No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3030 |
4. Check minimum number of eventsNone |
3030 |
5. Include endpointsNone |
3030 |
6. Filter based on genotype QC (FinnGen only) |
3030 |
Control definitions (FinnGen only)
- Control exclude
- H7_GLAUCOMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- H401
- Name in latin
- Glaucoma non hypertensivum [primarium/residuale]
Similar endpoints
↥List of similar endpoints to
Normotensive glaucoma
based on the number of shared cases.
Similar with more cases:
- Primary open-angle glaucoma, strict
- Primary open-angle glaucoma
- Glaucoma
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19419 | 12986 | 6379 |
| Only index persons | 18134 | 12188 | 5946 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.31 | 0.37 | 0.18 |
| Only index persons | 0.38 | 0.45 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 73.06 | 73.32 | 72.54 |
| Only index persons | 72.75 | 73.01 | 72.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3030 | 1941 | 1089 |
| Unadjusted period prevalence (%) | 0.60 | 0.66 | 0.48 |
| Median age at first event (years) | 71.59 | 70.98 | 72.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2691
- Matched controls
- 26908
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
58.9
323.0
569
122
S01EE01
ATC
latanoprost; ophthalmic
98.9
323.0
1468
322
S01EE04
ATC
travoprost; ophthalmic
58.4
323.0
477
99
H40.0
ICD-10 Finland
Glaucoma suspect
258.0
323.0
1071
69
S01EC04
ATC
brinzolamide; ophthalmic
141.5
323.0
1006
113
S01ED51
ATC
timolol, combinations; ophthalmic
87.9
323.0
1511
387
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
352.2
323.0
644
24
XCK00
NOMESCO Finland
Perimetry
28.8
323.0
921
478
114
Kela drug reimbursment
Glaucoma
334.0
323.0
2283
445
XCH05
NOMESCO Finland
Eye pressure longterm registration
731.0
323.0
323
5
H40.11
ICD-10 Finland
Low pressure glaucoma
4503599627370496.0
323.0
2679
7
S01ED01
ATC
timolol; ophthalmic
28.7
323.0
459
191
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
233.8
323.0
512
27
S01EE05
ATC
tafluprost; ophthalmic
81.3
323.0
766
131
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
2259.2
323.0
903
6
S01EE03
ATC
bimatoprost; ophthalmic
119.6
323.0
567
60
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
217.9
319.8
326
17
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
8.4
317.7
786
1259
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.0
299.7
857
1684
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
762.9
283.8
275
*
CHD00
NOMESCO Finland
Laser trabeculoplasty
2542.4
255.1
243
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.3
254.9
936
2441
S01EX03
ATC
NA
49.4
252.1
307
70
S01EC54
ATC
brinzolamide, combinations; ophthalmic
129.9
232.7
248
21
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
227.3
215
*
S01EC03
ATC
dorzolamide; ophthalmic
87.3
227.1
253
32
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.8
225.7
917
2610
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
193.2
222.9
230
13
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
43.3
221.7
277
71
H40.9
ICD-10 Finland
Glaucoma, unspecified
115.3
215.0
232
22
S01ED02
ATC
betaxolol; ophthalmic
108.7
210.9
229
23
CS494
NOMESCO Finland
Other visual field testing
31.1
203.8
275
98
XCH00
NOMESCO Finland
Eye pressure measurement
11.6
200.1
391
387
XCK10
NOMESCO Finland
Photography of fundus of eye
5.0
180.0
663
1644
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
+∞
151.5
144
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
24.3
144.8
209
93
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
133.2
1613
9514
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.7
126.4
1457
8238
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.5
122.3
394
811
WX140
NOMESCO Finland
Parabulbar anesthesy
6.6
121.7
335
565
S01EC01
ATC
acetazolamide; systemic
19.4
120.7
187
103
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
113.1
1254
6779
CHD35
NOMESCO Finland
Laser goniopuncture
+∞
110.1
105
*
CHC05
NOMESCO Finland
Iridotomy
44.7
103.4
128
30
H40
ICD-10 Finland
Glaucoma
35.5
101.5
132
39
CS2P4
NOMESCO Finland
Optic nerve head imaging
112.4
99.7
108
10
ZXA10
NOMESCO Finland
Bilateral
2.7
95.2
816
3714
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.2
78.0
1293
8028
S01EB01
ATC
pilocarpine; ophthalmic
75.1
64.4
73
10
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
59.6
57
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.5
59.3
529
2368
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.7
54.4
422
1739
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
18.8
52.9
82
45
CHD99
NOMESCO Finland
Other filtering operation
527.9
52.7
52
*
CFW99
NOMESCO Finland
Other operation on conjunctiva
254.7
49.2
50
*
H26.4
ICD-10 Finland
After-cataract
2.5
48.7
451
2041
F93
ICPC
Glaucoma
46.3
48.4
59
13
TCG20
NOMESCO Finland
Laser suture lysis in cornea or sclera
+∞
48.1
46
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
455.1
45.4
45
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
41.8
40
*
ZXC20
NOMESCO Finland
Use of chemical agents
5.0
39.2
131
273
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
393.0
39.2
39
*
F43
ICPC
Eye, Other diagnostic procedure
6.2
33.8
93
154
H52.1
ICD-10 Finland
Myopia
6.3
32.6
89
146
SPAT1009
SPAT
Measurement of intraocular pressure
6.4
32.0
86
138
H40.8
ICD-10 Finland
Other glaucoma
107.9
29.7
32
*
H25.0
ICD-10 Finland
Senile incipient cataract
2.4
28.3
256
1127
H40.1
ICD-10 Finland
Primary open-angle glaucoma
64.7
28.0
32
5
H53.4
ICD-10 Finland
Visual field defects
4.3
27.9
106
253
A98
ICPC
Health maint/preventive medicine
2.1
26.7
2477
22815
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
5.5
26.2
79
148
F38
ICPC
Eye, Other laboratory test NEC
13.5
25.5
44
33
S01EA03
ATC
apraclonidine; ophthalmic
9.8
25.2
51
53
S01EA02
ATC
dipivefrine; ophthalmic
131.2
24.6
26
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.4
24.2
121
367
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.9
23.8
147
517
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
54.5
23.1
27
5
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
22.9
22
*
WX002
NOMESCO Finland
Sedation and analgesia
1.7
22.1
594
3922
3651C
ICD-9 Finland
Glaucoma, Open-angle glaucoma[MATALAPAINEGLAUKOOMA]
+∞
21.9
21
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
3.7
21.6
97
271
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
9.0
21.3
45
51
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
20.6
280
1472
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
2.9
20.0
125
444
ZXA05
NOMESCO Finland
Left side
1.5
18.8
752
5451
WX110
NOMESCO Finland
Local anesthesy
1.4
18.2
1576
13339
CFB00
NOMESCO Finland
Suture of conjunctiva
26.9
17.8
24
9
H40.12
ICD-10 Finland
Pigmentary glaucoma
+∞
17.7
17
*
CHC03
NOMESCO Finland
Laser iridoplasty
95.7
17.6
19
*
3650A
ICD-9 Finland
Glaucoma, Borderline glaucoma [glaucoma suspect][SUSPICIO GLAUCOMATIS (AVOKULMA)]
+∞
16.7
16
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
7.5
16.4
38
51
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.0
16.1
92
309
XCW10
NOMESCO Finland
Assessment of vision
8.6
15.9
34
40
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
+∞
15.6
15
*
S01EX
ATC
Other antiglaucoma preparations
+∞
15.6
15
*
S01EX05
ATC
netarsudil; ophthalmic
+∞
15.6
15
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.0
14.3
84
289
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
7.2
14.0
33
46
SPAT1310
SPAT
Counselling related to known health issue
1.4
12.7
816
6397
H52.2
ICD-10 Finland
Astigmatism
4.7
12.4
41
88
CA1ME
NOMESCO Finland
Ultrasound oculometry
4.9
12.3
39
80
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
1.9
12.3
197
1101
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
11.6
1108
9238
3708
FHL
Trabeculectomy or equivalent
+∞
11.5
11
*
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
11.5
11
*
37597
ICD-8 Finland
Glaucoma, Suspicio glaucomatis
+∞
11.5
11
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
8.9
11.2
23
26
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
3.1
11.1
59
192
S01GX01
ATC
cromoglicic acid; ophthalmic
1.5
10.8
405
2853
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.7
10.7
71
265
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
1.9
10.4
151
814
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
+∞
10.4
10
*
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
+∞
10.4
10
*
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
2.8
10.2
62
222
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
3.5
10.1
46
134
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2.5
9.9
75
306
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.3
9.5
743
5965
H25.8
ICD-10 Finland
Other senile cataract
1.5
9.3
354
2499
SPAT1301
SPAT
No procedures
1.3
9.3
845
6935
H01.0
ICD-10 Finland
Blepharitis
2.0
9.2
118
610
-44
ICPC
Preventive immunization/medic
1.6
9.1
245
1597
H20.8
ICD-10 Finland
Other iridocyclitis
8.3
9.1
19
23
S01BC03
ATC
diclofenac; ophthalmic
2.5
9.0
66
264
ZXA00
NOMESCO Finland
Right side
1.3
9.0
728
5864
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.4
8.9
491
3716
H16.0
ICD-10 Finland
Corneal ulcer
2.2
8.8
89
416
R42
ICD-10 Finland
Dizziness and giddiness
1.4
8.8
603
4736
CD2S4
NOMESCO Finland
Photography of eye
5.5
8.6
24
44
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
8.2
8.6
18
22
WX142
NOMESCO Finland
Sub-tenon anesthesy
6.0
8.4
22
37
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
90.3
8.4
9
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
3.0
8.4
46
156
TCG10
NOMESCO Finland
Removal of sutures from cornea
4.8
8.4
26
54
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
+∞
8.3
8
*
CHD20
NOMESCO Finland
Posterior sclerotomy
+∞
8.3
8
*
S18
ICPC
Laceration/cut
1.3
8.2
1078
9256
H02.4
ICD-10 Finland
Ptosis of eyelid
2.2
8.1
82
386
CWD00
NOMESCO Finland
Reoperation for superficial heamorrhage in eye and adjacent structures
33.4
8.1
10
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.7
8.0
170
1041
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
5.3
8.0
23
44
SPAT1153
SPAT
Removal of sutures
1.3
7.9
835
6964
CKC12
NOMESCO Finland
Photocoagulation of retina
2.1
7.8
89
441
XF404
NOMESCO Finland
Ambulatory ECG
1.5
7.7
258
1767
SPAT1325
SPAT
Vaccination
1.3
7.6
956
8141
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.3
7.5
552
4368
S01BC05
ATC
ketorolac; ophthalmic
1.8
7.5
121
680
WX720
NOMESCO Finland
Own respiration
2.0
7.5
87
436
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
2.3
7.5
65
287
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
1.6
7.4
194
1258
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.3
7.4
707
5805
SPAT1312
SPAT
General health counselling
1.3
7.3
742
6139
CHF12
NOMESCO Finland
Endoscopic laser coagulation of ciliary body
+∞
7.3
7
*
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
7.3
932
7947
CFD10
NOMESCO Finland
Repair of conjunctiva
20.1
7.1
10
5
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.6
7.1
156
968
WX402
NOMESCO Finland
General anaesthesia
1.4
7.1
328
2403
I49.5
ICD-10 Finland
Sick sinus syndrome
1.7
7.1
130
765
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
7.0
1281
11360
SPAT1260
SPAT
Consultation of another employee
1.4
6.9
442
3418
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.2
6.9
1308
11642
Z01.9
ICD-10 Finland
Special examination, unspecified
1.7
6.9
135
810
H02
ICPC
Hearing complaint
1.4
6.8
351
2617
F29
ICPC
Eye symptom/complaint other
1.6
6.8
186
1219
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
2.9
6.8
37
127
-1
SPAT
NA
2.1
6.7
73
357
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
4.3
6.7
23
54
AA1AD
NOMESCO Finland
CT of head and brain
1.3
6.7
639
5235
J01CA04
ATC
amoxicillin; systemic
1.2
6.5
1843
17095
H47.2
ICD-10 Finland
Optic atrophy
5.7
6.4
17
30
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
6.4
1103
9684
CHB99
NOMESCO Finland
Other operation on anterior chamber and anterior chamber angle
70.0
6.4
7
*
H35.37
ICD-10 Finland
Macular holes
2.5
6.4
46
186
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
2.3
6.4
57
254
F99
ICPC
Eye/adnexa disease other
4.2
6.3
22
53
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
18.0
6.3
9
5
CHD60
NOMESCO Finland
Deep sclerectomy without implant
+∞
6.2
6
*
S01EXXX
ATC
NA
+∞
6.2
6
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
6.2
480
3815
H13
ICPC
Plugged feeling ear
1.3
6.2
466
3690
L03
ICPC
Low back symptom/complaint
1.3
6.1
546
4429
CKD40
NOMESCO Finland
Endophotocoagulation of retina
2.7
6.1
37
136
SPAT1281
SPAT
Other administrative function
1.5
6.1
181
1211
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.1
6.0
65
317
H91.1
ICD-10 Finland
Presbycusis
1.5
6.0
186
1254
K78
ICPC
Atrial fibrillation/flutter
1.5
6.0
233
1647
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCOMA_NTG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCOMA_NTG | 0.892 [0.81, 0.98] | 0.022 |
| Birth year | 0.993 [0.99, 1.0] | 0.113 |
During the follow-up period (1.1.1998 — 31.12.2019), 2411 out of 10420 females with H7_GLAUCOMA_NTG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCOMA_NTG | 0.969 [0.85, 1.1] | 0.63 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1393 out of 5088 males with H7_GLAUCOMA_NTG died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCOMA_NTG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.051% | 0.175% |
| 5 | 0.396% | 1.106% |
| 10 | 1.104% | 2.751% |
| 15 | 2.302% | 5.426% |
| 20 | 4.091% | 8.938% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCOMA_NTG – Normotensive glaucoma
GWS hits: 14
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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