🎉 Check out the future of Risteys: FinRegistry + FinnGen Risteys and let us know what you think 🙂

Glaucoma

H7_GLAUCOMA

glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H40-H42
Cause of death: ICD-10 H40-H42

2 out of 7 registries used, show all original rules.

20669

diagram downward connector

Check minimum number of events None

20669

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

20904

diagram downward connector
H7_GLAUCOMA

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 20904 11962 8942
Unadjusted prevalence (%) 5.07 5.20 4.92
Mean age at first event (years) 63.77 63.16 64.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.70 [1.47, 1.97] 5.2e-13 3300
15 years 0.01 1.16 [1.03, 1.31] 1.5e-2 1596
5 years 0.00 1.84 [1.64, 2.05] 8.8e-27 903
1 year 0.00 2.23 [1.88, 2.64] 1.8e-20 211

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_GLAUCOMA – Glaucoma
GWS hits: 81

Survival analyses between endpoints

Plot

before Glaucoma
after Glaucoma

loading spinner Loading survival analyses plot