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Respiratory tuberculosis, clinically confirmed

TBC_RESP_CLIN

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A16
  • Hospital discharge: ICD-9 011.X|012.X
  • Cause of death: ICD-10 A16
  • Cause of death: ICD-9 011.X|012.X

2 out of 7 registries used, show all original rules.

503

4. Check minimum number of events

None

503

5. Include endpoints

None

503

6. Filter based on genotype QC (FinnGen only)

503

Control definitions (FinnGen only)

Control exclude
TBC_RESP

Extra metadata

First used in FinnGen datafreeze
DF12
Parent code in ICD-10
A15-A19
Name in latin
Tuberculosis respiratoria neque bacteriologice neque histologice confirmata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 503 138 365
Unadjusted period prevalence (%) 0.13 0.05 0.16
Median age at first event (years) 61.28 54.20 63.96

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
464
Matched controls
4639
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
+∞
181.5
162
*
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
61.9
58
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
59.7
56
*
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
58.6
55
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
8.2
58.0
144
240
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.2
49.3
153
340
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
+∞
42.3
40
*
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
40.2
38
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
33.7
33.2
43
14
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
32.7
31
*
0120X
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, EPÄILTY]
+∞
32.7
31
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
29.5
28
*
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
29.5
28
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
7.2
26.9
68
108
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.0
19.3
134
556
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
73.0
18.9
21
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
18.6
205
1112
H02AB06
ATC
prednisolone; systemic
2.2
15.5
248
1573
TGC00
NOMESCO Finland
Bronchial lavation
7.4
15.5
37
54
0118X
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, EPÄILTY]
+∞
13.6
13
*
1240
FHL
Bronchoscopy
7.9
12.9
29
39
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
16.0
12.7
20
13
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
33.0
12.6
16
5
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.9
12.3
40
87
R03BB04
ATC
tiotropium bromide; inhalant
2.7
12.2
95
409
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
11.5
11
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.2
10.7
123
646
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
10.5
10
*
0112X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, EPÄILTY]
+∞
10.5
10
*
R03DA04
ATC
theophylline; systemic, rectal
2.7
9.6
69
281
A70
ICPC
Tuberculosis
102.0
9.4
10
*
M05BA04
ATC
alendronic acid; oral
3.0
9.4
54
193
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
4.7
8.6
28
62
J94.9
ICD-10 Finland
Pleural condition, unspecified
16.7
8.6
13
8
J45.8
ICD-10 Finland
Mixed asthma
4.8
8.4
27
59
R03BB01
ATC
ipratropium bromide; inhalant
2.7
8.4
57
228
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
8.4
8
*
A16.8
ICD-10 Finland
Other respiratory tuberculosis, without mention of bacteriological or histological confirmation
+∞
8.4
8
*
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.5
8.1
67
298
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.3
8.0
82
403
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
4.5
8.0
27
63
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.2
7.9
88
452
J96.1
ICD-10 Finland
Chronic respiratory failure
4.4
7.8
27
64
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.8
7.7
50
195
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
12.1
7.6
13
11
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.5
7.5
58
250
D86.0
ICD-10 Finland
Sarcoidosis of lung
13.6
7.4
12
9
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
7.3
7
*
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
+∞
7.3
7
*
GEA00
NOMESCO Finland
Mediastinoscopy
+∞
7.3
7
*
H02AB07
ATC
prednisone; oral
2.1
7.0
86
458
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.5
6.8
51
217
P01BA02
ATC
hydroxychloroquine; oral
2.9
6.8
39
141
J01MA14
ATC
moxifloxacin; systemic
2.5
6.7
52
222
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
5.6
6.7
18
33
J85.2
ICD-10 Finland
Abscess of lung without pneumonia
70.8
6.4
7
*
J85.1
ICD-10 Finland
Abscess of lung with pneumonia
70.8
6.4
7
*
5111B
ICD-9 Finland
Pleurisy, With effusion, with mention of a bacterial cause other than tuberculosis[PLEURITIS EXSUDATIVA ALIA DEFINITA]
70.8
6.4
7
*
L04AX01
ATC
azathioprine; systemic
4.1
6.4
23
58
L04AA13
ATC
leflunomide; oral
6.1
6.4
16
27
A02BC01
ATC
omeprazole; systemic
1.7
6.3
145
963
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
4.2
6.3
22
54
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
+∞
6.3
6
*
A16.4
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, without mention of bacteriological or histological confirmation
+∞
6.3
6
*
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
6.3
6
*
N02AC04
ATC
dextropropoxyphene; oral
2.8
6.2
37
137
GD1AD
NOMESCO Finland
Thorax CT examination
3.6
6.2
26
75
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.0
6.1
33
115
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
4.5
6.1
20
46
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.9
6.0
35
128

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: TBC_RESP_CLIN – Respiratory tuberculosis, clinically confirmed

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).