glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
229 |
4. Check minimum number of eventsNone |
229 |
5. Include endpointsNone |
229 |
6. Filter based on genotype QC (FinnGen only) |
229 |
Control definitions (FinnGen only)
- Control exclude
- H7_GLAUCOMA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H40
- Name in latin
- Glaucoma [secundarium] posttraumaticum
Similar endpoints
↥List of similar endpoints to
Glaucoma secondary to eye trauma
based on the number of shared cases.
Similar with more cases:
- Glaucoma
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2393 | 862 | 1511 |
| Only index persons | 2107 | 772 | 1335 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.02 | 0.04 |
| Only index persons | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 61.99 | 69.56 | 57.65 |
| Only index persons | 60.89 | 68.48 | 56.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 229 | 84 | 145 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | 61.20 | 58.27 | 62.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 203
- Matched controls
- 2030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
16384.0
258.4
190
*
114
Kela drug reimbursment
Glaucoma
247.7
168.0
158
28
S01ED51
ATC
timolol, combinations; ophthalmic
229.6
159.6
151
25
S01EE01
ATC
latanoprost; ophthalmic
126.3
108.7
111
19
S01ED01
ATC
timolol; ophthalmic
116.7
97.6
101
17
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
+∞
91.8
81
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
445.0
86.9
81
*
S01EC04
ATC
brinzolamide; ophthalmic
245.8
79.5
77
5
H40.0
ICD-10 Finland
Glaucoma suspect
151.1
69.1
70
7
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
+∞
68.7
62
*
S01EC01
ATC
acetazolamide; systemic
68.7
61.3
69
15
S01EX03
ATC
NA
140.6
58.6
60
6
XCK00
NOMESCO Finland
Perimetry
27.0
52.4
74
42
S01EC03
ATC
dorzolamide; ophthalmic
131.5
40.5
42
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
9.3
36.2
86
148
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
6.9
35.9
139
485
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
+∞
35.5
33
*
S01EE05
ATC
tafluprost; ophthalmic
66.2
33.6
38
7
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
+∞
33.2
31
*
S01EE03
ATC
bimatoprost; ophthalmic
195.7
32.7
33
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
32.1
30
*
S01EE04
ATC
travoprost; ophthalmic
49.7
31.2
37
9
CHD00
NOMESCO Finland
Laser trabeculoplasty
+∞
25.5
24
*
S01ED02
ATC
betaxolol; ophthalmic
148.2
25.2
26
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
8.0
24.8
61
103
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
23.4
22
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.5
22.7
123
516
WX140
NOMESCO Finland
Parabulbar anesthesy
13.9
22.4
39
34
XCH00
NOMESCO Finland
Eye pressure measurement
22.1
22.1
32
17
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
16.6
21.8
35
25
3656E
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA POSTTRAUMATICUM]
+∞
21.2
20
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
122.6
21.0
22
*
XCK10
NOMESCO Finland
Photography of fundus of eye
6.7
20.6
57
111
H40.9
ICD-10 Finland
Glaucoma, unspecified
81.5
20.1
22
*
S01EB01
ATC
pilocarpine; ophthalmic
77.5
19.1
21
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
36.8
18.4
23
7
H26.1
ICD-10 Finland
Traumatic cataract
58.2
18.3
21
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
+∞
18.0
17
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
32.1
17.8
23
8
CHC05
NOMESCO Finland
Iridotomy
69.4
17.0
19
*
CHD99
NOMESCO Finland
Other filtering operation
+∞
16.9
16
*
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
25.7
16.8
23
10
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.6
16.3
103
451
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
15.8
15
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
15.8
15
*
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
92.3
15.8
17
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.3
15.0
42
81
H27.0
ICD-10 Finland
Aphakia
161.0
14.7
15
*
S01EA02
ATC
dipivefrine; ophthalmic
+∞
13.7
13
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.8
13.6
49
127
S01EA03
ATC
apraclonidine; ophthalmic
30.7
13.2
17
6
XCH05
NOMESCO Finland
Eye pressure longterm registration
+∞
12.6
12
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.0
12.6
56
177
ZXA05
NOMESCO Finland
Left side
3.1
12.0
84
373
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
24.6
11.8
16
7
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
12.2
11.3
20
18
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
12.2
11.3
20
18
H40
ICD-10 Finland
Glaucoma
46.0
11.1
13
*
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
7.1
10.7
26
41
CHD35
NOMESCO Finland
Laser goniopuncture
+∞
10.5
10
*
H40.11
ICD-10 Finland
Low pressure glaucoma
+∞
10.5
10
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.7
10.4
36
88
S01BC03
ATC
diclofenac; ophthalmic
10.9
10.3
19
19
H26.4
ICD-10 Finland
After-cataract
4.2
10.0
40
113
ZXC20
NOMESCO Finland
Use of chemical agents
11.5
10.0
18
17
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
23.0
9.5
13
6
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
+∞
9.4
9
*
H40.8
ICD-10 Finland
Other glaucoma
+∞
9.4
9
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
9.4
9
*
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
52.3
8.8
10
*
H18.1
ICD-10 Finland
Bullous keratopathy
52.3
8.8
10
*
H04.10
ICD-10 Finland
Dry eye syndrome
4.2
8.6
33
90
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.3
8.4
25
52
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
+∞
8.4
8
*
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
8.4
8
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
18.1
8.2
12
7
WX142
NOMESCO Finland
Sub-tenon anesthesy
46.8
7.8
9
*
CS494
NOMESCO Finland
Other visual field testing
19.3
7.7
11
6
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
83.0
7.5
8
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
11.5
7.4
13
12
H25.1
ICD-10 Finland
Senile nuclear cataract
2.5
7.4
73
378
3650A
ICD-9 Finland
Glaucoma, Borderline glaucoma [glaucoma suspect][SUSPICIO GLAUCOMATIS (AVOKULMA)]
+∞
7.3
7
*
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
7.3
7
*
3708
FHL
Trabeculectomy or equivalent
+∞
7.3
7
*
CFW99
NOMESCO Finland
Other operation on conjunctiva
+∞
7.3
7
*
S01FA01
ATC
atropine; ophthalmic
31.2
7.2
9
*
H21.0
ICD-10 Finland
Hyphaema
41.5
6.8
8
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
12.8
6.7
11
9
H33.0
ICD-10 Finland
Retinal detachment with retinal break
6.6
6.6
16
26
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
72.0
6.5
7
*
H57.1
ICD-10 Finland
Ocular pain
11.5
6.4
11
10
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
6.3
6
*
3643
FHL
Vitrectomy through pars Plana
+∞
6.3
6
*
F93
ICPC
Glaucoma
+∞
6.3
6
*
87091
ICD-8 Finland
Open wound of eye and orbit, Perforans oculi, Sequelae
+∞
6.3
6
*
37405
ICD-8 Finland
Cataract, Traumatica
+∞
6.3
6
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
27.6
6.3
8
*
W44
ICD-10 Finland
Foreign body entering into or through eye or natural orifice
8.1
6.2
13
17
H34.8
ICD-10 Finland
Other retinal vascular occlusions
7.1
6.1
14
21
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
5
0
+∞
5.22
1.8
0.0
107.6
—
ng/l
—
5
0
121
897
1.74
4.10
9.6
6.9
1.2
1.2
mmol/l
0.22
105
757
200
1742
2.17
3.81
19.9
16.3
25.8
25.8
mg/l
0.00
166
1422
206
1818
2.33
3.75
23.4
18.7
139.5
139.7
mmol/l
0.64
201
1767
84
577
1.72
3.65
3.2
2.6
52.3
55.8
u/l
0.56
74
532
206
1825
2.28
3.60
23.8
18.8
4.0
4.0
mmol/l
0.24
200
1774
48
283
1.88
3.45
2.5
3.3
0.9
0.8
mmol/l
1.56
42
265
121
938
1.61
3.17
7.4
6.5
12.5
11.7
umol/l
0.20
112
890
59
382
1.73
3.10
1.8
1.8
950.6
1259.8
nmol/l
2.00
43
294
81
585
1.60
2.77
4.7
3.8
18.0
10.8
mg/mmol
0.36
58
389
49
311
1.73
2.75
1.8
1.9
—
—
—
0
0
105
812
1.54
2.63
6.5
5.9
1.2
1.2
mmol/l
0.10
98
731
7
15
4.78
2.61
1.3
1.2
—
—
—
0
0
163
1392
1.59
2.59
9.5
7.6
85.4
80.0
u/l
0.61
152
1295
59
402
1.63
2.53
1.5
1.9
445.9
430.4
pmol/l
0.15
47
344
65
468
1.54
2.19
2.6
2.0
3.2
3.3
mg/l
0.01
58
404
176
1559
1.56
2.11
4.3
4.4
1.9
2.0
mu/l
0.57
149
1389
30
180
1.77
2.04
10.5
4.3
3.3
1.6
mmol/l
0.70
25
144
13
57
2.36
2.01
1.5
1.5
—
—
—
0
0
22
121
1.91
1.96
1.8
1.5
—
—
—
0
0
15
74
2.10
1.79
1.5
1.9
—
—
—
0
0
14
68
2.13
1.74
1.4
1.6
—
—
—
0
0
5
13
3.91
1.72
5.0
2.6
—
—
—
0
0
149
1312
1.39
1.56
5.2
3.9
16.0
13.2
mm/h
0.84
138
1195
93
761
1.37
1.53
4.5
4.2
93.5
44.1
ng/l
0.47
71
562
198
1840
1.56
1.51
13.7
10.5
28.5
25.2
u/l
0.77
192
1764
74
585
1.39
1.49
3.9
3.3
2.3
2.3
mmol/l
0.02
61
515
21
126
1.73
1.46
1.3
1.6
—
—
—
0
0
184
1690
1.45
1.43
5.6
4.7
6.3
6.1
mmol/l
1.19
159
1539
90
743
1.35
1.37
2.0
2.0
94.6
93.1
pmol/l
0.11
45
402
81
660
1.35
1.34
2.4
2.2
78.8
77.3
nmol/l
0.16
74
580
32
220
1.53
1.33
1.9
1.9
—
—
—
0
0
10
48
2.13
1.29
1.2
1.2
—
—
—
0
0
17
100
1.76
1.27
4.7
3.0
1.0
1.1
%
0.23
17
100
48
362
1.41
1.26
4.7
3.7
119.7
178.7
ng/l
0.27
37
300
99
838
1.32
1.25
4.9
4.4
—
—
—
0
0
32
224
1.50
1.23
1.8
1.9
—
—
—
0
0
116
1012
1.30
1.15
10.8
9.4
4.3
4.3
e9/l
0.11
110
877
175
1619
1.34
1.09
8.3
6.2
43.0
41.0
mmol/mol
1.64
158
1502
7
32
2.22
1.09
1.7
1.4
—
—
—
0
0
92
784
1.29
1.07
7.9
4.8
34.3
35.0
g/l
0.56
87
737
101
872
1.28
1.06
5.6
5.1
2.5
2.7
ug/l
0.19
86
773
36
268
1.41
1.03
3.4
2.7
19.6
22.7
%
0.73
28
233
84
712
1.28
1.01
3.3
2.7
134.1
161.2
ug/l
0.69
76
655
7
35
2.03
1.01
1.3
1.5
—
—
—
0
0
25
174
1.49
1.00
3.0
2.7
4.4
6.0
ug/l
0.60
19
154
72
602
1.29
0.96
3.1
3.4
1704.0
1832.2
ng/l
0.11
64
522
59
482
1.30
0.94
3.3
2.8
18107.7
7585.1
umol/l
0.38
44
410
163
1507
1.28
0.93
19.6
17.0
39.0
39.1
%
0.04
93
1011
105
926
1.25
0.89
2.9
2.6
—
—
—
0
0
173
1616
1.29
0.88
4.6
4.1
1.3
1.3
mmol/l
0.10
150
1479
47
376
1.31
0.87
1.3
1.7
2.2
1.3
mg/l
0.52
38
295
32
241
1.38
0.87
4.3
6.8
1.5
1.2
mmol/l
0.17
26
189
82
705
1.25
0.86
5.3
4.1
—
—
—
0
0
8
45
1.81
0.85
3.9
1.8
—
—
—
0
0
6
32
1.90
0.82
1.3
1.4
—
—
—
0
0
135
1233
1.23
0.80
3.6
3.7
14.8
14.9
pmol/l
0.13
115
1095
177
1667
1.27
0.78
5.1
4.5
1.3
1.4
mmol/l
1.80
157
1531
98
870
1.22
0.75
4.9
3.9
0.0
0.0
estimate
0.00
23
172
178
1680
1.27
0.75
5.1
4.6
4.4
4.5
mmol/l
0.38
160
1554
5
24
2.11
0.75
1.8
1.3
—
—
—
0
0
182
1723
1.27
0.75
5.8
5.1
2.6
2.7
mmol/l
0.17
163
1581
79
687
1.23
0.74
5.2
4.6
23.0
21.3
%
0.39
37
355
14
92
1.56
0.74
1.8
2.0
0.9
1.5
ug/l
—
9
86
35
275
1.32
0.74
1.1
1.2
29.3
36.4
iu/ml
—
10
88
10
60
1.70
0.73
2.5
2.5
95.0
72.8
ug/min
—
5
38
5
26
1.94
0.71
3.8
5.1
—
—
—
0
0
20
144
1.43
0.71
2.7
3.7
1.9
1.9
mmol/l
0.01
13
104
9
58
1.57
0.70
1.3
1.6
—
—
—
0
0
7
41
1.73
0.70
1.0
1.5
—
—
—
0
0
7
41
1.73
0.70
1.0
1.5
—
—
—
0
0
7
43
1.65
0.67
1.0
1.1
—
—
—
0
0
97
870
1.20
0.66
6.8
5.4
0.0
0.0
estimate
0.00
23
170
7
44
1.61
0.65
1.0
1.4
—
3.3
—
0
11
8
50
1.62
0.62
1.3
1.5
—
—
—
0
0
50
423
1.23
0.60
2.5
2.5
—
—
—
0
0
0
22
0.00
0.59
0.0
2.1
—
4.6
—
0
5
31
249
1.28
0.58
1.1
1.3
36.8
16.7
u/ml
0.32
11
93
6
37
1.64
0.56
1.0
1.4
—
—
—
0
0
29
232
1.29
0.56
6.4
8.0
—
—
—
0
0
97
883
1.17
0.53
5.0
3.9
0.0
0.0
estimate
0.00
23
159
29
234
1.27
0.53
4.6
4.6
28.5
31.7
%
0.63
21
161
12
84
1.45
0.50
3.6
2.1
39.9
38.2
u/l
0.13
12
75
57
499
1.19
0.50
5.3
4.0
0.0
0.0
estimate
0.00
23
158
7
48
1.47
0.47
1.3
1.5
—
—
—
0
0
7
49
1.44
0.46
1.9
1.2
0.7
0.9
nmol/l
—
7
40
20
157
1.30
0.45
2.3
2.3
0.2
0.2
g/l
0.39
20
145
0
15
0.00
0.41
0.0
1.1
—
9.9
—
0
5
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
8
60
1.35
0.40
1.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
8
112
0.70
0.38
2.8
2.1
—
—
—
0
0
5
37
1.36
0.37
1.0
1.1
—
—
—
0
0
5
37
1.36
0.37
1.4
1.5
—
—
—
0
0
33
283
1.19
0.37
46.2
25.7
1.6
1.4
inr
0.25
13
34
9
71
1.28
0.36
1.9
2.5
—
—
—
0
0
171
1650
1.14
0.35
19.1
14.8
72.2
76.8
ml/min/173m2
1.50
141
1344
6
88
0.67
0.33
1.0
1.3
—
—
—
0
0
27
230
1.20
0.33
1.8
1.4
—
—
—
0
0
39
344
1.16
0.32
1.3
1.2
0.5
1.7
u/ml
—
9
99
35
307
1.17
0.31
3.5
2.9
1.9
1.1
e6/l
0.49
22
192
7
56
1.26
0.29
4.9
4.4
—
3.6
—
0
7
115
1095
1.10
0.27
3.5
3.2
79.0
51.9
u/l
0.82
102
1022
146
1407
1.10
0.27
24.5
19.8
13.9
13.8
%
0.48
141
1387
53
487
1.11
0.25
3.3
3.0
0.8
0.8
ug/l
0.04
36
314
14
115
1.23
0.24
1.6
1.7
—
—
—
0
0
23
200
1.17
0.23
3.9
3.6
—
—
—
0
0
5
40
1.26
0.22
1.0
1.2
—
—
—
0
0
8
101
0.78
0.21
2.6
2.0
—
—
—
0
0
34
307
1.13
0.21
1.9
1.9
29.9
29.4
s
0.24
34
299
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
5.3
—
85.0
—
0
11
0
12
0.00
0.21
0.0
1.7
—
3.3
—
0
7
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
9
113
0.79
0.20
1.7
1.6
—
—
—
0
0
14
164
0.84
0.19
3.5
2.8
64.8
66.5
g/l
0.58
14
145
8
71
1.13
0.16
1.1
2.4
4.3
3.1
g/l
—
8
56
8
71
1.13
0.16
1.1
2.4
10.9
10.1
g/l
—
8
62
56
529
1.08
0.15
4.0
3.3
0.8
0.6
e6/l
0.17
44
404
10
84
1.20
0.14
1.0
1.0
—
—
—
0
0
6
54
1.11
0.09
1.5
1.6
—
—
—
0
0
8
78
1.03
0.07
1.1
2.3
4.4
3.8
g/l
—
8
55
8
78
1.03
0.07
1.1
2.3
9.3
7.5
g/l
—
8
58
8
78
1.03
0.07
1.1
2.3
—
—
—
0
0
68
697
0.97
0.06
4.3
3.4
—
—
—
0
0
45
435
1.04
0.06
1.7
1.6
18.0
20.0
nmol/l
0.40
37
366
36
352
1.03
0.02
3.1
3.0
2.5
2.4
mmol/l
0.73
29
309
17
177
0.96
0.01
1.5
1.4
—
—
—
0
0
10
98
1.02
0.00
3.8
8.8
24.2
24.6
mmol/l
—
10
93
44
437
1.01
0.00
1.7
1.6
1.3
1.4
mmol/l
0.26
36
360
29
292
0.99
0.00
3.6
3.1
0.7
1.9
e6/l
1.26
16
180
5
53
0.94
0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
13.2
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
91.9
—
0
8
0
8
0.00
0.00
0.0
1.8
—
75.9
—
0
8
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
6
60
1.00
0.00
1.2
2.5
31.6
37.4
g/l
—
6
50
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
0.00
0.0
4.9
—
103.4
—
0
7
8
84
0.95
0.00
4.3
3.1
30.6
599.1
u/ml
—
8
70
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.0
—
132.2
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCSECTRAUMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECTRAUMA | 1.083 [0.92, 1.27] | 0.327 |
| Birth year | 0.994 [0.99, 1.0] | 0.134 |
During the follow-up period (1.1.1998 — 31.12.2019), 277 out of 736 females with H7_GLAUCSECTRAUMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECTRAUMA | 1.166 [0.99, 1.37] | 0.061 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 310 out of 1144 males with H7_GLAUCSECTRAUMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCSECTRAUMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.096% | 0.217% |
| 5 | 0.64% | 1.213% |
| 10 | 1.766% | 3.075% |
| 15 | 3.328% | 5.942% |
| 20 | 5.542% | 9.904% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCSECTRAUMA – Glaucoma secondary to eye trauma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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