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Ulcerative colitis (strict definition, require KELA, min 2 HDR)

K11_UC_STRICT2

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

K11_KELAUC
and K11_ULCERnumber of events
>1

6713

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K51
Hospital discharge: ICD-9 556
Hospital discharge: ICD-8 5631|569
Hospital discharge: excluded ICD-9 5564A
Cause of death: ICD-10 K51
Cause of death: ICD-9 556
Cause of death: ICD-8 5631|569
Cause of death: excluded ICD-9 5564A

2 out of 7 registries used, show all original rules.

6106

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Check minimum number of events None

6106

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Include endpoints None

6106

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Remove individuals based on genotype QC

5931

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K11_UC_STRICT2

Control definitions

Control conditions not K11_KELAUC

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3
Parent code in ICD-10 K50-K52
Name in latin Colitis ulcerosa

Summary Statistics

Key figures

All Female Male
Number of individuals 5931 3007 2924
Unadjusted prevalence (%) 1.44 1.31 1.61
Mean age at first event (years) 40.32 37.54 43.18

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.81 [1.38, 2.36] 1.5e-5 322
15 years 0.01 1.20 [0.91, 1.58] 1.9e-1 135
5 years 0.00 1.71 [1.20, 2.44] 2.9e-3 61
1 year 0.00 2.53 [1.48, 4.33] 6.8e-4 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: K11_UC_STRICT2 – Ulcerative colitis (strict definition, require KELA, min 2 HDR)
GWS hits: 44

Survival analyses between endpoints

Plot

before Ulcerative colitis (strict definition, require KELA, min 2 HDR)
after Ulcerative colitis (strict definition, require KELA, min 2 HDR)

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Drugs most likely to be purchased after Ulcerative colitis (strict definition, require KELA, min 2 HDR)