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Other papulosquamous disorders

EFO MESH Endpoint Browser PheWeb

L12_PAPULOSQUAOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L44
  • Cause of death: ICD-10 — L44

2 out of 7 registries used, show all original rules.

308

4. Check minimum number of events

None

308

5. Include endpoints

398

6. Filter based on genotype QC (FinnGen only)

398

Control definitions (FinnGen only)

Control exclude
L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L40-L45
Name in latin
Aliae morbositates papulosquamosae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3924 2160 1732
Only index persons 3067 1745 1322
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.05
Only index persons 0.06 0.06 0.05
Median age at first event (years)
Whole population 43.28 46.71 38.85
Only index persons 41.53 44.89 37.09

-FinnGen-

Key figures

All Female Male
Number of individuals 398 233 165
Unadjusted period prevalence (%) 0.08 0.08 0.07
Median age at first event (years) 49.32 44.57 56.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
360
Matched controls
3598
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L44.0
ICD-10 Finland
Pityriasis rubra pilaris
+∞
76.9
71
*
L44.8
ICD-10 Finland
Other specified papulosquamous disorders
422.2
70.2
68
*
L44.9
ICD-10 Finland
Papulosquamous disorder, unspecified
+∞
52.4
49
*
6970A
ICD-9 Finland
Lichen planus[LICHEN RUBER PLANUS]
+∞
52.4
49
*
D05BB02
ATC
acitretin; oral
76.4
52.0
58
9
D07AC01
ATC
betamethasone; topical
4.8
42.1
202
755
L44.2
ICD-10 Finland
Lichen striatus
+∞
40.4
38
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
62.4
38.3
44
8
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.2
36.2
96
172
L44.1
ICD-10 Finland
Lichen nitidus
+∞
32.8
31
*
D07XC01
ATC
betamethasone, combinations; topical
6.7
32.5
91
174
E0000UV
ATC
NA
3.8
30.9
207
952
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.6
28.3
116
339
D07AC13
ATC
mometasone; topical
3.5
25.5
155
632
D07AD01
ATC
clobetasol; topical
4.6
25.1
98
269
D05AX52
ATC
calcipotriol, combinations; topical
12.4
24.7
45
41
L43.8
ICD-10 Finland
Other lichen planus
66.9
22.1
25
*
D07AB02
ATC
hydrocortisone butyrate; topical
2.9
18.0
140
641
L44.3
ICD-10 Finland
Lichen ruber moniliformis
+∞
17.9
17
*
D07AB08
ATC
desonide; topical
4.4
17.4
68
182
D05AX02
ATC
calcipotriol; topical
11.6
17.3
32
30
E000001
ATC
NA
3.1
16.8
114
473
TQW80
NOMESCO Finland
Local dermatologic skincare
10.4
14.5
28
29
L26
ICD-10 Finland
Exfoliative dermatitis
145.2
13.5
14
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
145.2
13.5
14
*
E000003
ATC
NA
6.1
13.2
36
64
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
4.1
12.5
50
136
E000002
ATC
NA
3.3
12.4
68
239
L43.9
ICD-10 Finland
Lichen planus, unspecified
18.9
12.2
18
10
D02AE01
ATC
carbamide; topical
4.8
11.6
39
89
69619
ICD-8 Finland
Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)
+∞
11.5
11
*
D07AA02
ATC
hydrocortisone; topical
3.0
11.2
71
275
H02AB06
ATC
prednisolone; systemic
2.2
11.0
174
1088
134
Kela drug reimbursment
General erythroderma
113.2
10.5
11
*
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
24.2
10.3
14
6
L40.5
ICD-10 Finland
Arthropathic psoriasis
41.3
10.0
12
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.4
9.7
93
455
L40.8
ICD-10 Finland
Other psoriasis
46.0
7.7
9
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.8
7.6
49
192
R06AE07
ATC
cetirizine; oral
1.9
7.5
161
1084
69698
ICD-8 Finland
Psoriasis and similar disorders, Other disorders
+∞
7.3
7
*
L40
ICD-10 Finland
Psoriasis
14.1
6.9
11
8
D07AB01
ATC
clobetasone; topical
4.5
6.9
23
54
A46
ICD-10 Finland
Erysipelas
2.4
6.7
55
248
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.9
6.6
41
155
D07BC01
ATC
betamethasone and antiseptics; topical
2.6
6.6
46
190
L20.0
ICD-10 Finland
Besnier prurigo
3.1
6.6
35
122
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.2
6.4
23
58
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
18.4
6.3
9
5
69700
ICD-8 Finland
Lichen, Planus
+∞
6.3
6
*
69699
ICD-8 Finland
NA
+∞
6.3
6
*
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
6.3
6
*
319
Kela drug reimbursment
Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)
+∞
6.3
6
*
M25.5
ICD-10 Finland
Pain in joint
1.9
6.2
105
639
XQ848
NOMESCO Finland
Dermatological photography
5.4
6.1
17
33

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
124
4.47
18.90
1.9
1.2
—
—
—
0
0
233
1551
2.21
13.27
9.5
5.3
0.6
0.6
e9/l
1.03
210
1350
238
1601
2.21
13.16
9.4
5.3
2.1
2.0
e9/l
0.18
216
1424
233
1557
2.20
13.07
9.6
5.3
0.0
0.0
e9/l
0.58
210
1358
259
1819
2.21
12.63
12.8
8.6
4.3
4.1
e9/l
0.81
231
1587
236
1607
2.15
12.34
10.1
5.5
0.2
0.2
e9/l
1.37
216
1418
164
1024
2.02
10.27
9.3
5.4
—
—
—
0
0
216
1509
1.94
9.56
10.1
5.5
28.9
28.5
%
0.24
205
1422
82
406
2.28
9.26
1.5
1.3
352.9
493.5
titre
0.41
17
86
210
1467
1.91
9.16
10.5
5.7
8.5
8.4
%
0.29
201
1386
209
1459
1.91
9.13
10.2
5.4
3.1
2.8
%
1.26
201
1362
211
1486
1.89
8.89
9.7
5.3
55.5
56.5
%
0.56
200
1404
203
1413
1.89
8.86
10.3
5.5
0.7
0.6
%
0.41
195
1324
62
288
2.37
8.06
2.8
2.0
307.6
369.2
nmol/l
1.57
57
269
180
1256
1.79
7.38
5.9
4.9
35.6
35.6
g/l
0.05
166
1178
67
341
2.16
6.98
2.2
1.6
—
—
—
0
0
125
799
1.82
6.74
9.9
6.5
—
—
—
0
0
124
794
1.82
6.63
2.8
2.0
3.0
3.0
mg/l
0.02
109
679
14
29
4.97
6.50
1.2
1.3
—
—
—
0
0
79
439
2.00
6.50
2.9
2.2
2.3
2.4
g/l
0.39
74
403
291
2388
1.81
6.39
9.5
7.2
79.5
79.8
u/l
0.04
277
2234
112
707
1.81
6.23
6.2
4.4
—
—
—
0
0
51
243
2.26
6.23
2.9
2.6
66.5
67.0
g/l
0.20
44
223
68
366
2.03
6.09
1.8
1.4
—
—
—
0
0
24
80
3.13
5.91
1.5
1.3
260.5
305.1
ug/g
0.43
13
43
73
413
1.94
5.67
3.0
2.3
22.3
22.6
%
0.05
66
359
63
340
2.01
5.59
4.3
2.7
1.9
1.8
%
0.44
55
305
289
2416
1.72
5.39
4.7
3.9
14.9
14.7
pmol/l
0.56
259
2175
10
18
5.67
5.35
1.4
1.3
—
—
—
0
0
197
1504
1.61
5.20
6.8
6.5
1.2
1.2
mmol/l
0.62
172
1285
103
666
1.74
5.17
2.1
1.4
2.3
2.3
g/l
0.06
69
393
49
250
2.09
5.05
5.1
3.8
2.3
1.1
%
0.53
15
84
165
1218
1.61
4.94
2.2
1.9
101.5
95.5
pmol/l
0.73
95
634
46
232
2.11
4.89
5.3
3.9
0.4
0.2
%
0.46
15
76
184
1400
1.58
4.81
12.6
9.1
0.0
0.0
e9/l
0.24
158
1148
102
670
1.70
4.81
3.0
2.6
5.4
5.7
e6/l
0.09
95
598
17
52
3.37
4.80
2.9
3.3
4.7
4.4
e9/l
0.24
17
52
137
973
1.62
4.77
3.7
3.2
12.2
122.7
e6/l
1.02
111
752
44
221
2.11
4.73
4.8
3.8
0.1
0.4
%
—
8
55
17
53
3.31
4.67
3.1
3.5
59.8
58.9
%
0.10
17
53
199
1550
1.57
4.65
4.3
3.7
0.0
0.0
estimate
0.00
30
293
47
245
2.04
4.58
2.9
2.5
68.6
69.6
e9/l
0.08
34
191
117
813
1.62
4.40
5.2
4.3
—
—
—
0
0
276
2333
1.60
4.39
5.8
3.9
12.3
11.5
mm/h
0.46
255
2144
40
201
2.10
4.30
3.3
2.3
—
—
—
0
0
153
1138
1.56
4.29
4.5
3.7
32.9
67.9
e6/l
1.46
120
809
195
1531
1.54
4.28
4.2
3.7
0.0
0.0
estimate
0.00
33
302
48
259
1.97
4.26
8.0
7.5
—
—
—
0
0
195
1533
1.53
4.24
5.8
5.0
0.0
0.0
estimate
0.00
33
302
129
926
1.58
4.21
2.5
2.0
150.0
212.3
u/l
1.18
124
874
205
1634
1.53
4.15
6.3
6.2
11.0
11.3
umol/l
0.11
190
1538
178
1377
1.53
4.14
6.7
5.7
1.2
1.2
mmol/l
0.43
167
1248
33
156
2.22
4.13
3.2
3.4
24.5
24.1
mmol/l
0.26
25
143
107
743
1.60
3.99
1.5
1.3
0.8
2.1
u/ml
1.05
33
186
123
892
1.55
3.78
3.7
3.1
0.2
0.4
e6/l
1.07
99
676
120
866
1.55
3.77
3.5
3.0
—
—
—
0
0
51
293
1.85
3.76
3.5
3.6
2.1
2.0
mmol/l
0.10
42
220
326
2913
1.66
3.70
5.7
4.6
1.9
1.9
mu/l
0.22
303
2651
100
695
1.59
3.69
4.6
3.7
—
—
—
0
0
110
782
1.56
3.68
3.2
2.7
373.5
6439.1
umol/l
3.31
95
671
182
1440
1.49
3.68
3.3
2.7
97.2
104.0
ug/l
0.35
165
1340
127
935
1.53
3.62
3.8
3.1
6.6
7.5
mmol/l
2.12
110
778
256
2173
1.50
3.61
4.9
4.2
—
—
—
0
0
52
305
1.81
3.60
3.4
3.6
—
—
—
0
0
93
641
1.59
3.54
3.1
2.7
539.2
562.6
mosm/kgh2o
0.45
82
551
40
218
1.93
3.47
5.4
3.9
0.0
0.1
%
—
9
63
122
901
1.51
3.40
4.2
3.7
7.4
7.4
ph
0.71
19
154
10
27
3.77
3.37
1.6
1.2
—
—
—
0
0
11
32
3.51
3.35
1.4
1.6
—
—
—
0
0
348
3188
1.73
3.29
20.1
13.6
21.1
22.6
mg/l
0.39
279
2508
121
899
1.50
3.26
4.8
3.9
9.1
10.1
mg/mmol
0.13
86
546
134
1023
1.47
3.13
3.6
3.2
2.3
2.3
mmol/l
0.25
119
898
31
161
2.00
3.09
1.4
1.2
—
—
—
0
0
157
1246
1.43
2.96
2.6
2.1
—
—
—
0
0
303
2712
1.49
2.90
22.1
16.2
13.9
13.6
%
1.32
296
2670
216
1819
1.41
2.88
5.5
4.6
6.8
6.6
mmol/l
0.44
204
1684
25
124
2.08
2.83
1.3
1.6
29.5
24.9
iu/l
0.21
19
103
80
562
1.53
2.77
1.8
1.7
1163.5
1178.6
nmol/l
0.05
64
423
113
853
1.45
2.76
3.8
3.2
56.6
297.5
mg/l
1.10
80
534
72
495
1.55
2.75
3.1
3.5
0.8
0.8
mmol/l
0.91
66
462
89
641
1.50
2.75
1.7
1.7
462.7
451.9
pmol/l
0.09
74
533
6
10
6.07
2.70
1.2
1.2
—
—
—
0
0
100
743
1.46
2.64
1.6
1.6
18.7
20.7
nmol/l
0.74
91
634
61
408
1.58
2.62
3.6
1.9
112.0
118.9
ug/g
0.10
51
316
242
2103
1.38
2.55
5.4
4.4
114.2
3905.2
e6/l
—
5
34
37
219
1.76
2.52
1.2
1.3
133.0
150.3
iu/ml
0.14
18
84
76
541
1.50
2.47
2.9
2.9
2.4
2.4
mmol/l
1.83
66
476
358
3358
1.66
2.41
15.0
9.8
28.2
25.0
u/l
2.23
350
3234
13
52
2.55
2.38
3.8
2.6
—
—
—
0
0
17
78
2.23
2.34
1.1
1.3
—
2.6
—
0
10
124
977
1.39
2.34
3.5
2.5
68.6
58.0
u/l
0.35
110
913
52
345
1.58
2.32
1.3
1.5
—
—
—
0
0
76
550
1.47
2.28
1.4
1.3
26.0
41.0
iu/ml
0.62
19
179
72
516
1.48
2.27
1.4
1.3
1.1
9.8
u/ml
3.35
28
201
61
423
1.52
2.25
2.4
2.0
—
—
—
0
0
90
677
1.43
2.20
5.1
4.0
1.0
1.0
kg/l
0.22
13
99
14
61
2.34
2.17
1.4
1.7
—
—
—
0
0
59
413
1.50
2.09
1.4
1.2
—
—
—
0
0
6
15
4.04
2.04
1.5
1.9
—
—
—
0
0
107
841
1.37
2.02
4.7
4.0
0.0
0.0
estimate
0.00
30
296
9
32
2.85
2.01
2.4
3.6
—
—
—
0
0
43
284
1.58
1.97
1.5
1.4
—
—
—
0
0
33
204
1.67
1.96
1.1
1.5
—
—
—
0
0
80
603
1.41
1.93
1.7
1.9
—
—
—
0
0
53
371
1.49
1.88
28.1
21.9
1.1
1.3
inr
—
6
51
39
257
1.57
1.82
1.7
1.4
—
—
—
0
0
11
47
2.38
1.79
1.3
1.5
—
—
—
0
0
20
110
1.86
1.76
3.5
4.2
—
—
—
0
0
73
551
1.40
1.75
4.3
3.9
296.9
225.3
ng/l
0.15
55
424
9
36
2.53
1.75
1.9
1.2
—
—
—
0
0
40
268
1.55
1.74
1.3
1.2
—
—
—
0
0
22
127
1.78
1.68
1.6
2.2
65.1
3704.4
u/l
—
7
49
15
76
2.01
1.66
1.7
1.6
3.8
5.4
iu/l
—
7
26
306
2844
1.33
1.60
7.2
5.5
41.2
39.5
mmol/mol
1.70
286
2656
26
160
1.67
1.60
1.3
1.1
—
104.2
—
0
5
342
3235
1.41
1.58
20.9
15.5
139.4
139.7
mmol/l
1.21
330
3150
16
85
1.92
1.57
3.5
2.9
—
—
—
0
0
326
3061
1.36
1.57
5.3
4.2
4.6
4.6
mmol/l
0.59
306
2830
143
1212
1.28
1.55
6.8
8.8
1.1
1.2
inr
0.83
43
355
46
327
1.46
1.54
1.6
1.3
—
—
—
0
0
36
243
1.53
1.54
3.6
3.4
—
—
—
0
0
5
15
3.36
1.53
1.0
1.4
—
—
—
0
0
7
27
2.62
1.52
1.1
1.1
—
—
—
0
0
34
228
1.54
1.50
3.0
3.4
142.2
74.1
ng/l
0.96
29
209
342
3242
1.39
1.49
21.0
15.6
4.0
4.0
mmol/l
1.11
330
3154
20
117
1.75
1.48
1.3
1.3
—
—
—
0
0
10
45
2.25
1.47
1.0
1.0
—
—
—
0
0
7
28
2.53
1.46
1.3
1.5
—
—
—
0
0
46
331
1.44
1.45
7.2
7.1
1.2
1.2
mmol/l
0.01
35
263
12
59
2.07
1.45
2.9
2.7
17.8
16.1
%
—
7
26
5
16
3.15
1.44
1.6
1.4
127.4
127.7
nmol/l
—
5
16
18
298
0.59
1.42
1.2
1.3
—
—
—
0
0
63
482
1.36
1.41
1.4
1.6
—
—
—
0
0
9
40
2.28
1.41
3.4
14.1
5.4
6.4
mmol/l
—
9
33
7
29
2.44
1.40
1.7
1.0
—
—
—
0
0
7
29
2.44
1.40
3.1
2.7
—
—
—
0
0
138
1178
1.26
1.39
3.7
3.8
36.8
41.3
ng/l
0.17
84
815
19
112
1.73
1.38
1.2
1.3
0.1
4.4
u/ml
—
5
6
18
105
1.75
1.35
12.4
10.4
—
—
—
0
0
351
3353
1.40
1.35
23.0
15.6
76.0
75.7
umol/l
0.05
351
3353
17
98
1.77
1.33
1.1
1.1
—
—
—
0
0
348
3322
1.38
1.32
16.1
12.7
—
—
—
0
0
5
18
2.80
1.29
1.0
1.2
201.8
115.1
iu/ml
—
5
18
11
55
2.03
1.28
1.5
1.1
0.4
1.6
u/ml
—
5
27
8
35
2.31
1.27
1.8
1.6
—
—
—
0
0
8
35
2.31
1.27
1.3
1.9
14.2
16.8
ug/l
—
8
35
12
64
1.90
1.19
1.4
1.4
—
—
—
0
0
10
50
2.03
1.17
1.0
1.0
—
—
—
0
0
10
50
2.03
1.17
1.4
1.1
79.7
17.2
u/l
—
10
41
10
50
2.03
1.17
1.0
1.2
—
—
—
0
0
19
118
1.64
1.17
2.4
2.7
22.3
21.7
s
0.10
19
106
25
167
1.53
1.15
2.6
2.9
0.2
0.2
e6/l
0.06
25
162
368
3561
1.44
1.13
28.9
19.6
255.4
250.0
e9/l
0.77
356
3477
320
3037
1.27
1.12
5.1
4.3
6.2
5.9
mmol/l
2.27
293
2769
8
40
2.02
1.12
2.4
1.9
35.4
32.5
pg
—
8
40
232
2129
1.22
1.12
3.9
3.8
—
—
—
0
0
368
3563
1.44
1.11
28.8
19.5
30.3
30.2
pg
0.09
360
3516
368
3563
1.44
1.11
28.9
19.5
91.1
90.8
fl
0.66
360
3517
18
112
1.64
1.11
1.6
1.6
—
—
—
0
0
368
3564
1.43
1.09
29.0
19.6
4.5
4.5
e12/l
0.07
356
3468
7
32
2.21
1.08
3.7
2.7
—
—
—
0
0
368
3565
1.43
1.08
29.0
19.6
7.1
6.7
e9/l
2.10
356
3461
368
3567
1.42
1.05
29.0
19.6
134.9
134.9
g/l
0.02
361
3516
20
130
1.57
1.05
1.1
1.1
—
—
—
0
0
83
690
1.26
1.04
1.9
1.9
1.6
1.2
mg/l
0.72
63
534
320
3046
1.26
1.03
4.8
4.2
1.4
1.5
mmol/l
3.38
297
2798
22
148
1.51
1.00
4.6
3.9
—
—
—
0
0
11
61
1.83
0.99
1.5
1.4
—
—
—
0
0
113
979
1.22
0.97
3.0
2.3
—
—
—
0
0
32
236
1.39
0.93
1.7
1.3
—
—
—
0
0
308
2931
1.22
0.93
4.8
3.8
1.4
1.3
mmol/l
2.28
285
2680
25
345
0.71
0.91
1.7
1.7
—
—
—
0
0
28
203
1.41
0.90
5.3
3.6
5.2
5.1
kpa
0.40
28
190
6
30
2.01
0.87
1.0
1.1
—
—
—
0
0
8
44
1.83
0.86
1.1
1.2
—
—
—
0
0
13
80
1.65
0.85
1.2
1.3
—
—
—
0
0
29
214
1.38
0.85
2.7
2.8
85.6
189.5
ng/l
2.24
24
195
325
3122
1.22
0.82
5.7
4.7
2.7
2.7
mmol/l
0.45
303
2864
11
66
1.69
0.79
2.0
2.3
153.5
130.9
ug/min
—
5
33
13
197
0.65
0.77
1.3
1.4
—
—
—
0
0
15
100
1.52
0.74
1.5
1.6
224.6
305.8
mu/l
1.42
15
89
160
1461
1.16
0.73
4.2
4.0
—
—
—
0
0
9
56
1.62
0.73
3.0
2.5
—
—
—
0
0
99
871
1.18
0.72
3.4
3.3
—
—
—
0
0
9
57
1.59
0.71
6.7
3.6
—
—
—
0
0
9
58
1.56
0.70
6.7
4.0
—
—
—
0
0
26
196
1.35
0.69
1.2
1.3
—
39.7
—
0
12
307
2951
1.18
0.67
20.3
13.9
39.5
40.0
%
0.51
219
2193
107
959
1.16
0.62
4.5
3.0
—
—
—
0
0
28
218
1.31
0.62
2.2
2.4
—
15.0
—
0
9
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
20
149
1.36
0.59
12.9
8.9
—
—
—
0
0
17
123
1.40
0.59
1.4
1.4
—
—
—
0
0
8
53
1.52
0.58
1.8
1.5
—
—
—
0
0
17
125
1.38
0.54
1.1
1.1
—
—
—
0
0
18
134
1.36
0.54
1.4
1.4
—
—
—
0
0
18
134
1.36
0.54
1.4
1.4
—
—
—
0
0
14
100
1.41
0.52
1.5
1.4
—
—
—
0
0
92
827
1.15
0.52
2.0
1.6
1.5
1.3
mmol/l
1.36
78
699
24
189
1.29
0.51
2.5
3.9
—
—
—
0
0
18
136
1.34
0.50
1.4
1.4
—
—
—
0
0
7
46
1.53
0.48
1.1
1.2
—
—
—
0
0
7
47
1.50
0.48
3.4
2.2
68.8
59.0
%
—
7
47
24
191
1.27
0.47
1.5
1.2
—
—
—
0
0
7
48
1.47
0.47
7.0
3.6
—
—
—
0
0
7
48
1.47
0.47
1.0
1.6
—
—
—
0
0
9
131
0.68
0.43
2.4
3.0
33.3
2219.5
u/ml
—
9
112
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
17
132
1.30
0.41
1.9
1.8
—
—
—
0
0
5
34
1.48
0.40
1.2
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
5
35
1.43
0.39
2.2
2.9
—
—
—
0
0
100
925
1.11
0.36
4.7
5.0
5.0
2.8
ug/l
0.43
90
809
17
135
1.27
0.36
1.4
1.4
—
—
—
0
0
6
42
1.43
0.35
2.2
1.9
—
—
—
0
0
5
80
0.62
0.35
1.2
1.3
—
—
—
0
0
6
44
1.37
0.34
2.5
2.7
3.9
4.0
mmol/l
—
6
44
6
44
1.37
0.34
2.5
2.7
104.3
106.6
mmol/l
—
6
44
23
196
1.18
0.27
4.8
2.9
—
—
—
0
0
8
67
1.20
0.26
3.9
2.4
138.4
129.7
g/l
—
8
50
11
86
1.29
0.26
3.1
4.8
—
—
—
0
0
16
132
1.22
0.26
5.1
4.2
24.3
25.0
mmol/l
0.48
16
125
84
897
0.92
0.26
4.2
3.9
—
—
—
0
0
20
170
1.19
0.25
4.7
2.8
19.9
35.7
u/ml
1.13
20
161
5
38
1.32
0.23
1.4
1.5
—
—
—
0
0
5
38
1.32
0.23
1.4
1.5
—
—
—
0
0
5
38
1.32
0.23
1.4
1.5
—
—
—
0
0
5
38
1.32
0.23
1.4
1.5
—
—
—
0
0
5
38
1.32
0.23
11.2
4.2
—
—
—
0
0
5
41
1.22
0.22
1.2
1.5
—
—
—
0
0
51
552
0.91
0.21
3.4
3.0
0.6
0.8
ug/l
0.55
35
362
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.2
1.9
88.1
90.0
%
—
5
43
0
13
0.00
0.21
0.0
1.3
—
5202.4
—
0
7
18
156
1.16
0.19
3.6
3.8
—
—
—
0
0
7
59
1.19
0.18
2.0
1.5
—
—
—
0
0
13
152
0.85
0.17
1.4
1.9
—
—
—
0
0
5
67
0.74
0.17
1.8
1.6
—
—
—
0
0
8
69
1.16
0.16
7.5
4.5
14.7
24.8
mg/l
—
8
45
8
73
1.10
0.16
1.1
1.1
—
—
—
0
0
23
209
1.11
0.13
3.5
2.5
4.0
4.0
e9/l
0.02
18
168
10
86
1.17
0.11
1.3
1.2
—
—
—
0
0
29
270
1.08
0.11
4.6
3.7
—
—
—
0
0
31
331
0.93
0.10
1.7
1.7
—
—
—
0
0
5
44
1.14
0.10
2.8
2.7
—
—
—
0
0
5
64
0.78
0.08
1.8
1.5
—
—
—
0
0
5
64
0.78
0.08
1.8
1.5
—
—
—
0
0
107
1093
0.97
0.07
3.4
2.8
—
—
—
0
0
10
89
1.13
0.07
1.9
1.8
—
—
—
0
0
38
389
0.97
0.02
1.5
1.2
—
—
—
0
0
16
162
0.99
0.00
2.4
2.4
—
—
—
0
0
30
298
1.01
0.00
3.9
4.4
—
—
—
0
0
35
348
1.01
0.00
1.5
1.5
—
—
—
0
0
12
117
1.03
0.00
2.3
2.6
—
—
—
0
0
26
263
0.99
0.00
2.7
2.4
7.5
8.2
ug/l
0.07
26
228
31
313
0.99
0.00
3.7
4.3
18.6
22.2
ug/l
0.08
24
259
88
885
0.99
0.00
1.5
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
41.0
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
3695.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
0.00
1.0
1.1
—
—
—
0
0
6
67
0.89
0.00
2.2
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
16.0
—
0
6
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PAPULOSQUAOTH and mortality.

Females

Parameter HR [95% CI] p-value
L12_PAPULOSQUAOTH 1.183 [0.96, 1.46] 0.119
Birth year 0.99 [0.98, 1.0] 0.027

During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 1235 females with L12_PAPULOSQUAOTH died.

Males

Parameter HR [95% CI] p-value
L12_PAPULOSQUAOTH 1.496 [1.14, 1.97] 0.004
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 1017 males with L12_PAPULOSQUAOTH died.

Mortality risk

Mortality risk for people of age

years, who have L12_PAPULOSQUAOTH.

N-year risk Females Males
1 0.083% 0.332%
5 0.566% 1.753%
10 1.522% 4.204%
15 2.952% 7.479%
20 5.118% 12.236%

Relationships between endpoints

↥

Index endpoint: L12_PAPULOSQUAOTH – Other papulosquamous disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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