glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
327 |
4. Check minimum number of eventsNone |
327 |
5. Include endpointsNone |
327 |
6. Filter based on genotype QC (FinnGen only) |
312 |
Control definitions (FinnGen only)
- Control exclude
- H7_GLAUCOMA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- H40
- Name in latin
- Glaucoma [secundarium] postinflammatorium
Similar endpoints
↥List of similar endpoints to
Glaucoma secondary to eye inflammation
based on the number of shared cases.
Similar with more cases:
- Glaucoma
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2511 | 1296 | 1195 |
| Only index persons | 2084 | 1092 | 992 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 50.74 | 54.42 | 46.51 |
| Only index persons | 47.68 | 51.18 | 43.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 312 | 168 | 144 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | 48.57 | 50.02 | 46.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 327
- Matched controls
- 3270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
321.3
253
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
92.8
307.7
193
50
114
Kela drug reimbursment
Glaucoma
206.8
307.7
226
35
S01ED01
ATC
timolol; ophthalmic
217.6
307.7
174
17
S01ED51
ATC
timolol, combinations; ophthalmic
239.7
307.7
236
35
S01EC01
ATC
acetazolamide; systemic
192.3
301.1
148
14
S01EE01
ATC
latanoprost; ophthalmic
86.6
249.8
137
27
H20.1
ICD-10 Finland
Chronic iridocyclitis
794.6
203.3
180
5
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
+∞
193.6
166
*
S01BA07
ATC
fluorometholone; ophthalmic
78.4
173.7
95
17
S01EA05
ATC
brimonidine; ophthalmic
650.8
159.1
145
*
XCK00
NOMESCO Finland
Perimetry
34.0
159.0
110
48
S01BA01
ATC
dexamethasone; ophthalmic
32.0
151.6
107
49
S01EE05
ATC
tafluprost; ophthalmic
88.2
140.7
75
11
S01BA04
ATC
prednisolone; ophthalmic
42.0
138.0
87
28
H26.2
ICD-10 Finland
Complicated cataract
90.4
133.8
71
10
Z96.1
ICD-10 Finland
Presence of intraocular lens
13.7
126.1
162
218
S01BC03
ATC
diclofenac; ophthalmic
40.3
118.6
75
24
H40.0
ICD-10 Finland
Glaucoma suspect
198.4
117.2
116
9
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
55.5
108.9
63
14
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
11.4
99.4
136
193
S01FA04
ATC
cyclopentolate; ophthalmic
63.1
94.3
53
10
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
39.5
89.1
56
17
S01EC04
ATC
brinzolamide; ophthalmic
199.6
88.1
88
6
XCW99
NOMESCO Finland
Other investigative procedure of eye
11.3
86.4
110
140
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
80.6
74
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.5
72.4
94
121
XCH00
NOMESCO Finland
Eye pressure measurement
18.1
70.9
61
41
S01EA03
ATC
apraclonidine; ophthalmic
213.6
67.9
68
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.3
67.9
139
299
WX140
NOMESCO Finland
Parabulbar anesthesy
13.8
66.1
67
60
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
20.0
63.1
51
30
L04AX03
ATC
methotrexate; systemic
8.7
62.5
95
147
L04AB04
ATC
adalimumab; parenteral
25.3
60.7
44
20
XCK10
NOMESCO Finland
Photography of fundus of eye
8.8
59.8
89
134
S01EC03
ATC
dorzolamide; ophthalmic
684.1
59.7
57
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
6.2
59.6
209
723
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
175.5
56.9
58
*
S01EE03
ATC
bimatoprost; ophthalmic
104.7
56.1
60
7
L01BA01
ATC
methotrexate; systemic
13.3
53.1
54
48
H26.4
ICD-10 Finland
After-cataract
7.5
51.0
87
151
CJB10
NOMESCO Finland
Laser discission of secondary cataract
7.8
50.8
82
134
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.4
48.8
219
889
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
543.2
48.7
47
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.0
46.4
183
664
S01EX03, ,
ATC
140.1
46.1
48
*
H40.8
ICD-10 Finland
Other glaucoma
+∞
45.9
43
*
S01EE04
ATC
travoprost; ophthalmic
95.8
45.3
49
6
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
15.5
45.0
41
30
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
+∞
42.6
40
*
36401
ICD-8 Finland
Iritis, Iridocyclitis glaucomatosa. Syndroma Posner-Schlossman, heterochromia iridis
+∞
40.5
38
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
14.3
38.9
37
29
H40.9
ICD-10 Finland
Glaucoma, unspecified
214.2
37.6
38
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
37.2
35
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
10.0
36.3
44
50
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
+∞
35.0
33
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
+∞
35.0
33
*
S01ED02
ATC
betaxolol; ophthalmic
189.0
33.4
34
*
3656F
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA POST UVEITIDEM]
+∞
32.9
31
*
3656B
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUKOMASYKLIITTINEN KRIISI,SYNDR POSSNER-SCHOSSMAN]
+∞
31.8
30
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
344.1
31.4
31
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
29.6
28
*
ZXC20
NOMESCO Finland
Use of chemical agents
12.6
29.6
30
26
L88
ICPC
Rheumatoid/seropositive arthritis
9.0
29.2
38
47
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
306.4
28.2
28
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
27.5
26
*
S01FA01
ATC
atropine; ophthalmic
82.0
27.3
30
*
S01AD03
ATC
aciclovir; ophthalmic
9.4
27.1
34
40
CHD99
NOMESCO Finland
Other filtering operation
+∞
26.4
25
*
S01FA02
ATC
scopolamine; ophthalmic
31.4
26.0
34
12
ZXA00
NOMESCO Finland
Right side
3.4
25.3
134
549
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
+∞
25.3
24
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.5
25.2
72
193
H26.3
ICD-10 Finland
Drug-induced cataract
61.0
24.4
28
5
CHC05
NOMESCO Finland
Iridotomy
61.0
24.4
28
5
H16.0
ICD-10 Finland
Corneal ulcer
6.5
24.4
43
75
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.0
24.1
39
62
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.6
24.1
50
102
L04AX01
ATC
azathioprine; systemic
7.1
23.2
37
58
3663A
ICD-9 Finland
Cataract secondary to ocular disorders
246.6
22.9
23
*
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
129.1
22.9
24
*
H02AB06
ATC
prednisolone; systemic
3.1
22.4
202
1110
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
+∞
22.1
21
*
H20.8
ICD-10 Finland
Other iridocyclitis
123.3
21.9
23
*
S01EB01
ATC
pilocarpine; ophthalmic
82.3
21.0
23
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.3
20.0
43
90
S01EA02
ATC
dipivefrine; ophthalmic
+∞
20.0
19
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
78.2
19.9
22
*
H18.1
ICD-10 Finland
Bullous keratopathy
201.1
18.7
19
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
201.1
18.7
19
*
A07EC01
ATC
sulfasalazine; oral, rectal
4.5
18.7
50
126
H26.02
ICD-10 Finland
Presenil cataract
8.4
18.5
25
32
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
28.6
18.1
24
9
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
17.9
17
*
ZXA05
NOMESCO Finland
Left side
2.9
17.8
114
506
H30.2
ICD-10 Finland
Posterior cyclitis
100.6
17.7
19
*
XCH05
NOMESCO Finland
Eye pressure longterm registration
189.9
17.7
18
*
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
25.8
17.6
24
10
L04AA01
ATC
[U] ciclosporin
25.8
17.6
24
10
M45
ICD-10 Finland
Ankylosing spondylitis
8.0
17.2
24
32
S01BC05
ATC
ketorolac; ophthalmic
5.5
16.9
34
67
3708
FHL
Trabeculectomy or equivalent
+∞
16.8
16
*
ZXA10
NOMESCO Finland
Bilateral
3.1
16.5
86
338
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
6.8
16.1
26
41
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
23.5
15.8
22
10
36400
ICD-8 Finland
Iritis, Iridocyclitis acuta
40.2
15.6
19
5
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
15.1
14.8
24
17
CFW99
NOMESCO Finland
Other operation on conjunctiva
+∞
14.7
14
*
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
+∞
14.7
14
*
3640A
ICD-9 Finland
Disorders of iris and ciliary body, Acute and subacute iridocyclitis
156.7
14.6
15
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
5.1
14.6
32
68
Z94.7
ICD-10 Finland
Corneal transplant status
55.9
13.9
16
*
S01FA06
ATC
tropicamide; ophthalmic
78.5
13.7
15
*
CHD35
NOMESCO Finland
Laser goniopuncture
+∞
13.6
13
*
L04AA17
ATC
[U] adalimumab
+∞
13.6
13
*
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
+∞
13.6
13
*
H40.6
ICD-10 Finland
Glaucoma secondary to drugs
+∞
13.6
13
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.7
13.6
46
137
TCG10
NOMESCO Finland
Removal of sutures from cornea
145.8
13.6
14
*
H25.1
ICD-10 Finland
Senile nuclear cataract
2.5
13.4
111
549
H22.1*D86.8
ICD-10 Finland
Iridocyclitis in sarcoidosis
+∞
12.6
12
*
37403
ICD-8 Finland
Cataract, Complicata
+∞
12.6
12
*
CS2P4
NOMESCO Finland
Optic nerve head imaging
+∞
12.6
12
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
12.6
12
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
12.6
53
182
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.0
11.9
36
99
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
19.8
11.7
17
9
H221, M084,
ICD-10 Finland
+∞
11.5
11
*
L04AD01
ATC
ciclosporin; systemic
13.4
11.3
19
15
H57.1
ICD-10 Finland
Ocular pain
4.9
11.1
25
54
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
44.9
11.0
13
*
XCW10
NOMESCO Finland
Assessment of vision
22.4
10.8
15
7
S01AX11
ATC
[U] ofloxacin
5.1
10.7
23
48
CHD00
NOMESCO Finland
Laser trabeculoplasty
113.5
10.5
11
*
H21.0
ICD-10 Finland
Hyphaema
+∞
10.5
10
*
H221, M083,
ICD-10 Finland
+∞
10.5
10
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
10.5
10
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
10.5
10
*
H11.3
ICD-10 Finland
Conjunctival haemorrhage
4.6
10.2
25
58
H15.1
ICD-10 Finland
Episcleritis
12.7
10.0
17
14
H40.11
ICD-10 Finland
Low pressure glaucoma
56.7
9.7
11
*
H40
ICD-10 Finland
Glaucoma
56.7
9.7
11
*
CS494
NOMESCO Finland
Other visual field testing
18.2
9.5
14
8
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
102.9
9.5
10
*
S01FB01
ATC
phenylephrine; ophthalmic
+∞
9.4
9
*
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
+∞
9.4
9
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
11.1
9.4
17
16
H02AB07
ATC
prednisone; oral
2.6
9.4
59
252
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
11.9
9.2
16
14
H18.8
ICD-10 Finland
Other specified disorders of cornea
37.8
9.1
11
*
H20
ICD-10 Finland
Iridocyclitis
24.8
9.0
12
5
Z3231
NOMESCO Finland
Registered nurse
2.2
8.9
103
575
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
5.0
8.7
19
40
P01BA02
ATC
hydroxychloroquine; oral
3.1
8.6
39
139
L04AB05
ATC
certolizumab pegol; parenteral
28.4
8.5
11
*
S01BA09
ATC
clobetasone; ophthalmic
92.3
8.5
9
*
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
92.3
8.5
9
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
8.4
8
*
H44.4
ICD-10 Finland
Hypotony of eye
+∞
8.4
8
*
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
+∞
8.4
8
*
CJD20
NOMESCO Finland
Extracapsular cataract extraction with implantation of artificial lens in posterior chamber
+∞
8.4
8
*
CFD10
NOMESCO Finland
Repair of conjunctiva
+∞
8.4
8
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
5.0
8.2
18
38
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
7.9
125
777
L04AA13
ATC
[U] leflunomide
7.3
7.9
18
26
L04AB06
ATC
golimumab; parenteral
15.5
7.8
12
8
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
46.1
7.7
9
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
46.1
7.7
9
*
H22.1*M45
ICD-10 Finland
Iridocyclitis in ankylosing spondylitis
46.1
7.7
9
*
CA1ME
NOMESCO Finland
Ultrasound oculometry
18.9
7.6
11
6
L04AA11
ATC
[U] etanercept
81.9
7.4
8
*
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
81.9
7.4
8
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
81.9
7.4
8
*
H22.1
ICD-10 Finland
Iridocyclitis in other diseases classified elsewhere
+∞
7.3
7
*
M08.9
ICD-10 Finland
Juvenile arthritis, unspecified
+∞
7.3
7
*
7143D
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[OLIGARTHRITIS JUVENILIS]
+∞
7.3
7
*
TCH12
NOMESCO Finland
Sample aspiration from anterior chambre
+∞
7.3
7
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
30.7
7.2
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
7.1
151
1028
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.3
7.0
27
87
ZXE00
NOMESCO Finland
One hour or less
1.9
6.9
130
850
ZXD20
NOMESCO Finland
Day surgery
2.4
6.8
51
235
H18.4
ICD-10 Finland
Corneal degeneration
40.9
6.8
8
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
17.1
6.8
10
6
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
10.3
6.6
12
12
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
6.5
126
826
H27.1
ICD-10 Finland
Dislocation of lens
71.2
6.4
7
*
H18.2
ICD-10 Finland
Other corneal oedema
71.2
6.4
7
*
S01BC01
ATC
indometacin; ophthalmic
71.2
6.4
7
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
4.2
6.4
17
42
H25.0
ICD-10 Finland
Senile incipient cataract
3.0
6.4
28
98
H35.36
ICD-10 Finland
Macular cyst
18.4
6.3
9
5
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.3
68
365
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
6.3
6
*
H22.0*B00.5
ICD-10 Finland
Herpesviral iridocyclitis
+∞
6.3
6
*
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
6.3
6
*
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
+∞
6.3
6
*
CHB99
NOMESCO Finland
Other operation on anterior chamber and anterior chamber angle
+∞
6.3
6
*
3719
FHL
Other measure in this category
+∞
6.3
6
*
CGG60
NOMESCO Finland
Reinforcement of sclera using graft
+∞
6.3
6
*
3711
FHL
Cyclodiateria or cryocoagulation
+∞
6.3
6
*
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.5
6.1
21
63
CG2T4
NOMESCO Finland
Topography assessment of cornea
8.8
6.1
12
14
H01.0
ICD-10 Finland
Blepharitis
3.1
6.0
26
90
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
190
1173
2.48
14.35
11.1
5.9
2.62
2.78
%
0.63
183
1098
192
1200
2.45
13.98
10.9
5.7
57.87
57.65
%
0.09
186
1133
219
1454
2.53
13.94
11.6
9.4
4.01
4.08
e9/l
0.16
200
1274
192
1211
2.42
13.54
11.3
6.0
27.35
27.60
%
0.12
185
1140
29
76
4.09
10.18
1.7
1.4
1.30
0.07
iu/ml
—
8
17
182
1213
2.13
10.12
4.2
3.6
0.00
0.00
estimate
0.50
41
251
180
1209
2.09
9.64
6.0
4.9
0.00
0.00
estimate
-0.00
39
233
180
1222
2.05
9.22
4.3
3.7
0.06
0.00
estimate
0.49
35
224
234
1857
1.91
6.48
7.0
3.9
12.36
11.96
mm/h
0.20
228
1692
16
39
4.26
6.16
4.6
3.6
61.00
59.90
%
0.10
16
39
136
955
1.73
5.34
4.5
3.8
—
—
—
0
0
158
1174
1.67
4.91
6.7
7.3
1.22
1.21
mmol/l
0.35
132
1007
16
38
4.37
4.89
4.0
2.7
4.72
4.97
e9/l
0.13
16
38
14
29
4.99
4.87
1.3
1.3
—
—
—
0
0
10
15
6.84
4.50
1.0
1.0
—
—
—
0
0
13
29
4.62
4.29
1.0
1.0
—
—
—
0
0
231
1930
1.67
4.26
9.1
7.3
76.63
77.79
u/l
0.12
223
1796
130
978
1.55
3.52
2.5
2.2
78.33
76.22
nmol/l
0.41
120
870
56
340
1.78
3.52
1.9
2.1
2.33
2.37
g/l
0.23
50
312
140
1081
1.52
3.32
5.5
6.4
1.22
1.21
mmol/l
0.36
130
971
15
56
2.76
3.10
1.3
1.3
—
—
—
0
0
281
2545
1.74
3.07
18.5
14.1
20.97
23.27
mg/l
0.54
232
2014
12
36
3.42
3.05
1.0
8.2
—
304.71
—
0
7
79
547
1.59
3.02
4.5
3.9
1.01
1.02
kg/l
—
10
74
93
670
1.54
2.99
4.5
3.9
0.00
0.00
estimate
0.50
38
229
6
9
6.76
2.88
1.0
1.0
1245.83
1404.33
miu/ml
—
6
9
5
6
8.44
2.76
2.2
1.3
—
—
—
0
0
5
6
8.44
2.76
1.6
3.8
—
—
—
0
0
110
836
1.48
2.71
3.4
3.1
47.70
30.83
u/l
0.40
105
804
8
19
4.29
2.69
1.4
1.4
—
—
—
0
0
13
49
2.72
2.65
1.1
1.3
—
—
—
0
0
41
248
1.75
2.62
3.2
3.3
—
—
—
0
0
113
878
1.44
2.44
3.2
3.0
—
—
—
0
0
11
39
2.88
2.36
1.5
3.0
17.08
16.17
%
—
5
23
9
28
3.28
2.32
1.1
1.3
—
—
—
0
0
49
323
1.61
2.29
2.0
2.1
21.60
22.46
%
0.16
40
277
7
18
3.95
2.26
2.0
1.9
—
—
—
0
0
290
2697
1.67
2.26
15.6
9.9
26.56
26.54
u/l
0.00
284
2592
41
260
1.66
2.23
2.1
1.9
—
—
—
0
0
121
965
1.40
2.23
2.1
1.9
89.07
96.24
pmol/l
1.15
69
495
32
190
1.76
2.20
3.0
2.5
73.60
64.83
ml/min/173m2
—
10
80
138
1137
1.37
2.05
17.0
13.5
1.25
1.24
inr
0.05
52
327
128
1042
1.38
2.05
4.0
4.8
35.31
35.58
g/l
0.26
118
980
14
63
2.28
2.04
1.7
1.5
—
—
—
0
0
92
720
1.39
1.85
3.4
3.2
2138.77
1428.99
ng/l
0.53
82
603
5
12
4.21
1.83
1.8
2.3
662.20
983.42
u/ml
—
5
12
63
463
1.45
1.80
1.7
1.6
1334.23
1204.49
nmol/l
0.48
51
349
15
74
2.08
1.78
1.6
2.9
—
—
—
0
0
6
18
3.38
1.75
1.0
1.0
—
—
—
0
0
72
548
1.40
1.70
2.0
1.8
1.20
1.30
mg/l
0.18
60
422
6
19
3.20
1.67
1.5
2.4
13.33
13.19
%
—
6
19
39
265
1.54
1.63
2.2
1.9
—
—
—
0
0
212
1914
1.31
1.50
4.3
3.7
15.14
14.69
pmol/l
2.00
199
1716
55
408
1.42
1.50
1.3
1.3
87.98
47.91
iu/ml
0.35
15
132
85
682
1.33
1.44
3.3
3.0
0.09
0.33
e6/l
4.22
63
514
51
379
1.41
1.38
2.1
2.0
—
—
—
0
0
78
622
1.33
1.37
3.0
2.7
10997.45
5161.92
umol/l
0.34
64
535
40
285
1.46
1.36
6.1
9.6
1.14
1.25
mmol/l
0.06
29
230
297
2837
1.51
1.35
27.6
20.3
255.48
249.35
e9/l
0.73
290
2771
10
47
2.16
1.35
1.8
1.5
9954.50
10414.00
e6/l
—
10
29
297
2838
1.51
1.34
27.5
20.4
40.06
40.32
%
0.29
273
2665
297
2840
1.50
1.31
27.5
20.3
4.46
4.50
e12/l
0.79
288
2763
71
563
1.33
1.30
1.6
1.5
21.20
20.85
nmol/l
0.07
60
476
10
48
2.12
1.29
1.5
1.6
—
—
—
0
0
126
1081
1.27
1.28
2.7
2.6
113.00
118.72
ug/l
0.14
121
990
76
613
1.31
1.24
2.6
2.0
3.08
3.02
mg/l
0.07
66
523
180
1615
1.25
1.23
3.3
3.2
—
—
—
0
0
11
56
2.00
1.23
1.1
1.3
—
—
—
0
0
13
71
1.87
1.21
2.6
1.5
0.21
0.23
g/l
0.23
13
71
50
381
1.37
1.18
3.4
2.8
1.30
1.79
e6/l
0.34
28
216
33
234
1.46
1.16
1.8
2.4
49.07
29.95
u/l
1.04
28
198
50
384
1.36
1.13
1.3
1.3
63.56
13.33
u/ml
1.08
19
150
7
30
2.36
1.13
1.0
1.1
—
—
—
0
0
56
441
1.33
1.08
5.3
4.0
205.98
130.43
ng/l
0.29
46
343
65
523
1.30
1.08
1.8
1.7
390.68
442.20
pmol/l
1.38
53
450
52
406
1.33
1.06
3.1
2.6
0.80
1.01
e6/l
0.49
30
238
20
131
1.56
1.02
2.7
1.9
—
—
—
0
0
39
294
1.37
1.00
2.0
2.7
8.08
7.32
umol/l
0.14
33
257
13
76
1.74
1.00
1.5
2.4
—
—
—
0
0
21
140
1.53
1.00
4.3
8.3
23.91
24.96
mmol/l
1.21
21
140
13
77
1.72
0.96
2.6
1.5
1.22
1.13
g/l
0.48
13
77
163
1475
1.21
0.95
4.7
5.1
6.89
6.67
mmol/l
0.54
157
1372
251
2373
1.25
0.93
17.4
12.9
85.07
82.04
ml/min/173m2
1.26
213
1934
246
2322
1.24
0.91
5.0
4.5
1.95
1.91
mu/l
0.20
225
2107
147
1327
1.20
0.85
5.6
6.2
11.52
11.33
umol/l
0.08
142
1252
10
57
1.78
0.84
1.8
1.4
—
—
—
0
0
110
976
1.19
0.76
3.8
3.8
21.09
39.36
ng/l
2.45
71
662
5
24
2.10
0.75
1.0
1.2
—
—
—
0
0
15
100
1.52
0.74
1.8
2.1
1.57
4.95
ug/l
0.53
15
88
5
25
2.02
0.73
2.4
4.2
—
—
—
0
0
12
76
1.60
0.72
1.7
1.2
—
—
—
0
0
57
477
1.24
0.71
1.5
1.6
—
—
—
0
0
84
732
1.20
0.71
3.6
3.6
7.37
9.43
mg/mmol
0.35
53
460
5
27
1.86
0.68
2.2
2.0
—
—
—
0
0
89
783
1.19
0.67
2.2
2.5
60.66
62.06
u/l
0.08
80
721
5
28
1.80
0.66
1.0
1.1
—
—
—
0
0
7
44
1.60
0.65
1.1
1.3
—
—
—
0
0
7
44
1.60
0.65
1.1
1.3
—
—
—
0
0
74
644
1.19
0.63
1.7
1.7
1.46
1.37
mmol/l
0.31
61
546
24
309
0.76
0.61
3.8
4.4
35.35
31.92
%
0.68
17
208
0
20
0.00
0.60
0.0
1.0
—
38.09
—
0
11
0
20
0.00
0.60
0.0
1.0
—
526.55
—
0
11
8
124
0.64
0.55
1.1
1.6
—
—
—
0
0
9
62
1.46
0.53
1.2
1.7
—
—
—
0
0
20
153
1.33
0.51
9.1
9.7
94.63
94.60
%
0.01
20
153
18
233
0.76
0.49
1.2
1.7
—
—
—
0
0
13
94
1.40
0.46
4.1
2.2
—
—
—
0
0
18
138
1.32
0.46
1.7
1.4
—
—
—
0
0
27
222
1.24
0.42
3.3
4.2
0.83
1.78
mmol/l
0.66
22
172
5
32
1.57
0.42
1.0
1.3
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.4
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
22
270
0.80
0.41
2.5
4.5
2.56
8.95
ug/l
2.52
14
222
89
814
1.13
0.41
2.8
3.4
2.36
2.36
mmol/l
0.16
79
713
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
27
224
1.22
0.40
3.3
4.2
5.90
5.74
kpa
0.39
27
216
10
71
1.42
0.39
1.1
1.4
325.38
308.29
ug/g
—
5
39
0
19
0.00
0.39
0.0
1.7
—
183.83
—
0
19
10
135
0.73
0.37
3.6
3.0
19.40
37.01
u/ml
—
10
130
26
217
1.22
0.37
3.5
1.8
312.92
363.50
nmol/l
0.77
26
200
7
52
1.35
0.31
1.3
1.3
—
46.58
—
0
6
238
2322
1.09
0.27
6.3
5.5
40.79
39.82
mmol/mol
0.70
225
2171
16
132
1.22
0.26
1.5
1.7
—
—
—
0
0
18
151
1.20
0.25
1.1
1.2
18.94
133.34
iu/ml
—
7
57
19
161
1.19
0.24
1.4
1.9
—
—
—
0
0
15
124
1.22
0.24
1.1
1.0
—
—
—
0
0
86
809
1.09
0.24
5.5
4.8
4.34
2.59
ug/l
0.74
76
719
40
441
0.89
0.23
3.4
2.9
2.46
2.45
mmol/l
0.12
35
391
28
316
0.88
0.23
1.5
2.1
—
—
—
0
0
7
94
0.74
0.22
1.4
1.5
46.61
23.26
iu/l
—
7
82
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
27
302
0.88
0.20
8.8
7.5
—
—
—
0
0
6
48
1.25
0.20
2.2
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
250
2456
1.08
0.20
4.3
4.4
5.81
5.93
mmol/l
0.94
232
2258
6
51
1.18
0.19
1.0
1.2
—
—
—
0
0
57
532
1.09
0.19
1.4
1.2
0.79
1.48
u/ml
0.93
15
143
19
166
1.15
0.18
2.1
1.5
—
—
—
0
0
35
381
0.91
0.17
1.3
1.4
—
—
—
0
0
5
66
0.75
0.17
1.4
1.8
—
—
—
0
0
10
120
0.83
0.17
3.3
3.6
0.46
0.68
%
—
10
120
8
71
1.13
0.16
1.5
1.3
—
—
—
0
0
8
73
1.10
0.16
1.4
1.4
—
—
—
0
0
77
736
1.06
0.14
2.2
2.1
136.03
238.78
u/l
2.05
71
698
8
97
0.82
0.14
1.5
2.1
—
—
—
0
0
251
2478
1.06
0.13
4.2
4.2
1.48
1.46
mmol/l
0.35
234
2300
257
2542
1.05
0.11
4.7
4.7
2.64
2.77
mmol/l
1.41
242
2354
45
473
0.94
0.10
3.4
3.0
0.66
0.78
ug/l
0.66
34
297
6
55
1.09
0.09
1.2
1.3
—
—
—
0
0
27
287
0.94
0.08
1.3
2.0
—
—
—
0
0
5
63
0.79
0.08
1.0
1.5
—
—
—
0
0
5
63
0.79
0.08
1.0
1.5
—
—
—
0
0
5
63
0.79
0.08
1.0
1.5
—
—
—
0
0
5
65
0.77
0.08
1.4
1.8
—
—
—
0
0
6
70
0.85
0.07
1.2
1.6
—
—
—
0
0
19
176
1.08
0.07
4.2
3.5
5.14
5.14
kpa
0.00
19
170
10
89
1.13
0.07
1.2
1.6
—
—
—
0
0
8
95
0.84
0.06
1.4
1.9
—
—
—
0
0
238
2398
0.97
0.05
3.8
3.8
1.27
1.28
mmol/l
0.01
224
2212
170
1716
0.98
0.04
3.2
2.9
53.26
46.77
u/l
0.35
161
1613
57
581
0.98
0.03
2.1
2.3
—
—
—
0
0
20
192
1.04
0.02
4.0
3.7
4.52
4.34
kpa
0.18
20
184
66
651
1.02
0.02
5.2
4.2
19.34
21.54
%
0.63
41
311
250
2491
1.02
0.02
4.3
4.3
4.57
4.65
mmol/l
0.54
235
2325
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
0.30
—
0
9
6
65
0.92
-0.00
1.0
1.5
—
—
—
0
0
7
79
0.88
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
117
1170
1.00
-0.00
2.5
2.6
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.8
—
—
—
0
0
5
58
0.86
-0.00
1.2
1.3
—
—
—
0
0
6
67
0.89
-0.00
1.7
1.4
—
—
—
0
0
6
65
0.92
-0.00
5.7
4.2
—
2.73
—
0
11
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
9
94
0.96
-0.00
2.8
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
8
84
0.95
-0.00
1.5
1.4
317.25
280.61
mu/l
—
8
76
0
5
0.00
-0.00
0.0
1.8
—
31.20
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCSECINFLAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECINFLAM | 1.399 [1.15, 1.7] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.129 |
During the follow-up period (1.1.1998 — 31.12.2019), 148 out of 753 females with H7_GLAUCSECINFLAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECINFLAM | 1.0 [0.79, 1.26] | 0.997 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 629 males with H7_GLAUCSECINFLAM died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCSECINFLAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.159% | 0.192% |
| 5 | 0.754% | 1.124% |
| 10 | 1.798% | 2.812% |
| 15 | 3.606% | 5.501% |
| 20 | 6.519% | 9.447% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCSECINFLAM – Glaucoma secondary to eye inflammation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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