Lichen striatus

L12_LICHENSTRIA

lichen nitidus: a chronic inflammatory disease of unknown etiology characterized by 1–2 mm, discrete and uniform, shiny, flat-topped, pale flesh-colored or reddish-brown papules that may appear as hypopigmented against dark skin.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L44.2 Cause of death: ICD-10 — L44.2 2 out of 7 registries used, show all original rules.	44
4. Check minimum number of events None	44
5. Include endpoints None	44
6. Filter based on genotype QC (FinnGen only)	44

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L44
Name in latin: Lichen striatus

NAME	L12_LICHENSTRIA
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L442
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L442
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lichen striatus based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	349	226	121
Only index persons	288	194	94
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	15.40	17.57	10.72
Only index persons	23.01	27.33	14.10

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	44	35	9
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	36.66	33.76	47.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

5.60

2.49

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

211

2.33

1.79

7.0

9.7

3.6

3.8

e9/l

0.31

182

(40760892) CBC W Ordered Manual Differential panel - Blood

2.14

1.32

2.6

5.5

—

(40768804) Tissue Pathology biopsy report

123

1.96

1.28

2.7

2.0

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

182

1.87

1.16

2.6

4.0

6.0

6.4

mmol/l

0.38

163

(3026008) Bacteria identified in Urine by Culture

116

0.44

1.16

4.8

2.7

—

(3032080) INR in Blood by Coagulation assay

110

1.89

1.13

2.5

4.6

1.0

1.1

inr

—

(42870588) Differential panel, method unspecified - Blood

103

1.87

1.07

3.1

5.0

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.00

1.02

0.0

2.6

—

0.9

—

(3023368) Bacteria identified in Blood by Culture

1.96

0.97

3.7

4.7

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.12

0.75

2.2

8.6

122.2

123.4

g/l

—

(4035726)

1.88

0.68

2.2

1.3

—

(3013512) EKG study

0.53

0.64

4.8

3.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.62

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.62

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.61

0.0

1.5

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

182

1.42

0.46

6.1

5.8

8.7

10.8

umol/l

0.81

172

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

305

0.70

0.44

3.1

3.7

—

(3000850) Epithelial cells [#/volume] in Urine

1.50

0.43

3.1

2.5

11.5

7.2

e6/l

0.35

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.42

0.0

2.5

—

135.4

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.42

0.0

1.6

—

101.7

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.42

0.0

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.48

0.41

6.8

6.4

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

244

0.73

0.39

3.1

2.6

71.6

36.6

u/l

0.57

233

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

149

1.35

0.36

3.9

3.7

—

(3042936) Bacteria identified in Isolate by Culture

1.35

0.34

1.0

1.8

—

(1761868) Lipid panel - Serum or Plasma

119

0.69

0.33

3.4

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

113

1.35

0.32

1.4

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.66

0.29

2.2

1.8

—

(3021589) Normoblasts [#/volume] in Blood

153

1.30

0.29

5.5

8.7

0.0

e9/l

0.00

119

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.68

0.27

1.2

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

103

0.73

0.24

2.1

2.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.28

0.23

1.8

1.7

—

(3015736) pH of Urine

137

1.26

0.23

4.7

3.1

—

(3000494) Fungus identified in Specimen by Culture

1.25

0.23

1.0

1.4

—

(36660697) Celiac disease serology panel - Serum

1.25

0.23

1.2

1.0

—

(3002256) Pathology report gross observation

1.21

0.22

1.2

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.21

0.0

3.4

—

0.9

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.5

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

4.6

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.00

0.21

0.0

3.5

—

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.21

0.0

1.9

—

52.6

—

(3022313) Gas panel - Capillary blood

0.00

0.21

0.0

4.6

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

484.0

—

(4094501)

0.00

0.21

0.0

1.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.21

0.0

1.9

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.0

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.21

0.0

1.4

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.21

0.0

2.3

—

0.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.20

0.20

1.2

2.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

289

1.25

0.20

4.2

4.3

14.9

14.7

pmol/l

0.25

259

(40761511) CBC panel - Blood by Automated count

378

0.87

0.18

11.4

10.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.69

0.18

2.6

2.0

—

(3021960) Folate [Moles/volume] in Serum or Plasma

0.78

0.17

1.0

1.7

25.8

24.1

nmol/l

—

(3033658) Prothrombin time (PT) actual/Normal

0.78

0.16

2.3

3.1

91.1

95.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

345

1.24

0.15

12.5

11.6

40.4

40.1

0.19

271

(46235355) HIV 1 and 2 tests - Meaningful Use set

116

0.82

0.14

1.9

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

125

1.18

0.12

2.8

3.0

—

(40758558) Short blood count panel - Blood

1.18

0.10

8.8

7.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.81

0.09

1.6

2.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.85

0.08

1.5

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

366

0.91

0.08

13.4

11.6

15.8

19.6

mg/l

0.55

282

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

118

1.14

0.08

2.5

2.6

25.4

31.9

u/l

0.71

111

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.12

0.08

6.2

3.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.16

0.07

2.2

—

(3019150) Specific gravity of Urine by Refractometry

1.16

0.07

6.3

3.1

—

1.0

—

(3044640) Blood type and Crossmatch panel - Blood

102

0.85

0.07

2.6

1.9

—

(3003694) ABO and Rh group [Type] in Blood

103

0.84

0.07

2.9

1.7

—

(36304419) Bacteria [Presence] in Urine

103

1.09

0.02

3.2

2.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

123

1.08

0.02

1.5

1.9

95.5

94.5

pmol/l

—

(3044889) 12 lead EKG panel

213

1.07

0.02

3.7

3.0

—

(3018095) Leukocytes [#/volume] in Urine

134

1.07

0.01

2.7

4.0

36.6

30.7

e6/l

0.13

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

113

0.96

0.00

2.7

3.3

12.0

31.5

ng/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

135

1.05

0.00

4.7

3.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.05

0.00

2.4

2.5

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

108

1.02

0.00

3.4

2.3

44.0

63.8

u/l

1.43

(3048689) Calprotectin [Mass/mass] in Stool

0.88

0.00

1.8

1.4

39.0

169.8

ug/g

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.93

0.00

2.1

1.7

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

4.3

—

104.9

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3039000) Anion gap in Blood

0.00

0.0

4.3

—

10.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.4

—

(43055514) Macroprolactin [Presence] in Serum or Plasma

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3026782) Osmolality of Urine

1.00

0.00

1.6

2.7

589.1

572.6

mosm/kgh2o

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

99.8

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

133.0

—

(4306422)

0.00

0.0

1.0

—

(3030558) Cytomegalovirus DNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.8

—

100.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

3.5

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

3.2

—

83.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.2

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.6

—

48.1

—

(4268621)

0.00

0.0

1.8

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.5

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

374

1.12

0.00

14.0

13.0

67.8

70.7

umol/l

0.52

374

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

250

1.00

0.00

3.8

4.1

—

(3028626) Oxygen [Partial pressure] in Capillary blood

0.00

0.0

1.6

—

8.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.2

—

17.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.0

1.5

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(4146454)

0.00

0.0

3.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.4

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

0.94

0.00

1.3

3.3

240.9

1993.4

ng/l

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

-0.00

0.0

5.0

—

24.4

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

-0.00

0.0

3.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_LICHENSTRIA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_LICHENSTRIA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_LICHENSTRIA – Lichen striatus

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lichen striatus

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints