No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
483 |
4. Check minimum number of eventsNone |
483 |
5. Include endpointsNone |
483 |
6. Filter based on genotype QC (FinnGen only) |
470 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Chronic hepatitis NAS
based on the number of shared cases.
Similar with more cases:
- Chronic hepatitis, not elsewhere classified
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3280 | 1919 | 1341 |
| Only index persons | 2815 | 1703 | 1112 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.85 | 57.41 | 53.52 |
| Only index persons | 54.73 | 56.41 | 52.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 470 | 306 | 164 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | 53.60 | 53.21 | 54.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 483
- Matched controls
- 4830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
+∞
307.7
454
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
63.6
277.1
159
37
A05AA02
ATC
ursodeoxycholic acid; oral
47.4
191.7
116
32
L04AX01
ATC
azathioprine; systemic
24.5
186.9
146
84
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
62.2
154.5
87
17
K76.9
ICD-10 Finland
Liver disease, unspecified
46.7
141.6
85
22
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
890.9
140.3
131
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
10.4
125.4
174
247
K74.3
ICD-10 Finland
Primary biliary cirrhosis
62.1
107.0
60
11
A07EA06
ATC
budesonide; oral, local oral
14.2
100.6
100
87
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.9
96.7
171
314
K83.0
ICD-10 Finland
Cholangitis
33.0
80.9
53
18
K75.4
ICD-10 Finland
Autoimmune hepatitis
459.2
80.4
78
*
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
19.3
78.6
64
38
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
25.9
68.9
49
21
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
13.8
62.8
61
50
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
20.6
57.7
45
24
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
22.9
53.8
40
19
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.3
53.6
135
332
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.1
52.4
241
936
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
42.3
40
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
11.2
40.1
44
43
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
16.0
37.7
33
22
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
205.7
37.3
38
*
L04AA06
ATC
mycophenolic acid; systemic
12.8
37.2
37
31
H02AB06
ATC
prednisolone; systemic
3.1
32.5
304
1693
ZX120
NOMESCO Finland
Intravenous
4.4
32.0
92
245
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.1
31.9
236
1151
K51.5
ICD-10 Finland
Left sided colitis
8.0
30.6
43
58
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
7.5
30.2
45
65
UJF30
NOMESCO Finland
Ileoscopy through colon
4.1
29.6
95
274
R18
ICD-10 Finland
Ascites
10.0
27.4
32
34
C03DA01
ATC
spironolactone; oral
3.8
27.1
98
306
L04AD01
ATC
ciclosporin; systemic
10.0
26.4
31
33
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
9.7
25.9
31
34
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
9.4
25.3
31
35
UJF32
NOMESCO Finland
Coloscopy
2.8
24.8
177
823
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
29.4
24.8
33
12
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
22.7
22.4
32
15
L01BB02
ATC
mercaptopurine; oral
18.2
22.1
34
20
A07EC02
ATC
mesalazine; oral, rectal
4.5
21.7
57
140
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
4.8
21.1
50
113
UJK02
NOMESCO Finland
ERCP
7.8
20.6
29
39
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
50.3
20.3
24
5
Z94.4
ICD-10 Finland
Liver transplant status
42.0
19.7
24
6
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
19.5
140
642
N02AX02
ATC
tramadol; systemic, rectal
2.4
19.5
252
1514
C03CA01
ATC
furosemide; systemic
2.5
18.8
164
824
A02BC02
ATC
pantoprazole; systemic
2.6
18.3
366
2635
A06AD11
ATC
lactulose; oral
2.9
17.8
95
371
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
186.6
17.6
18
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
52.0
17.1
20
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
16.8
212
1240
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
175.8
16.6
17
*
H02AB07
ATC
prednisone; oral
2.8
16.0
96
399
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
15.7
15
*
L04AD02
ATC
tacrolimus; systemic
18.5
15.3
23
13
D64.9
ICD-10 Finland
Anaemia, unspecified
3.2
15.2
66
228
J01MA02
ATC
ciprofloxacin; systemic
2.2
14.9
210
1268
JJA20
NOMESCO Finland
Open biopsy of liver
82.7
14.7
16
*
5714B
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ACTIVA (HBSAG-)]
82.7
14.7
16
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
14.3
243
1569
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
43.9
14.2
17
*
K51.8
ICD-10 Finland
Other ulcerative colitis
6.9
14.1
22
33
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
16.4
14.1
22
14
D97
ICPC
Liver disease NOS
24.6
13.9
19
8
UJK12
NOMESCO Finland
Peroral cholangioscopy
+∞
13.6
13
*
C10AC01
ATC
colestyramine; oral
5.4
13.6
27
52
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
35.1
13.6
17
5
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
13.4
13.5
23
18
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.4
13.4
51
162
K72.9
ICD-10 Finland
Hepatic failure, unspecified
29.3
13.0
17
6
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.3
13.0
53
176
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
19.7
13.0
19
10
127
Kela drug reimbursment
Transplant complication
10.9
12.9
24
23
UJD02
NOMESCO Finland
Gastroscopy
3.9
12.7
39
107
R94.5
ICD-10 Finland
Abnormal results of liver function studies
10.5
12.6
24
24
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
12.6
12
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
12.3
73
299
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
4.1
12.2
34
87
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.6
11.9
41
122
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
11.7
87
397
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.5
11.3
81
363
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
11.2
130
716
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.7
10.8
25
55
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
10.7
105
539
A10AB05
ATC
insulin aspart; parenteral
2.9
10.7
53
197
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
61.4
10.7
12
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
9.5
10.6
21
23
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.7
10.6
25
56
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.5
10.3
73
325
A10AC01
ATC
insulin (human); parenteral
2.9
10.3
52
195
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
24.0
10.3
14
6
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
10.2
62
257
N02AA05
ATC
oxycodone; systemic
2.2
9.8
96
492
A10AE04
ATC
insulin glargine; parenteral
2.6
9.5
58
240
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
9.5
85
419
R50.9
ICD-10 Finland
Fever, unspecified
2.3
9.5
84
413
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
30.7
9.4
12
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.9
9.2
44
160
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.1
9.2
107
585
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.4
9.1
66
297
J01MA12
ATC
levofloxacin; systemic
2.1
9.1
100
535
WW500
NOMESCO Finland
Blood transfusion
4.0
9.1
26
68
R10.0
ICD-10 Finland
Acute abdomen
4.5
9.0
22
51
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
9.7
8.8
17
18
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.3
8.8
23
56
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
8.6
61
271
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
4.6
8.4
20
45
5719X
ICD-9 Finland
Chronic liver disease and cirrhosis, Unspecified chronic liver disease without mention of alcohol
91.6
8.4
9
*
JJ5AT, ,
NOMESCO Finland
91.6
8.4
9
*
K29.6
ICD-10 Finland
Other gastritis
9.7
8.3
16
17
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
8.2
119
701
H02AB04
ATC
methylprednisolone; systemic
2.2
8.2
80
408
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
17.5
8.1
12
7
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
34.0
8.1
10
*
XG410
NOMESCO Finland
Flow-volume spirometry
3.7
8.0
25
70
L04AA01
ATC
[U] ciclosporin
9.6
7.8
15
16
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.7
7.8
25
71
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
7.8
81
423
M05BA04
ATC
alendronic acid; oral
2.5
7.7
49
207
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.9
7.7
128
787
K50.8
ICD-10 Finland
Other Crohn disease
6.3
7.6
19
31
K92.1
ICD-10 Finland
Melaena
3.1
7.6
31
103
XW000
NOMESCO Finland
Bone marrow biopsy
3.7
7.5
24
68
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
3.5
7.5
26
78
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.5
7.5
18
41
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
81.3
7.4
8
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
13.6
7.4
12
9
S97
ICPC
Chronic ulcer skin
2.7
7.4
40
156
A02BC01
ATC
omeprazole; systemic
1.8
7.3
138
879
K73.1
ICD-10 Finland
Chronic lobular hepatitis, not elsewhere classified
+∞
7.3
7
*
B18.2
ICD-10 Finland
Chronic viral hepatitis C
7.5
7.2
16
22
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
7.2
50
220
K70.1
ICD-10 Finland
Alcoholic hepatitis
12.3
7.1
12
10
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
12.3
7.1
12
10
TPH07
NOMESCO Finland
Cathetrisation of artery
2.3
7.0
57
269
103
Kela drug reimbursment
Diabetes, insulin-treated
1.8
7.0
127
798
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
14.0
6.9
11
8
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.5
6.8
23
68
H02AB09
ATC
hydrocortisone; systemic
4.0
6.8
19
49
K74.0
ICD-10 Finland
Hepatic fibrosis
17.0
6.8
10
6
ZXD05
NOMESCO Finland
Urgent procedure
1.7
6.8
149
990
Z3231
NOMESCO Finland
Registered nurse
1.8
6.7
133
858
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.8
6.6
119
746
A46
ICD-10 Finland
Erysipelas
2.1
6.6
68
354
Z2221
NOMESCO Finland
Medical doctor
1.7
6.5
137
897
K92.0
ICD-10 Finland
Haematemesis
4.0
6.5
18
46
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
70.8
6.4
7
*
0709X
ICD-9 Finland
Viral hepatitis, Unspecified viral hepatitis without mention of hepatic coma
70.8
6.4
7
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.2
6.4
52
246
K70.4
ICD-10 Finland
Alcoholic hepatic failure
18.3
6.3
9
5
5739X
ICD-9 Finland
Other disorders of liver, Unspecified disorder of liver
+∞
6.3
6
*
5714X
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]
+∞
6.3
6
*
K75.2
ICD-10 Finland
Nonspecific reactive hepatitis
27.1
6.2
8
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.3
6.2
50
235
L28
ICPC
Limited function/disability (L)
1.9
6.2
84
480
A02BC03
ATC
lansoprazole; oral
1.7
6.2
144
967
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.9
6.2
28
99
K29
ICPC
Cardiovascular sympt/complt other
3.1
6.2
25
83
WX402
NOMESCO Finland
General anaesthesia
1.8
6.1
104
639
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
6.1
146
988
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.3
6.1
23
73
V03AE01
ATC
polystyrene sulfonate; oral
8.8
6.1
12
14
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.3
6.0
46
212
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
246
298
15.79
208.40
6.5
2.6
12.63
10.62
g/l
6.28
236
277
230
353
11.53
159.23
5.1
2.3
0.20
0.22
g/l
1.53
210
335
179
242
11.16
134.78
2.0
1.7
1.36
1.37
g/l
0.04
165
223
74
37
23.44
98.63
1.7
1.1
—
—
titre
—
0
0
51
14
40.61
82.76
1.2
1.1
—
—
—
0
0
373
1643
6.58
76.57
11.6
4.5
34.99
35.94
g/l
2.61
355
1540
181
446
5.89
73.83
6.9
2.6
20.59
8.78
umol/l
2.29
164
391
64
44
16.61
72.92
1.1
1.1
1.63
1.48
g/l
1.64
57
39
330
1352
5.55
72.64
10.4
3.2
52.45
30.37
u/l
6.68
316
1286
400
2095
6.29
60.52
16.9
6.1
16.84
10.74
umol/l
3.62
388
1989
164
494
4.51
50.27
2.7
2.1
25.50
23.14
%
0.82
138
426
169
522
4.44
50.09
2.6
2.1
2.30
2.37
g/l
0.63
156
480
60
71
9.51
47.84
4.8
6.0
2023.62
158.60
iu/ml
—
8
10
339
1744
4.17
47.41
16.0
12.0
1.16
1.19
inr
0.41
116
512
172
575
4.09
45.17
2.8
2.1
13.77
13.43
umol/l
0.20
158
532
57
70
9.10
44.08
1.3
1.2
280.50
225.11
u/ml
0.44
32
36
58
74
8.77
43.50
1.3
1.2
—
—
—
0
0
228
979
3.52
40.30
12.2
3.5
88.12
93.30
%
2.20
222
954
205
826
3.57
40.03
2.1
1.4
2.99
2.38
g/l
3.33
166
498
331
1822
3.60
38.49
13.6
5.7
2.90
2.81
%
0.29
322
1706
333
1855
3.56
37.65
13.5
5.6
56.48
57.29
%
0.62
326
1746
50
65
8.47
36.81
1.3
1.4
109.50
113.90
u/ml
—
8
10
333
1871
3.51
36.78
13.9
5.8
28.34
27.99
%
0.24
325
1761
254
1262
3.14
33.64
4.8
2.5
64.07
61.43
u/l
0.23
241
1167
72
152
5.39
33.21
4.4
3.3
871.05
1804.24
u/ml
0.32
67
133
367
2298
3.49
31.70
16.7
9.0
3.71
4.06
e9/l
2.74
345
2012
293
1656
2.96
29.47
3.3
2.3
74.52
76.73
nmol/l
0.72
276
1467
147
574
3.24
28.79
2.6
1.8
31.19
29.40
s
2.54
141
554
58
115
5.60
28.55
1.4
1.3
—
—
—
0
0
132
500
3.26
27.01
2.5
1.7
1.63
1.43
%
1.89
107
437
428
3088
4.39
26.84
23.4
7.4
107.32
77.36
u/l
16.50
417
2896
107
361
3.52
26.32
3.4
2.3
32.77
32.17
u/l
0.07
98
305
38
62
6.57
22.71
1.5
1.3
—
—
—
0
0
28
33
8.95
22.10
2.3
1.3
—
—
—
0
0
297
1902
2.46
20.09
10.6
6.4
1.21
1.22
mmol/l
0.71
254
1624
121
509
2.84
19.99
3.6
2.2
163.68
121.26
ug/g
0.80
104
410
26
33
8.27
19.33
1.0
1.0
—
—
—
0
0
101
392
2.99
19.28
4.1
4.6
3.25
26.69
ug/l
1.20
78
327
379
2747
2.76
19.23
9.8
3.1
131.44
45.27
u/l
12.09
362
2585
178
928
2.45
18.83
2.9
2.0
3.23
3.13
mg/l
0.18
160
787
53
144
4.01
17.62
1.7
1.9
1.35
1.50
g/l
0.51
46
127
397
3002
2.81
17.47
8.1
4.0
18.10
11.59
mm/h
10.34
378
2762
267
1727
2.22
16.35
9.0
5.6
1.21
1.22
mmol/l
0.45
249
1574
73
267
3.04
15.30
2.7
1.6
—
—
—
0
0
321
2281
2.21
14.96
8.6
4.5
7.04
6.61
mmol/l
1.35
307
2117
264
1756
2.11
14.39
3.6
2.6
217.67
119.35
ug/l
1.58
247
1606
166
931
2.19
14.05
1.4
1.2
1.60
1.36
u/ml
0.16
38
256
236
1541
2.04
13.13
2.2
1.9
97.50
96.55
pmol/l
0.11
136
759
163
966
2.04
11.54
3.3
2.1
—
—
—
0
0
41
126
3.46
11.36
1.6
1.6
0.05
0.13
iu/ml
—
6
22
18
18
10.34
9.59
5.6
2.6
77.44
101.72
%
1.65
18
18
30
84
3.74
9.53
1.5
1.8
—
—
—
0
0
145
879
1.93
9.30
1.7
1.5
18.75
21.59
nmol/l
1.55
134
741
33
104
3.33
8.80
1.9
1.2
—
—
—
0
0
8
0
+∞
8.35
5.8
0.0
—
—
—
0
0
18
24
7.75
8.23
1.7
1.8
11.50
11.52
umol/l
0.01
18
24
42
160
2.78
8.11
4.4
2.9
22.68
24.42
mmol/l
2.46
42
155
255
1892
1.74
8.10
3.5
2.4
—
—
—
0
0
104
588
1.98
8.06
2.0
1.9
—
—
—
0
0
14
13
11.05
7.84
1.9
1.6
10123.17
5352.43
e6/l
—
6
7
106
609
1.95
7.83
3.6
2.7
1.79
2.61
e6/l
0.83
62
294
198
1380
1.74
7.78
4.7
2.9
—
—
—
0
0
174
1172
1.76
7.70
4.8
2.9
50.45
102.27
e6/l
0.37
137
870
116
695
1.88
7.53
1.9
1.6
1157.56
1193.57
nmol/l
0.16
97
516
127
784
1.84
7.50
3.7
2.4
5.84
6.23
e6/l
0.11
115
698
17
25
7.01
7.35
1.2
1.2
—
—
—
0
0
159
1069
1.73
6.95
4.5
2.8
0.35
0.44
e6/l
0.32
126
770
29
98
3.08
6.93
2.4
1.6
—
—
—
0
0
108
651
1.85
6.82
3.5
2.5
0.98
0.96
e6/l
0.03
64
337
64
329
2.09
6.39
7.3
3.1
0.67
2.20
mmol/l
2.16
54
267
15
24
6.41
6.21
1.3
1.5
—
—
—
0
0
37
152
2.55
6.19
1.9
1.8
—
—
—
0
0
30
112
2.79
6.04
1.3
1.3
252.86
318.70
ug/g
0.81
21
62
148
1010
1.67
5.98
4.2
2.4
351.15
7887.47
umol/l
4.63
130
871
16
30
5.48
5.89
3.5
1.5
0.86
1.02
g/l
1.11
16
30
445
4043
2.28
5.82
31.5
13.1
18.29
21.65
mg/l
1.90
400
3142
28
103
2.82
5.79
2.0
1.4
—
—
—
0
0
21
66
3.28
5.66
3.3
3.4
4.38
4.40
e9/l
0.01
21
66
73
413
1.90
5.56
1.7
1.8
—
—
—
0
0
21
67
3.23
5.53
3.4
3.8
59.38
57.91
%
0.20
21
67
5
0
+∞
5.22
1.2
0.0
—
—
—
0
0
72
414
1.87
5.21
11.5
8.5
-0.12
1.25
mmol/l
1.21
52
336
43
208
2.17
5.02
1.8
1.7
—
—
—
0
0
71
417
1.82
4.80
1.8
1.8
—
—
—
0
0
119
808
1.63
4.78
1.7
1.7
468.95
434.97
pmol/l
0.59
98
667
11
18
6.23
4.62
2.6
2.9
36900.00
35222.50
ug/l
0.19
11
18
19
64
3.05
4.60
1.4
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
25
99
2.61
4.54
3.0
2.5
0.30
0.35
u/ml
0.38
13
58
8
8
10.14
4.53
1.1
1.0
—
—
—
0
0
31
137
2.35
4.48
1.4
1.2
28.00
3.13
u/ml
—
5
8
11
19
5.90
4.46
1.3
2.1
—
—
—
0
0
21
77
2.81
4.40
1.3
1.5
—
—
—
0
0
447
4140
2.07
4.38
30.6
14.9
138.88
139.74
mmol/l
10.73
440
4037
28
120
2.42
4.33
1.9
1.9
71.36
94.37
%
2.78
28
115
30
133
2.34
4.31
1.4
1.2
9.14
6.68
u/ml
—
7
26
161
1199
1.51
4.26
4.2
3.0
6.44
7.66
mmol/l
3.50
139
1003
106
720
1.60
4.21
3.7
3.8
192.57
238.81
ng/l
0.21
82
540
21
80
2.70
4.12
1.1
1.5
—
—
—
0
0
21
80
2.70
4.12
1.1
1.5
—
—
—
0
0
106
727
1.59
4.03
1.4
1.3
52.16
36.96
iu/ml
0.43
36
243
55
317
1.83
3.96
2.8
2.4
69.70
67.57
ml/min/173m2
0.13
22
132
446
4153
1.96
3.90
31.0
15.0
3.94
3.96
mmol/l
0.91
440
4044
42
223
1.97
3.87
4.5
3.1
1.30
1.74
mmol/l
0.23
30
165
159
1204
1.48
3.80
2.6
2.1
141.99
242.52
u/l
1.07
154
1131
19
72
2.71
3.77
1.1
1.2
—
—
—
0
0
54
315
1.80
3.75
4.3
3.3
1.22
1.23
mmol/l
0.46
49
273
127
921
1.51
3.74
1.9
1.7
2.21
1.08
mg/l
2.06
104
712
236
1940
1.42
3.59
4.6
3.6
0.00
0.00
estimate
0.50
52
387
10
21
4.84
3.57
3.4
3.1
4601.60
823.48
u/ml
—
10
21
171
1329
1.44
3.53
3.2
3.3
2.33
2.35
mmol/l
1.15
155
1172
6
6
10.10
3.50
1.3
3.8
—
—
—
0
0
41
225
1.90
3.45
2.0
1.4
—
—
—
0
0
25
114
2.26
3.41
1.8
2.2
12.65
11.57
mg/l
0.29
25
109
8
14
5.79
3.35
1.6
1.9
—
—
—
0
0
8
14
5.79
3.35
1.6
1.9
—
—
—
0
0
153
1175
1.44
3.34
4.8
3.7
21.96
7.52
mg/mmol
1.01
102
729
13
38
3.49
3.33
1.5
1.2
—
—
—
0
0
13
38
3.49
3.33
1.5
1.2
—
—
—
0
0
15
54
2.83
3.28
1.2
1.1
—
—
—
0
0
23
103
2.29
3.27
1.5
1.2
31.98
32.48
u/ml
—
5
10
13
39
3.40
3.24
1.5
1.2
—
—
—
0
0
13
39
3.40
3.24
1.5
1.2
—
—
—
0
0
13
39
3.40
3.24
1.5
1.2
—
—
—
0
0
8
15
5.40
3.20
1.5
1.2
9.78
8.65
ug/l
—
8
15
28
139
2.08
3.12
1.4
2.1
—
—
—
0
0
235
1971
1.37
3.00
4.7
3.6
0.00
0.01
estimate
0.50
45
350
232
1942
1.37
2.99
6.6
4.9
0.02
0.00
estimate
0.41
46
366
185
1502
1.38
2.85
4.5
3.4
46.89
36.27
ng/l
0.36
133
1000
98
711
1.47
2.83
1.4
1.3
24.71
11.32
u/ml
0.60
31
263
21
97
2.22
2.81
1.5
1.6
—
—
—
0
0
138
1069
1.41
2.81
2.9
3.0
2790.62
1036.75
ng/l
1.13
129
900
9
23
3.97
2.78
1.1
1.1
50.33
34.22
u/l
—
9
23
9
23
3.97
2.78
1.1
1.1
129.33
93.22
u/l
—
9
23
12
40
3.05
2.71
1.3
1.4
—
—
—
0
0
20
92
2.22
2.71
1.5
1.6
—
—
—
0
0
27
142
1.95
2.61
2.5
2.0
—
—
—
0
0
10
31
3.27
2.53
1.4
1.4
0.45
1.12
promille
—
5
22
7
16
4.42
2.48
1.1
1.6
—
—
—
0
0
16
70
2.33
2.44
1.6
1.6
—
—
—
0
0
16
70
2.33
2.44
1.6
1.6
—
—
—
0
0
12
46
2.65
2.37
1.5
1.4
—
—
—
0
0
25
134
1.91
2.31
1.9
1.8
—
—
—
0
0
11
40
2.79
2.28
2.0
1.9
90.24
90.17
%
0.02
11
40
8
24
3.37
2.19
3.9
1.2
—
—
—
0
0
8
24
3.37
2.19
1.8
3.0
—
—
—
0
0
8
24
3.37
2.19
1.3
1.3
2.01
1.92
mmol/l
—
8
24
6
14
4.33
2.15
1.0
1.1
—
—
—
0
0
12
49
2.49
2.12
1.3
1.4
—
—
—
0
0
14
62
2.30
2.09
1.4
1.5
—
—
—
0
0
14
62
2.30
2.09
1.4
1.5
—
—
—
0
0
11
43
2.59
2.09
1.4
1.5
—
—
—
0
0
11
43
2.59
2.09
1.4
1.5
—
—
—
0
0
10
37
2.74
2.08
1.6
2.0
—
—
—
0
0
15
69
2.21
2.06
2.4
2.4
16.55
16.02
%
—
6
37
14
63
2.26
2.02
1.4
1.4
—
—
—
0
0
14
63
2.26
2.02
1.4
1.4
—
—
—
0
0
14
63
2.26
2.02
1.4
1.4
—
—
—
0
0
14
63
2.26
2.02
1.4
1.4
—
—
—
0
0
23
126
1.87
2.02
3.1
3.7
1.36
1.37
mmol/l
0.01
23
120
7
173
0.40
1.94
1.3
1.5
—
—
—
0
0
8
27
2.99
1.94
1.5
1.2
—
—
—
0
0
21
114
1.88
1.90
2.3
2.6
—
—
—
0
0
0
52
0.00
1.89
0.0
1.5
—
—
—
0
0
5
12
4.20
1.82
2.6
1.5
20.20
34.58
umol/l
—
5
12
449
4321
1.56
1.72
28.0
10.1
40.55
25.66
u/l
14.09
443
4176
339
3134
1.27
1.65
4.3
4.0
14.77
14.76
pmol/l
0.02
315
2843
10
41
2.47
1.65
1.6
1.9
—
—
—
0
0
7
26
2.72
1.58
1.3
1.2
—
—
—
0
0
15
78
1.95
1.56
1.3
1.4
—
—
—
0
0
10
45
2.25
1.47
1.2
1.2
—
—
—
0
0
9
39
2.33
1.43
1.0
1.2
—
—
—
0
0
18
103
1.78
1.42
1.6
1.3
—
—
—
0
0
9
40
2.27
1.40
1.0
1.2
—
—
—
0
0
7
29
2.43
1.39
1.6
1.7
4.96
3.46
mg/l
—
7
29
89
717
1.30
1.37
2.7
2.8
2.46
2.45
mmol/l
0.34
80
633
403
3839
1.30
1.35
28.3
12.0
81.58
82.82
ml/min/173m2
0.47
364
3127
6
24
2.52
1.30
1.3
1.3
85.50
295.10
u/l
—
6
24
8
34
2.38
1.29
1.3
1.4
—
—
—
0
0
128
1086
1.24
1.29
2.0
1.6
1.39
1.38
mmol/l
0.05
119
919
393
3738
1.28
1.29
5.2
4.8
1.97
2.20
mu/l
0.30
369
3426
17
99
1.74
1.29
1.4
1.3
—
—
—
0
0
17
99
1.74
1.29
1.2
1.2
743.18
437.91
mg/l
0.37
17
91
26
383
0.66
1.25
1.5
1.7
—
—
—
0
0
6
25
2.42
1.24
1.5
1.0
—
—
—
0
0
30
205
1.49
1.23
1.0
1.0
—
—
—
0
0
5
19
2.65
1.22
1.0
1.4
—
—
—
0
0
5
19
2.65
1.22
3.2
1.9
—
—
—
0
0
5
20
2.52
1.15
1.0
1.0
—
—
—
0
0
16
95
1.71
1.15
2.3
2.5
127.20
76.71
ug/min
—
9
53
15
89
1.71
1.09
1.1
1.2
4.79
3.80
mmol/l
0.52
15
80
279
2586
1.19
1.08
3.0
3.1
—
—
—
0
0
64
511
1.29
1.07
5.3
4.4
33.62
32.03
%
0.54
52
347
7
36
1.96
0.97
2.9
2.1
—
—
—
0
0
15
94
1.61
0.91
1.7
1.6
9735.33
20064.56
e6/l
—
9
72
18
119
1.53
0.89
2.6
2.1
0.78
2998.46
u/l
—
5
43
10
56
1.80
0.88
1.5
1.3
8.02
7.34
mmol/l
—
10
46
19
128
1.50
0.87
1.4
1.4
317.60
246.91
miu/ml
—
10
63
6
30
2.01
0.87
2.5
1.3
9.45
6.94
u/l
—
6
25
11
64
1.74
0.87
1.4
1.8
—
—
—
0
0
16
104
1.56
0.85
1.1
1.2
—
—
—
0
0
50
402
1.27
0.82
3.7
3.0
—
—
—
0
0
6
33
1.83
0.79
2.7
1.6
11.32
17.95
ug/l
—
6
33
6
107
0.56
0.73
1.2
1.4
—
—
—
0
0
6
107
0.56
0.73
1.2
1.4
—
—
—
0
0
6
107
0.56
0.73
1.2
1.4
—
—
—
0
0
6
107
0.56
0.73
1.2
1.4
—
—
—
0
0
5
25
2.01
0.73
1.2
1.0
—
—
—
0
0
5
25
2.01
0.73
1.2
1.5
—
28.60
—
0
5
13
84
1.56
0.72
1.1
1.8
4.22
5.14
mmol/24h
0.44
13
73
7
40
1.76
0.71
1.9
1.8
—
—
—
0
0
7
40
1.76
0.71
1.9
1.8
—
—
—
0
0
7
40
1.76
0.71
1.0
1.3
—
—
—
0
0
7
40
1.76
0.71
1.9
1.8
—
—
—
0
0
20
143
1.42
0.71
1.5
1.6
—
—
—
0
0
15
101
1.50
0.71
1.2
1.1
—
—
—
0
0
9
146
0.61
0.70
1.4
1.4
—
—
—
0
0
5
27
1.86
0.68
2.0
1.8
—
—
—
0
0
5
27
1.86
0.68
2.0
1.8
—
—
—
0
0
5
28
1.79
0.66
1.2
1.5
—
—
—
0
0
8
49
1.64
0.62
1.3
1.5
—
—
—
0
0
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
413
4025
1.18
0.61
5.4
4.4
4.58
4.74
mmol/l
2.25
395
3752
8
55
1.46
0.56
1.0
1.3
0.63
0.57
nmol/l
—
8
50
85
753
1.16
0.56
1.6
1.5
—
—
—
0
0
115
1041
1.14
0.56
4.8
3.7
0.02
0.01
estimate
0.13
46
360
6
39
1.55
0.53
5.7
2.9
3.97
3.30
nmol/l
—
6
39
6
40
1.51
0.51
1.2
1.1
—
—
—
0
0
81
721
1.15
0.51
1.6
1.5
—
—
—
0
0
7
111
0.63
0.48
1.3
1.5
—
—
—
0
0
7
46
1.53
0.48
1.3
1.1
—
—
—
0
0
7
47
1.50
0.47
1.3
1.1
—
—
—
0
0
7
47
1.50
0.47
2.9
3.9
—
—
—
0
0
5
84
0.59
0.46
7.6
3.6
16.40
26.14
u/ml
—
5
84
402
3934
1.13
0.43
5.4
4.4
6.11
5.89
mmol/l
2.07
381
3609
408
4005
1.12
0.38
5.3
4.3
1.44
1.50
mmol/l
1.89
389
3717
9
68
1.33
0.38
1.2
1.5
—
—
—
0
0
18
143
1.27
0.37
1.2
1.1
—
—
—
0
0
11
145
0.75
0.35
2.8
1.7
—
—
—
0
0
91
839
1.10
0.34
5.2
3.8
1.02
1.02
kg/l
0.34
18
109
50
559
0.88
0.33
2.7
2.9
0.73
0.74
ug/l
0.01
42
351
159
1507
1.08
0.33
5.2
3.7
—
—
—
0
0
416
4097
1.11
0.31
5.6
4.9
2.66
2.81
mmol/l
2.71
394
3798
394
3873
1.09
0.30
4.7
3.9
1.33
1.28
mmol/l
0.67
377
3569
453
4491
1.14
0.25
44.6
19.3
39.28
40.30
%
3.07
418
4214
18
152
1.19
0.24
1.7
1.5
—
—
—
0
0
17
143
1.20
0.23
1.2
1.1
—
—
—
0
0
453
4493
1.13
0.23
43.8
19.3
4.36
4.50
e12/l
7.09
448
4368
33
295
1.13
0.23
1.2
1.2
70.84
129.85
iu/ml
—
10
124
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
23.57
—
0
10
21
240
0.87
0.21
1.7
1.7
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
93
979
0.94
0.20
4.9
4.4
2.06
2.45
ug/l
0.38
86
876
6
52
1.16
0.19
1.3
1.6
24.28
27.68
u/l
—
6
44
7
61
1.15
0.17
4.6
4.8
361.57
355.10
umol/l
—
7
52
5
68
0.73
0.17
1.0
1.2
3.60
4.54
u/ml
—
5
26
74
773
0.95
0.13
4.0
4.0
23.39
21.71
%
0.40
38
349
20
183
1.10
0.10
7.2
2.4
1.46
1.23
%
0.58
20
183
5
44
1.14
0.10
1.6
2.2
—
—
—
0
0
5
47
1.06
0.09
1.2
1.6
—
—
—
0
0
7
67
1.05
0.08
1.1
1.1
—
—
—
0
0
43
445
0.96
0.05
1.6
2.1
—
—
—
0
0
42
409
1.03
0.03
1.5
1.9
—
—
—
0
0
18
185
0.97
0.00
1.7
1.6
—
—
—
0
0
22
224
0.98
0.00
1.2
1.3
—
—
—
0
0
10
98
1.02
0.00
1.5
1.7
—
—
—
0
0
18
178
1.01
0.00
7.7
2.4
0.68
0.65
%
0.17
18
178
49
489
1.00
0.00
7.6
6.4
—
—
—
0
0
372
3723
1.00
0.00
7.4
5.5
40.61
39.55
mmol/mol
1.19
356
3481
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
15.0
2.9
106.00
105.76
mmol/l
—
5
55
5
59
0.85
-0.00
1.6
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CHRONHEP_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 2.925 [2.5, 3.42] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 1704 females with CHRONHEP_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 3.58 [2.98, 4.31] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 430 out of 1151 males with CHRONHEP_NAS died.
Mortality risk
Mortality risk for people of age
years, who have CHRONHEP_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.504% |
| 5 | 1.625% | 3.958% |
| 10 | 3.561% | 9.484% |
| 15 | 6.913% | 18.168% |
| 20 | 12.624% | 29.866% |
Relationships between endpoints
↥Index endpoint: CHRONHEP_NAS – Chronic hepatitis NAS
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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