No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
473 |
4. Check minimum number of eventsNone |
473 |
5. Include endpointsNone |
473 |
6. Filter based on genotype QC (FinnGen only) |
473 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Chronic hepatitis NAS
based on the number of shared cases.
Similar with more cases:
- Chronic hepatitis, not elsewhere classified
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3280 | 1919 | 1341 |
| Only index persons | 2815 | 1703 | 1112 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.85 | 57.41 | 53.52 |
| Only index persons | 54.73 | 56.41 | 52.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 473 | 311 | 162 |
| Unadjusted period prevalence (%) | 0.09 | 0.11 | 0.07 |
| Median age at first event (years) | 53.72 | 53.41 | 54.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 423
- Matched controls
- 4230
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
+∞
323.0
395
*
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
1627.0
128.0
118
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
51.3
114.4
137
39
L04AX01
ATC
azathioprine; systemic
24.5
89.2
130
75
A05AA02
ATC
ursodeoxycholic acid; oral
46.8
80.5
98
27
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
11.1
70.5
148
196
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
61.4
65.8
76
15
K76.9
ICD-10 Finland
Liver disease, unspecified
60.4
64.7
75
15
K75.4
ICD-10 Finland
Autoimmune hepatitis
653.6
59.2
57
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.9
57.6
150
274
K74.3
ICD-10 Finland
Primary biliary cirrhosis
71.4
49.6
56
9
A07EA06
ATC
budesonide; oral, local oral
15.4
45.5
77
60
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.4
42.5
207
749
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
41.3
39
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
34.9
33
*
K83.0
ICD-10 Finland
Cholangitis
30.2
34.5
46
17
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
18.5
31.0
48
29
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
33.8
31.0
40
13
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
13.6
29.7
52
43
H02AB06
ATC
prednisolone; systemic
3.2
29.2
259
1383
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.7
29.1
113
306
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
33.6
28.6
37
12
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.2
26.8
201
933
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
55.2
22.3
26
5
A02BC02
ATC
pantoprazole; systemic
2.8
21.0
312
2102
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
115.7
20.8
22
*
UJF32
NOMESCO Finland
Coloscopy
2.8
18.7
151
696
ZX120
NOMESCO Finland
Intravenous
4.1
18.4
78
223
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
21.2
18.0
26
13
UJF30
NOMESCO Finland
Ileoscopy through colon
4.1
17.8
75
213
N02AX02
ATC
tramadol; systemic, rectal
2.5
17.8
211
1205
L01BB02
ATC
mercaptopurine; oral
26.9
17.1
23
9
C03DA01
ATC
spironolactone; oral
3.9
17.0
74
216
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
15.3
16.0
26
18
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
11.9
16.0
29
26
H02AB07
ATC
prednisone; oral
3.3
15.8
90
322
K51.5
ICD-10 Finland
Left sided colitis
7.2
15.7
38
57
A06AD11
ATC
lactulose; oral
3.4
15.3
83
287
L04AA06
ATC
mycophenolic acid; systemic
11.9
15.0
27
24
Z94.4
ICD-10 Finland
Liver transplant status
26.1
14.8
20
8
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
5.2
14.7
46
96
5714B
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ACTIVA (HBSAG-)]
+∞
14.7
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
14.6
202
1206
A07EC02
ATC
mesalazine; oral, rectal
4.7
14.5
50
116
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
6.2
14.1
38
66
L04AD01
ATC
ciclosporin; systemic
9.1
14.0
29
34
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
7.6
13.8
32
45
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
13.6
13
*
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
41.5
13.2
16
*
C03CA01
ATC
furosemide; systemic
2.5
13.1
129
640
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.2
13.0
50
130
JJC00
NOMESCO Finland
Allogenic transplantation of liver
33.1
12.7
16
5
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
12.1
181
1088
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
12.0
108
507
JJA20
NOMESCO Finland
Open biopsy of liver
48.1
11.9
14
*
R94.5
ICD-10 Finland
Abnormal results of liver function studies
17.0
11.8
18
11
UJK02
NOMESCO Finland
ERCP
8.5
11.7
25
31
UJK12
NOMESCO Finland
Peroral cholangioscopy
66.8
11.7
13
*
D97
ICPC
Liver disease NOS
23.7
11.6
16
7
R18
ICD-10 Finland
Ascites
9.7
11.6
23
25
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
9.7
11.6
23
25
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
13.2
11.2
19
15
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
7.4
11.2
26
37
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
20.7
11.2
16
8
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
10.4
10.6
20
20
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
33.4
10.4
13
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
33.4
10.4
13
*
K72.9
ICD-10 Finland
Hepatic failure, unspecified
24.0
10.3
14
6
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
12.6
9.9
17
14
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.8
9.9
67
266
127
Kela drug reimbursment
Transplant complication
8.7
9.7
20
24
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
10.4
9.6
18
18
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.6
9.5
43
130
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
30.8
9.4
12
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
+∞
9.4
9
*
K50.8
ICD-10 Finland
Other Crohn disease
11.0
9.4
17
16
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.8
9.3
64
257
UJD02
NOMESCO Finland
Gastroscopy
4.1
9.3
35
90
H02AB04
ATC
methylprednisolone; systemic
2.5
9.1
74
327
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.4
9.0
84
399
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
9.0
108
578
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
9.8
8.8
17
18
J01MA02
ATC
ciprofloxacin; systemic
1.9
8.8
175
1140
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
8.7
53
195
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.7
8.6
60
243
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
10.3
8.6
16
16
R50.9
ICD-10 Finland
Fever, unspecified
2.5
8.5
69
306
5719X
ICD-9 Finland
Chronic liver disease and cirrhosis, Unspecified chronic liver disease without mention of alcohol
+∞
8.4
8
*
B18.2
ICD-10 Finland
Chronic viral hepatitis C
14.8
8.2
13
9
C10AC01
ATC
colestyramine; oral
5.3
8.0
23
45
B99
ICD-10 Finland
Other and unspecified infectious diseases
7.6
7.7
17
23
A10AE04
ATC
insulin glargine; parenteral
2.8
7.7
49
188
K74.0
ICD-10 Finland
Hepatic fibrosis
45.8
7.7
9
*
M05BA04
ATC
alendronic acid; oral
3.0
7.6
44
159
S97
ICPC
Chronic ulcer skin
3.6
7.6
33
97
K70.1
ICD-10 Finland
Alcoholic hepatitis
25.5
7.6
10
*
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
25.5
7.6
10
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.1
7.5
42
147
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
7.5
70
334
K75.2
ICD-10 Finland
Nonspecific reactive hepatitis
81.4
7.4
8
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.8
7.3
23
50
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
16.1
7.3
11
7
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
5.2
7.2
21
42
K51.8
ICD-10 Finland
Other ulcerative colitis
6.2
7.1
18
30
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
7.1
80
413
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
7.1
70
342
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.9
7.1
41
149
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
3.8
7.0
28
77
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
6.9
53
227
A02BC03
ATC
lansoprazole; oral
1.9
6.9
128
800
K72.1
ICD-10 Finland
Chronic hepatic failure
40.7
6.8
8
*
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.9
6.7
116
709
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
6.6
95
540
K92.1
ICD-10 Finland
Melaena
3.6
6.6
28
81
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
6.6
37
130
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
6.5
41
155
J01MA12
ATC
levofloxacin; systemic
2.0
6.5
83
452
A02BC01
ATC
omeprazole; systemic
1.8
6.5
119
741
B19.9
ICD-10 Finland
Unspecified viral hepatitis without hepatic coma
70.8
6.4
7
*
0709X
ICD-9 Finland
Viral hepatitis, Unspecified viral hepatitis without mention of hepatic coma
70.8
6.4
7
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
6.4
73
377
N02AA05
ATC
oxycodone; systemic
2.2
6.4
67
335
V03AE01
ATC
polystyrene sulfonate; oral
11.2
6.3
11
10
5714X
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]
+∞
6.3
6
*
C07AB07
ATC
bisoprolol; oral
1.7
6.2
182
1302
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
5.0
6.1
18
37
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
6.0
39
152
E0000UV
ATC
NA
1.7
6.0
164
1147
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
236
294
15.02
195.25
6.7
2.7
12.6
10.6
g/l
5.88
226
273
221
345
11.15
150.37
5.2
2.3
0.2
0.2
g/l
1.24
201
327
169
238
10.49
122.58
2.1
1.7
1.4
1.4
g/l
0.03
155
219
71
34
24.39
96.31
1.7
1.1
—
—
titre
—
0
0
50
13
42.89
82.28
1.2
1.1
—
—
—
0
0
363
1605
6.43
73.74
11.8
4.5
34.9
35.9
g/l
2.76
345
1501
176
435
5.85
71.46
7.0
2.6
20.9
8.9
umol/l
2.26
159
381
321
1322
5.44
69.80
10.6
3.2
51.8
30.1
u/l
6.26
307
1257
60
43
15.84
66.76
1.2
1.1
1.6
1.5
g/l
1.64
53
38
72
84
9.93
58.35
5.5
3.2
37.7
34.6
umol/l
0.46
65
72
390
2052
6.13
58.20
17.2
6.2
16.9
10.7
umol/l
3.53
378
1947
165
514
4.39
48.27
2.6
2.1
2.3
2.4
g/l
0.52
152
472
59
68
9.77
48.02
4.9
6.2
2023.6
158.6
iu/ml
—
8
10
158
486
4.38
46.86
2.7
2.2
25.3
23.1
%
0.70
134
419
168
568
4.04
43.32
2.8
2.1
13.8
13.5
umol/l
0.17
154
521
55
68
9.02
42.29
1.3
1.2
280.5
223.5
u/ml
0.45
32
35
56
72
8.69
41.73
1.3
1.2
—
—
—
0
0
49
64
8.43
35.94
1.3
1.4
104.7
113.9
u/ml
—
7
10
323
1814
3.46
35.51
13.6
5.6
56.5
57.3
%
0.59
316
1706
323
1829
3.42
34.71
14.0
5.8
28.3
28.0
%
0.22
315
1714
72
150
5.48
33.75
4.4
3.3
871.0
1828.4
u/ml
0.33
67
131
249
1240
3.13
32.82
4.9
2.4
63.5
56.8
u/l
1.52
237
1144
357
2249
3.40
30.05
17.0
9.0
3.7
4.1
e9/l
2.76
336
1968
285
1627
2.89
27.76
3.3
2.3
74.7
76.8
nmol/l
0.66
268
1442
143
562
3.21
27.65
2.6
1.8
31.1
29.4
s
2.33
137
543
129
486
3.27
26.67
2.5
1.7
1.6
1.4
%
1.56
104
424
105
353
3.54
25.99
3.4
2.3
32.7
32.3
u/l
0.05
96
299
418
3025
4.28
25.77
23.6
7.4
107.1
77.5
u/l
15.68
407
2837
54
112
5.31
25.24
1.4
1.3
—
—
—
0
0
115
421
3.29
24.76
14.9
20.6
1.2
1.2
inr
0.00
30
61
38
60
6.80
23.45
1.5
1.3
—
—
—
0
0
28
33
8.96
22.10
2.3
1.3
—
—
—
0
0
119
500
2.84
19.73
3.8
2.2
176.8
122.3
ug/g
1.04
101
402
100
387
3.01
19.22
4.1
4.6
3.2
26.8
ug/l
1.20
76
325
25
31
8.46
18.93
1.0
1.0
—
—
—
0
0
27
37
7.68
18.84
1.3
1.1
47.2
50.4
u/l
0.17
20
22
176
918
2.46
18.64
2.9
2.0
3.2
3.1
mg/l
0.20
158
777
288
1864
2.39
18.63
10.8
6.4
1.2
1.2
mmol/l
0.82
244
1579
369
2692
2.69
18.02
9.9
3.1
131.8
45.2
u/l
11.61
352
2532
53
144
4.02
17.63
1.7
1.9
1.3
1.5
g/l
0.51
46
127
388
2946
2.76
16.66
8.1
4.0
18.1
11.5
mm/h
10.28
369
2709
18
18
10.36
15.90
5.6
2.6
77.4
101.7
%
1.65
18
18
261
1693
2.21
15.81
9.1
5.6
1.2
1.2
mmol/l
0.54
242
1533
316
2230
2.26
15.29
8.6
4.5
7.0
6.6
mmol/l
1.38
302
2069
72
265
3.03
14.93
2.7
1.6
—
—
—
0
0
258
1726
2.09
13.73
3.6
2.6
215.6
118.0
ug/l
1.51
241
1576
18
23
8.10
13.23
2.2
1.6
10.4
4.6
u/l
0.59
12
12
18
24
7.76
12.78
1.7
1.8
11.5
11.5
umol/l
0.01
18
24
231
1525
2.01
12.31
2.2
1.9
97.6
96.5
pmol/l
0.12
134
753
156
909
2.07
11.63
1.4
1.2
1.6
1.4
u/ml
0.15
36
251
160
947
2.04
11.39
3.4
2.1
—
—
—
0
0
13
13
10.25
11.38
1.9
1.6
12107.8
5352.4
e6/l
—
5
7
40
122
3.49
11.22
1.6
1.6
0.1
0.1
iu/ml
—
6
22
17
25
7.02
11.08
1.2
1.2
—
—
—
0
0
142
869
1.91
8.82
1.7
1.5
19.0
21.7
nmol/l
1.44
131
731
33
104
3.34
8.80
1.9
1.2
—
—
—
0
0
104
574
2.04
8.70
2.0
1.9
—
—
—
0
0
14
22
6.53
8.57
1.3
1.5
—
—
—
0
0
16
29
5.68
8.55
3.5
1.5
0.9
1.0
g/l
1.05
16
29
8
0
+∞
8.35
5.8
0.0
—
—
—
0
0
28
83
3.52
8.20
1.6
1.8
—
—
—
0
0
248
1851
1.71
7.60
5.1
3.9
—
—
—
0
0
115
690
1.88
7.44
1.9
1.6
1149.6
1193.3
nmol/l
0.20
96
511
193
1356
1.72
7.30
4.8
2.9
—
—
—
0
0
102
596
1.91
7.14
3.7
2.7
1.9
2.7
e6/l
0.74
59
287
105
639
1.83
6.42
3.5
2.5
1.0
0.9
e6/l
0.04
61
331
154
1053
1.69
6.24
4.6
2.8
0.3
0.4
e6/l
0.40
121
756
11
19
5.90
6.13
1.3
2.1
—
—
—
0
0
73
400
1.98
6.13
1.7
1.8
—
—
—
0
0
27
95
2.95
6.04
2.4
1.6
—
—
—
0
0
62
324
2.05
5.93
7.5
3.1
0.7
2.2
mmol/l
1.81
46
255
21
64
3.39
5.93
3.3
3.3
4.4
4.4
e9/l
0.02
21
64
28
103
2.83
5.80
2.0
1.4
—
—
—
0
0
21
65
3.33
5.79
3.4
3.8
59.4
57.7
%
0.23
21
65
29
110
2.74
5.68
1.3
1.4
238.4
318.1
ug/g
1.07
20
60
143
984
1.65
5.56
4.3
2.4
355.5
7300.0
umol/l
4.16
124
838
435
3959
2.23
5.51
31.8
13.1
18.1
21.7
mg/l
2.03
390
3071
35
149
2.46
5.46
2.0
1.9
—
—
—
0
0
71
404
1.89
5.32
11.1
8.4
-0.5
1.2
mmol/l
2.00
50
323
71
404
1.89
5.32
1.8
1.8
—
—
—
0
0
5
0
+∞
5.22
1.2
0.0
—
—
—
0
0
43
205
2.21
5.20
1.8
1.7
—
—
—
0
0
19
61
3.20
4.97
1.4
1.6
—
—
—
0
0
117
789
1.64
4.85
1.7
1.7
468.3
436.1
pmol/l
0.54
96
649
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
25
96
2.69
4.81
3.0
2.5
0.3
0.4
u/ml
0.41
13
55
10
21
4.84
4.55
3.4
3.1
4601.6
823.5
u/ml
—
10
21
8
8
10.15
4.53
1.1
1.0
—
—
—
0
0
28
118
2.46
4.49
1.9
1.9
71.4
94.1
%
2.72
28
111
20
73
2.82
4.24
1.3
1.5
—
—
—
0
0
437
4053
2.03
4.15
30.9
14.9
138.9
139.7
mmol/l
10.18
430
3951
21
80
2.70
4.12
1.1
1.5
—
—
—
0
0
21
80
2.70
4.12
1.1
1.5
—
—
—
0
0
42
219
2.01
4.06
4.5
3.1
1.3
1.7
mmol/l
0.24
30
164
103
701
1.60
4.06
3.7
3.9
192.9
245.4
ng/l
0.23
79
525
19
71
2.75
3.87
1.1
1.2
—
—
—
0
0
29
134
2.24
3.82
1.3
1.2
28.0
3.1
u/ml
—
5
8
125
901
1.53
3.81
1.9
1.7
2.2
1.1
mg/l
2.05
102
697
169
1301
1.47
3.73
3.2
3.3
2.3
2.4
mmol/l
1.04
153
1138
53
309
1.81
3.69
2.9
2.4
70.1
67.9
ml/min/173m2
0.13
21
131
25
110
2.34
3.68
1.8
2.3
12.6
11.2
mg/l
0.41
25
105
436
4066
1.92
3.67
31.3
14.9
3.9
4.0
mmol/l
1.11
430
3958
28
130
2.23
3.65
1.4
1.2
10.4
6.7
u/ml
—
6
26
6
6
10.11
3.50
1.3
3.8
—
—
—
0
0
154
1184
1.45
3.36
2.7
2.1
144.0
244.6
u/l
1.04
149
1113
40
220
1.89
3.35
2.0
1.4
—
—
—
0
0
100
707
1.53
3.30
1.4
1.3
52.4
37.2
iu/ml
0.41
35
227
12
38
3.21
3.23
1.3
1.3
—
—
—
0
0
229
1899
1.40
3.23
4.6
3.5
0.0
0.0
estimate
0.00
43
360
8
15
5.40
3.20
1.5
1.2
9.8
8.7
ug/l
—
8
15
51
308
1.74
3.17
4.4
3.3
1.2
1.2
mmol/l
0.55
46
267
149
1151
1.43
3.14
5.0
3.9
22.8
7.7
mg/mmol
1.02
98
712
14
50
2.85
3.11
1.2
1.1
—
—
—
0
0
21
94
2.29
3.01
1.5
1.6
—
—
—
0
0
182
1469
1.39
2.94
4.5
3.5
47.5
36.8
ng/l
0.35
130
976
20
89
2.30
2.91
1.4
1.6
—
—
—
0
0
9
23
3.97
2.78
1.1
1.1
50.3
40.7
u/l
—
9
18
9
23
3.97
2.78
1.1
1.1
129.3
101.8
u/l
—
9
18
7
14
5.06
2.73
1.7
1.9
—
—
—
0
0
7
14
5.06
2.73
1.7
1.9
—
—
—
0
0
11
37
3.02
2.71
1.5
1.1
—
—
—
0
0
11
37
3.02
2.71
1.5
1.1
—
—
—
0
0
27
141
1.97
2.66
2.5
2.0
—
—
—
0
0
11
38
2.94
2.59
1.5
1.1
—
—
—
0
0
11
38
2.94
2.59
1.5
1.1
—
—
—
0
0
11
38
2.94
2.59
1.5
1.1
—
—
—
0
0
228
1936
1.34
2.58
4.8
3.6
0.0
0.0
estimate
0.50
43
343
225
1908
1.34
2.57
6.7
4.9
0.0
0.0
estimate
0.41
44
359
12
44
2.77
2.56
1.5
1.4
—
—
—
0
0
26
136
1.96
2.56
1.4
2.1
—
—
—
0
0
26
136
1.96
2.56
1.4
2.1
4.0
3.8
g/l
0.51
20
105
26
136
1.96
2.56
1.4
2.1
8.6
7.3
g/l
1.44
21
110
25
129
1.99
2.55
1.4
2.1
3.4
3.1
g/l
0.60
20
106
134
1053
1.38
2.49
2.9
3.0
2874.2
1042.5
ng/l
1.15
125
886
11
40
2.79
2.39
2.0
1.9
90.2
90.2
%
0.02
11
40
25
133
1.93
2.36
1.9
1.8
—
—
—
0
0
12
47
2.59
2.28
1.3
1.4
—
—
—
0
0
8
23
3.52
2.28
1.8
3.2
—
—
—
0
0
8
23
3.52
2.28
1.3
1.3
2.0
1.9
mmol/l
—
8
23
6
13
4.66
2.28
1.0
1.1
—
—
—
0
0
23
122
1.93
2.20
3.1
3.1
1.4
1.4
mmol/l
0.02
23
116
8
24
3.37
2.19
3.9
1.2
—
—
—
0
0
92
693
1.41
2.18
1.4
1.3
25.3
11.5
u/ml
0.60
30
258
15
68
2.25
2.13
2.4
2.4
16.6
16.0
%
—
6
36
10
37
2.74
2.11
1.6
2.0
—
—
—
0
0
8
25
3.24
2.10
1.5
1.2
—
—
—
0
0
14
62
2.30
2.09
1.4
1.5
—
—
—
0
0
14
62
2.30
2.09
1.4
1.5
—
—
—
0
0
6
15
4.04
2.04
1.2
1.6
—
—
—
0
0
21
111
1.93
2.04
2.3
2.6
—
—
—
0
0
14
63
2.26
2.03
1.4
1.4
—
—
—
0
0
14
63
2.26
2.03
1.4
1.4
—
—
—
0
0
14
63
2.26
2.03
1.4
1.4
—
—
—
0
0
14
63
2.26
2.03
1.4
1.4
—
—
—
0
0
0
52
0.00
1.89
0.0
1.5
—
—
—
0
0
5
12
4.20
1.82
2.6
1.5
20.2
34.6
umol/l
—
5
12
10
41
2.47
1.76
1.6
1.9
—
—
—
0
0
15
77
1.98
1.61
1.3
1.4
—
—
—
0
0
439
4229
1.53
1.61
28.2
10.1
40.1
25.6
u/l
13.16
433
4088
7
26
2.72
1.58
1.3
1.2
—
—
—
0
0
331
3073
1.26
1.48
4.3
4.0
14.7
14.8
pmol/l
0.09
307
2787
10
45
2.25
1.47
1.2
1.2
—
—
—
0
0
9
38
2.39
1.46
1.0
1.2
—
—
—
0
0
9
39
2.33
1.43
1.0
1.2
—
—
—
0
0
24
371
0.63
1.42
1.4
1.7
—
—
—
0
0
7
29
2.43
1.39
1.6
1.7
5.0
3.5
mg/l
—
7
29
127
1070
1.26
1.37
2.0
1.6
1.4
1.4
mmol/l
0.03
118
906
17
97
1.78
1.36
1.2
1.2
743.2
418.4
mg/l
0.40
17
89
87
702
1.29
1.33
2.8
2.8
2.5
2.4
mmol/l
0.50
78
619
17
98
1.76
1.32
1.4
1.3
—
—
—
0
0
9
175
0.50
1.31
1.8
1.5
—
—
—
0
0
30
202
1.52
1.31
1.0
1.0
—
—
—
0
0
6
24
2.52
1.30
1.3
1.3
85.5
295.1
u/l
—
6
24
8
34
2.38
1.29
1.3
1.4
—
—
—
0
0
17
100
1.73
1.25
1.6
1.3
—
—
—
0
0
6
25
2.42
1.24
1.5
1.0
—
—
—
0
0
393
3752
1.28
1.22
28.6
12.0
81.3
82.8
ml/min/173m2
0.58
355
3049
5
19
2.65
1.22
1.0
1.4
—
—
—
0
0
5
19
2.65
1.22
3.2
1.9
—
—
—
0
0
16
94
1.73
1.19
2.6
2.6
127.2
76.7
ug/min
—
9
53
15
87
1.75
1.16
1.1
1.2
4.8
3.8
mmol/l
0.53
15
78
5
20
2.52
1.15
1.0
1.0
—
—
—
0
0
384
3664
1.26
1.14
5.3
4.8
2.0
2.2
mu/l
0.30
360
3356
272
2527
1.18
1.00
3.0
3.2
—
—
—
0
0
7
35
2.01
1.00
2.9
2.1
—
—
—
0
0
11
61
1.82
0.99
1.4
1.8
—
—
—
0
0
63
509
1.27
0.98
5.3
4.5
33.6
32.0
%
0.53
51
342
19
126
1.53
0.92
1.4
1.4
317.6
239.6
miu/ml
—
10
62
50
397
1.29
0.90
3.7
3.0
—
—
—
0
0
8
47
1.71
0.81
1.3
1.6
—
—
—
0
0
6
33
1.83
0.79
2.7
1.6
11.3
18.0
ug/l
—
6
33
14
90
1.57
0.79
1.8
1.6
9735.3
17620.4
e6/l
—
9
70
20
141
1.44
0.76
1.5
1.5
—
—
—
0
0
7
38
1.85
0.74
1.0
1.2
—
—
—
0
0
15
100
1.52
0.73
1.2
1.1
—
—
—
0
0
6
107
0.56
0.73
1.2
1.4
—
—
—
0
0
6
107
0.56
0.73
1.2
1.4
—
—
—
0
0
6
107
0.56
0.73
1.2
1.4
—
—
—
0
0
6
107
0.56
0.73
1.2
1.4
—
—
—
0
0
5
25
2.01
0.73
1.2
1.0
—
—
—
0
0
5
25
2.01
0.73
1.2
1.5
—
28.6
—
0
5
7
39
1.81
0.72
1.9
1.8
—
—
—
0
0
7
39
1.81
0.72
1.9
1.8
—
—
—
0
0
7
39
1.81
0.72
1.9
1.8
—
—
—
0
0
17
117
1.47
0.72
2.7
2.1
0.8
3065.7
u/l
—
5
42
5
26
1.93
0.71
1.2
1.4
—
—
—
0
0
9
144
0.62
0.70
1.4
1.4
—
—
—
0
0
5
27
1.86
0.68
2.0
1.8
—
—
—
0
0
5
27
1.86
0.68
2.0
1.8
—
—
—
0
0
5
27
1.86
0.68
2.0
1.8
—
—
—
0
0
5
27
1.86
0.68
2.0
1.8
—
—
—
0
0
15
103
1.47
0.65
1.1
1.2
—
—
—
0
0
5
29
1.73
0.64
1.2
1.1
—
—
—
0
0
404
3934
1.18
0.63
5.4
4.4
4.6
4.7
mmol/l
1.89
386
3660
5
30
1.67
0.61
2.8
1.3
10.3
6.9
u/l
—
5
25
7
111
0.63
0.59
1.3
1.5
—
—
—
0
0
6
40
1.51
0.51
1.2
1.1
—
—
—
0
0
9
65
1.39
0.51
1.2
1.5
—
—
—
0
0
112
1021
1.13
0.49
4.9
3.7
0.0
0.0
estimate
0.14
44
353
7
45
1.56
0.49
2.9
4.0
—
—
—
0
0
7
46
1.53
0.48
1.3
1.1
—
—
—
0
0
80
715
1.14
0.48
1.6
1.5
—
—
—
0
0
394
3849
1.14
0.48
5.4
4.4
6.1
5.9
mmol/l
2.10
373
3530
7
47
1.50
0.47
1.3
1.1
—
—
—
0
0
82
739
1.13
0.44
1.7
1.5
—
—
—
0
0
48
550
0.86
0.43
2.7
2.9
0.7
0.7
ug/l
0.03
40
348
90
819
1.12
0.42
5.3
3.8
1.0
1.0
kg/l
0.35
18
108
371
3622
1.11
0.41
32.9
14.0
38.9
40.1
%
1.85
261
2659
399
3914
1.12
0.39
5.3
4.3
1.4
1.5
mmol/l
1.87
380
3626
156
1475
1.09
0.34
5.3
3.6
—
—
—
0
0
11
142
0.77
0.31
2.8
1.7
—
—
—
0
0
385
3782
1.10
0.31
4.7
3.9
1.3
1.3
mmol/l
0.72
368
3482
7
53
1.33
0.31
1.0
1.2
0.6
0.6
nmol/l
—
7
48
406
4006
1.10
0.26
5.7
4.9
2.7
2.8
mmol/l
2.27
384
3705
5
39
1.28
0.23
6.6
2.9
4.2
3.3
nmol/l
—
5
39
26
229
1.14
0.22
2.2
2.2
14.0
13.7
nmol/l
0.06
21
209
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
91
961
0.93
0.21
5.0
4.4
2.1
2.5
ug/l
0.38
84
861
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
6
51
1.18
0.19
1.3
1.6
24.3
28.1
u/l
—
6
43
7
59
1.19
0.18
4.6
4.7
361.6
360.4
umol/l
—
7
51
21
236
0.88
0.17
1.7
1.7
—
—
—
0
0
72
758
0.94
0.16
4.1
4.1
23.2
21.7
%
0.32
36
347
20
222
0.90
0.14
1.2
1.3
—
—
—
0
0
41
438
0.93
0.13
1.6
2.1
—
—
—
0
0
17
151
1.13
0.13
1.8
1.5
—
—
—
0
0
16
142
1.13
0.13
1.1
1.1
—
—
—
0
0
362
3653
0.96
0.11
7.5
5.6
40.6
39.5
mmol/mol
1.14
346
3413
31
289
1.08
0.11
1.2
1.2
70.8
122.7
iu/ml
—
10
122
5
44
1.14
0.10
1.2
1.6
—
—
—
0
0
7
65
1.08
0.08
1.1
1.1
—
—
—
0
0
19
179
1.06
0.05
7.5
2.4
1.5
1.2
%
0.55
19
179
15
142
1.06
0.02
1.1
1.1
—
—
—
0
0
49
481
1.02
0.02
7.6
6.3
—
—
—
0
0
41
402
1.02
0.01
1.5
1.9
—
—
—
0
0
10
98
1.02
0.00
1.5
1.7
—
—
—
0
0
18
181
0.99
0.00
1.7
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
0.00
1.2
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
25.5
—
0
9
5
59
0.85
0.00
1.6
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CHRONHEP_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 2.925 [2.5, 3.42] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 1704 females with CHRONHEP_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 3.58 [2.98, 4.31] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 430 out of 1151 males with CHRONHEP_NAS died.
Mortality risk
Mortality risk for people of age
years, who have CHRONHEP_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.504% |
| 5 | 1.625% | 3.958% |
| 10 | 3.561% | 9.484% |
| 15 | 6.913% | 18.168% |
| 20 | 12.624% | 29.866% |
Relationships between endpoints
↥Index endpoint: CHRONHEP_NAS – Chronic hepatitis NAS
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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