This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Constitutional tall stature
E4_TALL
endocrine system disease: A disease involving the endocrine system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
200 |
4. Check minimum number of eventsNone |
200 |
5. Include endpointsNone |
200 |
6. Filter based on genotype QC (FinnGen only) |
200 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Constitutional tall stature
based on the number of shared cases.
Similar with more cases:
- Other endocrine disorders
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 200 | 133 | 67 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | 8.09 | 8.14 | 7.97 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 177
- Matched controls
- 1770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E34.40
ICD-10 Finland
Constitutional tall stature
+∞
126.8
106
*
E34.45
ICD-10 Finland
Abnormal growth increase
+∞
98.3
85
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
29.4
35.5
48
22
E34.35
ICD-10 Finland
Abnormal growth retardation
162.8
14.7
15
*
E30.1
ICD-10 Finland
Precocious puberty
+∞
9.5
9
*
E34.30
ICD-10 Finland
Short stature NOS
94.3
8.5
9
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
+∞
7.3
7
*
E34.4
ICD-10 Finland
Constitutional tall stature
+∞
7.3
7
*
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
11.6
6.9
12
11
E22.80
ICD-10 Finland
Central precocious puberty
+∞
6.3
6
*
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: E4_TALL – Constitutional tall stature
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).