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Primary open-angle glaucoma, strict

H7_GLAUCOMA_POAG

open-angle glaucoma: Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H40.1
Hospital discharge: ICD-9 3651[A|C|E|X]
Hospital discharge: ICD-8 37510
Hospital discharge: excluded ICD-10 H40.10, H40.12
Cause of death: ICD-10 H40.1
Cause of death: ICD-9 3651[A|C|E|X]
Cause of death: ICD-8 37510
Cause of death: excluded ICD-10 H40.10, H40.12

2 out of 7 registries used, show all original rules.

8810

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Check minimum number of events None

8810

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Include endpoints None

8810

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Remove individuals based on genotype QC

8529

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H7_GLAUCOMA_POAG

Control definitions

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4
Parent code in ICD-10 H40
Name in latin Glaucoma simplex primarium

Summary Statistics

Key figures

All Female Male
Number of individuals 8529 4652 3877
Unadjusted prevalence (%) 2.07 2.02 2.13
Mean age at first event (years) 67.87 67.64 68.15

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.72 [1.34, 2.19] 1.4e-5 1491
15 years 0.01 1.22 [1.03, 1.44] 1.9e-2 750
5 years 0.00 1.79 [1.54, 2.08] 3.9e-14 408
1 year 0.00 2.27 [1.80, 2.85] 4.0e-12 101

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_GLAUCOMA_POAG – Primary open-angle glaucoma, strict
GWS hits: 48

Survival analyses between endpoints

Plot

before Primary open-angle glaucoma, strict
after Primary open-angle glaucoma, strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Primary open-angle glaucoma, strict

Endpoint not on priority list, no data to show.