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Glaucoma, exfoliation


glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H40.10
Hospital discharge: ICD-9 3651B
Hospital discharge: ICD-8 37512
Cause of death: ICD-10 H40.10
Cause of death: ICD-9 3651B
Cause of death: ICD-8 37512

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4
Parent code in ICD-10 H401
Name in latin Glaucoma capsulare [primarium/residuale] cum syndromate exfoliationis

Summary Statistics

Key figures

All Female Male
Number of individuals 3424 1890 1534
Unadjusted prevalence (%) 0.83 0.82 0.84
Mean age at first event (years) 71.20 70.85 71.64


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.37 [1.96, 2.85] 2.1e-19 851
15 years 0.01 1.47 [1.22, 1.76] 3.5e-5 453
5 years 0.00 1.78 [1.47, 2.16] 3.5e-9 229
1 year 0.00 2.23 [1.65, 3.01] 1.9e-7 56

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: H7_GLAUCOMA_XFG – Glaucoma, exfoliation
GWS hits: 10

Survival analyses between endpoints


before Glaucoma, exfoliation
after Glaucoma, exfoliation

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Drugs most likely to be purchased after Glaucoma, exfoliation

Endpoint not on priority list, no data to show.