Inflammatory bowel disease, strict (require KELA)

K11_IBD_STRICT

inflammatory bowel disease: A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions

K11_KELAIBD

8162

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

8162

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Remove individuals based on genotype QC

7625

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K11_IBD_STRICT

Control definitions

Control exclude K11_IBD_STRICT_PSC
Control conditions not K11_KELAIBD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF9

Similar endpoints

List of similar endpoints to Inflammatory bowel disease, strict (require KELA) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 7625 3979 3646
Unadjusted prevalence (%) 2.02 1.89 2.19
Mean age at first event (years) 39.06 36.86 41.46

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.14 [0.83, 1.56] 4.2e-1 373
15 years 0.01 0.82 [0.62, 1.09] 1.7e-1 161
5 years 0.00 1.38 [1.02, 1.87] 3.7e-2 69
1 year 0.00 1.95 [1.17, 3.26] 1.1e-2 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: K11_IBD_STRICT – Inflammatory bowel disease, strict (require KELA)
GWS hits: 52

Survival analyses between endpoints

Plot

before Inflammatory bowel disease, strict (require KELA)
after Inflammatory bowel disease, strict (require KELA)

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Drugs most likely to be purchased after Inflammatory bowel disease, strict (require KELA)