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Juvenile Open Angle Glaucoma

EFO Endpoint Browser PheWeb

H7_GLAUCOMA_JOAG

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Pre-conditions: 4<=EVENT_AGE<=40

Registry filters:

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

214

6. Filter based on genotype QC (FinnGen only)

214

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF6

Case counts by codes

↥

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1785 745 1023
Only index persons 1675 714 961
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.03 0.03 0.04
Median age at first event (years)
Whole population 34.05 34.02 34.02
Only index persons 33.98 34.03 33.95

-FinnGen-

Key figures

All Female Male
Number of individuals 214 112 102
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 34.90 34.46 35.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
197
Matched controls
1969
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
114
Kela drug reimbursment
Glaucoma
372.8
186.1
169
31
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
298.0
162.4
149
20
S01ED51
ATC
timolol, combinations; ophthalmic
95.7
115.6
124
34
S01EE01
ATC
latanoprost; ophthalmic
133.8
110.6
112
19
S01ED01
ATC
timolol; ophthalmic
145.7
88.3
89
11
XCK00
NOMESCO Finland
Perimetry
38.3
70.4
91
43
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
163.7
65.6
66
6
S01EX03
ATC
NA
271.7
59.6
58
*
H40.0
ICD-10 Finland
Glaucoma suspect
24.6
53.8
79
52
S01EC03
ATC
dorzolamide; ophthalmic
607.1
49.7
47
*
S01EC04
ATC
brinzolamide; ophthalmic
50.7
48.8
58
16
S01EC01
ATC
acetazolamide; systemic
65.3
46.7
53
11
XCW99
NOMESCO Finland
Other investigative procedure of eye
14.4
43.5
80
89
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
43.3
40
*
S01EE03
ATC
bimatoprost; ophthalmic
90.9
39.8
43
6
S01EE05
ATC
tafluprost; ophthalmic
44.8
39.4
48
14
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
241.4
39.4
39
*
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
34.4
32
*
XCK10
NOMESCO Finland
Photography of fundus of eye
11.1
33.9
70
93
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
45.1
33.0
40
11
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.7
30.0
81
164
H40.9
ICD-10 Finland
Glaucoma, unspecified
87.6
27.6
30
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.1
26.5
56
74
Z96.1
ICD-10 Finland
Presence of intraocular lens
11.7
25.5
49
54
H40.11
ICD-10 Finland
Low pressure glaucoma
50.2
25.4
30
7
S01EE04
ATC
travoprost; ophthalmic
54.0
24.0
28
6
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
18.7
24.0
37
24
XCH00
NOMESCO Finland
Eye pressure measurement
14.9
22.0
37
30
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
21.2
20
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
16.4
19.9
32
23
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.3
19.1
92
330
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
+∞
19.1
18
*
CHD99
NOMESCO Finland
Other filtering operation
+∞
19.1
18
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.8
19.0
60
138
CHD00
NOMESCO Finland
Laser trabeculoplasty
110.7
18.9
20
*
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
209.0
18.9
19
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.0
18.7
105
434
H26.4
ICD-10 Finland
After-cataract
13.0
18.6
33
30
S01ED02
ATC
betaxolol; ophthalmic
58.4
18.3
21
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
73.7
18.1
20
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
9.4
17.6
37
47
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
16.9
16
*
S01EA02
ATC
dipivefrine; ophthalmic
+∞
16.9
16
*
S01EA03
ATC
apraclonidine; ophthalmic
+∞
16.9
16
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
10.4
16.2
32
36
WX140
NOMESCO Finland
Parabulbar anesthesy
16.6
15.8
25
17
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
29.8
14.6
19
7
3708
FHL
Trabeculectomy or equivalent
+∞
13.7
13
*
S01EB01
ATC
pilocarpine; ophthalmic
149.8
13.6
14
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
53.7
13.0
15
*
CS494
NOMESCO Finland
Other visual field testing
18.9
12.8
19
11
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
26.4
12.7
17
7
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
12.6
12
*
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
23.1
12.2
17
8
H40.12
ICD-10 Finland
Pigmentary glaucoma
69.2
11.7
13
*
S01BC03
ATC
diclofenac; ophthalmic
14.9
11.7
19
14
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
11.6
11
*
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
16.3
11.6
18
12
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
37.4
11.4
14
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
18.4
11.4
17
10
H3603, E103
ICD-10 Finland
NA
13.9
11.4
19
15
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.7
11.3
33
67
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
19.2
10.9
16
9
XCH05
NOMESCO Finland
Eye pressure longterm registration
29.9
10.9
14
5
3651E
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA INFANTILE SEU JUVENILE]
+∞
10.5
10
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
4.8
10.4
35
84
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
9.3
10.3
21
25
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
15.7
10.2
16
11
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
4.7
10.1
35
86
CKC15
NOMESCO Finland
Panretinal photocoagulation
42.4
10.1
12
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
21.4
9.9
14
7
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
6.0
9.8
27
51
A10AA02
ATC
NA
6.5
9.7
25
43
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.1
9.6
26
48
ZXA10
NOMESCO Finland
Bilateral
3.4
9.5
51
184
S01EC54
ATC
brinzolamide, combinations; ophthalmic
23.0
9.5
13
6
Q15.0
ICD-10 Finland
Congenital glaucoma
+∞
9.4
9
*
A10AA01
ATC
NA
6.2
9.1
24
43
H04AA01
ATC
glucagon; nasal, parenteral
6.4
8.9
23
40
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.5
8.9
26
53
A10AE04
ATC
insulin glargine; parenteral
4.5
8.9
32
82
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
9.2
8.5
17
20
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.1
8.4
20
31
37597
ICD-8 Finland
Glaucoma, Suspicio glaucomatis
+∞
8.4
8
*
H26.2
ICD-10 Finland
Complicated cataract
15.3
8.3
13
9
CKD40
NOMESCO Finland
Endophotocoagulation of retina
23.1
8.1
11
5
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.2
8.1
21
37
103
Kela drug reimbursment
Diabetes, insulin-treated
2.8
8.0
57
248
H16.0
ICD-10 Finland
Corneal ulcer
5.8
8.0
22
42
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.9
8.0
56
239
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
46.8
7.8
9
*
H40
ICD-10 Finland
Glaucoma
46.8
7.8
9
*
ZXC20
NOMESCO Finland
Use of chemical agents
46.8
7.8
9
*
H40.8
ICD-10 Finland
Other glaucoma
46.8
7.8
9
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
19.3
7.7
11
6
A10AE05
ATC
insulin detemir; parenteral
4.7
7.6
25
59
ZXA05
NOMESCO Finland
Left side
2.8
7.5
54
236
H27.0
ICD-10 Finland
Aphakia
+∞
7.3
7
*
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
+∞
7.3
7
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
12.7
7.2
12
10
H25.1
ICD-10 Finland
Senile nuclear cataract
3.4
7.1
35
118
H04.10
ICD-10 Finland
Dry eye syndrome
3.7
7.0
30
91
CKC10
NOMESCO Finland
Local photocoagulation of retina
11.5
6.9
12
11
T89
ICPC
Diabetes insulin dependent
5.0
6.8
21
46
Z94.7
ICD-10 Finland
Corneal transplant status
41.5
6.8
8
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
10.6
6.6
12
12
ZXA00
NOMESCO Finland
Right side
2.5
6.5
54
254
S01FA04
ATC
cyclopentolate; ophthalmic
14.9
6.5
10
7
H40.1
ICD-10 Finland
Primary open-angle glaucoma
72.1
6.5
7
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
72.1
6.5
7
*
CHD35
NOMESCO Finland
Laser goniopuncture
72.1
6.5
7
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
72.1
6.5
7
*
H3603, E113
ICD-10 Finland
NA
27.6
6.3
8
*
S01FA01
ATC
atropine; ophthalmic
27.6
6.3
8
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.6
6.1
20
47
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
6.4
6.1
15
25
CHC05
NOMESCO Finland
Iridotomy
10.5
6.1
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
77
408
2.39
8.04
5.8
3.4
932.6
231.0
mg/l
0.39
51
271
78
431
2.27
7.27
7.0
4.0
18.9
10.6
mg/mmol
0.43
53
284
28
103
2.98
5.97
7.4
3.4
147.0
79.1
ng/l
0.92
28
95
79
470
2.08
5.90
5.6
3.2
6.9
8.4
mmol/l
2.36
72
408
11
21
5.47
5.58
1.2
1.4
—
—
—
0
0
40
188
2.39
5.27
2.6
1.7
—
—
—
0
0
21
72
3.13
5.03
4.7
7.0
23.0
24.8
mmol/l
1.15
21
72
11
25
4.58
4.62
2.4
2.7
—
—
—
0
0
94
643
1.82
4.38
9.9
6.6
1.2
1.2
mmol/l
0.74
89
594
24
97
2.66
4.31
3.0
2.8
67.7
68.1
g/l
0.08
24
89
7
6
12.00
4.30
57.0
30.8
8.9
6.4
ug/l
—
7
6
7
6
12.00
4.30
2.6
1.8
—
—
—
0
0
39
200
2.16
4.16
5.2
2.0
23.3
24.0
%
0.13
34
168
63
385
1.90
4.16
5.8
4.4
—
—
—
0
0
68
429
1.86
4.05
7.8
3.8
7.4
7.4
ph
0.03
17
81
101
718
1.77
4.05
14.8
7.5
1.2
1.2
mmol/l
0.13
88
613
37
191
2.13
3.88
16.5
6.2
1.1
1.0
mmol/l
0.82
37
179
35
181
2.12
3.65
1.7
1.5
—
—
—
0
0
197
1757
2.53
3.50
20.5
12.6
139.3
139.6
mmol/l
1.64
192
1715
30
149
2.18
3.46
7.1
3.2
—
—
—
0
0
10
27
3.84
3.39
1.0
1.1
—
—
—
0
0
70
468
1.74
3.36
6.1
2.8
125.4
165.9
e6/l
0.09
57
355
197
1765
2.46
3.32
21.3
12.6
4.0
4.0
mmol/l
0.47
192
1716
64
419
1.75
3.30
5.6
2.6
0.2
0.3
e6/l
1.36
51
312
6
7
8.77
3.28
1.0
1.0
1025.8
1190.1
miu/ml
—
6
7
8
15
5.49
3.22
1.5
1.3
31.3
33.5
pg
—
8
15
24
112
2.29
3.21
11.1
3.3
1.5
2.2
mmol/l
0.37
19
83
79
552
1.68
3.21
6.3
3.2
25.2
135.5
e6/l
1.08
59
380
19
80
2.51
3.16
2.0
2.5
—
—
—
0
0
66
441
1.72
3.15
5.9
3.6
0.0
0.0
estimate
0.50
30
169
64
424
1.73
3.15
4.9
2.6
—
—
—
0
0
68
459
1.71
3.12
1.9
2.1
194.9
197.9
u/l
0.01
63
437
80
567
1.66
3.05
9.8
5.5
—
—
—
0
0
109
839
1.61
2.96
5.4
3.2
0.0
0.0
estimate
0.00
32
176
110
856
1.59
2.80
5.5
3.2
0.0
0.0
estimate
0.00
30
170
79
570
1.61
2.76
5.9
6.5
1.1
1.1
inr
0.31
36
183
141
1168
1.61
2.72
6.3
4.0
—
—
—
0
0
121
968
1.58
2.70
7.8
4.8
6.9
6.6
mmol/l
0.89
116
887
138
1141
1.59
2.65
3.6
3.2
—
—
—
0
0
28
151
1.98
2.62
3.2
2.7
1.8
1.7
%
0.20
28
137
68
479
1.62
2.59
3.9
3.3
2.3
2.3
mmol/l
0.34
62
418
50
327
1.69
2.54
5.9
2.4
5.2
4.9
e6/l
0.09
45
285
39
238
1.78
2.52
4.2
3.0
38.7
200.1
ng/l
1.27
31
156
107
843
1.54
2.49
7.1
4.4
0.0
0.0
estimate
0.00
33
174
9
27
3.43
2.42
4.9
2.3
—
—
—
0
0
110
876
1.53
2.41
9.5
5.9
0.6
0.5
e9/l
1.19
98
785
98
764
1.52
2.36
14.8
8.7
0.0
0.0
e9/l
0.65
81
627
9
28
3.31
2.33
2.9
1.5
—
—
—
0
0
9
28
3.31
2.33
4.1
2.2
4.9
5.1
kpa
—
9
28
9
28
3.31
2.33
4.1
2.2
9.1
9.3
kpa
—
9
28
53
360
1.63
2.32
4.0
3.1
—
—
—
0
0
110
881
1.51
2.32
9.5
5.9
0.0
0.0
e9/l
0.54
98
790
113
914
1.50
2.25
9.7
6.2
0.2
0.2
e9/l
0.41
101
828
20
104
2.02
2.08
14.4
8.9
—
—
—
0
0
108
877
1.47
2.04
5.1
5.7
9.4
10.5
umol/l
1.01
99
834
111
909
1.46
1.99
9.5
6.0
1.7
1.9
e9/l
0.83
101
825
7
21
3.41
1.98
7.6
3.5
—
—
—
0
0
7
21
3.41
1.98
5.4
2.7
—
—
—
0
0
5
11
4.63
1.95
1.2
1.1
—
—
—
0
0
6
16
3.83
1.95
7.7
2.2
61.7
64.9
%
—
6
16
99
797
1.45
1.93
10.2
5.9
0.7
0.7
%
0.15
92
750
7
22
3.25
1.89
1.4
1.2
—
—
—
0
0
102
828
1.44
1.89
10.2
6.1
8.5
8.3
%
0.28
96
791
54
386
1.53
1.88
1.9
1.7
0.8
1.0
mg/l
0.38
44
295
13
59
2.28
1.88
2.2
1.9
1.2
1.4
g/l
0.36
13
52
56
406
1.51
1.83
3.4
2.4
—
—
—
0
0
82
642
1.45
1.83
8.2
4.6
35.7
36.4
g/l
0.51
76
607
101
825
1.42
1.78
10.1
5.8
2.7
2.8
%
0.10
95
780
121
1022
1.42
1.76
12.3
9.5
4.3
4.0
e9/l
0.71
103
903
103
846
1.42
1.75
9.7
5.7
59.4
57.0
%
1.17
97
809
103
852
1.40
1.66
10.0
5.9
26.9
28.8
%
0.87
97
812
59
443
1.46
1.61
1.8
1.7
1.4
1.4
mmol/l
0.02
51
383
22
130
1.77
1.60
5.0
4.8
0.1
0.5
%
—
7
30
13
64
2.10
1.57
3.9
3.0
—
—
—
0
0
17
286
0.56
1.50
1.5
1.3
—
—
—
0
0
42
299
1.50
1.49
5.9
2.4
501.6
555.3
mosm/kgh2o
0.76
37
252
57
432
1.44
1.48
1.3
1.3
2.1
1.3
u/ml
0.23
19
130
66
514
1.41
1.47
5.2
2.9
—
—
—
0
0
9
38
2.43
1.47
3.0
1.3
—
—
—
0
0
13
66
2.03
1.47
4.2
1.4
—
—
—
0
0
174
1596
1.48
1.44
5.0
4.5
1.8
1.8
mu/l
0.23
162
1479
146
1299
1.39
1.43
10.1
7.1
78.8
75.8
u/l
0.40
139
1224
14
75
1.93
1.38
7.2
3.6
122.7
133.9
g/l
0.90
14
75
6
23
2.65
1.37
1.2
1.3
—
—
—
0
0
23
145
1.66
1.36
7.8
11.8
13.6
12.4
kpa
0.33
23
140
23
145
1.66
1.36
7.8
11.8
4.9
5.1
kpa
0.47
23
138
28
186
1.58
1.35
1.4
1.2
—
—
—
0
0
12
62
1.99
1.30
7.4
2.6
1.3
1.6
%
0.33
12
62
32
225
1.50
1.21
3.9
2.3
—
—
—
0
0
6
26
2.34
1.19
9.0
2.7
—
—
—
0
0
57
448
1.37
1.19
6.3
4.8
—
—
—
0
0
21
135
1.62
1.16
5.6
4.9
0.0
0.2
%
—
9
41
22
144
1.59
1.14
5.6
4.7
0.7
0.8
%
—
9
45
8
40
2.04
1.13
3.5
16.8
1.1
1.1
mmol/l
—
8
35
7
31
2.30
1.11
7.9
3.4
61.6
56.8
%
—
7
31
7
31
2.30
1.11
6.4
3.2
4.5
4.7
e9/l
—
7
31
69
567
1.32
1.07
1.8
1.8
94.6
94.7
pmol/l
0.00
39
294
11
60
1.88
1.05
1.5
1.6
0.2
0.2
g/l
0.35
11
60
171
1595
1.36
1.00
8.8
4.9
44.3
38.9
mmol/mol
5.12
160
1508
144
1313
1.30
0.99
4.1
3.9
14.5
14.6
pmol/l
0.02
131
1207
5
23
2.20
0.98
3.8
3.6
—
—
—
0
0
10
55
1.86
0.93
2.2
1.2
—
—
—
0
0
22
153
1.49
0.90
12.2
19.7
1.0
1.3
inr
—
7
24
8
42
1.94
0.89
1.0
1.2
—
—
—
0
0
8
43
1.89
0.88
1.0
1.3
—
—
—
0
0
11
64
1.76
0.88
1.5
1.3
—
—
—
0
0
28
206
1.41
0.87
1.7
2.3
4.4
5.9
umol/l
0.98
21
176
19
129
1.52
0.87
5.7
4.9
0.0
0.0
%
—
7
34
11
65
1.73
0.84
10.9
17.1
—
—
—
0
0
16
106
1.55
0.81
2.2
2.7
160.9
3249.5
u/l
—
9
48
16
106
1.55
0.81
1.2
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
70
598
1.25
0.79
3.3
3.1
43.1
30.3
ng/l
0.30
43
346
10
60
1.70
0.73
5.1
8.5
—
—
—
0
0
5
25
2.02
0.73
1.2
1.2
—
—
—
0
0
65
556
1.24
0.72
2.4
2.2
—
—
—
0
0
23
303
0.73
0.69
1.9
1.8
—
—
—
0
0
176
1677
1.28
0.66
4.6
3.8
6.5
5.8
mmol/l
3.06
162
1565
14
95
1.51
0.66
4.3
2.3
—
—
—
0
0
31
245
1.31
0.64
1.5
1.6
1421.5
1227.7
nmol/l
0.47
25
187
8
53
1.53
0.59
8.6
14.3
1.6
1.4
%
—
8
48
0
23
0.00
0.58
0.0
3.4
—
46.1
—
0
23
5
86
0.57
0.57
1.2
1.4
—
—
—
0
0
5
88
0.56
0.57
1.2
1.5
—
—
—
0
0
8
55
1.47
0.56
1.1
1.3
—
—
—
0
0
18
236
0.74
0.54
1.4
1.9
—
—
—
0
0
20
258
0.75
0.54
2.9
2.2
61.9
103.0
ug/g
1.07
15
207
19
144
1.35
0.53
8.8
4.7
—
—
—
0
0
184
1776
1.26
0.51
5.0
3.9
4.6
4.7
mmol/l
0.44
171
1671
49
423
1.21
0.50
3.6
2.4
351.2
8339.1
umol/l
2.18
41
373
10
68
1.49
0.48
1.0
1.1
—
—
—
0
0
10
68
1.49
0.48
15.6
3.7
25.5
24.7
mmol/l
—
10
68
5
85
0.58
0.46
1.2
1.4
—
—
—
0
0
16
121
1.35
0.45
2.7
3.3
—
—
—
0
0
17
130
1.33
0.45
7.6
12.8
94.7
96.1
%
0.64
17
125
5
31
1.63
0.43
1.8
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
3.5
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
—
—
0
0
30
252
1.22
0.40
1.5
1.4
544.0
482.9
titre
—
5
55
16
124
1.31
0.40
1.7
1.3
—
—
—
0
0
9
67
1.36
0.38
4.6
3.4
—
—
—
0
0
206
2029
1.41
0.38
27.7
17.6
6.9
6.6
e9/l
1.16
201
1988
41
358
1.18
0.38
4.9
3.4
1.0
1.0
kg/l
—
8
40
46
406
1.17
0.37
9.3
7.1
—
—
—
0
0
12
157
0.75
0.37
1.3
1.4
—
—
—
0
0
182
1769
1.19
0.37
5.0
3.8
1.4
1.4
mmol/l
0.31
169
1660
6
42
1.44
0.36
2.2
2.8
—
—
—
0
0
45
504
0.86
0.34
2.2
2.0
—
—
—
0
0
183
1783
1.18
0.33
20.0
12.0
22.4
21.7
mg/l
0.11
156
1382
6
47
1.28
0.32
5.8
2.7
—
—
—
0
0
176
1711
1.16
0.32
4.5
3.5
1.3
1.3
mmol/l
0.41
162
1597
7
55
1.28
0.30
5.9
4.9
—
—
—
0
0
184
1797
1.17
0.30
5.6
4.2
2.8
2.9
mmol/l
0.37
172
1687
20
167
1.22
0.29
1.3
1.1
—
—
—
0
0
11
85
1.31
0.28
8.5
10.6
0.9
0.7
%
0.84
11
85
46
417
1.13
0.27
3.4
3.4
—
—
—
0
0
11
86
1.29
0.26
8.5
10.6
1.5
1.7
%
0.29
11
86
35
315
1.13
0.23
1.5
1.3
27.0
30.6
iu/ml
—
6
94
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
3.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
262.8
—
0
5
0
10
0.00
0.21
0.0
6.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
150.7
—
0
10
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
17
197
0.85
0.20
1.4
1.4
—
—
—
0
0
7
59
1.19
0.18
1.6
1.2
—
64.3
—
0
7
18
204
0.87
0.17
1.3
1.3
—
—
—
0
0
5
70
0.71
0.17
2.0
2.2
—
—
—
0
0
11
92
1.21
0.16
4.5
9.4
—
—
—
0
0
71
678
1.07
0.15
2.4
1.8
—
—
—
0
0
29
314
0.91
0.14
1.4
1.2
1.0
6.4
u/ml
2.35
11
132
131
1279
1.06
0.13
5.5
3.8
11.5
9.4
mm/h
1.05
124
1185
12
104
1.16
0.12
1.2
1.1
—
—
—
0
0
12
136
0.88
0.11
1.5
4.5
2.0
38.0
ug/l
—
7
113
31
290
1.08
0.11
2.1
1.6
—
—
—
0
0
14
125
1.13
0.10
5.4
2.8
3.7
4.1
e9/l
—
9
107
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
74
763
0.95
0.09
3.0
2.4
—
—
—
0
0
10
113
0.88
0.08
4.2
1.9
—
—
—
0
0
5
63
0.79
0.08
1.2
1.1
—
—
—
0
0
40
418
0.95
0.08
2.0
1.7
—
—
—
0
0
10
89
1.13
0.07
4.1
2.0
—
—
—
0
0
41
395
1.05
0.06
1.6
1.4
3.0
2.4
g/l
0.58
29
259
170
1715
0.96
0.06
20.4
12.2
39.5
40.9
%
1.45
136
1363
191
1897
1.06
0.06
17.1
11.2
—
—
—
0
0
19
178
1.07
0.06
1.7
1.5
—
—
—
0
0
27
257
1.06
0.06
1.3
1.5
—
—
—
0
0
30
313
0.95
0.05
2.8
2.7
0.6
0.8
ug/l
1.15
18
169
12
110
1.10
0.05
1.0
1.5
—
—
—
0
0
12
111
1.09
0.04
1.3
1.2
—
—
—
0
0
12
113
1.07
0.02
2.0
1.7
1.3
1.7
g/l
0.42
12
104
21
217
0.96
0.01
1.2
1.2
—
—
—
0
0
52
526
0.98
0.00
3.9
3.9
1.7
2.0
ug/l
0.39
46
474
11
106
1.04
0.00
4.0
2.0
—
—
—
0
0
11
114
0.96
0.00
4.2
1.6
—
—
—
0
0
11
114
0.96
0.00
4.2
1.9
—
—
—
0
0
10
99
1.01
0.00
1.0
1.1
—
—
—
0
0
54
541
1.00
0.00
1.6
1.6
—
—
—
0
0
11
113
0.97
0.00
4.1
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.2
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
7
76
0.92
0.00
6.7
2.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
12
120
1.00
0.00
1.7
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
57.0
—
0
6
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
18.3
—
0
6
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
8
83
0.96
0.00
6.4
2.6
22.3
42.8
u/ml
—
8
78
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_GLAUCOMA_JOAG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCOMA_JOAG.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: H7_GLAUCOMA_JOAG – Juvenile Open Angle Glaucoma

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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