glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
316 |
4. Check minimum number of eventsNone |
316 |
5. Include endpointsNone |
316 |
6. Filter based on genotype QC (FinnGen only) |
316 |
Control definitions (FinnGen only)
- Control exclude
- H7_GLAUCOMA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- H40
- Name in latin
- Glaucoma [secundarium] postinflammatorium
Similar endpoints
↥List of similar endpoints to
Glaucoma secondary to eye inflammation
based on the number of shared cases.
Similar with more cases:
- Glaucoma
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2511 | 1296 | 1195 |
| Only index persons | 2084 | 1092 | 992 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 50.74 | 54.42 | 46.51 |
| Only index persons | 47.68 | 51.18 | 43.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 316 | 172 | 144 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 48.13 | 50.02 | 45.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 275
- Matched controls
- 2749
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
267.3
211
*
S01ED51
ATC
timolol, combinations; ophthalmic
224.0
210.7
200
32
114
Kela drug reimbursment
Glaucoma
185.4
196.6
191
33
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
+∞
159.3
137
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
429.0
158.6
145
7
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
99.7
149.7
159
37
S01ED01
ATC
timolol; ophthalmic
204.4
145.5
141
14
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
715.7
131.9
120
*
S01EC01
ATC
acetazolamide; systemic
133.6
118.5
121
16
S01EE01
ATC
latanoprost; ophthalmic
103.9
106.0
112
18
H40.0
ICD-10 Finland
Glaucoma suspect
293.0
99.8
96
5
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
78.6
75.1
83
15
XCK00
NOMESCO Finland
Perimetry
36.8
75.0
97
40
Z96.1
ICD-10 Finland
Presence of intraocular lens
14.7
67.9
127
151
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
65.2
60
*
S01EC04
ATC
brinzolamide; ophthalmic
99.7
63.5
68
9
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
24.5
59.3
86
50
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
38.5
58.3
74
26
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
319.0
53.1
52
*
S01EE03
ATC
bimatoprost; ophthalmic
319.0
53.1
52
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
11.3
51.9
109
151
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
7.4
51.8
182
572
S01EA03
ATC
apraclonidine; ophthalmic
130.7
50.8
53
5
S01BC03
ATC
diclofenac; ophthalmic
37.5
50.3
64
22
H26.2
ICD-10 Finland
Complicated cataract
59.5
49.3
57
12
S01EE05
ATC
tafluprost; ophthalmic
41.9
46.0
57
17
XCW99
NOMESCO Finland
Other investigative procedure of eye
11.1
44.9
93
121
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
43.4
43.2
53
15
S01EC03
ATC
dorzolamide; ophthalmic
246.7
42.1
42
*
H40.8
ICD-10 Finland
Other glaucoma
+∞
39.5
37
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
+∞
37.3
35
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
10.5
37.3
78
100
S01FA04
ATC
cyclopentolate; ophthalmic
52.1
37.2
44
10
S01EE04
ATC
travoprost; ophthalmic
79.8
37.1
41
6
S01EX03
ATC
NA
206.2
35.7
36
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.1
35.4
176
711
Z01.0
ICD-10 Finland
Examination of eyes and vision
6.5
33.9
102
227
CJB10
NOMESCO Finland
Laser discission of secondary cataract
10.9
33.8
68
80
WX140
NOMESCO Finland
Parabulbar anesthesy
17.4
33.7
54
38
36401
ICD-8 Finland
Iritis, Iridocyclitis glaucomatosa. Syndroma Posner-Schlossman, heterochromia iridis
+∞
33.0
31
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.0
32.9
70
91
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.0
32.8
141
475
H40.9
ICD-10 Finland
Glaucoma, unspecified
364.0
32.6
32
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
27.3
32.1
44
19
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
31.9
30
*
XCK10
NOMESCO Finland
Photography of fundus of eye
8.0
30.5
75
123
H26.4
ICD-10 Finland
After-cataract
9.0
30.5
69
99
XCH00
NOMESCO Finland
Eye pressure measurement
17.9
30.5
48
32
3656F
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA POST UVEITIDEM]
+∞
29.7
28
*
3656B
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUKOMASYKLIITTINEN KRIISI,SYNDR POSSNER-SCHOSSMAN]
+∞
28.6
27
*
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
14.8
25.4
43
34
CHC05
NOMESCO Finland
Iridotomy
+∞
25.4
24
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
273.9
25.1
25
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
74.5
24.3
27
*
S01ED02
ATC
betaxolol; ophthalmic
74.5
24.3
27
*
S01FA01
ATC
atropine; ophthalmic
136.9
24.0
25
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
18.6
23.5
36
22
S01EB01
ATC
pilocarpine; ophthalmic
+∞
23.3
22
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
23.3
22
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
25.7
23.2
32
14
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
238.2
21.9
22
*
L04AB04
ATC
adalimumab; parenteral
21.6
21.4
31
16
S01FA02
ATC
scopolamine; ophthalmic
28.1
20.9
28
11
CHD99
NOMESCO Finland
Other filtering operation
+∞
20.0
19
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
20.0
19
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
+∞
20.0
19
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
113.3
19.8
21
*
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
203.3
18.8
19
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
15.2
18.2
30
22
3663A
ICD-9 Finland
Cataract secondary to ocular disorders
56.6
18.2
21
*
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
17.9
17
*
ZXA00
NOMESCO Finland
Right side
3.4
17.9
113
471
H20.8
ICD-10 Finland
Other iridocyclitis
101.7
17.8
19
*
H02AB06
ATC
prednisolone; systemic
3.0
17.1
166
925
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
8.3
16.9
38
52
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
43.0
16.6
20
5
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
50.8
16.2
19
*
36400
ICD-8 Finland
Iritis, Iridocyclitis acuta
63.9
16.0
18
*
H26.3
ICD-10 Finland
Drug-induced cataract
23.8
15.8
22
10
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.8
15.2
39
65
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
14.7
14
*
S01EA02
ATC
dipivefrine; ophthalmic
+∞
14.7
14
*
ZXC20
NOMESCO Finland
Use of chemical agents
13.6
14.7
25
20
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.5
13.7
51
132
XCH05
NOMESCO Finland
Eye pressure longterm registration
79.2
13.7
15
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
79.2
13.7
15
*
H26.02
ICD-10 Finland
Presenil cataract
14.8
13.5
22
16
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
42.3
13.3
16
*
S01BC05
ATC
ketorolac; ophthalmic
7.2
13.3
32
49
L88
ICPC
Rheumatoid/seropositive arthritis
8.0
12.9
29
40
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
25.8
12.6
17
7
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
12.6
12
*
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
+∞
12.6
12
*
ZXA05
NOMESCO Finland
Left side
2.8
12.5
97
442
H16.0
ICD-10 Finland
Corneal ulcer
7.0
12.3
30
47
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
19.1
12.2
18
10
S01FA06
ATC
tropicamide; ophthalmic
48.9
12.0
14
*
L04AA01
ATC
[U] ciclosporin; systemic
20.0
11.7
17
9
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
+∞
11.5
11
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
11.5
11
*
3708
FHL
Trabeculectomy or equivalent
+∞
11.5
11
*
Z94.7
ICD-10 Finland
Corneal transplant status
125.0
11.5
12
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.3
11.5
35
73
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
21.1
11.3
16
8
3640A
ICD-9 Finland
Disorders of iris and ciliary body, Acute and subacute iridocyclitis
62.5
10.7
12
*
A07EC01
ATC
sulfasalazine; oral, rectal
4.2
10.5
41
111
H40.6
ICD-10 Finland
Glaucoma secondary to drugs
+∞
10.5
10
*
37403
ICD-8 Finland
Cataract, Complicata
+∞
10.5
10
*
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
34.0
10.4
13
*
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
9.0
10.3
21
25
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
7.0
10.0
24
37
M45
ICD-10 Finland
Ankylosing spondylitis
9.3
10.0
20
23
L04AX01
ATC
azathioprine; systemic
6.1
9.8
26
46
TCG10
NOMESCO Finland
Removal of sutures from cornea
57.1
9.7
11
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
9.5
84
404
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
9.4
9
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
+∞
9.4
9
*
H221, M084
ICD-10 Finland
NA
+∞
9.4
9
*
CHD35
NOMESCO Finland
Laser goniopuncture
+∞
9.4
9
*
CFW99
NOMESCO Finland
Other operation on conjunctiva
+∞
9.4
9
*
CHD00
NOMESCO Finland
Laser trabeculoplasty
38.0
9.1
11
*
CA1ME
NOMESCO Finland
Ultrasound oculometry
28.5
8.5
11
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
8.3
8.5
18
23
H15.1
ICD-10 Finland
Episcleritis
13.3
8.5
14
11
H40.11
ICD-10 Finland
Low pressure glaucoma
92.8
8.5
9
*
H22.1*D86.8
ICD-10 Finland
Iridocyclitis in sarcoidosis
92.8
8.5
9
*
H21.0
ICD-10 Finland
Hyphaema
92.8
8.5
9
*
H22.1*M45
ICD-10 Finland
Iridocyclitis in ankylosing spondylitis
+∞
8.4
8
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
+∞
8.4
8
*
H44.4
ICD-10 Finland
Hypotony of eye
+∞
8.4
8
*
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
+∞
8.4
8
*
H221, M083
ICD-10 Finland
NA
+∞
8.4
8
*
S01AX11
ATC
[U] ofloxacin; ophthalmic
6.2
8.2
21
36
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.3
8.1
29
73
H11.3
ICD-10 Finland
Conjunctival haemorrhage
5.7
7.7
21
39
ZXA10
NOMESCO Finland
Bilateral
2.5
7.6
64
296
L04AA13
ATC
leflunomide; oral
8.0
7.5
16
21
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
82.2
7.5
8
*
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
82.2
7.5
8
*
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
+∞
7.3
7
*
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
+∞
7.3
7
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
7.3
7
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
+∞
7.3
7
*
L04AA17
ATC
[U] adalimumab; parenteral
30.9
7.2
9
*
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
30.9
7.2
9
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.2
7.1
26
67
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
7.0
6.9
16
24
H04.10
ICD-10 Finland
Dry eye syndrome
3.1
6.8
36
126
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
17.2
6.8
10
6
H40
ICD-10 Finland
Glaucoma
41.1
6.8
8
*
L04AB06
ATC
golimumab; parenteral
23.2
6.7
9
*
S01AD03
ATC
aciclovir; ophthalmic
4.4
6.7
23
56
H02AB07
ATC
prednisone; oral
2.6
6.5
50
220
H27.0
ICD-10 Finland
Aphakia
71.4
6.5
7
*
S01BC01
ATC
indometacin; ophthalmic
71.4
6.5
7
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
71.4
6.5
7
*
S01FB01
ATC
phenylephrine; ophthalmic (sympathomimetics excl. antiglaucoma prep.)
71.4
6.5
7
*
CFD10
NOMESCO Finland
Repair of conjunctiva
71.4
6.5
7
*
CS2P4
NOMESCO Finland
Optic nerve head imaging
71.4
6.5
7
*
L04AD01
ATC
ciclosporin; systemic
8.5
6.4
13
16
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
6.3
6
*
TCH12
NOMESCO Finland
Sample aspiration from anterior chambre
+∞
6.3
6
*
7143D
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[OLIGARTHRITIS JUVENILIS]
+∞
6.3
6
*
3719
FHL
Other measure in this category
+∞
6.3
6
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
6.3
6
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
6.3
6
*
M08.9
ICD-10 Finland
Juvenile arthritis, unspecified
+∞
6.3
6
*
CHB99
NOMESCO Finland
Other operation on anterior chamber and anterior chamber angle
+∞
6.3
6
*
H18.8
ICD-10 Finland
Other specified disorders of cornea
27.4
6.3
8
*
L04AB05
ATC
certolizumab pegol; parenteral
27.4
6.3
8
*
P01BA02
ATC
hydroxychloroquine; oral
3.3
6.1
29
94
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.8
6.1
24
67
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
209
1406
2.44
12.53
11.2
9.4
4.0
4.1
e9/l
0.18
191
1230
181
1154
2.33
12.14
11.0
5.7
57.9
57.6
%
0.11
175
1085
181
1165
2.30
11.72
11.5
5.9
27.2
27.6
%
0.22
174
1086
29
75
4.16
10.37
1.8
1.5
1.3
0.1
iu/ml
—
8
17
173
1172
2.05
8.93
4.2
3.6
0.0
0.0
estimate
0.00
32
228
171
1174
1.99
8.29
5.9
5.0
0.0
0.0
estimate
0.00
35
228
171
1187
1.96
7.89
4.2
3.7
0.1
0.0
estimate
0.49
31
219
16
36
4.63
6.78
4.6
3.5
61.0
60.0
%
0.08
16
36
16
36
4.63
6.78
4.0
2.6
4.7
5.0
e9/l
0.14
16
36
14
28
5.19
6.77
1.3
1.4
—
—
—
0
0
10
14
7.34
6.73
1.0
1.0
—
—
—
0
0
13
27
4.98
6.03
1.0
1.0
—
—
—
0
0
224
1788
1.87
5.91
7.1
3.9
12.3
12.0
mm/h
0.14
218
1627
155
1140
1.71
5.14
6.5
7.4
1.2
1.2
mmol/l
0.36
128
971
130
928
1.68
4.71
4.4
3.8
—
—
—
0
0
12
34
3.63
3.80
1.0
7.8
—
304.7
—
0
7
221
1866
1.61
3.68
9.3
7.2
76.6
77.8
u/l
0.12
213
1734
138
1050
1.56
3.61
5.3
6.5
1.2
1.2
mmol/l
0.37
128
937
127
949
1.57
3.60
2.5
2.2
78.4
76.5
nmol/l
0.36
117
841
55
333
1.79
3.50
1.9
2.1
2.3
2.4
g/l
0.12
49
305
15
54
2.87
3.30
1.3
1.2
—
—
—
0
0
6
8
7.62
3.06
1.0
1.0
1245.8
1401.0
miu/ml
—
6
8
13
45
2.97
3.06
1.1
1.3
—
—
—
0
0
5
5
10.13
2.99
2.2
1.4
—
—
—
0
0
8
18
4.53
2.81
1.4
1.4
—
—
—
0
0
5
6
8.44
2.76
1.6
3.8
—
—
—
0
0
270
2455
1.69
2.74
18.8
14.2
21.2
23.3
mg/l
0.45
223
1939
40
240
1.76
2.63
3.2
3.3
—
—
—
0
0
32
179
1.88
2.63
3.0
2.6
73.6
63.9
ml/min/173m2
—
10
72
11
38
2.96
2.61
1.5
2.6
17.1
16.2
%
—
5
22
110
852
1.45
2.44
3.2
3.0
—
—
—
0
0
7
17
4.19
2.37
2.0
1.9
—
—
—
0
0
104
804
1.44
2.31
3.4
3.1
49.1
30.9
u/l
0.41
99
773
118
935
1.42
2.29
2.1
1.9
89.3
96.0
pmol/l
1.00
68
477
48
316
1.61
2.26
2.0
2.1
21.6
22.2
%
0.10
40
270
5
9
5.62
2.22
1.0
1.1
—
—
%
—
0
0
87
656
1.45
2.20
4.5
3.9
0.0
0.0
estimate
0.50
34
224
8
24
3.39
2.19
1.1
1.3
—
—
—
0
0
279
2598
1.63
2.09
15.8
9.9
26.6
26.2
u/l
0.06
273
2495
39
251
1.63
2.02
2.2
1.9
—
—
—
0
0
124
1012
1.37
1.96
4.1
4.7
35.4
35.6
g/l
0.10
114
949
62
451
1.47
1.87
1.8
1.6
1340.2
1204.5
nmol/l
0.50
50
340
6
17
3.58
1.84
1.5
2.5
13.3
13.2
%
—
6
17
5
12
4.21
1.83
1.8
2.3
662.2
983.4
u/ml
—
5
12
70
525
1.43
1.80
2.0
1.8
1.2
1.3
mg/l
0.22
58
405
90
707
1.38
1.78
3.4
3.2
2171.8
1451.1
ng/l
0.52
80
592
6
18
3.38
1.75
1.0
1.0
—
—
—
0
0
11
48
2.34
1.72
1.5
1.6
—
—
—
0
0
206
1845
1.33
1.65
4.4
3.7
15.1
14.7
pmol/l
1.95
193
1650
5
14
3.61
1.62
1.2
1.0
43.6
44.1
u/l
—
5
8
53
389
1.44
1.54
1.2
1.3
88.0
48.3
iu/ml
0.34
15
126
123
1038
1.30
1.47
2.7
2.5
112.6
120.5
ug/l
0.20
118
947
37
255
1.51
1.47
2.2
1.9
—
—
—
0
0
14
73
1.96
1.46
1.6
2.9
—
—
—
0
0
76
601
1.35
1.42
3.0
2.7
11710.0
5377.7
umol/l
0.35
60
512
75
592
1.35
1.42
2.6
2.0
3.1
3.0
mg/l
0.05
65
502
10
46
2.21
1.41
1.8
1.5
9954.5
10739.9
e6/l
—
10
28
12
60
2.04
1.40
1.8
1.5
—
—
—
0
0
50
371
1.41
1.37
3.4
2.8
1.3
1.8
e6/l
0.31
28
208
82
663
1.32
1.32
3.4
2.9
0.1
0.3
e6/l
4.08
60
498
65
508
1.35
1.31
1.8
1.7
390.7
440.9
pmol/l
1.32
53
438
33
228
1.50
1.31
1.8
2.4
49.1
30.0
u/l
1.04
28
193
49
366
1.40
1.30
1.2
1.2
67.1
13.6
u/ml
1.10
18
143
52
393
1.39
1.29
3.1
2.6
0.8
1.0
e6/l
0.56
30
227
11
55
2.04
1.29
1.1
1.3
—
—
—
0
0
49
367
1.40
1.28
2.1
2.0
—
—
—
0
0
13
70
1.89
1.26
2.6
1.4
0.2
0.2
g/l
0.20
13
70
56
431
1.36
1.25
5.3
4.0
206.0
132.4
ng/l
0.28
46
338
69
550
1.33
1.23
1.6
1.5
21.6
20.8
nmol/l
0.15
58
463
38
275
1.43
1.21
6.0
9.8
0.9
1.3
mmol/l
0.24
28
220
20
126
1.63
1.17
2.7
1.9
—
—
—
0
0
171
1538
1.24
1.13
3.3
3.2
—
—
—
0
0
13
73
1.81
1.12
1.7
1.9
—
—
—
0
0
21
136
1.58
1.11
4.3
8.5
23.9
24.9
mmol/l
1.16
21
136
38
284
1.38
1.03
2.1
2.5
8.2
7.4
umol/l
0.15
32
249
13
76
1.74
1.00
2.6
1.5
1.2
1.1
g/l
0.55
13
76
5
23
2.19
0.98
1.0
1.2
—
—
—
0
0
158
1425
1.22
0.97
4.7
5.2
6.9
6.7
mmol/l
0.45
152
1326
242
2282
1.26
0.95
17.4
12.9
84.7
81.5
ml/min/173m2
1.35
205
1851
56
450
1.30
0.95
1.4
1.6
—
—
—
0
0
237
2235
1.24
0.90
5.1
4.4
2.0
1.9
mu/l
0.16
216
2022
6
29
2.09
0.90
1.0
1.1
—
—
—
0
0
37
288
1.32
0.80
6.4
8.0
104.4
104.1
mmol/l
0.14
37
280
142
1290
1.18
0.76
5.7
6.1
11.7
11.3
umol/l
0.13
137
1217
9
55
1.65
0.74
1.9
1.3
—
—
—
0
0
5
25
2.02
0.73
2.4
4.2
—
—
—
0
0
5
25
2.02
0.73
1.0
1.1
—
—
—
0
0
12
76
1.60
0.72
1.7
1.2
—
—
—
0
0
9
57
1.60
0.71
1.2
1.7
—
—
—
0
0
20
145
1.40
0.67
9.1
10.0
94.6
94.6
%
0.01
20
145
7
43
1.64
0.67
1.1
1.3
—
—
—
0
0
7
43
1.64
0.67
1.1
1.3
—
—
—
0
0
5
29
1.74
0.64
1.0
1.1
—
—
—
0
0
72
628
1.19
0.61
1.7
1.7
1.4
1.4
mmol/l
0.29
60
530
105
949
1.16
0.58
3.9
3.9
21.5
40.0
ng/l
2.37
67
642
26
204
1.30
0.56
3.5
1.9
312.9
363.4
nmol/l
0.77
26
188
14
99
1.43
0.55
1.7
2.1
0.2
5.0
ug/l
0.98
14
87
24
303
0.77
0.54
3.8
4.5
35.4
31.8
%
0.72
17
202
13
91
1.45
0.54
4.1
2.2
—
—
—
0
0
16
212
0.74
0.50
1.3
1.7
—
—
—
0
0
85
764
1.15
0.50
2.2
2.5
60.4
56.2
u/l
0.57
76
702
18
136
1.34
0.50
1.7
1.4
—
—
—
0
0
7
50
1.41
0.45
1.3
1.3
—
46.6
—
0
6
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
32
1.57
0.42
1.0
1.3
—
—
—
0
0
18
142
1.28
0.39
1.1
1.2
18.9
142.5
iu/ml
—
7
57
0
19
0.00
0.39
0.0
1.1
—
39.0
—
0
10
0
19
0.00
0.39
0.0
1.0
—
502.9
—
0
10
8
111
0.71
0.38
1.1
1.5
—
—
—
0
0
22
266
0.81
0.37
2.5
4.4
2.6
9.0
ug/l
2.52
14
221
10
134
0.74
0.35
3.6
3.0
19.4
36.9
u/ml
—
10
129
230
2232
1.11
0.34
20.5
15.0
39.0
40.1
%
0.92
158
1632
26
220
1.20
0.33
3.4
4.3
6.0
5.7
kpa
0.79
26
212
6
47
1.28
0.32
1.0
1.2
—
—
—
0
0
243
2368
1.11
0.32
4.4
4.4
5.8
5.9
mmol/l
1.01
226
2174
84
783
1.10
0.28
2.8
3.5
2.4
2.4
mmol/l
0.20
74
678
38
425
0.88
0.27
3.3
2.9
2.5
2.4
mmol/l
0.08
33
377
8
67
1.20
0.26
1.5
1.3
—
—
—
0
0
10
77
1.31
0.26
3.2
2.3
81.9
89.4
%
—
10
72
26
297
0.86
0.25
1.5
2.2
—
—
—
0
0
229
2239
1.08
0.23
6.6
5.5
40.9
39.9
mmol/mol
0.75
217
2091
7
91
0.76
0.23
3.3
1.7
—
—
—
0
0
7
93
0.75
0.22
1.4
1.5
46.6
23.3
iu/l
—
7
81
56
518
1.10
0.22
1.4
1.2
0.8
1.5
u/ml
0.94
15
137
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
26
292
0.88
0.21
9.0
7.6
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
8
71
1.13
0.16
1.4
1.4
—
—
—
0
0
10
83
1.21
0.15
1.2
1.6
—
—
—
0
0
34
368
0.91
0.15
1.4
1.4
—
—
—
0
0
242
2385
1.06
0.15
4.2
4.2
1.5
1.5
mmol/l
0.40
225
2207
248
2447
1.06
0.14
4.8
4.7
2.6
2.8
mmol/l
1.26
233
2258
17
151
1.13
0.13
1.4
1.9
—
—
—
0
0
14
123
1.14
0.12
1.1
1.0
—
—
—
0
0
25
272
0.91
0.12
1.3
2.1
—
—
—
0
0
18
162
1.12
0.12
2.1
1.5
—
—
—
0
0
75
721
1.05
0.12
2.2
2.1
138.0
231.6
u/l
1.78
69
685
80
771
1.05
0.11
5.7
4.8
4.1
2.6
ug/l
0.55
71
681
14
124
1.14
0.11
1.4
1.7
—
—
—
0
0
64
614
1.05
0.11
5.2
4.2
19.6
21.4
%
0.48
40
294
162
1648
0.97
0.09
3.2
2.9
54.2
46.9
u/l
0.38
154
1549
5
48
1.04
0.09
2.4
1.5
—
—
—
0
0
5
61
0.82
0.08
1.4
1.8
—
—
—
0
0
5
62
0.80
0.08
1.2
1.6
—
—
—
0
0
5
62
0.80
0.08
1.4
1.8
—
—
—
0
0
5
65
0.77
0.08
1.4
1.4
—
—
—
0
0
7
80
0.87
0.07
1.6
1.4
298.7
280.0
mu/l
—
7
72
8
92
0.87
0.07
1.4
1.9
—
—
—
0
0
8
95
0.84
0.06
1.5
2.1
—
—
—
0
0
43
445
0.96
0.05
3.5
3.0
0.7
0.8
ug/l
0.59
33
284
20
189
1.06
0.05
4.0
3.8
4.5
4.3
kpa
0.19
20
181
12
111
1.08
0.04
1.9
4.9
23.3
24.1
mmol/l
0.56
12
99
241
2398
1.02
0.03
4.4
4.3
4.6
4.6
mmol/l
0.39
227
2232
55
561
0.98
0.03
2.1
2.3
—
—
—
0
0
230
2309
0.99
0.01
3.9
3.8
1.3
1.3
mmol/l
0.02
216
2125
18
173
1.04
0.01
3.9
3.5
5.2
5.1
kpa
0.18
18
160
113
1129
1.00
0.00
4.2
4.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
1.3
—
0
6
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
7
75
0.93
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
0.00
1.2
1.7
—
—
—
0
0
6
64
0.94
0.00
5.7
4.2
—
3.0
—
0
9
0
9
0.00
0.00
0.0
1.1
—
0.3
—
0
9
5
56
0.89
0.00
1.2
1.3
—
—
—
0
0
5
59
0.85
0.00
1.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
5
53
0.94
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
79
1.01
0.00
1.4
1.6
—
116.0
—
0
5
6
68
0.88
0.00
3.8
2.1
25.6
24.9
mmol/l
—
6
55
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCSECINFLAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECINFLAM | 1.399 [1.15, 1.7] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.129 |
During the follow-up period (1.1.1998 — 31.12.2019), 148 out of 753 females with H7_GLAUCSECINFLAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECINFLAM | 1.0 [0.79, 1.26] | 0.997 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 629 males with H7_GLAUCSECINFLAM died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCSECINFLAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.159% | 0.192% |
| 5 | 0.754% | 1.124% |
| 10 | 1.798% | 2.812% |
| 15 | 3.606% | 5.501% |
| 20 | 6.519% | 9.447% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCSECINFLAM – Glaucoma secondary to eye inflammation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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