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Primary angle-closure glaucoma

DOID EFO Endpoint Browser PheWeb

H7_GLAUCCLOSEPRIM

primary angle closure glaucoma: The sudden increase of intraocular pressure, resulting in pain and an abrupt decrease in visual acuity.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H40.2
  • Hospital discharge: ICD-9 — 3652
  • Hospital discharge: ICD-8 — 37500|37511
  • Cause of death: ICD-10 — H40.2
  • Cause of death: ICD-9 — 3652
  • Cause of death: ICD-8 — 37500|37511

2 out of 7 registries used, show all original rules.

1725

4. Check minimum number of events

None

1725

5. Include endpoints

None

1725

6. Filter based on genotype QC (FinnGen only)

1662

Control definitions (FinnGen only)

Control exclude
H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H40
Name in latin
Glaucoma congestivum primarium

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17902 11851 5834
Only index persons 13200 8791 4409
Unadjusted period prevalence (%)
Whole population 0.28 0.34 0.16
Only index persons 0.27 0.32 0.17
Median age at first event (years)
Whole population 68.78 69.73 66.90
Only index persons 67.76 68.71 65.87

-FinnGen-

Key figures

All Female Male
Number of individuals 1662 976 686
Unadjusted period prevalence (%) 0.33 0.35 0.31
Median age at first event (years) 66.64 66.28 67.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1725
Matched controls
17250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
S01EC03
ATC
dorzolamide; ophthalmic
66.2
314.0
173
29
CHC05
NOMESCO Finland
Iridotomy
773.4
307.7
794
19
S01EA05
ATC
brimonidine; ophthalmic
202.6
307.7
315
19
XCK00
NOMESCO Finland
Perimetry
22.5
307.7
469
282
S01EC01
ATC
acetazolamide; systemic
48.3
307.7
287
71
H40.0
ICD-10 Finland
Glaucoma suspect
151.1
307.7
548
53
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
260.5
307.7
369
18
114
Kela drug reimbursment
Glaucoma
91.4
307.7
1025
272
S01EE03
ATC
bimatoprost; ophthalmic
49.4
307.7
205
47
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
+∞
307.7
625
*
S01EX03, ,
ATC
60.0
307.7
243
47
S01EE01
ATC
latanoprost; ophthalmic
50.8
307.7
672
214
S01ED51
ATC
timolol, combinations; ophthalmic
86.4
307.7
984
261
S01EE05
ATC
tafluprost; ophthalmic
42.5
307.7
288
81
S01ED01
ATC
timolol; ophthalmic
44.3
307.7
429
128
S01EC04
ATC
brinzolamide; ophthalmic
81.2
307.7
415
67
H40.9
ICD-10 Finland
Glaucoma, unspecified
224.3
307.7
216
11
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
16384.0
307.7
994
*
S01EB01
ATC
pilocarpine; ophthalmic
150.1
307.7
245
19
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
27.9
280.8
194
78
S01EE04
ATC
travoprost; ophthalmic
37.4
265.0
166
49
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.4
245.7
687
1874
S01EC54
ATC
brinzolamide, combinations; ophthalmic
114.0
228.9
117
11
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
31.4
211.1
139
48
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
533.4
195.6
191
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
1046.2
194.7
187
*
S01EA03
ATC
apraclonidine; ophthalmic
35.4
187.9
119
36
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.5
186.6
440
1013
XCH00
NOMESCO Finland
Eye pressure measurement
9.0
179.3
238
302
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.8
176.5
380
804
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.2
176.4
1149
5573
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.6
175.9
558
1631
S01ED02
ATC
betaxolol; ophthalmic
59.7
171.5
96
17
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
304.6
164.8
165
6
H40
ICD-10 Finland
Glaucoma
49.7
161.8
94
20
CS494
NOMESCO Finland
Other visual field testing
18.7
160.8
130
75
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
24.1
159.3
115
51
H40.21
ICD-10 Finland
Intermittent glaucoma with closed ventricular angle
+∞
144.9
137
*
H40.11
ICD-10 Finland
Low pressure glaucoma
70.7
124.9
68
10
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
+∞
123.4
117
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.0
111.4
914
4668
H40.29
ICD-10 Finland
Other [primary] glaucoma with closed ventricular angle
+∞
110.6
105
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.1
102.0
325
922
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.9
100.5
940
5066
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
6.7
96.8
161
260
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
936.5
91.7
89
*
3652B
ICD-9 Finland
Glaucoma, Primary angle-closure glaucoma[KROONINEN AHDASKULMAGLAUKOOMA]
+∞
83.0
79
*
S01BA07
ATC
fluorometholone; ophthalmic
10.6
79.0
88
87
WX140
NOMESCO Finland
Parabulbar anesthesy
5.1
78.1
177
381
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.4
78.1
334
1142
CHD00
NOMESCO Finland
Laser trabeculoplasty
204.1
75.8
78
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
15.5
71.9
63
42
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
71.2
975
5980
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.9
66.5
393
1607
H26.4
ICD-10 Finland
After-cataract
2.9
63.2
357
1421
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.1
62.4
184
486
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
60.8
58
*
3652A
ICD-9 Finland
Glaucoma, Primary angle-closure glaucoma[AKUUTTI AHDASKULMAGLAUKOOMA]
+∞
57.6
55
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
53.4
51
*
XCH05
NOMESCO Finland
Eye pressure longterm registration
85.8
52.2
58
7
H40.8
ICD-10 Finland
Other glaucoma
523.1
51.7
51
*
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
92.9
49.1
54
6
37511
ICD-8 Finland
Glaucoma, Chronicum irritativum sive congestivum
+∞
43.9
42
*
37500
ICD-8 Finland
Glaucoma, Primary, acute
+∞
41.8
40
*
CHD99
NOMESCO Finland
Other filtering operation
+∞
40.8
39
*
ZXA10
NOMESCO Finland
Bilateral
2.2
40.3
426
2227
XCW10
NOMESCO Finland
Assessment of vision
9.3
38.7
47
52
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
38.7
37
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
6.1
37.9
67
114
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
37.6
36
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
4.9
37.4
85
182
S01EA02
ATC
dipivefrine; ophthalmic
364.7
36.1
36
*
H40.2
ICD-10 Finland
Primary angle-closure glaucoma
+∞
35.5
34
*
SPAT1009
SPAT
Measurement of intraocular pressure
6.9
35.4
55
82
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
6.2
33.4
58
97
CS2P4
NOMESCO Finland
Optic nerve head imaging
41.9
33.2
41
10
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.7
32.5
52
80
F93
ICPC
Glaucoma
34.1
31.0
40
12
H26.2
ICD-10 Finland
Complicated cataract
6.9
30.2
47
70
H40.12
ICD-10 Finland
Pigmentary glaucoma
307.6
29.9
30
*
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
29.2
28
*
S01BA01
ATC
dexamethasone; ophthalmic
3.6
29.1
100
292
S01FA01
ATC
atropine; ophthalmic
10.9
26.9
29
27
A10AA01, ,
ATC
4.7
26.3
61
133
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
26.2
195
868
ZXA05
NOMESCO Finland
Left side
1.8
26.2
525
3357
CHD35
NOMESCO Finland
Laser goniopuncture
+∞
26.1
25
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
9.8
25.9
30
31
S01BC03
ATC
diclofenac; ophthalmic
4.1
25.6
71
178
CHC03
NOMESCO Finland
Laser iridoplasty
+∞
25.1
24
*
3708
FHL
Trabeculectomy or equivalent
+∞
25.1
24
*
H3603, E103,
ICD-10 Finland
23.8
24.8
35
15
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.8
24.3
76
208
H57.1
ICD-10 Finland
Ocular pain
3.8
24.0
75
205
CFW99
NOMESCO Finland
Other operation on conjunctiva
+∞
24.0
23
*
S01BA04
ATC
prednisolone; ophthalmic
4.1
23.3
65
164
H43.1
ICD-10 Finland
Vitreous haemorrhage
4.0
22.5
65
168
CKC15
NOMESCO Finland
Panretinal photocoagulation
6.5
22.2
36
56
H16.0
ICD-10 Finland
Corneal ulcer
3.1
22.1
96
324
CHC00
NOMESCO Finland
Iridotomy
+∞
21.9
21
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
21.9
21
*
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
116.5
21.6
23
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
3.8
21.1
65
176
CKC12
NOMESCO Finland
Photocoagulation of retina
3.2
20.8
82
261
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
7.7
20.0
28
37
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
8.2
19.7
26
32
A10AB01
ATC
insulin (human); parenteral
3.4
19.4
71
216
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
19.4
203
1036
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
+∞
18.8
18
*
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
192.0
18.6
19
*
ZXA00
NOMESCO Finland
Right side
1.6
18.2
522
3615
H25.0
ICD-10 Finland
Senile incipient cataract
2.2
18.2
155
729
H26.02
ICD-10 Finland
Presenil cataract
3.6
18.2
59
166
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.5
17.9
121
514
F43
ICPC
Eye, Other diagnostic procedure
4.3
17.9
46
109
CKD40
NOMESCO Finland
Endophotocoagulation of retina
4.9
17.8
39
81
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
17.7
17
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
3.7
17.1
54
149
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
3.6
16.9
56
160
3650A
ICD-9 Finland
Glaucoma, Borderline glaucoma [glaucoma suspect][SUSPICIO GLAUCOMATIS (AVOKULMA)]
+∞
16.7
16
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
13.7
16.0
27
20
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
4.6
15.7
37
82
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
11.9
15.1
27
23
H25.8
ICD-10 Finland
Other senile cataract
1.8
15.0
274
1672
H36.00
ICD-10 Finland
Diabetic background retinopathy
4.6
15.0
35
77
E10
ICD-10 Finland
Type 1 diabetes mellitus
4.9
14.8
32
66
CHD10
NOMESCO Finland
Trabeculectomy
+∞
14.6
14
*
H40.1
ICD-10 Finland
Primary open-angle glaucoma
80.8
14.6
16
*
37597
ICD-8 Finland
Glaucoma, Suspicio glaucomatis
+∞
13.6
13
*
CHB99
NOMESCO Finland
Other operation on anterior chamber and anterior chamber angle
141.1
13.5
14
*
H52.0
ICD-10 Finland
Hypermetropia
3.6
13.1
43
122
3661A
ICD-9 Finland
Cataract, Senile cataract
3.5
13.1
45
132
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.2
13.0
34
82
A10AA02, ,
ATC
2.6
12.9
73
285
S01BC05
ATC
ketorolac; ophthalmic
2.2
12.8
105
486
A10AB04
ATC
insulin lispro; parenteral
3.1
12.7
52
170
CKD60
NOMESCO Finland
Anterior vitrectomy
4.8
12.6
28
59
H04AA01
ATC
glucagon; nasal, parenteral
4.7
12.6
29
63
S01EX
ATC
Other antiglaucoma preparations
+∞
12.5
12
*
ZXC20
NOMESCO Finland
Use of chemical agents
3.1
12.4
51
167
ZYC01
NOMESCO Finland
Remote contact by phone
2.3
12.4
92
408
F38
ICPC
Eye, Other laboratory test NEC
4.4
12.2
30
69
H3601, E103,
ICD-10 Finland
11.8
11.8
21
18
S01FA04
ATC
cyclopentolate; ophthalmic
4.2
11.8
31
75
T89
ICPC
Diabetes insulin dependent
2.8
11.7
59
217
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
2.5
11.5
70
284
CA1ME
NOMESCO Finland
Ultrasound oculometry
5.1
11.5
24
48
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
11.9
11.3
20
17
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
9.0
11.3
23
26
A10AB05
ATC
insulin aspart; parenteral
1.9
11.2
136
729
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
4.7
11.0
25
54
H44.5
ICD-10 Finland
Degenerated conditions of globe
43.6
10.9
13
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.6
10.9
60
232
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
3.4
10.8
39
118
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
10.6
10.8
20
19
S01EE51
ATC
latanoprost and netarsudil; ophthalmic
110.7
10.4
11
*
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
10.4
10
*
Q15.0
ICD-10 Finland
Congenital glaucoma
+∞
10.4
10
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
8.5
10.0
21
25
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
4.2
9.9
26
63
H35.36
ICD-10 Finland
Macular cyst
5.2
9.8
20
39
E0000UV, ,
ATC
1.4
9.8
626
4981
Z94.0
ICD-10 Finland
Kidney transplant status
4.9
9.8
21
43
A10AE06
ATC
insulin degludec; parenteral
2.6
9.6
55
217
A10AC01
ATC
insulin (human); parenteral
1.8
9.6
143
821
R42
ICD-10 Finland
Dizziness and giddiness
1.5
9.5
413
3063
CKD15
NOMESCO Finland
Injection of vitreous substitute
9.1
9.5
19
21
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.6
9.5
52
201
3704
FHL
Iridectomy
+∞
9.4
9
*
TCG20
NOMESCO Finland
Laser suture lysis in cornea or sclera
+∞
9.4
9
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
21.8
9.4
13
6
H3603, E113,
ICD-10 Finland
4.4
9.1
22
50
ZXE00
NOMESCO Finland
One hour or less
1.4
9.0
594
4741
127
Kela drug reimbursment
Transplant complication
3.9
8.9
25
64
H21.0
ICD-10 Finland
Hyphaema
12.6
8.9
15
12
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
3.6
8.8
28
78
CKD20
NOMESCO Finland
Removal of vitreous body substitute
7.2
8.7
20
28
WX002
NOMESCO Finland
Sedation and analgesia
1.5
8.7
327
2353
Z3231
NOMESCO Finland
Registered nurse
1.4
8.6
432
3283
CHC10
NOMESCO Finland
Peripheral iridectomy
90.5
8.4
9
*
137
Kela drug reimbursment
Uraemia requiring dialysis
4.7
8.4
19
41
3711
FHL
Cyclodiateria or cryocoagulation
+∞
8.3
8
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2.4
8.2
54
228
A10AE05
ATC
insulin detemir; parenteral
2.0
8.2
89
460
F99
ICPC
Eye/adnexa disease other
4.8
8.1
18
38
171
Kela drug reimbursment
Degludekinsuliini
17.3
8.1
12
7
CFB00
NOMESCO Finland
Suture of conjunctiva
45.2
7.7
9
*
H36.01
ICD-10 Finland
Diabetic maculopathy
3.5
7.7
26
76
S18
ICPC
Laceration/cut
1.3
7.6
720
6030
H54.0
ICD-10 Finland
Blindness, binocular
18.4
7.6
11
6
H27.1
ICD-10 Finland
Dislocation of lens
6.7
7.6
18
27
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
7.6
514
4095
H31.4
ICD-10 Finland
Choroidal detachment
25.1
7.6
10
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.8
7.6
118
687
L04AA06
ATC
mycophenolic acid; systemic
3.3
7.5
28
87
CKC20
NOMESCO Finland
Cryopexy of undetached retina
10.1
7.5
14
14
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
7.1
7.5
17
24
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
3.9
7.4
21
54
S01AD03
ATC
aciclovir; ophthalmic
2.2
7.3
61
286
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
+∞
7.3
7
*
3705
FHL
Iridectomy or iridotomy using a laser under general anesthesia
+∞
7.3
7
*
3650B
ICD-9 Finland
Glaucoma, Borderline glaucoma [glaucoma suspect][SUSPICIO GLAUCOMATIS (AHDASKULMA)]
+∞
7.3
7
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
7.3
7
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
6.9
7.3
17
25
H3600, E103,
ICD-10 Finland
6.1
7.1
18
30
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
2.7
7.0
37
141
XCD20
NOMESCO Finland
Photoangiography of eye
2.7
6.9
36
136
S01FA02
ATC
scopolamine; ophthalmic
4.0
6.9
19
48
CWD00
NOMESCO Finland
Reoperation for superficial heamorrhage in eye and adjacent structures
40.2
6.8
8
*
CH2X4
NOMESCO Finland
Optical coherence tomography (OCT) of iris and iridocorneal angle
22.6
6.7
9
*
F01
ICPC
Eye pain
2.5
6.5
39
158
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
6.2
6.5
16
26
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
1.8
6.4
86
478
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
70.1
6.4
7
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.5
6.3
190
1303
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
9.3
6.3
12
13
H54.4
ICD-10 Finland
Blindness, monocular
9.3
6.3
12
13
N02BE01
ATC
paracetamol; systemic, rectal
1.4
6.3
1439
13490
H21.5
ICD-10 Finland
Other adhesions and disruptions of iris and ciliary body
+∞
6.3
6
*
S01EB02
ATC
carbachol; ophthalmic
+∞
6.3
6
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
6.3
6
*
SPAT1312
SPAT
General health counselling
1.3
6.2
432
3439
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
6.2
633
5318
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
6.2
235
1690
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
6.3
6.2
15
24
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
6.1
420
3339
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
6.0
978
8705
H25.2
ICD-10 Finland
Senile cataract, morgagnian type
5.2
6.0
17
33
B05DA
ATC
Isotonic solutions
5.2
6.0
17
33

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
475
3611
1.44
9.61
5.4
4.6
0.00
0.00
estimate
0.50
178
1172
713
5895
1.36
8.50
2.3
2.3
80.61
79.78
nmol/l
0.29
616
5133
887
7599
1.34
8.29
7.2
6.8
1.22
1.22
mmol/l
0.20
725
6450
817
6940
1.34
7.97
6.5
6.0
1.21
1.21
mmol/l
0.19
726
6257
705
5869
1.34
7.85
4.6
4.1
53.44
65.18
ng/l
0.31
554
4455
1442
13399
1.46
7.79
18.4
16.3
—
—
—
0
0
190
1246
1.59
7.74
4.5
3.9
1.23
1.23
mmol/l
0.03
166
1076
58
261
2.26
7.66
4.6
3.1
60.76
58.86
%
0.58
58
261
241
1672
1.51
7.63
2.0
1.8
—
—
—
0
0
188
1248
1.57
7.27
3.5
3.7
—
—
—
0
0
563
4573
1.34
7.26
2.2
2.1
150.78
215.78
u/l
2.14
508
4261
781
6654
1.32
7.20
6.2
5.7
0.00
0.00
estimate
-0.00
185
1214
1320
12128
1.38
7.15
5.3
5.0
1.94
2.13
mu/l
1.09
1164
10856
55
251
2.23
7.05
4.0
2.9
4.50
4.34
e9/l
0.21
55
251
1190
10801
1.33
6.71
7.7
7.6
80.77
80.54
u/l
0.05
1114
10064
778
6670
1.30
6.68
4.8
4.2
0.00
0.00
estimate
0.75
190
1346
785
6739
1.30
6.67
4.9
4.2
0.00
0.00
estimate
0.80
176
1202
1477
13877
1.45
6.67
22.2
20.2
139.50
139.58
mmol/l
0.49
1440
13494
1479
13908
1.44
6.56
22.5
20.4
4.00
3.99
mmol/l
0.65
1441
13505
637
5334
1.31
6.46
4.3
3.9
5.84
5.79
ph
0.11
19
244
1058
9501
1.29
6.15
5.9
5.3
98.90
2060.95
e6/l
—
10
160
837
7314
1.28
5.96
18.5
18.4
1.29
1.35
inr
0.89
251
1990
16
30
5.37
5.84
1.7
1.6
—
—
—
0
0
1406
13177
1.36
5.75
18.8
17.0
25.07
26.32
mg/l
0.64
1170
10693
163
1107
1.52
5.70
6.0
4.6
—
—
—
0
0
674
5755
1.28
5.69
10.9
10.2
0.00
0.00
e9/l
0.38
569
4651
547
4553
1.29
5.63
5.1
4.0
7.40
7.40
ph
0.16
122
825
1505
14278
1.42
5.59
27.5
25.1
39.40
39.12
%
0.96
1370
13169
1505
14282
1.42
5.55
27.5
25.0
247.29
245.43
e9/l
0.48
1463
13816
1505
14283
1.42
5.53
27.3
24.9
30.31
30.37
pg
0.63
1480
13990
1505
14283
1.42
5.53
27.4
25.0
6.98
6.87
e9/l
0.56
1456
13759
1505
14283
1.42
5.53
27.4
24.9
91.56
91.62
fl
0.21
1479
13990
1505
14284
1.42
5.52
27.5
25.0
4.37
4.38
e12/l
0.37
1454
13765
389
3098
1.33
5.50
3.7
3.0
520.54
533.66
mosm/kgh2o
0.58
337
2638
1505
14288
1.42
5.48
27.7
25.1
131.59
132.13
g/l
0.69
1478
14000
1465
13859
1.38
5.32
11.7
11.2
23.03
24.46
u/l
3.83
1403
13250
753
6573
1.26
5.14
4.8
4.7
34.63
34.71
g/l
0.15
679
6062
533
4475
1.28
5.01
3.4
2.4
73.40
77.68
u/l
0.07
484
4083
396
3202
1.31
4.98
3.4
2.7
4.38
5.52
e6/l
1.66
360
2877
1098
10036
1.26
4.92
4.4
4.1
15.21
15.10
pmol/l
0.66
972
8929
712
6204
1.25
4.85
6.1
6.1
—
—
—
0
0
1057
9628
1.25
4.84
5.6
4.8
—
—
—
0
0
843
7498
1.24
4.74
5.6
6.1
11.07
11.97
umol/l
1.68
781
7090
533
4508
1.26
4.66
3.5
3.1
6.91
6.86
mmol/l
0.11
447
3698
315
2493
1.32
4.60
1.3
1.2
1.95
1.52
u/ml
0.20
94
611
403
3307
1.29
4.48
1.8
1.7
20328341.57
24028836.88
pmol/l
0.06
305
2676
937
8460
1.24
4.48
5.3
4.8
7.05
6.83
mmol/l
2.13
882
7961
70
412
1.73
4.42
1.4
1.4
—
—
—
0
0
549
4683
1.25
4.42
4.2
3.8
8.92
9.06
mg/mmol
0.03
345
2858
59
333
1.80
4.31
1.6
1.9
9.76
12.71
mg/l
1.68
51
308
1316
12362
1.27
4.30
7.2
6.4
41.90
40.72
mmol/mol
3.78
1184
11201
587
5061
1.24
4.26
2.8
3.1
1494.62
1737.90
ng/l
0.99
503
4362
489
4132
1.26
4.24
3.9
3.3
0.42
0.54
e6/l
0.59
404
3193
11
21
5.26
4.14
5.8
5.0
—
—
—
0
0
626
5451
1.23
4.11
3.0
2.8
142.87
140.91
ug/l
0.07
554
4928
773
6881
1.22
4.10
5.6
5.7
0.19
0.19
e9/l
0.10
670
5939
288
2291
1.31
4.03
1.9
1.9
30.16
29.89
s
0.18
279
2210
147
1051
1.44
4.02
1.8
1.5
—
—
—
0
0
21
81
2.61
3.98
1.0
1.2
—
—
—
0
0
596
5182
1.23
3.93
3.7
3.6
—
—
—
0
0
1362
12893
1.27
3.90
5.2
5.0
6.22
6.05
mmol/l
3.35
1205
11454
517
4433
1.24
3.88
3.6
3.2
442.35
348.73
mg/l
0.16
328
2736
1096
10136
1.22
3.88
4.4
4.2
14.73
14.51
mm/h
0.16
1005
9251
747
6654
1.22
3.87
5.5
5.5
0.04
0.04
e9/l
0.02
640
5666
154
1120
1.41
3.84
1.7
1.5
—
—
—
0
0
394
3282
1.26
3.82
1.8
1.8
1353.54
1169.82
nmol/l
2.30
288
2433
21
83
2.55
3.80
1.1
1.2
—
—
—
0
0
55
318
1.75
3.74
3.9
4.4
—
—
—
0
0
742
6641
1.21
3.57
5.5
5.5
0.62
0.61
e9/l
0.54
637
5649
518
4480
1.22
3.53
4.1
3.5
41.86
81.63
e6/l
1.62
420
3479
460
3934
1.23
3.49
2.2
2.2
3.14
3.14
mg/l
0.01
392
3309
21
87
2.43
3.47
2.3
2.4
—
—
—
0
0
1171
10961
1.21
3.42
21.2
20.2
15.52
15.41
%
0.23
1145
10755
755
6789
1.20
3.40
5.5
5.6
1.83
1.89
e9/l
0.32
659
5906
137
999
1.40
3.39
4.3
7.0
24.38
24.65
mmol/l
0.32
127
941
463
3974
1.23
3.38
3.9
3.3
—
—
—
0
0
14
48
2.93
3.30
2.3
2.4
—
—
—
0
0
168
1275
1.35
3.27
4.7
3.6
95.00
96.40
ng/l
0.07
136
1066
1370
13053
1.24
3.25
5.5
5.3
2.57
2.63
mmol/l
1.62
1225
11710
59
363
1.65
3.25
2.7
2.2
186.60
69.83
ug/min
0.46
37
213
288
2360
1.26
3.18
2.9
3.1
0.81
0.81
mmol/l
0.12
260
2172
582
5139
1.20
3.14
4.5
3.9
103.16
126.77
e6/l
0.37
450
3727
190
1479
1.32
3.12
2.9
2.5
4.77
6.80
ug/l
1.90
156
1257
718
6472
1.19
3.05
2.0
2.1
96.74
93.68
pmol/l
0.83
334
3222
54
331
1.65
3.04
4.9
5.4
8.45
8.35
kpa
0.19
54
325
54
331
1.65
3.04
4.9
5.4
5.10
5.09
kpa
0.01
54
325
54
331
1.65
3.04
4.9
5.3
2.24
2.89
mmol/l
0.97
40
232
512
4483
1.20
3.00
4.7
4.3
—
—
—
0
0
19
81
2.36
2.99
1.1
1.1
—
—
—
0
0
15
57
2.65
2.96
1.3
1.4
—
—
—
0
0
404
3464
1.22
2.94
1.7
1.6
1.36
1.34
mmol/l
0.12
322
2874
589
5233
1.19
2.93
3.4
3.4
2.35
2.36
mmol/l
0.52
501
4488
143
1079
1.35
2.91
3.3
4.0
0.11
0.11
%
0.03
35
360
140
1053
1.36
2.91
3.1
5.0
—
—
—
0
0
502
4400
1.20
2.90
4.4
4.4
—
—
—
0
0
96
677
1.44
2.90
1.4
1.4
—
—
—
0
0
134
1007
1.36
2.81
3.4
4.0
2.42
0.37
%
0.48
26
295
37
209
1.79
2.80
1.8
1.3
—
—
—
0
0
1276
12138
1.20
2.73
4.2
4.2
1.26
1.28
mmol/l
0.78
1124
10745
187
1482
1.29
2.71
1.3
1.3
—
—
—
0
0
164
1277
1.31
2.71
1.8
1.6
—
—
—
0
0
1327
12671
1.20
2.71
4.9
4.7
4.51
4.55
mmol/l
0.64
1184
11431
1315
12548
1.20
2.69
4.8
4.7
1.50
1.47
mmol/l
1.10
1174
11233
849
7817
1.17
2.68
8.0
8.9
4.34
4.22
e9/l
0.69
735
6773
396
3422
1.20
2.64
4.9
4.0
—
—
—
0
0
595
5356
1.17
2.44
2.2
2.2
—
—
—
0
0
135
1039
1.32
2.44
3.4
3.7
0.97
0.62
%
0.79
35
366
694
6323
1.16
2.44
5.9
6.1
8.99
8.89
%
0.39
630
5846
147
1149
1.31
2.39
3.4
3.9
1.64
0.91
%
0.86
39
431
849
7864
1.16
2.37
3.0
3.1
53.91
53.96
u/l
0.00
758
7120
32
183
1.76
2.36
1.8
1.3
120.22
113.09
u/ml
—
9
31
86
620
1.41
2.35
5.0
4.2
—
—
—
0
0
43
268
1.62
2.33
1.4
1.3
4.86
43.49
e6/l
1.04
37
208
43
268
1.62
2.33
1.5
1.3
198.24
714.56
e6/l
0.62
37
217
689
6297
1.16
2.29
5.7
5.8
2.85
2.81
%
0.18
625
5815
1023
9621
1.16
2.28
4.5
4.2
—
—
—
0
0
15
66
2.28
2.24
2.3
2.7
1576.00
1853.64
ml
0.59
15
55
671
6137
1.15
2.18
5.8
5.8
0.66
0.66
%
0.08
608
5662
191
1562
1.25
2.18
1.4
1.3
565.11
554.25
titre
0.03
47
362
62
430
1.46
2.11
1.5
1.4
242.81
282.63
ug/g
0.93
37
247
468
4176
1.17
2.11
5.8
5.2
2.74
4.37
ug/l
0.88
409
3693
375
3289
1.18
2.09
4.5
4.1
—
—
—
0
0
180
1470
1.25
2.09
5.6
7.9
120.20
118.92
g/l
0.35
173
1420
342
2983
1.18
2.04
1.6
1.6
1.28
1.40
mg/l
0.30
270
2321
65
460
1.43
2.01
1.8
1.9
20.82
21.53
s
0.65
60
420
235
1984
1.21
2.00
7.9
5.4
1.06
1.03
mmol/l
0.97
214
1794
194
1606
1.23
2.00
5.3
7.4
94.80
95.20
%
0.31
183
1539
22
387
0.56
1.97
1.2
1.4
—
—
—
0
0
190
1573
1.23
1.96
1.6
1.4
—
—
—
0
0
258
2203
1.20
1.95
2.9
2.5
2.24
2.29
g/l
0.65
229
2018
229
1934
1.21
1.95
1.3
1.2
—
—
—
0
0
249
2128
1.20
1.87
2.4
2.1
—
—
—
0
0
337
2960
1.17
1.85
5.4
4.7
1.02
1.02
kg/l
0.28
55
468
8
181
0.44
1.81
1.4
1.7
—
—
—
0
0
94
721
1.32
1.81
3.2
3.9
42.41
80.46
u/ml
1.81
87
695
7
23
3.05
1.80
1.0
1.2
—
—
—
0
0
29
176
1.66
1.80
1.2
1.5
72.64
63.05
%
0.61
14
123
701
6501
1.13
1.76
2.8
2.7
—
—
—
0
0
695
6443
1.13
1.76
5.9
6.0
25.78
26.42
%
0.77
628
5973
122
976
1.27
1.72
3.0
3.8
7.42
7.41
ph
0.40
19
124
422
3797
1.15
1.67
1.5
1.6
22.11
20.40
nmol/l
1.34
354
3160
42
286
1.48
1.63
1.2
1.1
21.16
9.07
u/ml
—
5
21
122
987
1.25
1.59
3.1
3.8
5.19
5.17
kpa
0.09
115
931
112
899
1.26
1.56
1.2
1.2
—
—
—
0
0
239
2074
1.18
1.53
3.0
2.6
21.94
22.05
%
0.04
194
1746
339
3027
1.15
1.50
4.1
4.1
185.06
272.02
ng/l
0.66
289
2562
78
601
1.31
1.49
3.4
4.1
24.73
25.03
mmol/l
0.36
68
546
162
1361
1.21
1.49
2.1
2.7
66.13
66.07
g/l
0.04
142
1224
85
663
1.30
1.49
1.4
1.3
—
—
—
0
0
210
1809
1.18
1.47
5.5
7.1
1.14
1.24
mmol/l
0.13
164
1437
271
2384
1.16
1.47
2.9
2.5
12.14
12.22
umol/l
0.05
245
2205
255
2233
1.17
1.47
1.5
1.4
2.40
2.55
g/l
0.71
151
1285
80
1020
0.77
1.45
4.0
3.4
—
—
—
0
0
35
236
1.49
1.45
1.4
1.2
—
—
—
0
0
39
269
1.46
1.45
7.9
1.4
0.94
0.84
nmol/l
0.33
30
217
210
1816
1.18
1.42
5.6
7.0
5.05
5.11
kpa
0.30
198
1720
210
1817
1.18
1.41
5.6
7.0
12.15
11.89
kpa
0.29
200
1722
22
134
1.65
1.39
1.3
1.4
16.51
28.99
%
—
10
95
37
257
1.45
1.34
3.9
3.3
—
—
—
0
0
0
41
0.00
1.31
0.0
1.2
—
67.05
—
0
31
6
24
2.51
1.30
1.0
1.0
—
—
—
0
0
54
408
1.33
1.23
2.1
3.5
—
—
—
0
0
341
3089
1.13
1.22
3.1
3.1
2.47
2.47
mmol/l
0.29
302
2691
35
246
1.43
1.21
1.3
1.2
—
—
—
0
0
41
558
0.73
1.21
1.3
1.3
—
—
—
0
0
8
37
2.17
1.21
1.1
1.1
1563.25
1735.19
miu/ml
—
8
37
34
238
1.44
1.21
1.7
2.0
—
—
—
0
0
232
2054
1.15
1.18
1.3
1.2
31.81
42.13
iu/ml
0.93
73
657
5
20
2.50
1.15
1.0
1.0
—
—
—
0
0
671
6325
1.10
1.15
5.7
5.8
58.93
58.29
%
0.72
607
5866
87
707
1.24
1.15
2.7
3.0
4.41
4.37
pmol/l
0.20
72
610
5
21
2.38
1.09
1.2
1.0
18.80
165.75
ng/l
—
5
13
58
453
1.29
1.07
12.9
11.8
—
—
—
0
0
37
270
1.38
1.07
1.6
1.7
3.84
4.86
mmol/24h
1.56
30
223
24
161
1.50
1.07
1.5
2.1
—
—
—
0
0
148
1278
1.17
1.06
1.3
1.3
—
—
—
0
0
400
3689
1.11
1.06
2.7
2.8
4488.55
7844.92
umol/l
0.82
330
3146
75
608
1.24
1.03
1.4
1.2
—
—
—
0
0
9
46
1.96
1.03
1.1
1.3
—
—
—
0
0
133
1142
1.18
1.03
2.0
2.6
—
—
—
0
0
13
75
1.74
1.02
7.8
6.1
—
—
—
0
0
20
131
1.53
1.00
1.2
1.1
2.67
5.09
u/ml
0.79
12
65
494
4619
1.10
0.99
2.5
2.5
—
—
—
0
0
38
283
1.35
0.99
1.1
1.1
—
—
—
0
0
90
749
1.21
0.98
3.7
2.4
1.30
1.13
%
0.85
90
743
0
29
0.00
0.97
0.0
2.5
—
40.16
—
0
22
139
1204
1.17
0.97
2.1
2.0
363.65
377.09
nmol/l
0.34
124
1088
14
85
1.65
0.94
1.1
1.3
—
—
—
0
0
16
101
1.59
0.93
1.8
1.3
0.34
0.46
g/l
1.18
11
68
16
101
1.59
0.93
1.8
1.3
2.62
2.92
g/l
0.46
11
69
16
101
1.59
0.93
1.8
1.3
5.31
7.26
g/l
2.18
11
68
94
1112
0.84
0.93
1.6
1.5
—
—
—
0
0
26
184
1.42
0.91
1.4
1.1
393.68
305.13
u/ml
0.54
19
99
374
3466
1.10
0.90
6.8
6.7
—
—
—
0
0
151
1327
1.15
0.89
1.9
2.0
182.92
152.85
ug/g
0.32
117
1034
36
271
1.34
0.89
1.3
1.5
—
—
—
0
0
40
306
1.31
0.89
1.2
1.3
60.72
59.78
mmol/l
0.06
32
245
16
103
1.56
0.87
1.1
1.2
—
—
—
0
0
84
706
1.20
0.85
3.1
3.8
—
—
—
0
0
17
112
1.52
0.85
2.1
1.6
9.85
10.62
%
0.31
17
112
180
1608
1.13
0.85
4.5
4.6
—
—
—
0
0
16
104
1.54
0.84
1.9
1.3
—
—
—
0
0
6
31
1.94
0.84
2.7
1.2
—
—
—
0
0
28
205
1.37
0.83
1.3
1.3
65971.33
56082.07
e6/l
0.12
15
120
381
3554
1.09
0.81
2.4
2.4
—
—
—
0
0
0
24
0.00
0.79
0.0
7.3
—
—
—
0
0
9
151
0.59
0.78
1.0
1.2
—
—
—
0
0
0
28
0.00
0.76
0.0
6.8
—
—
—
0
0
12
185
0.65
0.75
2.9
3.9
—
—
—
0
0
18
124
1.46
0.75
1.2
1.2
331.08
323.59
nmol/l
—
10
102
41
514
0.79
0.75
1.3
1.4
—
—
—
0
0
22
158
1.40
0.74
1.4
1.2
—
—
nmol/l
—
0
0
24
176
1.37
0.72
1.4
1.4
—
—
—
0
0
5
25
2.00
0.72
1.2
1.2
—
—
—
0
0
43
344
1.26
0.72
1.4
1.3
—
—
—
0
0
25
185
1.36
0.72
1.1
1.1
7.00
129.40
iu/ml
—
6
29
143
1275
1.13
0.72
7.7
7.6
—
—
—
0
0
441
4161
1.08
0.72
2.8
3.2
30.35
34.00
u/l
1.71
409
3934
7
40
1.75
0.71
1.1
1.2
—
—
—
0
0
36
455
0.79
0.71
4.3
3.3
0.77
0.82
nmol/l
0.49
29
360
73
619
1.19
0.71
2.9
2.7
—
—
—
0
0
65
546
1.20
0.70
2.8
3.5
73.14
75.84
mg/l
0.02
48
457
65
546
1.20
0.70
2.8
3.5
46.61
164.18
mg/l
0.61
48
454
7
41
1.71
0.70
3.0
2.0
10.00
11.06
%
—
7
33
40
319
1.26
0.69
2.1
2.7
16.68
15.64
%
0.71
23
163
13
85
1.53
0.69
1.5
2.7
—
—
—
0
0
5
27
1.85
0.68
1.4
1.5
—
—
—
0
0
5
93
0.54
0.67
1.0
1.1
—
9.34
—
0
20
43
348
1.24
0.66
1.4
2.3
132.24
126.62
g/l
0.77
34
252
41
330
1.25
0.66
1.1
1.1
—
964.55
—
0
11
278
2582
1.09
0.66
3.1
2.9
1.51
1.38
e6/l
0.12
176
1500
63
532
1.19
0.65
2.8
3.5
1.92
1.63
ratio
—
8
45
27
348
0.77
0.63
3.8
4.0
28.42
26.20
mg/l
0.12
15
228
28
217
1.30
0.62
1.7
1.5
—
—
—
0
0
28
217
1.30
0.62
2.4
2.8
—
—
—
0
0
151
1370
1.11
0.59
9.8
6.5
11.28
10.69
mmol/l
0.45
143
1290
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
6
35
1.72
0.57
1.2
2.7
—
—
—
0
0
162
1479
1.11
0.57
4.9
3.4
1.90
2.10
mmol/l
0.25
142
1237
15
107
1.41
0.55
6.5
4.9
—
25.35
—
0
31
212
1969
1.09
0.53
1.3
1.2
18.52
14.35
u/ml
0.33
81
682
16
117
1.37
0.52
1.3
1.0
13.00
2.92
u/ml
—
8
36
6
40
1.50
0.51
1.3
1.3
—
—
—
0
0
6
40
1.50
0.51
3.2
2.0
30.67
26.59
%
—
6
34
17
126
1.35
0.51
2.4
3.2
20.43
22.98
mg/l
0.06
12
95
22
170
1.30
0.51
1.3
1.2
—
—
—
0
0
9
64
1.41
0.51
2.7
3.2
13.54
13.36
%
—
9
64
92
820
1.13
0.51
7.3
10.2
—
—
—
0
0
96
859
1.12
0.50
2.7
2.5
—
—
—
0
0
28
225
1.25
0.49
1.3
1.4
759.30
1614.18
e6/l
2.48
23
163
13
178
0.73
0.48
1.4
1.3
—
—
—
0
0
342
3249
1.07
0.48
1.4
1.3
—
—
—
0
0
35
420
0.83
0.48
2.6
2.7
—
—
—
0
0
15
199
0.75
0.46
3.5
5.8
8.54
7.64
mmol/l
0.44
15
167
22
173
1.28
0.46
1.0
1.1
—
—
—
0
0
23
182
1.27
0.46
3.0
1.6
0.75
0.85
g/l
0.12
17
137
153
1414
1.09
0.45
2.1
2.5
67.06
69.49
e9/l
0.41
122
1091
12
86
1.40
0.44
1.3
1.2
1.97
1.58
u/ml
—
6
49
256
2418
1.07
0.43
3.3
3.0
1.83
2.66
e6/l
1.51
152
1344
39
331
1.18
0.43
3.0
2.5
—
—
—
0
0
8
56
1.43
0.42
1.3
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
28
231
1.22
0.41
1.4
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
60
530
1.14
0.40
2.6
2.8
0.60
0.25
g/l
0.56
20
185
15
114
1.32
0.40
1.7
1.2
—
33.00
—
0
7
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
5
34
1.47
0.40
1.4
1.5
—
—
—
0
0
22
177
1.25
0.40
1.6
2.0
—
—
—
0
0
8
60
1.33
0.40
1.0
1.1
—
12.75
—
0
15
377
3615
1.05
0.40
4.2
3.9
88.70
86.34
%
0.99
371
3523
7
102
0.69
0.39
1.7
1.8
—
—
—
0
0
8
61
1.31
0.39
1.0
1.0
—
—
—
0
0
52
456
1.14
0.39
5.6
4.8
—
—
—
0
0
96
877
1.10
0.38
2.8
3.2
5.50
4.58
e9/l
0.27
60
660
36
419
0.86
0.37
1.3
1.2
—
—
—
0
0
5
37
1.35
0.37
1.4
1.2
—
—
—
0
0
30
253
1.19
0.36
1.8
2.0
2.17
1.66
mmol/l
0.61
30
246
9
70
1.29
0.36
1.2
1.3
—
—
—
0
0
200
1892
1.06
0.34
2.2
2.5
1.73
1.83
%
0.81
167
1655
6
44
1.36
0.34
1.0
2.0
14.97
15.05
pmol/l
—
6
32
6
45
1.33
0.33
2.0
1.9
—
—
—
0
0
15
188
0.80
0.33
1.3
1.2
—
—
—
0
0
20
164
1.22
0.32
2.8
2.4
1.05
1.38
g/24h
—
10
74
184
1741
1.06
0.32
3.3
3.9
12.34
20.83
ug/l
0.53
149
1437
6
47
1.28
0.32
1.0
1.3
108.83
166.52
mmol/24h
—
6
47
33
380
0.87
0.32
1.3
1.6
—
—
—
0
0
28
239
1.17
0.31
3.1
2.5
—
—
—
0
0
40
352
1.14
0.31
3.8
8.4
105.53
105.39
mmol/l
0.06
34
312
40
352
1.14
0.31
3.8
8.4
11.65
10.95
mmol/l
0.55
34
312
15
186
0.80
0.31
1.3
1.6
—
—
—
0
0
7
54
1.30
0.30
1.1
1.2
9.71
23.85
%
—
7
48
55
497
1.11
0.29
3.8
7.3
1.26
1.36
mmol/l
0.48
45
433
249
2387
1.05
0.29
3.3
3.2
0.75
0.79
ug/l
0.26
186
1655
13
103
1.26
0.28
4.3
3.1
—
—
—
0
0
24
280
0.86
0.28
1.4
1.5
—
—
—
0
0
8
62
1.29
0.28
1.0
1.0
—
—
—
0
0
160
1517
1.06
0.28
2.9
3.0
232.89
233.73
ng/l
0.01
147
1396
73
673
1.09
0.27
1.4
2.0
1.24
2.08
ug/l
0.50
57
579
37
329
1.13
0.26
1.2
1.1
—
—
—
0
0
9
72
1.25
0.25
1.2
2.0
—
46.34
—
0
5
9
74
1.22
0.25
28.1
13.8
—
—
—
0
0
6
85
0.70
0.24
1.0
1.1
—
—
—
0
0
7
92
0.76
0.22
1.4
2.4
—
—
—
0
0
83
777
1.07
0.22
4.1
2.8
0.14
0.38
e6/l
2.25
83
759
10
79
1.27
0.22
1.3
1.4
1919.10
1791.76
ml
—
10
74
374
3644
1.03
0.21
3.6
3.2
—
—
—
0
0
164
1571
1.05
0.21
2.6
2.6
7.20
9.10
umol/l
0.54
132
1375
0
11
0.00
0.21
0.0
1.5
—
29.60
—
0
5
0
10
0.00
0.21
0.0
1.9
—
1.65
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
29
325
0.89
0.21
1.2
2.6
32.91
33.03
umol/l
0.01
23
284
31
277
1.12
0.21
1.2
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
8
102
0.78
0.21
1.3
1.2
—
—
—
0
0
47
512
0.92
0.21
2.7
2.5
37.99
37.21
g/l
0.40
38
439
72
673
1.07
0.20
3.4
5.8
1.53
1.53
%
0.01
62
629
17
145
1.17
0.20
1.2
1.4
—
—
—
0
0
19
164
1.16
0.20
1.1
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
2.0
2.6
—
—
—
0
0
150
1439
1.05
0.19
1.7
2.1
0.20
0.20
g/l
0.10
140
1336
33
299
1.11
0.18
1.8
3.0
—
—
—
0
0
16
185
0.86
0.18
2.6
2.7
—
—
—
0
0
40
367
1.09
0.18
1.1
1.3
—
23.91
—
0
7
12
100
1.20
0.18
1.1
1.3
—
53.00
—
0
10
7
62
1.13
0.17
1.4
1.6
—
—
—
0
0
5
68
0.73
0.17
1.0
1.2
144.40
129.77
nmol/l
—
5
68
5
69
0.72
0.17
1.8
4.3
—
—
—
0
0
96
1007
0.95
0.17
1.5
1.4
—
—
—
0
0
16
139
1.15
0.16
1.0
1.1
—
—
—
0
0
70
663
1.06
0.15
3.5
5.9
0.91
0.87
%
0.27
61
621
14
121
1.16
0.15
1.3
1.1
—
—
—
0
0
17
192
0.88
0.14
1.2
1.2
—
—
—
0
0
11
93
1.18
0.14
1.6
2.3
—
—
—
0
0
11
93
1.18
0.14
2.3
3.0
—
—
—
0
0
137
1326
1.04
0.13
3.6
2.3
44.84
34.89
u/l
0.70
108
1132
192
1871
1.03
0.13
4.8
4.8
34.18
33.36
%
0.42
126
1190
21
190
1.11
0.12
1.3
1.3
47.80
32.75
iu/l
0.86
15
159
45
424
1.06
0.12
1.6
1.6
—
—
—
0
0
10
86
1.16
0.11
1.3
1.8
—
—
—
0
0
23
249
0.92
0.10
1.6
1.5
—
—
—
0
0
11
125
0.88
0.10
1.1
1.1
—
—
—
0
0
1043
10488
0.99
0.09
25.7
22.6
330.30
330.96
g/l
1.58
1032
10377
68
654
1.04
0.09
2.0
2.0
—
—
—
0
0
63
605
1.04
0.09
2.0
3.2
87.72
2528.22
u/ml
0.85
49
517
172
1757
0.98
0.09
1.3
1.3
—
—
—
0
0
6
58
1.03
0.08
1.2
2.7
368.50
1630.14
u/ml
—
6
58
31
328
0.94
0.08
2.0
1.7
—
—
—
0
0
27
254
1.06
0.07
1.9
2.8
—
—
—
0
0
8
77
1.04
0.07
1.5
1.6
—
—
—
0
0
7
84
0.83
0.07
1.1
1.1
—
—
—
0
0
9
84
1.07
0.07
1.2
1.6
124.33
86.74
umol/l
—
9
84
30
316
0.95
0.07
1.3
1.2
—
—
—
0
0
9
88
1.02
0.07
3.8
1.7
43.81
37.92
%
—
9
88
29
275
1.06
0.06
1.3
1.7
3.60
4.52
iu/l
—
8
87
16
173
0.92
0.06
2.6
3.0
—
—
—
0
0
69
671
1.03
0.06
1.2
1.2
118.84
128.84
iu/ml
0.08
19
251
13
119
1.09
0.06
1.5
1.2
—
—
—
0
0
13
119
1.09
0.06
1.5
1.2
—
—
—
0
0
11
100
1.10
0.05
1.0
1.3
—
—
—
0
0
118
1160
1.02
0.05
1.4
1.5
—
—
—
0
0
17
159
1.07
0.05
1.1
1.9
199.00
201.56
pmol/l
0.04
17
147
72
704
1.02
0.04
1.8
2.2
11.60
12.21
nmol/l
0.21
64
613
13
140
0.93
0.04
1.1
1.2
—
—
—
0
0
84
855
0.98
0.04
1.2
1.3
—
—
—
0
0
12
129
0.93
0.03
1.2
1.4
—
—
—
0
0
12
129
0.93
0.03
1.2
1.4
—
—
—
0
0
12
128
0.94
0.02
1.2
1.4
—
—
—
0
0
12
127
0.94
0.01
1.2
1.4
—
—
—
0
0
37
377
0.98
0.01
1.6
1.7
16364.85
16393.52
e6/l
0.00
26
275
78
787
0.99
0.01
1.7
1.7
1.24
1.51
g/l
0.52
71
707
13
136
0.96
0.00
1.1
1.6
—
—
—
0
0
10
95
1.05
0.00
1.1
1.1
—
—
—
0
0
12
121
0.99
0.00
1.2
1.5
—
—
—
0
0
17
169
1.01
0.00
1.0
1.3
26.64
10.24
u/l
—
10
135
19
189
1.01
0.00
1.3
1.5
—
—
—
0
0
36
359
1.00
0.00
1.1
1.1
—
—
—
0
0
48
479
1.00
0.00
3.9
3.1
—
—
—
0
0
85
851
1.00
0.00
4.7
3.8
—
—
—
0
0
10
96
1.04
0.00
1.1
1.1
—
—
—
0
0
17
166
1.02
0.00
1.5
1.2
—
—
—
0
0
17
166
1.02
0.00
1.1
1.2
—
—
—
0
0
22
216
1.02
0.00
1.1
1.7
50.27
41.42
nmol/l
0.69
22
204
78
778
1.00
0.00
1.3
1.8
1.50
1.53
g/l
0.13
66
671
10
102
0.98
0.00
1.0
1.2
—
—
—
0
0
12
123
0.98
0.00
1.2
1.2
—
—
—
0
0
18
177
1.02
0.00
1.1
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
2.38
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
16.38
—
0
5
7
79
0.89
0.00
2.9
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
9
97
0.93
-0.00
1.1
1.0
289.67
298.78
mg/l
—
9
83
7
76
0.92
-0.00
1.9
1.9
9.71
9.90
mmol/l
—
7
76
5
52
0.96
-0.00
1.2
1.3
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
61
610
1.00
-0.00
2.5
2.7
10.07
10.45
g/l
0.33
52
534
7
72
0.97
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
8
85
0.94
-0.00
3.0
1.8
16.38
16.78
%
—
8
79
8
85
0.94
-0.00
1.6
1.4
12.96
15.27
umol/l
—
8
79
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_GLAUCCLOSEPRIM and mortality.

Females

Parameter HR [95% CI] p-value
H7_GLAUCCLOSEPRIM 1.071 [0.99, 1.16] 0.085
Birth year 0.992 [0.98, 1.0] 0.045

During the follow-up period (1.1.1998 — 31.12.2019), 2692 out of 7308 females with H7_GLAUCCLOSEPRIM died.

Males

Parameter HR [95% CI] p-value
H7_GLAUCCLOSEPRIM 1.093 [0.98, 1.22] 0.115
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 1312 out of 3811 males with H7_GLAUCCLOSEPRIM died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCCLOSEPRIM.

N-year risk Females Males
1 0.064% 0.193%
5 0.526% 1.222%
10 1.319% 3.23%
15 2.475% 5.968%
20 4.646% 9.811%

Relationships between endpoints

↥

Index endpoint: H7_GLAUCCLOSEPRIM – Primary angle-closure glaucoma

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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