Juvenile Open Angle Glaucoma

H7_GLAUCOMA_JOAG

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Pre-conditions: 4<=EVENT_AGE<=40

Registry filters:

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

215

6. Filter based on genotype QC (FinnGen only)

211

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1785 745 1023
Only index persons 1675 714 961
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.03 0.03 0.04
Median age at first event (years)
Whole population 34.05 34.02 34.02
Only index persons 33.98 34.03 33.95

-FinnGen-

Key figures

All Female Male
Number of individuals 211 112 99
Unadjusted period prevalence (%) 0.04 0.04 0.05
Median age at first event (years) 34.88 34.46 35.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
215
Matched controls
2150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
220.5
309.6
160
28
114
Kela drug reimbursment
Glaucoma
274.9
307.7
187
51
S01ED51
ATC
timolol, combinations; ophthalmic
68.1
212.2
135
52
S01EE01
ATC
latanoprost; ophthalmic
74.9
204.6
122
37
S01ED01
ATC
timolol; ophthalmic
95.0
190.0
104
21
S01EA05
ATC
brimonidine; ophthalmic
97.4
142.8
76
12
XCK00
NOMESCO Finland
Perimetry
30.7
125.8
96
55
S01EC04
ATC
brinzolamide; ophthalmic
53.0
115.0
69
19
H40.0
ICD-10 Finland
Glaucoma suspect
28.0
113.0
88
52
S01EC01
ATC
acetazolamide; systemic
56.5
108.9
64
16
S01EE05
ATC
tafluprost; ophthalmic
42.1
85.8
54
17
S01EE03
ATC
bimatoprost; ophthalmic
61.5
84.2
48
10
XCW99
NOMESCO Finland
Other investigative procedure of eye
13.5
74.4
89
107
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
26.1
66.4
49
24
S01EX03, ,
ATC
281.8
62.8
61
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
12.0
60.4
74
90
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
23.1
59.5
46
25
XCK10
NOMESCO Finland
Photography of fundus of eye
10.3
53.7
74
104
XCH00
NOMESCO Finland
Eye pressure measurement
15.6
51.4
49
40
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
51.1
47
*
S01EC03
ATC
dorzolamide; ophthalmic
166.0
50.3
51
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.3
45.0
94
207
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
103.9
39.4
42
5
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
38.7
36
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
10.8
36.8
44
50
Z96.1
ICD-10 Finland
Presence of intraocular lens
8.2
35.8
56
89
H40.9
ICD-10 Finland
Glaucoma, unspecified
104.0
32.8
35
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
10.6
30.4
36
40
H40.11
ICD-10 Finland
Low pressure glaucoma
64.5
29.1
33
6
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.6
27.6
107
379
CJB10
NOMESCO Finland
Laser discission of secondary cataract
8.9
27.2
37
49
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
28.5
26.7
36
15
S01EE04
ATC
travoprost; ophthalmic
46.6
26.7
32
8
H26.4
ICD-10 Finland
After-cataract
8.0
25.5
38
56
WX140
NOMESCO Finland
Parabulbar anesthesy
10.4
25.3
30
33
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
256.2
23.1
23
*
S01ED02
ATC
betaxolol; ophthalmic
56.2
21.6
25
5
CHD00
NOMESCO Finland
Laser trabeculoplasty
85.6
21.1
23
*
CHD99
NOMESCO Finland
Other filtering operation
+∞
20.1
19
*
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
115.8
19.9
21
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
115.8
19.9
21
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.7
19.8
116
521
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
6.5
19.2
34
60
Z3229
NOMESCO Finland
Other healthcare associate professional
5.6
18.9
40
84
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.0
18.5
69
228
S01EA02
ATC
dipivefrine; ophthalmic
73.1
18.0
20
*
H04AA01
ATC
glucagon; nasal, parenteral
8.6
17.8
24
31
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
30.4
16.9
22
8
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
183.7
16.7
17
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
7.0
16.7
27
43
H20.1
ICD-10 Finland
Chronic iridocyclitis
33.0
16.4
21
7
S01EA03
ATC
apraclonidine; ophthalmic
33.0
16.4
21
7
S01EB01
ATC
pilocarpine; ophthalmic
91.9
15.8
17
*
H3603, E103,
ICD-10 Finland
31.3
15.5
20
7
XCH05
NOMESCO Finland
Eye pressure longterm registration
48.9
15.3
18
*
A10AB05
ATC
insulin aspart; parenteral
4.7
15.2
39
96
3708
FHL
Trabeculectomy or equivalent
+∞
14.8
14
*
ZXA10
NOMESCO Finland
Bilateral
3.6
14.5
59
204
A10AA02, ,
ATC
6.2
14.2
26
47
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
19.2
14.1
21
12
S01EC54
ATC
brinzolamide, combinations; ophthalmic
32.5
14.1
18
6
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
21.9
14.1
20
10
A10AB01
ATC
insulin (human); parenteral
5.7
14.1
28
55
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.9
14.0
34
80
A10AA01, ,
ATC
6.2
13.7
25
45
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
13.7
13
*
S01BA04
ATC
prednisolone; ophthalmic
19.9
13.7
20
11
S01BC03
ATC
diclofenac; ophthalmic
16.5
13.4
21
14
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
20.7
13.2
19
10
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.5
12.9
22
37
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
74.4
12.7
14
*
3651E
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA INFANTILE SEU JUVENILE]
+∞
12.6
12
*
S01BA07
ATC
fluorometholone; ophthalmic
15.6
12.5
20
14
A10AC01
ATC
insulin (human); parenteral
4.1
12.5
38
106
S01BA01
ATC
dexamethasone; ophthalmic
6.3
12.5
22
38
H16.0
ICD-10 Finland
Corneal ulcer
5.2
12.3
27
58
CS494
NOMESCO Finland
Other visual field testing
12.1
11.8
21
19
A10AE05
ATC
insulin detemir; parenteral
5.2
11.5
25
53
H40.12
ICD-10 Finland
Pigmentary glaucoma
45.8
11.0
13
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
22.9
10.8
15
7
103
Kela drug reimbursment
Diabetes, insulin-treated
2.9
10.7
66
287
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.9
10.5
64
276
37597
ICD-8 Finland
Glaucoma, Suspicio glaucomatis
115.4
10.5
11
*
Q15.0
ICD-10 Finland
Congenital glaucoma
+∞
10.5
10
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
20.0
10.4
15
8
H40
ICD-10 Finland
Glaucoma
24.8
10.4
14
6
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
21.3
9.9
14
7
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
57.7
9.7
11
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.5
9.6
22
32
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
13.2
9.5
16
13
S01FA01
ATC
atropine; ophthalmic
31.6
9.5
12
*
XCW10
NOMESCO Finland
Assessment of vision
22.9
9.5
13
6
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
+∞
9.4
9
*
A10AE04
ATC
insulin glargine; parenteral
3.5
9.4
35
112
ZXA05
NOMESCO Finland
Left side
2.7
9.2
60
267
A10AB04
ATC
insulin lispro; parenteral
4.8
9.1
21
47
H40.8
ICD-10 Finland
Other glaucoma
25.3
9.0
12
5
CHC05
NOMESCO Finland
Iridotomy
25.3
9.0
12
5
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
8.2
8.9
19
25
H54.4
ICD-10 Finland
Blindness, monocular
52.2
8.7
10
*
Z94.7
ICD-10 Finland
Corneal transplant status
93.6
8.5
9
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
12.4
8.2
14
12
CKC15
NOMESCO Finland
Panretinal photocoagulation
18.0
8.2
12
7
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.7
8.1
27
80
CHD35
NOMESCO Finland
Laser goniopuncture
46.7
7.8
9
*
CFW99
NOMESCO Finland
Other operation on conjunctiva
46.7
7.8
9
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.8
7.7
42
169
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
14.0
7.5
12
9
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
82.8
7.5
8
*
H26.2
ICD-10 Finland
Complicated cataract
9.9
7.4
14
15
WX002
NOMESCO Finland
Sedation and analgesia
2.6
7.4
48
211
H3600, E103,
ICD-10 Finland
12.6
7.2
12
10
CKD40
NOMESCO Finland
Endophotocoagulation of retina
14.4
7.0
11
8
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
17.4
6.8
10
6
H27.0
ICD-10 Finland
Aphakia
41.4
6.8
8
*
H40.1
ICD-10 Finland
Primary open-angle glaucoma
41.4
6.8
8
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
41.4
6.8
8
*
ZXA00
NOMESCO Finland
Right side
2.4
6.8
58
290
A10AD01
ATC
insulin (human); parenteral
7.2
6.6
15
22
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.8
6.6
21
60
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
7.8
6.5
14
19
T89
ICPC
Diabetes insulin dependent
3.6
6.5
22
66
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
71.9
6.5
7
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
9.7
6.4
12
13
CG2T4
NOMESCO Finland
Topography assessment of cornea
18.7
6.3
9
5
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
6.3
6
*
H18.2
ICD-10 Finland
Other corneal oedema
+∞
6.3
6
*
3711
FHL
Cyclodiateria or cryocoagulation
+∞
6.3
6
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
+∞
6.3
6
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.1
6.1
14
21
H04.10
ICD-10 Finland
Dry eye syndrome
2.8
6.1
33
131
Z3231
NOMESCO Finland
Registered nurse
2.2
6.1
65
354
CKC12
NOMESCO Finland
Photocoagulation of retina
5.3
6.0
17
34

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
77
409
2.38
7.98
5.8
3.3
932.62
228.57
mg/l
0.39
51
274
78
432
2.26
7.21
6.9
3.9
18.92
10.58
mg/mmol
0.43
53
285
28
103
2.98
5.96
7.4
3.4
147.00
79.10
ng/l
0.92
28
95
79
472
2.07
5.81
5.6
3.2
6.95
8.39
mmol/l
2.31
72
416
40
189
2.37
5.21
2.6
1.7
—
—
—
0
0
21
72
3.12
5.03
4.7
7.0
22.96
24.84
mmol/l
1.15
21
72
40
200
2.23
4.55
5.2
2.0
23.11
24.00
%
0.19
35
168
94
644
1.82
4.34
9.9
6.6
1.22
1.21
mmol/l
0.59
89
599
24
97
2.66
4.31
3.0
2.8
67.71
68.13
g/l
0.08
24
89
7
6
12.00
4.30
57.0
30.8
8.93
6.40
ug/l
—
7
6
7
6
12.00
4.30
2.6
1.8
—
—
—
0
0
11
21
5.46
4.20
1.2
1.4
—
—
—
0
0
63
387
1.89
4.08
5.8
4.4
—
—
—
0
0
68
429
1.86
4.05
7.7
3.8
7.40
7.40
ph
0.03
17
82
101
719
1.76
4.02
14.8
7.5
1.22
1.21
mmol/l
0.20
89
621
37
191
2.13
3.88
16.5
6.2
1.07
1.01
mmol/l
0.82
37
179
11
25
4.58
3.67
2.4
2.7
—
—
—
0
0
35
181
2.12
3.65
1.7
1.5
—
—
—
0
0
71
468
1.77
3.61
6.0
2.8
123.34
165.95
e6/l
0.10
58
355
198
1763
2.56
3.59
20.5
12.5
139.27
139.65
mmol/l
1.57
193
1721
65
419
1.79
3.56
5.5
2.6
0.15
0.33
e6/l
1.35
51
313
92
658
1.70
3.47
8.0
10.2
1.08
1.17
inr
0.94
43
209
80
551
1.72
3.46
6.2
3.2
24.97
135.81
e6/l
1.09
60
379
30
149
2.18
3.46
7.1
3.2
—
—
—
0
0
198
1771
2.49
3.40
21.3
12.6
3.98
3.95
mmol/l
0.48
193
1722
67
441
1.75
3.40
5.8
3.6
0.00
0.01
estimate
0.50
30
169
6
7
8.77
3.28
1.0
1.0
1025.83
1190.14
miu/ml
—
6
7
8
15
5.49
3.22
1.5
1.3
31.25
33.47
pg
—
8
15
19
80
2.51
3.16
2.0
2.5
—
—
—
0
0
64
424
1.73
3.14
4.9
2.6
—
—
—
0
0
68
459
1.70
3.12
1.9
2.1
194.87
197.93
u/l
0.01
63
437
110
842
1.63
3.09
5.4
3.2
0.00
0.01
estimate
0.50
32
185
39
223
1.91
3.09
3.6
2.4
3.42
2.72
e6/l
0.12
24
117
111
857
1.61
2.97
5.5
3.2
0.00
0.00
estimate
-0.00
30
170
93
690
1.61
2.92
4.1
3.0
5.81
5.84
ph
0.05
13
70
10
27
3.83
2.92
1.0
1.1
—
—
—
0
0
7
13
5.52
2.89
1.6
1.4
—
—
—
0
0
142
1170
1.63
2.86
6.2
3.9
—
—
—
0
0
109
847
1.58
2.78
10.5
6.2
—
—
—
0
0
69
481
1.64
2.76
3.8
3.3
2.33
2.35
mmol/l
0.34
63
425
121
970
1.57
2.65
7.8
4.8
6.91
6.56
mmol/l
0.91
116
888
108
844
1.56
2.65
7.0
4.4
0.00
0.00
estimate
-0.00
33
174
28
152
1.97
2.57
3.2
2.7
1.80
1.72
%
0.20
28
138
138
1145
1.57
2.56
3.6
3.2
—
—
—
0
0
54
360
1.67
2.55
4.0
3.1
—
—
—
0
0
50
327
1.69
2.53
5.9
2.4
5.19
4.81
e6/l
0.10
45
289
111
881
1.54
2.49
9.4
5.9
0.59
0.54
e9/l
1.22
99
791
111
883
1.53
2.45
9.4
5.9
0.04
0.04
e9/l
0.67
99
793
39
240
1.76
2.45
4.2
3.0
38.74
200.02
ng/l
1.27
31
156
9
27
3.43
2.42
4.9
2.3
—
—
—
0
0
114
916
1.52
2.38
9.6
6.2
0.20
0.18
e9/l
0.42
102
830
9
28
3.31
2.33
4.1
2.2
4.87
5.11
kpa
—
9
28
9
28
3.31
2.33
4.1
2.2
9.10
9.25
kpa
—
9
28
98
766
1.51
2.31
14.8
8.7
0.00
0.00
e9/l
0.65
81
628
109
880
1.48
2.15
5.1
5.7
9.35
10.49
umol/l
1.08
100
837
20
104
2.02
2.08
14.4
8.9
—
—
—
0
0
112
914
1.47
2.07
9.4
6.0
1.75
1.86
e9/l
0.72
102
836
55
387
1.57
2.07
1.9
1.7
0.79
0.96
mg/l
0.37
44
296
8
26
3.15
2.03
5.3
2.4
8.46
8.58
kpa
—
8
26
7
21
3.41
1.98
7.6
3.5
—
—
—
0
0
7
21
3.41
1.98
5.4
2.7
—
—
—
0
0
5
11
4.62
1.95
1.2
1.1
—
—
—
0
0
6
16
3.83
1.95
7.7
2.2
61.67
64.91
%
—
6
16
83
645
1.47
1.94
8.1
4.6
35.82
36.47
g/l
0.45
77
612
7
22
3.25
1.89
1.4
1.2
—
—
—
0
0
99
799
1.44
1.89
10.2
5.9
0.72
0.70
%
0.16
92
751
13
59
2.28
1.88
2.2
1.9
1.25
1.41
g/l
0.36
13
52
122
1024
1.44
1.88
12.2
9.5
4.32
4.03
e9/l
0.76
104
904
102
833
1.43
1.80
10.2
6.1
8.53
8.31
%
0.36
96
795
60
443
1.49
1.79
1.8
1.7
1.43
1.41
mmol/l
0.04
52
383
101
830
1.41
1.69
10.1
5.8
2.71
2.81
%
0.17
95
788
56
413
1.48
1.68
3.6
2.4
—
—
—
0
0
103
851
1.40
1.67
9.7
5.7
59.25
56.94
%
1.11
97
814
58
435
1.46
1.59
1.3
1.3
2.14
1.30
u/ml
0.23
19
131
103
857
1.39
1.58
10.0
5.9
26.98
28.74
%
0.77
97
819
13
64
2.10
1.57
3.9
3.0
—
—
—
0
0
22
131
1.76
1.56
5.0
4.7
0.32
0.63
%
0.55
11
43
17
288
0.56
1.54
1.5
1.3
—
—
—
0
0
9
37
2.49
1.50
2.9
1.7
—
—
—
0
0
175
1602
1.50
1.49
5.0
4.5
1.82
1.78
mu/l
0.22
163
1485
147
1304
1.40
1.49
10.0
7.1
78.77
75.76
u/l
0.40
140
1231
9
38
2.43
1.47
3.0
1.3
—
—
—
0
0
13
66
2.03
1.47
4.2
1.4
—
—
—
0
0
66
515
1.41
1.45
5.2
2.9
—
—
—
0
0
33
226
1.54
1.40
3.8
2.3
—
—
—
0
0
14
75
1.93
1.38
7.2
3.6
122.71
133.89
g/l
0.90
14
75
6
23
2.65
1.37
1.2
1.3
—
—
—
0
0
23
145
1.66
1.35
7.8
11.8
4.90
5.10
kpa
0.47
23
138
23
145
1.66
1.35
7.8
11.8
13.58
12.45
kpa
0.33
23
140
42
305
1.47
1.35
6.0
2.5
502.46
547.24
mosm/kgh2o
0.60
37
259
28
187
1.57
1.32
1.4
1.2
—
—
—
0
0
12
62
1.99
1.30
7.4
2.6
1.31
1.57
%
0.33
12
62
6
26
2.34
1.19
9.0
2.7
—
—
—
0
0
21
136
1.60
1.13
5.6
4.8
0.00
0.27
%
—
10
45
8
40
2.04
1.13
3.5
16.8
1.06
1.08
mmol/l
—
8
35
7
31
2.30
1.11
7.9
3.4
61.57
56.81
%
—
7
31
7
31
2.30
1.11
6.4
3.2
4.45
4.66
e9/l
—
7
31
22
145
1.58
1.11
5.6
4.7
0.64
0.91
%
0.42
11
55
69
567
1.32
1.07
1.8
1.8
94.63
94.68
pmol/l
0.00
39
294
145
1317
1.31
1.06
4.1
3.9
14.55
14.56
pmol/l
0.02
132
1211
11
60
1.88
1.05
6.7
2.6
0.65
0.70
%
0.21
11
60
11
60
1.88
1.05
1.5
1.6
0.21
0.22
g/l
0.35
11
60
172
1602
1.37
1.04
8.7
4.9
44.25
38.91
mmol/mol
5.09
161
1515
11
61
1.85
1.00
4.9
8.4
—
—
—
0
0
5
23
2.20
0.98
3.8
3.6
—
—
—
0
0
10
55
1.86
0.93
2.2
1.2
—
—
—
0
0
8
42
1.94
0.89
1.0
1.2
—
—
—
0
0
71
599
1.28
0.89
3.4
3.1
42.35
30.19
ng/l
0.29
44
349
8
43
1.89
0.88
1.0
1.3
—
—
—
0
0
11
64
1.76
0.88
1.5
1.3
—
—
—
0
0
28
207
1.41
0.85
1.7
2.3
4.40
5.93
umol/l
0.99
21
177
19
130
1.51
0.84
5.7
4.9
0.00
0.05
%
—
8
39
11
65
1.73
0.84
10.9
17.1
—
—
—
0
0
16
106
1.55
0.81
1.2
1.2
—
—
—
0
0
32
245
1.36
0.80
1.5
1.6
1444.35
1227.71
nmol/l
0.57
26
187
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
16
107
1.54
0.78
2.2
2.7
160.93
3186.79
u/l
—
9
49
0
27
0.00
0.78
0.0
1.3
—
11.87
—
0
22
5
25
2.02
0.73
1.2
1.2
—
—
—
0
0
177
1683
1.29
0.71
4.6
3.8
6.46
5.81
mmol/l
3.02
163
1570
65
558
1.24
0.70
2.4
2.2
—
—
—
0
0
23
303
0.73
0.69
1.9
1.8
—
—
—
0
0
23
172
1.38
0.67
9.7
7.9
102.17
104.13
mmol/l
1.03
23
172
5
28
1.80
0.66
10.6
4.3
270.00
327.55
umol/l
—
5
22
14
96
1.49
0.63
4.3
2.2
—
—
—
0
0
8
53
1.53
0.59
8.6
14.3
1.61
1.45
%
—
8
48
50
425
1.23
0.59
3.6
2.4
353.90
8213.40
umol/l
2.18
42
379
0
23
0.00
0.58
0.0
3.4
—
46.07
—
0
23
5
86
0.57
0.57
1.2
1.4
—
—
—
0
0
5
88
0.56
0.57
1.2
1.5
—
—
—
0
0
8
55
1.47
0.56
1.1
1.3
—
—
—
0
0
18
235
0.74
0.53
1.4
1.9
—
—
—
0
0
19
144
1.35
0.53
8.8
4.7
—
—
—
0
0
185
1785
1.26
0.52
5.0
3.9
4.65
4.73
mmol/l
0.45
172
1684
42
358
1.22
0.49
4.9
3.4
1.02
1.02
kg/l
—
8
40
10
68
1.49
0.48
1.0
1.1
—
—
—
0
0
10
68
1.49
0.48
15.6
3.7
25.53
24.74
mmol/l
—
10
68
207
2034
1.48
0.47
27.7
17.5
40.13
41.01
%
1.36
200
1936
47
407
1.20
0.47
9.1
7.0
—
—
—
0
0
5
85
0.58
0.46
1.2
1.4
—
—
—
0
0
16
121
1.35
0.45
2.7
3.3
—
—
—
0
0
17
130
1.33
0.45
7.6
12.8
94.72
96.12
%
0.64
17
125
0
15
0.00
0.41
0.0
2.5
—
—
—
0
0
0
15
0.00
0.41
0.0
3.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
7.48
—
0
5
30
252
1.22
0.40
1.5
1.4
544.00
482.91
titre
—
5
55
16
124
1.31
0.40
1.7
1.3
—
—
—
0
0
12
158
0.75
0.38
1.3
1.4
—
—
—
0
0
9
67
1.36
0.38
4.6
3.4
—
—
—
0
0
207
2038
1.42
0.38
27.6
17.5
6.88
6.59
e9/l
1.20
202
1997
183
1778
1.20
0.37
5.0
3.8
1.42
1.45
mmol/l
0.34
170
1673
45
507
0.86
0.37
2.2
2.0
—
—
—
0
0
184
1790
1.19
0.36
19.9
12.0
22.28
21.63
mg/l
0.10
157
1388
6
42
1.44
0.36
2.2
2.7
—
—
—
0
0
177
1720
1.16
0.33
4.5
3.5
1.35
1.29
mmol/l
0.44
163
1606
6
47
1.28
0.32
5.8
2.7
—
—
—
0
0
185
1806
1.17
0.31
5.6
4.2
2.80
2.86
mmol/l
0.39
173
1701
36
317
1.16
0.31
1.5
1.3
27.00
30.15
iu/ml
—
6
96
7
55
1.28
0.30
5.9
4.9
—
—
—
0
0
11
85
1.31
0.28
8.5
10.6
0.89
0.67
%
0.84
11
85
20
168
1.21
0.28
1.3
1.1
—
—
—
0
0
46
417
1.13
0.27
3.4
3.4
—
—
—
0
0
11
86
1.29
0.26
8.5
10.6
1.47
1.67
%
0.29
11
86
5
71
0.70
0.26
2.0
2.2
—
—
—
0
0
13
106
1.24
0.23
1.2
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
262.80
—
0
5
0
10
0.00
0.21
0.0
3.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
150.70
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
6.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
7
59
1.19
0.18
1.6
1.2
—
64.29
—
0
7
18
204
0.87
0.17
1.3
1.3
—
—
—
0
0
132
1284
1.07
0.16
5.5
3.8
11.44
9.44
mm/h
0.98
125
1190
11
92
1.21
0.16
4.5
9.4
—
—
—
0
0
71
679
1.07
0.14
2.4
1.8
—
—
—
0
0
12
136
0.88
0.11
1.5
4.5
2.03
37.99
ug/l
—
7
113
74
766
0.95
0.11
3.0
2.4
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
5
45
1.11
0.10
4.0
4.5
3.80
3.84
mmol/l
—
5
45
10
114
0.87
0.09
4.2
1.9
—
—
—
0
0
40
420
0.94
0.09
2.0
1.7
—
—
—
0
0
31
292
1.07
0.09
2.1
1.6
—
—
—
0
0
192
1904
1.08
0.08
17.1
11.2
—
—
—
0
0
5
63
0.79
0.08
1.2
1.1
—
—
—
0
0
30
316
0.94
0.07
1.4
1.2
0.97
6.39
u/ml
2.34
12
132
19
204
0.92
0.07
1.4
1.4
—
—
—
0
0
10
89
1.13
0.07
4.1
2.0
—
—
—
0
0
30
313
0.95
0.05
2.8
2.7
0.61
0.80
ug/l
1.15
18
169
12
110
1.10
0.05
1.0
1.5
—
—
—
0
0
19
179
1.07
0.05
1.7
1.5
—
—
—
0
0
41
397
1.04
0.05
1.6
1.4
2.99
2.40
g/l
0.57
29
261
27
259
1.05
0.04
1.3
1.5
—
—
—
0
0
12
112
1.08
0.03
1.3
1.2
—
—
—
0
0
21
218
0.96
0.02
1.2
1.2
—
—
—
0
0
12
113
1.07
0.02
2.0
1.7
1.30
1.67
g/l
0.42
12
104
52
526
0.98
0.00
3.9
3.9
1.66
2.00
ug/l
0.39
46
474
11
114
0.96
0.00
4.1
1.9
—
—
—
0
0
136
1358
1.00
0.00
3.6
2.9
46.87
44.76
u/l
0.15
125
1294
11
107
1.03
0.00
4.0
1.9
—
—
—
0
0
54
543
0.99
0.00
1.6
1.6
—
—
—
0
0
11
115
0.95
0.00
4.2
1.6
—
—
—
0
0
11
115
0.95
0.00
4.2
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.18
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
57.02
—
0
6
12
120
1.00
-0.00
1.7
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
7
76
0.92
-0.00
6.7
2.8
—
—
—
0
0
8
83
0.96
-0.00
6.4
2.6
22.25
42.79
u/ml
—
8
78
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
18.33
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
10
100
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_GLAUCOMA_JOAG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCOMA_JOAG.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H7_GLAUCOMA_JOAG – Juvenile Open Angle Glaucoma

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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