Glaucoma

H7_GLAUCOMA

glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions None

414262

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H40-H42
Cause of death: ICD-10 H40-H42

2 out of 7 registries used, show all original rules.

19992

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Check minimum number of events None

19992

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Remove individuals based on genotype QC

18902

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H7_GLAUCOMA

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 18902 10807 8095
Unadjusted prevalence (%) 5.01 5.13 4.87
Mean age at first event (years) 63.82 63.17 64.69

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.70 [1.49, 1.93] 1.4e-15 2657
15 years 0.01 1.10 [0.98, 1.24] 9.5e-2 1329
5 years 0.00 1.72 [1.54, 1.93] 6.8e-22 739
1 year 0.00 2.14 [1.79, 2.56] 9.7e-17 175

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_GLAUCOMA – Glaucoma
GWS hits: 64

Survival analyses between endpoints

Plot

before Glaucoma
after Glaucoma

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