatitis B virus infection: A viral infection caused by the hepatitis B virus.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1256 |
4. Check minimum number of eventsNone |
1256 |
5. Include endpointsNone |
1256 |
6. Filter based on genotype QC (FinnGen only) |
1256 |
Control definitions (FinnGen only)
- Control exclude
- K11_LIVER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K70-K77
- Name in latin
- Hepatitis chronica non alibi classificata
Similar endpoints
↥List of similar endpoints to
Chronic hepatitis, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7890 | 4726 | 3100 |
| Only index persons | 6673 | 4123 | 2550 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.14 | 0.09 |
| Only index persons | 0.13 | 0.15 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 55.74 | 57.47 | 53.03 |
| Only index persons | 54.41 | 56.19 | 51.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1256 | 812 | 444 |
| Unadjusted period prevalence (%) | 0.25 | 0.28 | 0.20 |
| Median age at first event (years) | 54.57 | 54.18 | 55.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1128
- Matched controls
- 11277
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
+∞
323.0
505
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
142.4
323.0
438
50
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
+∞
323.0
397
*
L04AX01
ATC
azathioprine; systemic
34.6
308.9
411
184
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
575.0
241.0
231
5
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
13.9
218.8
413
451
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
+∞
210.1
195
*
K76.9
ICD-10 Finland
Liver disease, unspecified
588.0
203.6
196
*
A05AA02
ATC
ursodeoxycholic acid; oral
64.0
195.5
226
44
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
9.6
182.3
426
670
K75.4
ICD-10 Finland
Autoimmune hepatitis
+∞
171.3
160
*
A07EA06
ATC
budesonide; oral, local oral
21.6
163.1
247
144
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
63.6
157.1
182
34
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
+∞
136.3
128
*
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
135.2
127
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
122.1
115
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.7
118.8
566
2006
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
34.1
101.4
133
44
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.6
95.4
324
763
K83.0
ICD-10 Finland
Cholangitis
30.9
83.5
112
40
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
59.4
79.4
93
17
H02AB06
ATC
prednisolone; systemic
3.3
78.2
699
3732
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.4
78.1
555
2499
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
109.0
75.0
81
8
Z94.4
ICD-10 Finland
Liver transplant status
363.6
69.4
69
*
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
240.9
67.0
68
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
15.1
65.3
111
81
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
26.0
63.5
89
37
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
169.4
61.6
64
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
608.7
59.3
58
*
L01BB02
ATC
mercaptopurine; oral
29.8
57.8
78
28
L04AA06
ATC
mycophenolic acid; systemic
16.4
55.6
91
60
UJF30
NOMESCO Finland
Ileoscopy through colon
4.7
54.3
206
516
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
19.0
51.8
80
45
C03DA01
ATC
spironolactone; oral
4.5
50.1
195
499
5714X
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]
+∞
49.3
47
*
UJF32
NOMESCO Finland
Coloscopy
2.8
46.6
390
1794
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
66.6
44.5
51
8
K51.5
ICD-10 Finland
Left sided colitis
9.5
43.9
93
106
L04AD01
ATC
ciclosporin; systemic
11.3
43.1
83
79
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
11.3
43.1
83
79
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
422.3
41.4
41
*
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
40.9
39
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
6.0
40.6
118
216
H02AB07
ATC
prednisone; oral
3.3
40.5
240
864
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
411.5
40.4
40
*
A02BC02
ATC
pantoprazole; systemic
2.4
39.7
802
5712
A07EC02
ATC
mesalazine; oral, rectal
5.1
39.3
132
286
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
207.1
39.1
40
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
39.0
543
3215
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.4
38.9
151
381
127
Kela drug reimbursment
Transplant complication
13.3
38.5
68
54
R94.5
ICD-10 Finland
Abnormal results of liver function studies
20.6
38.2
57
29
R18
ICD-10 Finland
Ascites
14.8
37.3
63
45
K72.9
ICD-10 Finland
Hepatic failure, unspecified
196.4
37.0
38
*
ZX120
NOMESCO Finland
Intravenous
3.6
36.0
178
555
C03CA01
ATC
furosemide; systemic
2.6
35.6
334
1594
N02AX02
ATC
tramadol; systemic, rectal
2.2
35.4
540
3284
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
19.8
35.1
53
28
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
22.7
34.6
50
23
K74.0
ICD-10 Finland
Hepatic fibrosis
+∞
33.5
32
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
6.5
33.3
90
149
JJA20
NOMESCO Finland
Open biopsy of liver
90.3
31.9
35
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.5
30.7
291
1381
J01MA02
ATC
ciprofloxacin; systemic
2.1
30.5
480
2899
D97
ICPC
Liver disease NOS
39.3
30.4
38
10
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
30.3
286
1351
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
10.0
29.7
60
63
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
106.2
28.8
31
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
153.9
28.8
30
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.3
28.7
320
1641
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.4
28.7
306
1535
JJ5AT
NOMESCO Finland
NA
288.3
27.9
28
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.9
27.6
122
344
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
27.6
445
2687
UJK02
NOMESCO Finland
ERCP
8.6
26.3
58
71
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
11.6
26.3
49
44
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
26.1
25
*
A10AE04
ATC
insulin glargine; parenteral
3.3
26.1
140
461
C10AC01
ATC
colestyramine; oral
6.6
25.5
67
107
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.7
25.4
118
347
A06AD11
ATC
lactulose; oral
2.7
25.2
189
777
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.9
24.8
169
652
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
9.6
23.4
48
52
T90
ICPC
Diabetes non-insulin dependent
2.2
23.3
276
1434
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
23.0
22
*
A07AA11
ATC
rifaximin; oral
+∞
23.0
22
*
H02AB04
ATC
methylprednisolone; systemic
2.4
21.2
207
977
R50.9
ICD-10 Finland
Fever, unspecified
2.5
20.8
182
811
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
78.3
20.7
23
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
20.3
157
652
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
48.9
20.2
24
5
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.5
19.9
171
753
5714B
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ACTIVA (HBSAG-)]
+∞
19.8
19
*
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
106.9
19.6
21
*
K50.8
ICD-10 Finland
Other Crohn disease
7.6
19.3
45
61
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
10.6
19.2
37
36
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
19.0
268
1486
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.7
19.0
66
148
A10BA02
ATC
metformin; oral
2.0
19.0
301
1746
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.2
18.9
207
1027
J01MA12
ATC
levofloxacin; systemic
2.2
18.8
223
1147
K70.1
ICD-10 Finland
Alcoholic hepatitis
+∞
18.8
18
*
UJK12
NOMESCO Finland
Peroral cholangioscopy
28.4
18.8
25
9
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.6
18.7
150
634
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
18.3
177
828
K50.1
ICD-10 Finland
Crohn disease of large intestine
10.6
18.2
35
34
JN3AD
NOMESCO Finland
Abdominal CT examination
3.2
18.2
102
344
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
+∞
17.7
17
*
K76.89
ICD-10 Finland
Other specified diseases of liver
96.6
17.6
19
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
17.4
91
293
L04AA01
ATC
[U] ciclosporin; systemic
7.1
17.3
42
61
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
5.2
17.2
53
105
A10BH01
ATC
sitagliptin; oral
2.7
17.1
122
482
B18.2
ICD-10 Finland
Chronic viral hepatitis C
10.9
17.0
32
30
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
3.9
17.0
70
186
K92.0
ICD-10 Finland
Haematemesis
6.3
16.9
45
74
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.6
16.9
78
228
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
16.8
133
556
UJD02
NOMESCO Finland
Gastroscopy
3.6
16.8
78
229
K75.2
ICD-10 Finland
Nonspecific reactive hepatitis
+∞
16.7
16
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.7
16.6
123
496
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.6
15.9
55
124
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
15.8
115
459
K70.4
ICD-10 Finland
Alcoholic hepatic failure
+∞
15.7
15
*
K70.0
ICD-10 Finland
Alcoholic fatty liver
162.1
15.5
16
*
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
7.8
15.4
35
46
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.5
15.0
35
48
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
10.2
15.0
29
29
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
12.6
14.9
26
21
K75.8
ICD-10 Finland
Other specified inflammatory liver diseases
+∞
14.6
14
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
+∞
14.6
14
*
5719X
ICD-9 Finland
Chronic liver disease and cirrhosis, Unspecified chronic liver disease without mention of alcohol
+∞
14.6
14
*
K73.1
ICD-10 Finland
Chronic lobular hepatitis, not elsewhere classified
+∞
14.6
14
*
B19.9
ICD-10 Finland
Unspecified viral hepatitis without hepatic coma
151.9
14.5
15
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
7.0
14.5
35
51
K51.8
ICD-10 Finland
Other ulcerative colitis
7.0
14.5
35
51
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.1
14.4
82
280
E66.00
ICD-10 Finland
Metabolic syndrome
3.2
14.4
76
247
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
14.4
192
1030
A02BC03
ATC
lansoprazole; oral
1.8
14.3
330
2148
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
14.2
305
1942
A02BC01
ATC
omeprazole; systemic
1.8
14.1
301
1911
C07AA05
ATC
propranolol; systemic
1.9
14.1
236
1382
SPAT1262
SPAT
Handing over of treatment supplies
2.0
14.0
208
1164
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
13.7
578
4439
P01BA02
ATC
hydroxychloroquine; oral
2.5
13.7
111
470
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
10.6
13.3
25
24
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
13.2
92
358
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
13.1
188
1035
H02AB09
ATC
hydrocortisone; systemic
4.7
13.1
44
97
TK800
NOMESCO Finland
Hemodialysis
5.0
13.0
41
84
A10BG03
ATC
pioglitazone; oral
4.6
13.0
45
102
K50.0
ICD-10 Finland
Crohn disease of small intestine
6.7
12.8
32
49
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.3
12.7
119
546
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.3
12.7
65
208
K83.1
ICD-10 Finland
Obstruction of bile duct
7.9
12.6
28
36
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
9.4
12.5
25
27
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.3
12.5
123
577
XW000
NOMESCO Finland
Bone marrow biopsy
3.4
12.4
60
184
K50.9
ICD-10 Finland
Crohn disease, unspecified
6.3
12.3
32
52
160
Kela drug reimbursment
exenatide
4.8
12.3
40
85
E66.8
ICD-10 Finland
Other obesity
2.9
12.3
77
282
E66.01
ICD-10 Finland
Obesity due to excess calories
2.4
12.3
111
499
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
5.0
12.1
38
78
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
27.0
12.1
16
6
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
13.5
12.0
20
15
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
12.0
247
1540
P01AB01
ATC
metronidazole; oral, rectal
1.6
11.8
440
3232
WX402
NOMESCO Finland
General anaesthesia
1.9
11.7
195
1129
57300
ICD-8 Finland
Other diseases of liver, Hepatitis NUD
+∞
11.5
11
*
K76.7
ICD-10 Finland
Hepatorenal syndrome
+∞
11.5
11
*
5739X
ICD-9 Finland
Other disorders of liver, Unspecified disorder of liver
121.2
11.4
12
*
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
5.5
11.4
33
62
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.1
11.4
62
208
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.1
11.3
141
733
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.6
11.3
51
148
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
9.0
11.3
23
26
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
25.3
11.2
15
6
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
25.3
11.2
15
6
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
11.1
282
1865
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.6
11.1
80
318
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
10.9
170
961
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.0
10.9
62
213
WW500
NOMESCO Finland
Blood transfusion
3.3
10.9
55
175
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
12.1
10.9
19
16
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
10.8
225
1401
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
10.7
10.8
20
19
UJF92
NOMESCO Finland
Capsular endoscopy
4.2
10.5
39
96
57309
ICD-8 Finland
Other diseases of liver, Unspecified
+∞
10.4
10
*
A10AE05
ATC
insulin detemir; parenteral
2.8
10.4
67
251
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
7.0
10.1
24
35
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
10.1
89
395
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
10.1
190
1144
H26.3
ICD-10 Finland
Drug-induced cataract
8.5
10.1
21
25
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.9
9.9
58
204
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.3
9.9
89
400
A10BH05
ATC
linagliptin; oral
3.1
9.9
54
182
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
9.8
143
786
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
9.8
136
737
H03AA01
ATC
levothyroxine sodium; systemic
1.6
9.8
260
1734
A10BJ06
ATC
semaglutide; parenteral
3.3
9.7
48
151
A02BA02
ATC
ranitidine; systemic
1.7
9.7
204
1274
K29.6
ICD-10 Finland
Other gastritis
6.4
9.6
24
38
M05BA04
ATC
alendronic acid; oral
2.2
9.6
96
455
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.8
9.5
39
106
N02AA05
ATC
oxycodone; systemic
1.9
9.4
149
845
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
7.6
9.4
21
28
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
100.8
9.4
10
*
K70.2
ICD-10 Finland
Alcoholic fibrosis and sclerosis of liver
+∞
9.4
9
*
K75.3
ICD-10 Finland
Granulomatous hepatitis, not elsewhere classified
+∞
9.4
9
*
K74.2
ICD-10 Finland
Hepatic fibrosis with hepatic sclerosis
+∞
9.4
9
*
K71.2
ICD-10 Finland
Toxic liver disease with acute hepatitis
+∞
9.4
9
*
E0000UV
ATC
NA
1.5
9.4
420
3178
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
2.8
9.2
56
203
WX892
NOMESCO Finland
Monitored bed care
2.3
9.2
83
371
A07EA02
ATC
hydrocortisone; rectal
3.9
9.2
36
94
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
9.1
128
699
N06AB04
ATC
citalopram; systemic
1.7
9.0
228
1499
C08CA01
ATC
amlodipine; oral
1.5
9.0
338
2452
C07AB07
ATC
bisoprolol; oral
1.5
8.7
444
3436
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
50.4
8.7
10
*
PC2DE
NOMESCO Finland
Ultrasound examination of liver vasculature with Doppler method
50.4
8.7
10
*
K92.1
ICD-10 Finland
Melaena
2.6
8.7
62
246
AA1AD
NOMESCO Finland
CT of head and brain
1.6
8.6
224
1478
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
3.8
8.6
35
95
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
27.7
8.5
11
*
7904A
ICD-9 Finland
Nonspecific findings on examination of blood, Nonspecific elevation oflevels of transaminase or lactic acid dehydrogenase [LDH]
90.7
8.4
9
*
E66.9
ICD-10 Finland
Obesity, unspecified
2.9
8.4
49
173
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
4.9
8.4
26
54
WX872
NOMESCO Finland
Intensive care
2.7
8.4
57
221
5714A
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA PERSISTENS]
+∞
8.3
8
*
K71.9
ICD-10 Finland
Toxic liver disease, unspecified
+∞
8.3
8
*
K29.7
ICD-10 Finland
Gastritis, unspecified
2.9
8.3
48
169
WX002
NOMESCO Finland
Sedation and analgesia
1.6
8.2
210
1377
J01FF01
ATC
clindamycin; systemic
1.5
8.1
282
1999
E83.1
ICD-10 Finland
Disorders of iron metabolism
11.8
8.1
14
12
3AC01
NOMESCO Finland
NA
6.9
8.1
19
28
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
22.2
8.0
11
5
S97
ICPC
Chronic ulcer skin
2.5
8.0
59
241
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.1
8.0
41
134
C07AG02
ATC
carvedilol; oral
2.5
8.0
61
252
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
7.3
8.0
18
25
N05CF01
ATC
zopiclone; oral
1.5
7.9
317
2322
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
7.8
7.9
17
22
N03AX16
ATC
pregabalin; oral
1.6
7.9
239
1640
N30.0
ICD-10 Finland
Acute cystitis
1.8
7.9
150
907
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.8
7.9
47
170
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
7.8
532
4335
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
7.8
127
728
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.1
7.8
90
453
K51
ICD-10 Finland
Ulcerative colitis
7.0
7.8
18
26
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.5
7.7
60
251
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
7.7
349
2621
A10BJ02
ATC
liraglutide; parenteral
3.5
7.6
34
100
RS120
NOMESCO Finland
NA
18.5
7.6
11
6
M35.1
ICD-10 Finland
Other overlap syndromes
11.9
7.6
13
11
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
7.5
105
571
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.7
7.5
158
982
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
7.5
289
2094
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
7.5
293
2133
A46
ICD-10 Finland
Erysipelas
1.8
7.4
132
779
JN4BD
NOMESCO Finland
Extensive body CT
1.9
7.4
111
621
J01DB01
ATC
cefalexin; oral
1.5
7.4
878
7918
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.4
7.3
60
257
K76.6
ICD-10 Finland
Portal hypertension
+∞
7.3
7
*
K75.0
ICD-10 Finland
Abscess of liver
+∞
7.3
7
*
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
9.4
7.3
14
15
K81.9
ICD-10 Finland
Cholecystitis, unspecified
5.2
7.3
21
41
TKC20
NOMESCO Finland
Catheterisation of bladder
2.2
7.3
73
348
Z94.0
ICD-10 Finland
Kidney transplant status
5.8
7.2
19
33
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
4.7
7.2
23
50
L04AB04
ATC
adalimumab; parenteral
3.7
7.2
29
79
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.1
7.2
79
391
A10BX04
ATC
[U] exenatide; parenteral
5.1
7.1
21
42
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.7
7.1
47
182
R4110
NOMESCO Finland
Physiotherapy
1.5
7.1
274
1986
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.2
7.0
25
61
177
Kela drug reimbursment
Insulin glargine 300 U / ml
3.9
7.0
27
71
K90.0
ICD-10 Finland
Coeliac disease
2.9
7.0
40
140
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.4
7.0
58
253
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.0
6.9
90
475
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.6
6.9
49
197
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.6
6.9
46
179
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
6.7
6.8
16
24
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
3.6
6.8
29
83
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
6.8
134
818
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
40.3
6.8
8
*
L04AA05
ATC
[U] tacrolimus; systemic
40.3
6.8
8
*
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
16.8
6.7
10
6
RS220
NOMESCO Finland
NA
4.1
6.7
24
59
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
4.1
6.7
24
59
R53
ICD-10 Finland
Malaise and fatigue
1.6
6.7
199
1357
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
6.7
245
1750
JN4CD
NOMESCO Finland
Very extensive body CT
2.7
6.7
43
163
205
Kela drug reimbursment
Chronic hypertension
1.5
6.6
239
1700
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
6.5
6.6
16
25
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
12.3
6.6
11
9
A41.8
ICD-10 Finland
Other specified sepsis
4.4
6.6
22
51
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.9
6.5
38
136
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.7
6.5
26
71
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.5
6.5
46
185
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
6.2
6.5
16
26
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.5
126
767
R03AC02
ATC
salbutamol; inhalant
1.4
6.5
535
4459
N17.8
ICD-10 Finland
Other acute renal failure
5.4
6.5
18
34
A07AA09
ATC
vancomycin; oral
4.3
6.4
22
52
R06.0
ICD-10 Finland
Dyspnoea
1.5
6.4
234
1669
SPAT1255
SPAT
Intravenous administration of medicine
2.1
6.4
67
324
198
Kela drug reimbursment
Sorafenib
70.2
6.4
7
*
0705A
ICD-9 Finland
Viral hepatitis, Other specified viral hepatitis without mention of hepatic coma
70.2
6.4
7
*
N06AX11
ATC
mirtazapine; oral
1.4
6.4
310
2344
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.0
6.4
80
418
A10BK03
ATC
empagliflozin; oral
2.0
6.4
72
363
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
6.4
241
1732
J01DA01
ATC
[U] cefalexin; systemic
1.4
6.3
645
5559
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.0
6.3
81
426
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.7
6.3
140
882
WX882
NOMESCO Finland
High dependency care
3.2
6.3
31
100
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.9
6.3
85
458
JDA42
NOMESCO Finland
Other endoscopic haemostatic procedure in stomach or pylorus
18.1
6.3
9
5
57308
ICD-8 Finland
Other diseases of liver, Alii definiti
+∞
6.3
6
*
57001
ICD-8 Finland
Acute and subacute necrosis of liver, Hepatitis subacuta degenerativa
+∞
6.3
6
*
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.2
138
870
1280
FHL
Endoscopic retrograde cholangiography and pancreaticography
26.8
6.2
8
*
6611
FHL
Needle biopsy in the operating room
26.8
6.2
8
*
M81.8
ICD-10 Finland
Other osteoporosis
7.1
6.2
14
20
A10BX07
ATC
[U] liraglutide; parenteral
4.1
6.2
22
54
M10.9
ICD-10 Finland
Gout, unspecified
2.3
6.2
53
234
J05AB11
ATC
valaciclovir; oral
1.7
6.2
136
854
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.9
6.2
90
498
A10AB06
ATC
insulin glulisine; parenteral
5.4
6.2
17
32
R11
ICD-10 Finland
Nausea and vomiting
2.0
6.1
76
396
L28
ICPC
Limited function/disability (L)
1.6
6.1
143
913
A10BK01
ATC
dapagliflozin; oral
2.5
6.1
46
191
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
218
87
30.11
318.93
1.2
1.1
1.6
1.5
g/l
1.29
194
82
496
185
43.66
307.65
1.8
1.1
317.4
83.5
titre
2.79
96
17
665
824
16.03
307.65
5.8
2.0
0.2
0.2
g/l
2.51
627
782
534
536
16.59
307.65
2.0
1.8
1.5
1.5
g/l
0.04
494
492
708
693
22.12
307.65
7.4
2.9
12.4
10.3
g/l
17.71
675
632
533
1090
7.76
273.49
7.3
2.5
15.5
7.3
umol/l
5.24
492
936
939
3321
8.24
272.60
11.2
3.0
48.1
30.5
u/l
19.88
913
3160
1030
4221
9.00
247.69
12.5
4.3
35.6
36.0
g/l
1.76
995
3918
148
43
38.88
237.85
1.1
1.0
281.6
309.3
mg/l
1.22
129
38
144
44
36.84
228.01
1.2
1.0
—
—
—
0
0
199
147
15.90
218.94
6.3
2.2
40.4
30.5
umol/l
3.42
184
117
504
1215
6.26
212.06
2.7
2.3
25.5
22.9
%
2.45
435
1036
521
1313
6.07
208.34
2.6
2.2
2.4
2.4
g/l
1.29
489
1222
1083
5242
8.74
198.91
17.6
5.7
15.3
10.7
umol/l
7.55
1063
4963
526
1440
5.56
188.94
2.7
2.3
14.6
13.4
umol/l
2.37
498
1326
139
67
23.20
187.31
1.5
1.1
349.3
60.0
titre
—
41
9
164
132
14.14
170.78
2.0
1.7
0.7
0.9
g/l
0.53
124
98
683
2506
4.78
166.64
12.4
3.5
91.1
93.1
%
1.23
667
2442
595
2018
4.70
159.54
2.1
1.4
3.0
2.2
g/l
12.35
482
1196
163
186
9.92
133.58
6.4
5.7
1193.3
331.8
iu/ml
1.10
30
25
901
4848
4.04
113.22
14.2
5.6
57.0
56.7
%
0.29
879
4534
906
4917
4.02
111.80
14.6
5.9
28.1
28.4
%
0.51
882
4581
152
198
8.60
111.78
1.3
1.2
—
—
—
0
0
390
1231
4.14
109.11
2.3
1.8
1.6
1.4
%
3.37
340
1099
145
190
8.50
105.99
1.3
1.2
346.9
246.1
u/ml
2.12
84
113
129
147
9.67
105.31
2.6
3.1
955.4
2242.4
u/ml
0.34
14
13
824
4318
3.64
104.61
3.7
2.2
74.6
77.3
nmol/l
2.07
771
3872
664
3118
3.40
99.19
4.9
2.4
59.8
56.1
u/l
0.83
632
2890
189
354
6.11
98.93
4.5
3.1
356.9
3942.1
u/ml
0.70
169
309
96
80
12.91
96.99
1.1
1.0
—
—
—
0
0
982
5957
3.97
94.97
17.3
8.9
3.7
4.0
e9/l
6.65
909
5223
132
177
8.22
94.42
1.2
1.4
110.2
105.4
u/ml
0.20
22
36
1148
7958
6.15
87.90
25.0
7.0
100.3
76.4
u/l
31.43
1128
7474
400
1467
3.53
87.31
2.6
2.1
30.4
29.4
s
2.42
386
1422
158
291
6.07
83.74
1.3
1.3
—
—
—
0
0
1051
6960
4.13
82.44
10.5
2.8
119.3
44.5
u/l
30.86
1008
6503
66
40
17.36
79.33
33.0
30.4
117.0
137.4
ug/l
0.93
59
31
263
780
4.00
77.99
11.4
6.8
9.0
9.0
mmol/l
0.03
252
740
839
4947
3.10
77.67
9.2
6.5
1.2
1.2
mmol/l
0.45
726
4160
109
147
8.02
77.33
1.5
1.2
—
—
—
0
0
86
95
9.64
71.48
1.2
1.1
48.8
53.4
u/l
0.42
59
66
777
4519
2.89
71.39
7.5
5.8
1.2
1.2
mmol/l
0.61
732
4069
765
4435
2.85
70.33
3.8
2.7
209.7
113.1
ug/l
5.72
722
4103
138
269
5.64
68.53
4.8
3.3
1.6
1.4
mg/l
1.05
129
248
278
933
3.54
67.99
3.7
2.2
33.1
36.2
u/l
0.62
249
795
308
1138
3.26
64.23
14.2
22.5
1.2
1.3
inr
0.57
50
152
503
2438
2.77
64.08
2.9
2.1
3.1
3.0
mg/l
0.52
452
2077
285
1012
3.35
63.37
3.7
4.6
257.7
246.3
u/l
0.29
278
967
488
2359
2.75
62.11
1.5
1.2
1.3
1.7
u/ml
0.46
116
633
37
11
34.63
58.04
1.8
1.1
17.4
16.9
umol/l
0.16
30
11
363
1595
2.79
54.52
4.5
3.2
0.8
0.8
mmol/l
3.70
344
1490
318
1304
2.93
54.36
3.7
2.2
150.9
109.4
ug/g
2.00
272
1023
1045
7663
3.16
53.47
8.4
4.0
17.9
11.6
mm/h
26.69
990
7083
153
401
4.21
52.83
1.9
1.5
5.0
11.0
u/ml
0.93
13
11
70
89
8.27
51.94
2.3
1.3
—
—
—
0
0
258
964
3.11
51.85
4.3
4.2
3.0
19.2
ug/l
2.09
213
786
302
1248
2.87
50.52
7.4
5.1
1.1
1.0
mmol/l
0.55
291
1152
37
19
20.03
47.74
2.2
1.5
4416.8
4704.1
e6/l
0.03
20
11
857
5847
2.47
47.73
8.4
4.6
7.1
6.6
mmol/l
5.03
828
5452
55
58
9.87
47.12
2.0
1.5
5.4
7.3
u/l
0.21
32
27
51
51
10.38
45.36
1.3
1.1
19.9
14.9
u/l
0.84
46
44
239
952
2.87
42.18
2.2
2.1
356.6
377.1
nmol/l
0.43
223
874
122
322
4.09
41.49
2.1
1.6
233.3
166.7
titre
—
9
12
445
2436
2.28
39.64
3.3
2.2
—
—
—
0
0
82
170
5.09
37.67
3.7
3.8
43.6
2080.0
u/ml
0.78
77
162
182
664
3.04
37.40
2.4
1.5
—
—
—
0
0
130
396
3.55
35.85
2.0
2.0
1.2
1.5
g/l
3.71
117
349
232
1003
2.61
34.40
3.1
2.9
2.2
1.8
%
4.11
222
903
48
64
7.76
34.13
1.1
1.2
—
—
—
0
0
116
343
3.62
33.41
2.4
1.9
—
—
—
0
0
133
432
3.32
33.10
3.9
3.9
23.7
24.2
mmol/l
1.01
124
389
37
37
10.27
32.83
1.8
1.3
10.6
8.5
ug/l
1.45
37
37
697
4825
2.00
31.16
5.4
3.8
—
—
—
0
0
87
223
4.12
30.66
1.5
1.2
1.4
6.2
u/ml
0.52
13
17
603
4033
1.95
29.11
2.4
1.9
97.4
96.0
pmol/l
0.25
323
2027
191
828
2.54
27.81
5.1
3.5
1.5
2.0
mmol/l
0.93
152
662
192
835
2.53
27.76
5.2
3.4
5.7
5.8
kpa
2.00
183
808
97
292
3.52
27.12
1.5
1.2
10.0
5.2
u/ml
0.79
29
45
96
288
3.53
26.98
1.5
1.2
33.5
2.8
u/ml
0.54
17
27
57
116
5.10
26.71
3.1
2.2
21.7
5.4
umol/l
1.55
46
76
425
2603
1.96
25.88
3.9
2.5
1831.8
5669.1
umol/l
2.24
378
2269
483
3111
1.90
25.10
3.9
3.1
7.0
7.5
mmol/l
1.55
417
2635
283
1516
2.12
24.88
2.1
1.8
—
—
—
0
0
97
311
3.30
24.54
1.5
1.2
44.7
24.9
u/ml
0.46
14
18
98
319
3.25
24.19
1.7
1.6
0.1
0.1
iu/ml
0.05
18
57
281
1534
2.07
23.34
3.5
2.7
2.7
2.6
e6/l
0.04
168
808
75
210
3.73
23.33
1.6
1.9
1.0
0.8
nmol/l
1.28
62
176
70
189
3.86
22.94
5.0
3.3
4.0
4.2
e9/l
0.24
70
189
57
133
4.44
22.68
1.6
1.3
40.8
58.6
u/ml
—
6
6
461
3021
1.83
22.00
4.7
3.9
13.4
7.1
mg/mmol
1.23
305
1854
422
2692
1.85
21.96
4.4
2.9
0.3
0.4
e6/l
0.79
333
1999
1175
10407
3.00
21.83
31.5
12.8
17.2
22.8
mg/l
11.19
1055
8093
70
196
3.72
21.78
5.2
3.6
57.8
57.6
%
0.03
70
196
287
1629
1.99
21.17
3.4
2.6
0.9
1.0
e6/l
0.22
174
901
81
256
3.31
20.95
1.5
1.2
—
—
—
0
0
333
2025
1.88
19.82
3.4
2.5
5.7
6.2
e6/l
0.24
295
1785
25
29
8.78
19.82
1.1
1.1
—
—
—
0
0
163
763
2.31
19.72
1.6
3.1
69.1
67.1
g/l
1.85
149
703
840
6705
1.76
19.16
6.0
4.2
94.7
2463.3
e6/l
—
7
95
362
2286
1.82
18.97
1.7
1.5
18.6
21.1
nmol/l
2.67
328
1945
105
408
2.72
18.87
1.6
1.2
4.0
1.1
u/ml
—
5
35
111
450
2.61
18.34
2.0
2.1
48.0
39.0
u/l
2.85
102
399
290
1726
1.88
18.27
2.0
1.7
1100.8
1199.0
nmol/l
1.05
234
1292
72
233
3.22
17.93
1.6
1.2
43.9
48.8
u/ml
0.13
17
25
202
1069
2.06
17.87
2.0
1.7
—
—
—
0
0
67
208
3.35
17.84
1.7
1.7
—
—
—
0
0
156
762
2.20
16.95
3.7
3.5
85.4
80.9
ng/l
0.26
143
676
132
604
2.32
16.77
4.1
3.3
5.0
5.1
kpa
1.26
123
567
199
1078
2.01
16.43
2.0
1.8
—
—
—
0
0
125
573
2.31
15.79
4.1
3.3
0.9
1.9
mmol/l
1.75
94
432
437
3036
1.67
15.76
2.6
2.1
370.9
212.8
u/l
0.44
416
2862
23
32
7.30
15.71
3.1
2.9
528.0
931.8
u/ml
—
5
5
64
210
3.16
15.59
1.7
1.4
—
—
—
0
0
16
14
11.56
15.33
1.1
1.0
—
—
—
0
0
36
80
4.60
15.24
1.3
1.1
—
—
—
0
0
36
80
4.60
15.24
1.3
1.2
—
—
—
0
0
1175
10709
2.51
15.02
30.6
14.5
139.1
139.7
mmol/l
13.96
1159
10419
36
82
4.49
14.79
1.3
1.1
—
—
—
0
0
36
82
4.49
14.79
1.3
1.1
—
—
—
0
0
36
82
4.49
14.79
1.3
1.1
—
—
—
0
0
644
4993
1.59
14.52
4.5
3.6
0.0
0.0
estimate
0.00
129
927
79
305
2.70
14.37
2.2
2.3
199.5
181.5
%
1.09
72
291
1175
10742
2.46
14.32
30.9
14.6
3.9
4.0
mmol/l
2.69
1160
10430
119
557
2.26
14.30
1.7
1.6
—
—
—
0
0
74
282
2.73
13.81
1.4
1.5
266.2
306.6
ug/g
0.87
46
165
190
1074
1.91
13.72
8.4
7.9
4.9
5.1
kpa
2.78
185
1026
28
55
5.18
13.67
1.4
1.6
—
—
—
0
0
641
5024
1.56
13.37
6.1
4.8
0.0
0.0
estimate
0.40
132
943
107
495
2.27
13.21
10.2
11.5
—
—
—
0
0
152
807
2.01
13.16
2.6
2.5
68.3
68.4
ml/min/173m2
0.01
60
325
645
5076
1.56
13.11
4.6
3.6
0.0
0.0
estimate
0.05
127
904
29
61
4.84
13.11
1.1
2.1
0.2
0.2
e9/l
0.27
23
55
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
73
284
2.67
13.09
3.1
2.8
0.3
0.4
u/ml
0.91
45
160
187
1070
1.88
12.97
8.5
7.9
0.5
1.2
mmol/l
1.23
140
849
470
3459
1.57
12.76
3.1
3.3
2.3
2.4
mmol/l
0.86
408
3025
133
687
2.05
12.41
4.2
2.8
4.9
4.5
kpa
1.03
124
662
29
64
4.61
12.40
1.1
2.1
566.3
586.7
e6/l
0.04
23
56
47
148
3.26
12.28
3.0
3.4
1.2
1.2
%
0.00
34
121
151
822
1.95
12.15
8.2
7.1
1.7
1.3
mmol/l
3.00
145
787
18
26
7.01
11.87
1.4
1.2
—
—
—
0
0
65
258
2.60
11.23
2.8
1.6
—
—
—
0
0
28
66
4.32
11.05
1.4
1.9
9.3
11.7
%
0.67
16
33
27
63
4.36
10.80
1.6
1.9
—
—
—
0
0
144
803
1.90
10.75
4.2
3.4
1.2
1.2
mmol/l
1.11
134
687
68
284
2.47
10.58
2.2
2.2
11.6
11.5
mg/l
0.03
63
259
59
236
2.57
10.05
2.4
2.8
24.0
25.1
mmol/l
1.11
54
210
329
2337
1.55
9.98
2.0
1.7
1.7
1.0
mg/l
3.20
264
1769
130
727
1.88
9.61
2.7
2.9
153.1
165.1
ng/l
0.18
121
659
97
491
2.06
9.56
10.8
9.8
24.1
24.5
mmol/l
0.52
92
461
22
49
4.55
9.32
2.5
3.0
2820.2
1053.1
u/ml
0.64
22
49
14
20
7.07
9.30
1.1
1.3
—
—
—
0
0
50
193
2.66
9.17
1.6
1.5
—
—
—
0
0
298
2107
1.54
9.13
1.7
1.6
52632042.1
20917329.7
pmol/l
0.38
247
1745
22
50
4.46
9.10
1.4
1.2
—
—
—
0
0
22
50
4.46
9.10
1.4
1.2
—
—
—
0
0
367
2719
1.49
8.99
2.8
2.9
1767.2
1049.4
ng/l
0.98
307
2265
79
379
2.16
8.96
5.0
3.6
24.0
25.0
mmol/l
2.04
74
358
13
7
18.75
8.94
1.0
1.0
—
—
—
0
0
37
125
3.02
8.67
1.5
1.4
—
—
—
0
0
50
200
2.56
8.56
2.4
2.1
126.1
131.2
g/l
0.66
38
149
1082
9928
1.65
8.51
26.8
11.8
82.8
82.5
ml/min/173m2
0.17
961
8138
76
367
2.14
8.49
2.5
2.0
1.2
1.8
ug/l
0.31
69
326
11
13
8.53
8.47
1.2
2.5
—
—
—
0
0
1055
9628
1.60
8.41
5.5
4.8
1.9
2.0
mu/l
0.30
994
8847
104
566
1.91
8.35
1.6
1.5
—
—
—
0
0
36
124
2.96
8.17
1.5
1.4
—
—
—
0
0
18
38
4.79
8.13
1.7
2.2
63.3
117.3
umol/l
—
7
24
63
287
2.26
8.12
1.6
4.1
37.4
38.2
mg/l
0.03
54
240
63
287
2.26
8.12
1.6
4.1
43.7
63.9
mg/l
0.45
55
240
30
93
3.28
8.10
3.1
3.4
58.9
53.6
%
0.50
15
66
37
131
2.88
8.00
1.1
1.1
—
—
—
0
0
265
1874
1.52
8.00
3.6
3.6
170.4
410.7
ng/l
2.26
201
1392
35
121
2.95
7.90
1.5
1.4
—
—
—
0
0
35
121
2.95
7.90
1.5
1.4
—
—
—
0
0
46
185
2.54
7.81
1.3
1.4
—
—
—
0
0
376
2864
1.45
7.81
1.9
1.7
1.5
1.4
mmol/l
1.34
336
2415
915
8146
1.45
7.81
4.4
4.1
14.8
14.7
pmol/l
0.44
856
7444
35
122
2.92
7.79
1.5
1.4
—
—
—
0
0
35
122
2.92
7.79
1.5
1.4
—
—
—
0
0
972
8772
1.48
7.57
37.8
15.8
14.2
13.6
%
17.63
964
8572
1183
11196
1.97
7.52
30.3
9.8
42.4
26.0
u/l
47.59
1172
10813
23
63
3.70
7.48
2.5
1.7
—
—
—
0
0
470
3753
1.40
7.42
4.2
3.3
36.1
46.6
ng/l
0.42
344
2496
62
292
2.18
7.40
2.7
2.7
—
—
—
0
0
262
1899
1.48
6.93
1.3
1.3
38.8
31.5
iu/ml
0.46
92
606
59
280
2.16
6.92
1.6
4.1
1.0
1.3
ratio
—
5
27
155
1007
1.62
6.72
3.9
2.9
—
—
—
0
0
27
89
3.08
6.64
1.3
1.1
54.2
24.3
u/ml
—
6
8
40
165
2.47
6.48
2.0
1.7
—
—
—
0
0
45
196
2.34
6.48
1.1
1.3
—
—
—
0
0
45
196
2.34
6.48
1.1
1.3
—
—
—
0
0
1042
9627
1.48
6.36
8.2
5.4
41.3
39.4
mmol/mol
6.31
992
8955
65
333
2.00
6.26
2.0
1.7
—
—
—
0
0
66
341
1.99
6.21
1.5
2.7
3.1
3.1
g/l
0.01
54
276
69
363
1.95
6.17
1.6
2.6
4.1
3.6
g/l
1.97
54
270
69
363
1.95
6.17
1.6
2.6
7.7
7.3
g/l
0.61
56
283
69
363
1.95
6.17
1.6
2.6
—
—
—
0
0
69
363
1.95
6.17
2.2
1.8
—
—
—
0
0
472
3859
1.36
6.15
4.8
3.7
—
—
—
0
0
99
587
1.75
6.07
7.2
7.7
23.3
24.6
mmol/l
2.29
94
547
65
337
1.98
6.07
1.7
2.7
14.8
10.2
g/l
4.54
57
295
49
232
2.16
5.83
2.0
1.6
—
—
—
0
0
13
28
4.68
5.74
1.2
2.1
—
—
—
0
0
42
188
2.28
5.72
3.1
2.4
16.8
16.3
%
0.30
27
96
763
6749
1.33
5.65
3.1
3.0
—
—
—
0
0
28
104
2.73
5.62
2.3
1.7
—
—
—
0
0
24
82
2.96
5.59
1.3
1.3
—
—
—
0
0
24
83
2.93
5.48
1.3
1.3
—
—
—
0
0
25
89
2.85
5.43
1.4
1.4
15.1
11.0
mmol/l
1.13
13
18
243
1813
1.42
5.42
1.3
1.3
14.0
11.1
u/ml
0.23
75
716
47
226
2.12
5.40
2.0
1.7
—
—
—
0
0
16
43
3.76
5.37
1.3
1.2
—
—
—
0
0
16
43
3.76
5.37
1.3
1.2
—
—
—
0
0
23
79
2.95
5.32
1.1
1.1
—
—
—
0
0
23
79
2.95
5.32
2.0
1.4
1.1
1.2
promille
0.11
16
64
15
40
3.78
5.10
1.2
1.3
—
—
—
0
0
55
287
1.96
5.08
1.6
2.7
37.8
38.4
g/l
0.27
48
255
53
278
1.95
4.84
1.6
2.8
0.0
0.0
g/l
0.50
48
260
29
119
2.47
4.82
1.2
1.4
282.8
322.4
pmol/l
0.31
22
97
332
2665
1.33
4.65
5.0
3.9
0.0
0.0
estimate
0.04
132
918
1066
10030
1.42
4.62
4.9
3.9
1.4
1.3
mmol/l
3.57
1001
9235
56
305
1.88
4.59
1.6
3.0
0.7
1.1
g/l
0.36
50
277
25
99
2.56
4.48
1.7
2.4
33.7
32.4
pg
0.92
25
99
1077
10178
1.41
4.31
5.9
4.4
6.2
5.9
mmol/l
9.49
1011
9305
1102
10466
1.43
4.19
5.6
4.3
4.6
4.7
mmol/l
6.55
1043
9733
30
136
2.24
4.04
2.2
1.6
—
—
—
0
0
33
156
2.15
4.02
1.1
1.1
—
—
—
0
0
21
81
2.62
3.98
1.4
2.0
639.3
690.2
e6/l
0.11
12
27
276
2203
1.32
3.96
4.8
3.9
1.0
1.0
kg/l
0.08
52
316
36
179
2.04
3.87
1.8
1.6
—
—
—
0
0
18
65
2.79
3.86
1.1
1.2
—
—
—
0
0
20
79
2.56
3.64
1.4
1.8
—
—
—
0
0
63
999
0.61
3.62
1.6
1.7
—
—
—
0
0
113
794
1.47
3.48
2.0
2.3
5.7
7.4
ug/l
0.77
101
702
12
36
3.36
3.48
1.2
1.3
—
—
—
0
0
1091
10406
1.37
3.48
5.5
4.3
1.4
1.5
mmol/l
8.06
1027
9631
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
15
52
2.91
3.47
1.1
1.2
—
—
—
0
0
53
313
1.72
3.40
1.3
1.1
—
—
—
0
0
18
70
2.59
3.39
2.6
1.6
—
—
—
0
0
46
261
1.79
3.38
1.4
1.3
575.7
514.0
mg/l
0.18
46
247
230
1828
1.32
3.37
2.8
2.9
2.5
2.4
mmol/l
1.35
199
1598
13
42
3.12
3.37
1.0
1.3
—
—
—
0
0
13
42
3.12
3.37
1.2
1.0
1742.1
1717.2
miu/ml
0.02
13
42
1111
10645
1.38
3.28
6.0
4.8
2.7
2.8
mmol/l
5.38
1043
9849
52
309
1.71
3.28
1.3
1.1
—
—
—
0
0
53
319
1.69
3.20
1.3
1.3
244.5
235.4
miu/ml
0.06
20
148
58
359
1.65
3.15
1.7
1.7
—
—
—
0
0
13
44
2.97
3.14
1.5
2.3
65.9
62.1
ug/l
0.08
13
44
13
45
2.91
3.03
1.8
2.0
—
—
—
0
0
13
45
2.91
3.03
1.8
2.0
—
—
—
0
0
7
12
5.86
3.02
1.3
1.1
—
—
—
0
0
9
21
4.31
2.99
1.3
1.4
-1.2
1.9
mmol/l
—
9
21
167
1294
1.34
2.92
5.4
4.3
31.2
32.0
%
0.39
135
866
6
9
6.69
2.87
1.2
1.1
—
—
—
0
0
6
9
6.69
2.87
1.0
1.0
—
—
—
0
0
1019
9696
1.27
2.79
32.4
13.8
39.1
40.0
%
2.44
747
7105
21
97
2.18
2.78
1.6
1.7
—
—
—
0
0
92
652
1.44
2.76
2.4
2.2
13.2
12.9
nmol/l
0.09
78
580
5
6
8.36
2.75
1.0
1.2
—
—
—
0
0
41
243
1.71
2.66
2.2
2.4
116.1
83.4
ug/min
0.33
24
141
16
67
2.41
2.64
1.6
1.2
—
—
—
0
0
6
11
5.48
2.54
1.0
1.0
—
—
—
0
0
19
88
2.18
2.51
1.6
2.5
—
—
—
0
0
21
102
2.08
2.48
1.3
1.2
—
—
—
0
0
12
283
0.42
2.47
1.8
1.4
—
—
—
0
0
22
109
2.04
2.47
1.6
1.6
—
—
—
0
0
10
34
2.96
2.41
1.2
1.7
—
—
—
0
0
13
52
2.52
2.36
1.1
1.2
—
—
—
0
0
50
324
1.57
2.33
4.3
3.9
1.4
1.3
mmol/l
0.64
50
318
19
92
2.08
2.27
3.7
2.1
—
—
—
0
0
77
555
1.41
2.16
1.4
1.3
—
—
—
0
0
7
20
3.51
2.05
1.0
1.3
—
—
—
0
0
224
1885
1.23
2.05
1.5
1.5
—
—
—
0
0
36
224
1.63
2.01
1.6
1.4
12606.1
986.4
e6/l
0.47
29
185
36
224
1.63
2.01
1.4
1.4
47.4
13.6
e6/l
0.72
27
179
10
38
2.64
2.01
1.1
1.3
—
—
—
0
0
5
11
4.56
1.94
1.2
1.4
—
—
—
0
0
8
27
2.97
1.93
2.4
1.7
—
—
—
0
0
28
166
1.70
1.88
2.2
1.5
—
—
—
0
0
23
129
1.80
1.86
2.3
1.5
—
—
—
0
0
26
428
0.60
1.85
1.7
1.5
—
—
—
0
0
13
59
2.22
1.84
1.2
1.1
1.1
1.1
ratio
—
5
19
75
556
1.37
1.82
1.1
1.0
—
—
—
0
0
5
13
3.86
1.71
1.2
1.2
—
—
—
0
0
14
68
2.07
1.70
1.4
1.1
—
—
—
0
0
24
142
1.70
1.65
1.1
1.0
4.4
1.8
u/ml
—
7
66
20
113
1.78
1.61
1.2
1.1
—
—
—
0
0
10
43
2.34
1.60
1.3
2.2
—
—
—
0
0
12
236
0.50
1.60
1.2
1.4
—
—
—
0
0
12
236
0.50
1.60
1.2
1.4
—
—
—
0
0
12
236
0.50
1.60
1.2
1.4
—
—
—
0
0
12
235
0.51
1.58
1.2
1.4
—
—
—
0
0
11
50
2.21
1.57
1.0
1.2
—
—
—
0
0
45
315
1.44
1.54
2.3
2.1
10941.7
2768.3
u/l
0.56
17
128
5
15
3.34
1.52
1.4
2.1
—
—
—
0
0
7
27
2.60
1.51
1.0
1.3
—
—
—
0
0
14
255
0.54
1.48
1.3
1.5
—
—
—
0
0
39
269
1.46
1.45
1.5
1.3
9.5
10.3
u/l
0.18
31
213
7
152
0.46
1.44
1.4
1.5
—
—
—
0
0
1191
11713
1.32
1.42
45.6
18.9
234.9
254.9
e9/l
15.82
1179
11429
10
46
2.18
1.40
4.7
3.1
—
—
—
0
0
38
264
1.45
1.38
1.5
1.7
53.8
38.8
nmol/l
1.24
38
252
5
17
2.95
1.36
2.0
1.7
—
—
—
0
0
9
42
2.15
1.33
1.1
1.0
—
—
—
0
0
1191
11722
1.31
1.33
45.5
18.9
6.5
6.6
e9/l
1.43
1176
11406
6
24
2.51
1.30
1.0
1.1
99.7
100.3
%
—
6
24
6
24
2.51
1.30
1.0
1.1
—
—
—
0
0
1191
11725
1.30
1.30
45.7
19.0
133.2
135.7
g/l
6.49
1182
11560
8
34
2.36
1.29
1.0
1.1
—
—
—
0
0
10
48
2.09
1.28
1.8
1.7
—
—
—
0
0
10
48
2.09
1.28
1.8
1.7
—
—
—
0
0
10
48
2.09
1.28
1.8
1.7
—
—
—
0
0
10
48
2.09
1.28
1.8
1.7
—
—
—
0
0
8
35
2.29
1.27
8.3
4.7
—
—
—
0
0
40
287
1.41
1.24
1.2
1.2
—
—
—
0
0
1190
11721
1.29
1.23
45.4
18.9
4.4
4.5
e12/l
8.24
1175
11403
19
117
1.63
1.18
1.1
1.1
—
—
—
0
0
19
118
1.62
1.15
1.2
1.1
—
—
—
0
0
83
674
1.25
1.12
1.3
1.2
153.0
222.8
u/ml
0.63
76
619
7
31
2.26
1.10
1.1
1.2
—
—
—
0
0
7
31
2.26
1.10
1.1
1.1
—
—
—
0
0
22
144
1.54
1.09
1.0
1.0
—
—
—
0
0
8
41
1.96
1.09
3.5
2.5
—
—
—
0
0
7
32
2.19
1.08
1.1
1.2
—
—
—
0
0
38
279
1.37
1.06
1.1
1.1
—
—
—
0
0
20
129
1.56
1.06
1.6
1.4
—
—
—
0
0
5
22
2.28
1.03
1.6
1.4
—
—
—
0
0
7
34
2.06
1.03
2.0
1.5
—
—
—
0
0
25
171
1.47
1.02
1.4
1.2
1.6
4.1
u/ml
0.79
14
44
5
23
2.18
0.98
1.4
1.1
—
—
—
0
0
10
54
1.86
0.96
1.3
1.1
—
—
—
0
0
9
51
1.77
0.94
3.8
1.4
—
—
—
0
0
9
51
1.77
0.94
1.1
1.1
—
—
—
0
0
7
37
1.90
0.94
1.9
1.9
—
—
—
0
0
7
37
1.90
0.94
1.9
1.9
—
—
—
0
0
33
243
1.37
0.93
1.6
1.7
14776.7
14654.4
e6/l
0.01
22
188
9
52
1.74
0.92
3.8
1.4
—
—
—
0
0
6
28
2.15
0.91
1.2
1.1
—
—
—
0
0
6
29
2.07
0.89
7.2
3.2
—
—
—
0
0
6
29
2.07
0.89
1.0
1.1
—
—
—
0
0
6
29
2.07
0.89
7.2
3.2
—
—
—
0
0
14
87
1.62
0.87
1.6
1.6
—
—
—
0
0
14
87
1.62
0.87
1.6
1.6
—
—
—
0
0
14
87
1.62
0.87
1.6
1.6
—
—
—
0
0
6
30
2.00
0.87
1.0
1.1
—
—
—
0
0
37
284
1.31
0.82
1.4
1.3
—
—
—
0
0
0
26
0.00
0.78
0.0
1.0
—
31.5
—
0
26
18
124
1.46
0.75
2.6
1.5
—
—
—
0
0
138
1227
1.14
0.74
8.7
6.3
—
—
—
0
0
7
38
1.85
0.73
1.9
1.9
—
—
—
0
0
11
170
0.64
0.71
1.2
1.1
0.4
2.4
u/ml
—
6
73
9
58
1.56
0.70
3.8
1.4
—
—
—
0
0
80
686
1.18
0.69
2.6
3.4
4.4
4.6
pmol/l
0.92
75
601
35
275
1.28
0.68
1.4
1.4
—
—
—
0
0
15
215
0.69
0.68
4.6
3.7
20.8
33.5
u/ml
1.15
15
210
133
1485
0.88
0.68
2.5
2.9
0.7
0.8
ug/l
0.26
89
947
15
103
1.46
0.65
1.2
1.0
—
—
—
0
0
14
201
0.69
0.64
1.8
1.6
—
—
—
0
0
20
146
1.38
0.64
2.5
1.5
—
—
—
0
0
12
79
1.52
0.62
1.2
1.1
—
—
—
0
0
23
173
1.34
0.62
1.5
1.2
5.4
5.3
u/ml
0.01
16
64
54
455
1.20
0.59
1.4
1.3
34.4
30.0
iu/l
0.33
45
381
8
53
1.51
0.58
1.0
1.3
—
90.0
—
0
8
23
175
1.32
0.58
4.0
3.0
0.8
0.8
nmol/l
0.08
15
140
33
267
1.24
0.54
1.4
1.5
125.9
222.9
pmol/l
0.77
33
262
6
39
1.54
0.53
1.2
1.2
123.3
109.6
%
—
6
31
20
153
1.31
0.50
1.6
1.4
7.9
7.5
mmol/l
0.16
15
105
14
102
1.38
0.47
3.1
3.7
—
—
—
0
0
189
2025
0.92
0.47
3.7
4.0
22.0
21.3
%
0.22
82
925
104
1143
0.90
0.44
1.6
2.0
—
—
—
0
0
28
229
1.23
0.44
1.8
1.6
—
—
—
0
0
34
287
1.19
0.40
1.4
2.0
3.1
4.9
iu/l
—
10
104
17
214
0.79
0.38
3.4
3.5
43.4
21.2
mg/l
1.22
12
132
11
147
0.75
0.37
1.5
1.6
—
—
—
0
0
22
180
1.23
0.36
1.1
1.1
—
10.3
—
0
13
48
424
1.14
0.34
1.6
1.7
4.5
4.3
mg/l
0.04
37
305
43
377
1.15
0.34
2.4
1.8
—
—
—
0
0
84
771
1.10
0.32
1.2
1.2
174.8
138.7
iu/ml
0.35
28
316
55
606
0.90
0.28
1.7
1.8
—
—
—
0
0
8
65
1.23
0.27
1.8
1.7
—
—
—
0
0
194
1856
1.05
0.26
1.5
1.4
—
—
—
0
0
5
43
1.16
0.21
1.2
2.2
28.1
202.2
ug/l
—
5
38
0
13
0.00
0.21
0.0
6.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
48
1.25
0.20
1.8
1.8
—
—
—
0
0
44
479
0.92
0.20
1.6
1.7
—
—
—
0
0
15
175
0.86
0.19
1.1
1.1
—
—
—
0
0
35
383
0.91
0.18
1.3
1.4
—
—
—
0
0
15
173
0.87
0.16
2.5
1.7
—
—
—
0
0
258
2515
1.03
0.16
4.4
4.6
1.8
2.3
ug/l
1.15
235
2277
14
122
1.15
0.13
1.1
1.2
—
—
—
0
0
42
393
1.07
0.13
1.5
1.4
—
—
—
0
0
18
161
1.12
0.13
1.1
1.1
—
—
—
0
0
5
65
0.77
0.08
1.4
1.3
—
—
—
0
0
9
104
0.86
0.06
1.6
1.4
5.4
2.9
ug/l
—
9
90
101
1022
0.99
0.02
1.6
1.9
—
—
—
0
0
15
156
0.96
0.00
3.9
5.3
363.0
363.2
umol/l
0.00
15
140
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
5.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_CHRONHEP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHRONHEP | 2.604 [2.3, 2.95] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.142 |
During the follow-up period (1.1.1998 — 31.12.2019), 918 out of 3652 females with K11_CHRONHEP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHRONHEP | 3.327 [2.86, 3.87] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 739 out of 2256 males with K11_CHRONHEP died.
Mortality risk
Mortality risk for people of age
years, who have K11_CHRONHEP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.215% | 0.576% |
| 5 | 1.371% | 4.121% |
| 10 | 3.587% | 9.979% |
| 15 | 6.769% | 19.304% |
| 20 | 12.043% | 30.726% |
Relationships between endpoints
↥Index endpoint: K11_CHRONHEP – Chronic hepatitis, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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