Juvenile Open Angle Glaucoma

H7_GLAUCOMA_JOAG

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Pre-conditions: 4<=EVENT_AGE<=40

Registry filters:

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

197

6. Filter based on genotype QC (FinnGen only)

193

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1785 745 1023
Only index persons 1675 714 961
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.03 0.03 0.04
Median age at first event (years)
Whole population 34.05 34.02 34.02
Only index persons 33.98 34.03 33.95

-FinnGen-

Key figures

All Female Male
Number of individuals 193 105 88
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 34.81 34.61 35.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
197
Matched controls
1969
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
114
Kela drug reimbursment
Glaucoma
372.8
186.1
169
31
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
298.0
162.4
149
20
S01ED51
ATC
timolol, combinations; ophthalmic
95.7
115.6
124
34
S01EE01
ATC
latanoprost; ophthalmic
133.8
110.6
112
19
S01ED01
ATC
timolol; ophthalmic
145.7
88.3
89
11
XCK00
NOMESCO Finland
Perimetry
38.3
70.4
91
43
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
163.7
65.6
66
6
S01EX03
ATC
NA
271.7
59.6
58
*
H40.0
ICD-10 Finland
Glaucoma suspect
24.6
53.8
79
52
S01EC03
ATC
dorzolamide; ophthalmic
607.1
49.7
47
*
S01EC04
ATC
brinzolamide; ophthalmic
50.7
48.8
58
16
S01EC01
ATC
acetazolamide; systemic
65.3
46.7
53
11
XCW99
NOMESCO Finland
Other investigative procedure of eye
14.4
43.5
80
89
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
43.3
40
*
S01EE03
ATC
bimatoprost; ophthalmic
90.9
39.8
43
6
S01EE05
ATC
tafluprost; ophthalmic
44.8
39.4
48
14
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
241.4
39.4
39
*
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
34.4
32
*
XCK10
NOMESCO Finland
Photography of fundus of eye
11.1
33.9
70
93
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
45.1
33.0
40
11
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.7
30.0
81
164
H40.9
ICD-10 Finland
Glaucoma, unspecified
87.6
27.6
30
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.1
26.5
56
74
Z96.1
ICD-10 Finland
Presence of intraocular lens
11.7
25.5
49
54
H40.11
ICD-10 Finland
Low pressure glaucoma
50.2
25.4
30
7
S01EE04
ATC
travoprost; ophthalmic
54.0
24.0
28
6
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
18.7
24.0
37
24
XCH00
NOMESCO Finland
Eye pressure measurement
14.9
22.0
37
30
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
21.2
20
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
16.4
19.9
32
23
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.3
19.1
92
330
CHD99
NOMESCO Finland
Other filtering operation
+∞
19.1
18
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
+∞
19.1
18
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.8
19.0
60
138
CHD00
NOMESCO Finland
Laser trabeculoplasty
110.7
18.9
20
*
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
209.0
18.9
19
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.0
18.7
105
434
H26.4
ICD-10 Finland
After-cataract
13.0
18.6
33
30
S01ED02
ATC
betaxolol; ophthalmic
58.4
18.3
21
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
73.7
18.1
20
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
9.4
17.6
37
47
S01EA03
ATC
apraclonidine; ophthalmic
+∞
16.9
16
*
S01EA02
ATC
dipivefrine; ophthalmic
+∞
16.9
16
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
16.9
16
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
10.4
16.2
32
36
WX140
NOMESCO Finland
Parabulbar anesthesy
16.6
15.8
25
17
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
29.8
14.6
19
7
3708
FHL
Trabeculectomy or equivalent
+∞
13.7
13
*
S01EB01
ATC
pilocarpine; ophthalmic
149.8
13.6
14
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
53.7
13.0
15
*
CS494
NOMESCO Finland
Other visual field testing
18.9
12.8
19
11
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
26.4
12.7
17
7
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
12.6
12
*
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
23.1
12.2
17
8
H40.12
ICD-10 Finland
Pigmentary glaucoma
69.2
11.7
13
*
S01BC03
ATC
diclofenac; ophthalmic
14.9
11.7
19
14
Z3229
NOMESCO Finland
Other healthcare associate professional
5.5
11.6
35
74
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
11.6
11
*
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
16.3
11.6
18
12
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
37.4
11.4
14
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
18.4
11.4
17
10
H3603, E103
ICD-10 Finland
NA
13.9
11.4
19
15
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.7
11.3
33
67
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
19.2
10.9
16
9
XCH05
NOMESCO Finland
Eye pressure longterm registration
29.9
10.9
14
5
3651E
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA INFANTILE SEU JUVENILE]
+∞
10.5
10
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
4.8
10.4
35
84
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
9.3
10.3
21
25
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
15.7
10.2
16
11
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
4.7
10.1
35
86
CKC15
NOMESCO Finland
Panretinal photocoagulation
42.4
10.1
12
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
21.4
9.9
14
7
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
6.0
9.8
27
51
A10AA02
ATC
NA
6.5
9.7
25
43
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.1
9.6
26
48
ZXA10
NOMESCO Finland
Bilateral
3.4
9.5
51
184
S01EC54
ATC
brinzolamide, combinations; ophthalmic
23.0
9.5
13
6
Q15.0
ICD-10 Finland
Congenital glaucoma
+∞
9.4
9
*
A10AA01
ATC
NA
6.2
9.1
24
43
H04AA01
ATC
glucagon; nasal, parenteral
6.4
8.9
23
40
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.5
8.9
26
53
A10AE04
ATC
insulin glargine; parenteral
4.5
8.9
32
82
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
9.2
8.5
17
20
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.1
8.4
20
31
37597
ICD-8 Finland
Glaucoma, Suspicio glaucomatis
+∞
8.4
8
*
H26.2
ICD-10 Finland
Complicated cataract
15.3
8.3
13
9
CKD40
NOMESCO Finland
Endophotocoagulation of retina
23.1
8.1
11
5
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.2
8.1
21
37
103
Kela drug reimbursment
Diabetes, insulin-treated
2.8
8.0
57
248
H16.0
ICD-10 Finland
Corneal ulcer
5.8
8.0
22
42
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.9
8.0
56
239
ZXC20
NOMESCO Finland
Use of chemical agents
46.8
7.8
9
*
H40
ICD-10 Finland
Glaucoma
46.8
7.8
9
*
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
46.8
7.8
9
*
H40.8
ICD-10 Finland
Other glaucoma
46.8
7.8
9
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
19.3
7.7
11
6
A10AE05
ATC
insulin detemir; parenteral
4.7
7.6
25
59
ZXA05
NOMESCO Finland
Left side
2.8
7.5
54
236
H27.0
ICD-10 Finland
Aphakia
+∞
7.3
7
*
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
+∞
7.3
7
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
12.7
7.2
12
10
H25.1
ICD-10 Finland
Senile nuclear cataract
3.4
7.1
35
118
H04.10
ICD-10 Finland
Dry eye syndrome
3.7
7.0
30
91
CKC10
NOMESCO Finland
Local photocoagulation of retina
11.5
6.9
12
11
T89
ICPC
Diabetes insulin dependent
5.0
6.8
21
46
Z94.7
ICD-10 Finland
Corneal transplant status
41.5
6.8
8
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
10.6
6.6
12
12
ZXA00
NOMESCO Finland
Right side
2.5
6.5
54
254
S01FA04
ATC
cyclopentolate; ophthalmic
14.9
6.5
10
7
CHD35
NOMESCO Finland
Laser goniopuncture
72.1
6.5
7
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
72.1
6.5
7
*
H40.1
ICD-10 Finland
Primary open-angle glaucoma
72.1
6.5
7
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
72.1
6.5
7
*
H3603, E113
ICD-10 Finland
NA
27.6
6.3
8
*
S01FA01
ATC
atropine; ophthalmic
27.6
6.3
8
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.6
6.1
20
47
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
6.4
6.1
15
25
CHC05
NOMESCO Finland
Iridotomy
10.5
6.1
11
11

Mortality – FinRegistry

Association

Association between endpoint H7_GLAUCOMA_JOAG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCOMA_JOAG.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H7_GLAUCOMA_JOAG – Juvenile Open Angle Glaucoma

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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