Other papulosquamous disorders

L12_PAPULOSQUAOTH

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L44 Cause of death: ICD-10 — L44 2 out of 7 registries used, show all original rules.	308
4. Check minimum number of events None	308
5. Include endpoints L12_PITYRIASISRUBRA L12_LICHENNITI L12_LICHENSTRIA L12_LICHENRUBER L12_INFANTPAPACRO L12_PAPULOSQUONAS	398
6. Filter based on genotype QC (FinnGen only)	398

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L40-L45
Name in latin: Aliae morbositates papulosquamosae

NAME	L12_PAPULOSQUAOTH
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	L12_PITYRIASISRUBRA\|L12_LICHENNITI\|L12_LICHENSTRIA\|L12_LICHENRUBER\|L12_INFANTPAPACRO\|L12_PAPULOSQUONAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L44
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L44
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other papulosquamous disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3924	2160	1732
Only index persons	3067	1745	1322
Unadjusted period prevalence (%)
Whole population	0.06	0.06	0.05
Only index persons	0.06	0.06	0.05
Median age at first event (years)
Whole population	43.28	46.71	38.85
Only index persons	41.53	44.89	37.09

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	398	233	165
Unadjusted period prevalence (%)	0.08	0.08	0.07
Median age at first event (years)	49.32	44.57	56.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
360: Matched controls
3598

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L44.0

ICD-10 Finland

Pityriasis rubra pilaris

+∞

76.9

L44.8

ICD-10 Finland

Other specified papulosquamous disorders

422.2

70.2

6970A

ICD-9 Finland

Lichen planus[LICHEN RUBER PLANUS]

+∞

52.4

L44.9

ICD-10 Finland

Papulosquamous disorder, unspecified

+∞

52.4

D05BB02

ATC

acitretin; oral

76.4

52.0

D07AC01

ATC

betamethasone; topical

4.8

42.1

202

755

L44.2

ICD-10 Finland

Lichen striatus

+∞

40.4

L40.0

ICD-10 Finland

Psoriasis vulgaris

62.4

38.3

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

7.2

36.2

172

L44.1

ICD-10 Finland

Lichen nitidus

+∞

32.8

D07XC01

ATC

betamethasone, combinations; topical

6.7

32.5

174

E0000UV

ATC

3.8

30.9

207

952

L30.9

ICD-10 Finland

Dermatitis, unspecified

4.6

28.3

116

339

D07AC13

ATC

mometasone; topical

3.5

25.5

155

632

D07AD01

ATC

clobetasol; topical

4.6

25.1

269

D05AX52

ATC

calcipotriol, combinations; topical

12.4

24.7

L43.8

ICD-10 Finland

Other lichen planus

66.9

22.1

D07AB02

ATC

hydrocortisone butyrate; topical

2.9

18.0

140

641

L44.3

ICD-10 Finland

Lichen ruber moniliformis

+∞

17.9

D07AB08

ATC

desonide; topical

4.4

17.4

182

D05AX02

ATC

calcipotriol; topical

11.6

17.3

E000001

ATC

3.1

16.8

114

473

TQW80

NOMESCO Finland

Local dermatologic skincare

10.4

14.5

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

145.2

13.5

L26

ICD-10 Finland

Exfoliative dermatitis

145.2

13.5

E000003

ATC

6.1

13.2

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

4.1

12.5

136

E000002

ATC

3.3

12.4

239

L43.9

ICD-10 Finland

Lichen planus, unspecified

18.9

12.2

D02AE01

ATC

carbamide; topical

4.8

11.6

69619

ICD-8 Finland

Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)

+∞

11.5

D07AA02

ATC

hydrocortisone; topical

3.0

11.2

275

H02AB06

ATC

prednisolone; systemic

2.2

11.0

174

1088

134

Kela drug reimbursment

General erythroderma

113.2

10.5

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

24.2

10.3

L40.5

ICD-10 Finland

Arthropathic psoriasis

41.3

10.0

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

2.4

9.7

455

L40.8

ICD-10 Finland

Other psoriasis

46.0

7.7

D07BA04

ATC

hydrocortisone and antiseptics; topical

2.8

7.6

192

R06AE07

ATC

cetirizine; oral

1.9

7.5

161

1084

69698

ICD-8 Finland

Psoriasis and similar disorders, Other disorders

+∞

7.3

L40

ICD-10 Finland

Psoriasis

14.1

6.9

D07AB01

ATC

clobetasone; topical

4.5

6.9

A46

ICD-10 Finland

Erysipelas

2.4

6.7

248

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

2.9

6.6

155

D07BC01

ATC

betamethasone and antiseptics; topical

2.6

6.6

190

L20.0

ICD-10 Finland

Besnier prurigo

3.1

6.6

122

R21

ICD-10 Finland

Rash and other nonspecific skin eruption

4.2

6.4

L40.3

ICD-10 Finland

Pustulosis palmaris et plantaris

18.4

6.3

M07.3

ICD-10 Finland

Other psoriatic arthropathies

+∞

6.3

69699

ICD-8 Finland

+∞

6.3

319

Kela drug reimbursment

Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)

+∞

6.3

69700

ICD-8 Finland

Lichen, Planus

+∞

6.3

M25.5

ICD-10 Finland

Pain in joint

1.9

6.2

105

639

XQ848

NOMESCO Finland

Dermatological photography

5.4

6.1

Mortality – FinRegistry

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Association

Association between endpoint L12_PAPULOSQUAOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_PAPULOSQUAOTH	1.183 [0.96, 1.46]	0.119
Birth year	0.99 [0.98, 1.0]	0.027

During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 1235 females with L12_PAPULOSQUAOTH died.

Males

Parameter	HR [95% CI]	p-value
L12_PAPULOSQUAOTH	1.496 [1.14, 1.97]	0.004
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 1017 males with L12_PAPULOSQUAOTH died.

Mortality risk

Mortality risk for people of age

years, who have L12_PAPULOSQUAOTH.

N-year risk	Females	Males
1	0.083%	0.332%
5	0.566%	1.753%
10	1.522%	4.204%
15	2.952%	7.479%
20	5.118%	12.236%

Relationships between endpoints

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Index endpoint: L12_PAPULOSQUAOTH – Other papulosquamous disorders

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other papulosquamous disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints