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Other papulosquamous disorders

EFO MESH Endpoint Browser PheWeb

L12_PAPULOSQUAOTH

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L44
  • Cause of death: ICD-10 — L44

2 out of 7 registries used, show all original rules.

327

4. Check minimum number of events

None

327

5. Include endpoints

417

6. Filter based on genotype QC (FinnGen only)

392

Control definitions (FinnGen only)

Control exclude
L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L40-L45
Name in latin
Aliae morbositates papulosquamosae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3924 2160 1732
Only index persons 3067 1745 1322
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.05
Only index persons 0.06 0.06 0.05
Median age at first event (years)
Whole population 43.28 46.71 38.85
Only index persons 41.53 44.89 37.09

-FinnGen-

Key figures

All Female Male
Number of individuals 392 229 163
Unadjusted period prevalence (%) 0.08 0.08 0.07
Median age at first event (years) 50.24 46.10 56.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
417
Matched controls
4170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D05BB02
ATC
acitretin; oral
71.1
120.2
66
11
L44.0
ICD-10 Finland
Pityriasis rubra pilaris
+∞
89.9
83
*
L44.8
ICD-10 Finland
Other specified papulosquamous disorders
+∞
80.9
75
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.6
65.6
111
191
D07AC01
ATC
betamethasone; topical
5.3
63.4
251
924
L44.9
ICD-10 Finland
Papulosquamous disorder, unspecified
237.4
60.8
61
*
6970A
ICD-9 Finland
Lichen planus[LICHEN RUBER PLANUS]
+∞
56.6
53
*
D07XC01
ATC
betamethasone; topical
6.2
52.5
107
219
L44.2
ICD-10 Finland
Lichen striatus
+∞
51.1
48
*
D07AD01
ATC
clobetasol; topical
5.1
48.2
130
340
L40.0
ICD-10 Finland
Psoriasis vulgaris
73.9
46.3
52
8
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.6
45.4
149
453
D05AX52
ATC
calcipotriol, combinations; topical
11.4
43.9
48
47
D07AC13
ATC
mometasone; topical
4.0
41.1
184
693
E0000UV, ,
ATC
3.8
39.2
250
1182
L44.1
ICD-10 Finland
Lichen nitidus
+∞
39.2
37
*
D05AX02
ATC
calcipotriol; topical
15.2
38.7
35
25
D07AB02
ATC
hydrocortisone butyrate; topical
3.3
30.7
179
772
E000001, ,
ATC
3.5
29.0
130
474
L43.8
ICD-10 Finland
Other lichen planus
155.4
28.0
29
*
TQW80
NOMESCO Finland
Local dermatologic skincare
10.1
27.4
32
34
L04AX03
ATC
methotrexate; systemic
4.4
23.7
66
171
L44.3
ICD-10 Finland
Lichen ruber moniliformis
+∞
23.1
22
*
E000003, ,
ATC
5.6
21.0
42
82
E000002, ,
ATC
3.5
19.4
75
244
D07AB08
ATC
desonide; topical
3.5
18.8
75
249
L43.9
ICD-10 Finland
Lichen planus, unspecified
33.1
17.2
22
7
D02AE01
ATC
carbamide; topical
4.1
16.3
47
124
L40.5
ICD-10 Finland
Arthropathic psoriasis
+∞
15.7
15
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
166.0
15.6
16
*
L26
ICD-10 Finland
Exfoliative dermatitis
155.2
14.6
15
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.4
13.3
115
569
D07AB01
ATC
clobetasone; topical
5.7
13.2
25
46
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.2
12.3
34
87
D07AA02
ATC
hydrocortisone; topical
2.6
12.1
82
361
69619
ICD-8 Finland
Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)
+∞
11.5
11
*
H02AB06
ATC
prednisolone; systemic
2.0
11.0
207
1373
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.8
10.7
56
216
XQ848
NOMESCO Finland
Dermatological photography
5.1
10.4
22
45
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
15.1
10.1
16
11
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
18.1
9.5
14
8
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
9.4
9
*
R06AE07
ATC
cetirizine; oral
1.9
9.2
189
1268
134
Kela drug reimbursment
General erythroderma
37.6
9.1
11
*
D07BC01
ATC
betamethasone and antiseptics; topical
2.6
8.8
56
238
L40.9
ICD-10 Finland
Psoriasis, unspecified
28.2
8.5
11
*
319
Kela drug reimbursment
Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)
+∞
8.4
8
*
E000006, ,
ATC
3.0
7.9
36
128
L40.8
ICD-10 Finland
Other psoriasis
45.8
7.7
9
*
XQ800
NOMESCO Finland
Prick test
2.8
7.6
39
148
L04AX01
ATC
azathioprine; systemic
3.7
7.5
24
68
A07AA02
ATC
nystatin; oral
3.2
7.4
30
100
L43.0
ICD-10 Finland
Hypertrophic lichen planus
+∞
7.3
7
*
69698
ICD-8 Finland
Psoriasis and similar disorders, Other disorders
+∞
7.3
7
*
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.2
7.2
19
47
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
4.2
7.2
19
47
ZY010
NOMESCO Finland
Hospital outpatient
3.1
7.1
29
97
N05BB01
ATC
hydroxyzine; systemic
2.9
7.0
34
125
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.5
7.0
46
198
A46
ICD-10 Finland
Erysipelas
2.2
7.0
64
319
J01FF01
ATC
clindamycin; systemic
1.9
7.0
116
716
M25.5
ICD-10 Finland
Pain in joint
1.8
6.9
137
892
L20.0
ICD-10 Finland
Besnier prurigo
2.6
6.9
42
175
L40
ICD-10 Finland
Psoriasis
11.2
6.8
12
11
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.5
122
778
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
6.4
122
782
S87
ICPC
Dermatitis/atopic eczema
5.3
6.4
18
35
A10BJ06
ATC
semaglutide; parenteral
3.2
6.3
24
77
69700
ICD-8 Finland
Lichen, Planus
+∞
6.3
6
*
L44.4
ICD-10 Finland
Infantile papular acrodermatitis [Giannotti-Crosti]
+∞
6.3
6
*
69699, ,
ICD-8 Finland
+∞
6.3
6
*
D02AX
ATC
Other emollients and protectives
3.6
6.2
20
57
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.1
6.2
59
299
S29
ICPC
Skin symptom/complaint other
1.9
6.0
81
464
L01BA01
ATC
methotrexate; systemic
4.0
6.0
17
44

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
56
130
4.82
23.03
1.8
1.2
—
—
—
0
0
248
1638
2.27
14.69
9.4
5.2
0.59
0.56
e9/l
1.10
220
1428
248
1643
2.26
14.51
9.4
5.2
0.04
0.04
e9/l
0.71
220
1435
253
1692
2.26
14.43
9.3
5.2
2.07
1.99
e9/l
0.23
228
1511
252
1697
2.23
13.94
9.8
5.5
0.22
0.19
e9/l
1.52
227
1497
274
1909
2.27
13.93
12.6
8.7
4.35
4.07
e9/l
0.93
242
1667
233
1533
2.18
13.51
10.0
5.9
—
—
—
0
0
91
433
2.41
11.35
1.5
1.3
352.94
479.11
titre
0.36
17
90
230
1596
1.98
10.57
9.9
5.5
29.06
28.42
%
0.37
221
1514
225
1551
1.98
10.53
10.3
5.6
8.54
8.41
%
0.29
216
1467
224
1543
1.98
10.49
10.0
5.4
3.17
2.77
%
1.46
216
1453
218
1495
1.96
10.27
9.9
5.4
0.70
0.65
%
0.65
210
1404
199
1332
1.94
9.98
2.5
2.3
77.21
75.78
nmol/l
0.30
183
1202
225
1571
1.94
9.93
9.5
5.2
55.44
56.53
%
0.68
216
1488
65
302
2.37
8.42
2.7
2.0
308.33
368.93
nmol/l
1.59
60
282
72
352
2.26
8.29
2.1
1.6
—
—
—
0
0
191
1331
1.80
7.89
6.0
4.8
35.58
35.63
g/l
0.04
177
1250
134
840
1.88
7.78
9.4
6.6
—
—
—
0
0
54
250
2.33
7.03
2.9
2.6
66.66
66.95
g/l
0.11
47
228
72
378
2.09
6.89
1.8
1.4
—
—
—
0
0
51
235
2.33
6.71
3.3
2.5
9.67
10.49
g/l
0.90
46
214
305
2509
1.80
6.55
9.7
7.2
79.65
79.41
u/l
0.03
292
2351
82
460
1.97
6.53
3.2
2.2
2.31
2.35
g/l
0.34
77
422
128
829
1.78
6.51
2.8
2.0
2.97
2.99
mg/l
0.02
111
708
68
357
2.08
6.50
4.1
2.6
1.89
1.79
%
0.28
60
319
200
1474
1.69
6.35
12.2
9.0
0.00
0.00
e9/l
0.24
167
1205
111
698
1.80
6.20
2.9
2.6
5.33
5.75
e6/l
0.17
104
635
77
432
1.96
6.11
3.3
2.3
22.34
22.79
%
0.10
70
373
19
53
3.71
6.11
2.7
3.2
4.53
4.36
e9/l
0.13
19
53
19
54
3.64
5.95
2.9
3.5
58.37
58.54
%
0.02
19
54
148
1022
1.69
5.90
3.6
3.2
15.84
123.89
e6/l
1.05
120
792
208
1581
1.63
5.64
7.1
6.5
1.21
1.22
mmol/l
0.37
184
1360
166
1195
1.65
5.58
4.4
3.7
31.05
65.23
e6/l
1.56
129
852
52
262
2.13
5.52
5.0
3.9
2.24
1.18
%
0.53
17
107
49
242
2.16
5.47
5.2
4.0
0.43
0.15
%
0.47
15
86
51
257
2.12
5.41
2.8
2.5
67.98
70.48
e9/l
0.26
36
198
108
701
1.73
5.32
2.1
1.4
2.26
2.29
g/l
0.05
68
416
47
231
2.17
5.31
4.6
3.9
0.46
0.66
%
0.39
13
85
173
1274
1.61
5.22
2.2
1.9
99.88
95.70
pmol/l
0.46
100
663
301
2542
1.66
5.06
4.7
3.9
14.88
14.70
pmol/l
0.60
270
2292
43
208
2.19
5.06
3.3
2.3
—
—
—
0
0
24
88
2.83
5.03
1.5
1.3
260.54
313.30
ug/g
0.54
13
46
134
935
1.64
4.99
3.6
3.1
0.20
0.43
e6/l
1.38
108
708
52
273
2.03
4.96
7.8
8.0
—
—
—
0
0
210
1638
1.57
4.86
4.2
3.7
0.00
0.00
estimate
-0.00
31
304
291
2448
1.62
4.86
5.7
3.9
12.40
11.56
mm/h
0.50
270
2255
14
29
4.96
4.85
1.2
1.3
—
—
—
0
0
175
1310
1.58
4.84
3.6
3.5
5.83
5.85
ph
0.02
12
110
130
909
1.62
4.77
3.5
3.0
—
—
—
0
0
189
1446
1.56
4.72
7.1
5.8
1.21
1.22
mmol/l
0.17
178
1318
216
1708
1.55
4.62
6.5
6.1
10.84
11.19
umol/l
0.21
201
1610
206
1620
1.54
4.47
4.2
3.7
0.00
0.00
estimate
-0.00
36
334
206
1621
1.54
4.45
5.7
5.0
0.00
0.00
estimate
-0.00
34
315
101
674
1.66
4.42
3.0
2.9
528.45
550.83
mosm/kgh2o
0.46
89
579
122
856
1.60
4.36
5.2
4.3
—
—
—
0
0
108
742
1.61
4.19
4.4
3.7
—
—
—
0
0
344
3061
1.71
4.18
5.7
4.7
1.92
1.90
mu/l
0.13
318
2795
117
821
1.59
4.16
3.1
2.7
372.97
6583.37
umol/l
3.54
103
714
368
3343
1.86
4.08
19.9
13.6
21.07
22.65
mg/l
0.44
296
2639
113
792
1.59
4.02
1.5
1.3
3.53
2.13
u/ml
0.21
34
200
43
228
1.99
4.00
5.3
4.0
0.00
0.22
%
—
9
73
9
14
6.54
4.00
2.7
2.4
740.22
898.00
u/ml
—
9
14
134
984
1.53
3.86
3.7
3.2
6.65
7.52
mmol/l
1.83
118
829
53
306
1.84
3.84
3.8
3.6
1.97
1.96
mmol/l
0.00
45
237
269
2281
1.51
3.83
4.9
4.2
—
—
—
0
0
10
20
5.09
3.71
1.9
1.5
—
—
—
0
0
132
974
1.52
3.69
2.5
2.1
149.69
210.81
u/l
1.21
127
921
129
951
1.52
3.62
4.9
3.7
7.39
7.40
ph
0.47
21
162
86
583
1.60
3.48
1.8
1.7
1163.12
1173.48
nmol/l
0.04
69
437
47
270
1.83
3.46
7.5
7.1
1.12
1.32
mmol/l
1.33
47
261
142
1078
1.48
3.42
3.8
3.1
2.35
2.35
mmol/l
0.17
129
953
189
1517
1.45
3.41
3.4
2.7
99.61
103.12
ug/l
0.16
171
1412
127
943
1.50
3.41
4.4
3.8
11.97
9.91
mg/mmol
0.23
90
574
25
115
2.25
3.36
3.6
2.0
10.26
10.28
g/l
0.01
20
103
11
28
4.01
3.31
1.5
1.2
—
—
—
0
0
330
2962
1.55
3.25
22.2
15.9
14.91
14.78
%
0.15
324
2924
119
894
1.46
2.97
3.7
3.2
61.76
284.32
mg/l
1.06
84
564
82
573
1.54
2.90
2.9
2.9
2.41
2.45
mmol/l
1.58
71
502
105
773
1.48
2.90
1.6
1.5
18.40
20.62
nmol/l
0.95
95
661
64
423
1.61
2.87
3.5
2.0
107.63
117.80
ug/g
0.16
54
327
76
526
1.54
2.80
3.1
3.5
0.79
0.82
mmol/l
1.28
70
494
377
3526
1.72
2.75
15.0
9.7
27.95
25.07
u/l
2.03
369
3398
11
34
3.29
2.74
1.4
1.6
—
—
—
0
0
14
54
2.65
2.73
3.6
2.6
—
—
—
0
0
93
676
1.48
2.72
1.7
1.7
461.31
8881442.80
pmol/l
0.50
77
563
31
169
1.90
2.71
1.4
1.3
—
—
—
0
0
6
10
6.07
2.70
1.2
1.2
—
—
—
0
0
163
1316
1.39
2.69
2.6
2.0
—
—
—
0
0
254
2208
1.38
2.65
5.3
4.4
114.20
3500.89
e6/l
—
5
38
88
639
1.48
2.58
1.8
1.9
—
—
—
0
0
56
368
1.60
2.58
1.4
1.5
—
—
—
0
0
223
1907
1.36
2.53
5.4
4.6
6.77
6.61
mmol/l
0.44
212
1763
13
51
2.60
2.46
1.3
1.5
—
—
—
0
0
18
83
2.22
2.44
1.1
1.3
—
2.56
—
0
10
15
64
2.39
2.41
1.4
1.7
—
—
—
0
0
65
450
1.53
2.40
2.3
2.0
—
—
—
0
0
38
231
1.71
2.36
1.2
1.3
133.02
158.03
iu/ml
0.22
18
88
76
547
1.48
2.33
1.4
1.3
1.14
9.19
u/ml
3.35
29
216
25
134
1.92
2.32
1.3
1.5
29.52
27.45
iu/l
0.08
19
109
63
437
1.52
2.30
1.3
1.2
—
—
—
0
0
80
583
1.46
2.30
1.4
1.3
24.90
38.75
iu/ml
0.60
20
200
177
1477
1.34
2.29
15.9
13.3
1.11
1.23
inr
1.59
50
427
36
219
1.70
2.24
1.1
1.5
—
—
—
0
0
38
235
1.68
2.23
4.0
3.4
158.37
74.88
ng/l
1.43
33
217
73
528
1.46
2.18
3.1
2.9
2.21
2.59
e6/l
0.14
37
284
44
285
1.61
2.17
1.3
1.2
—
—
—
0
0
10
36
2.82
2.15
2.3
3.3
—
—
—
0
0
15
68
2.25
2.13
1.3
1.2
392.33
242.18
u/ml
—
9
38
325
2988
1.40
2.13
7.0
5.5
40.95
39.48
mmol/mol
1.48
303
2789
127
1020
1.35
2.08
3.4
2.5
68.38
62.72
u/l
0.16
114
953
7
20
3.54
2.06
1.6
2.2
43.34
36.45
%
—
7
20
41
265
1.61
2.04
1.6
1.4
—
—
—
0
0
10
39
2.60
1.95
2.0
2.0
—
—
—
0
0
21
114
1.89
1.91
3.6
4.2
—
—
—
0
0
46
314
1.52
1.83
1.5
1.4
—
—
—
0
0
8
29
2.79
1.80
1.1
1.1
—
—
—
0
0
360
3396
1.44
1.79
21.1
15.5
139.46
139.73
mmol/l
1.09
348
3308
14
67
2.13
1.78
1.4
1.4
—
—
—
0
0
131
1080
1.31
1.76
3.5
3.2
29.54
30.94
u/l
0.41
123
1033
77
586
1.39
1.75
4.1
3.9
277.41
295.72
ng/l
0.03
59
449
6
18
3.37
1.75
1.5
1.8
—
—
—
0
0
13
61
2.17
1.73
2.8
2.7
17.56
16.37
%
—
8
27
5
13
3.88
1.72
1.0
1.2
—
—
—
0
0
23
134
1.76
1.70
1.7
2.2
65.14
3559.35
u/l
—
7
51
360
3405
1.42
1.68
21.2
15.6
3.99
3.97
mmol/l
0.94
348
3314
20
112
1.83
1.67
11.6
10.2
—
—
—
0
0
92
727
1.34
1.65
5.1
3.9
1.02
1.02
kg/l
0.07
14
104
21
120
1.79
1.65
1.1
1.3
0.14
3.81
u/ml
—
5
7
10
41
2.47
1.65
3.3
13.9
5.42
6.40
mmol/l
—
10
34
343
3221
1.37
1.65
5.2
4.2
4.56
4.65
mmol/l
0.76
323
2987
370
3519
1.46
1.65
22.8
15.6
77.65
75.74
umol/l
0.37
370
3519
22
128
1.76
1.64
1.3
1.3
—
—
—
0
0
48
340
1.47
1.62
1.6
1.3
—
—
—
0
0
109
890
1.30
1.56
4.7
4.0
0.00
0.00
estimate
-0.00
31
308
67
509
1.38
1.55
1.5
1.6
—
—
—
0
0
8
33
2.45
1.54
3.4
2.6
—
—
—
0
0
15
79
1.93
1.51
1.7
1.6
3.79
5.32
iu/l
—
7
27
48
347
1.43
1.47
7.0
7.4
1.18
1.29
mmol/l
0.06
37
279
37
254
1.50
1.46
3.5
3.4
—
—
—
0
0
339
3194
1.33
1.46
5.0
4.3
6.14
5.89
mmol/l
1.83
311
2921
9
38
2.40
1.46
1.9
1.2
—
—
—
0
0
11
52
2.15
1.45
1.0
1.0
—
—
—
0
0
11
52
2.15
1.45
1.5
1.1
73.29
16.64
u/l
0.45
11
43
17
95
1.82
1.45
1.8
1.5
12.69
9.52
u/l
0.24
12
72
5
16
3.15
1.44
1.0
1.4
—
—
—
0
0
365
3482
1.39
1.41
16.1
12.7
—
—
—
0
0
7
29
2.44
1.40
1.3
1.5
—
—
—
0
0
23
143
1.64
1.38
1.0
1.1
—
—
—
0
0
5
17
2.96
1.36
1.6
1.5
127.40
141.18
nmol/l
—
5
17
16
90
1.81
1.35
3.3
2.9
—
—
—
0
0
9
42
2.17
1.34
2.2
1.9
35.78
32.57
pg
—
9
42
20
317
0.61
1.34
1.2
1.3
—
—
—
0
0
387
3737
1.49
1.32
29.0
19.6
254.69
250.32
e9/l
0.60
374
3647
387
3739
1.49
1.29
28.9
19.5
30.28
30.23
pg
0.22
379
3690
387
3739
1.49
1.29
28.9
19.5
91.21
90.79
fl
0.97
379
3691
5
18
2.80
1.29
1.0
1.2
201.80
115.14
iu/ml
—
5
18
387
3740
1.48
1.28
29.1
19.6
4.48
4.49
e12/l
0.20
374
3639
8
35
2.31
1.27
1.3
1.9
14.19
16.76
ug/l
—
8
35
387
3741
1.48
1.26
29.0
19.6
7.09
6.72
e9/l
2.12
374
3631
8
36
2.25
1.25
1.8
1.5
—
—
—
0
0
18
108
1.70
1.24
1.4
1.6
231.44
308.63
mu/l
1.52
18
97
387
3743
1.47
1.24
29.1
19.7
134.87
134.96
g/l
0.04
380
3690
11
56
1.99
1.23
1.0
1.1
—
—
—
0
0
338
3206
1.29
1.22
4.8
4.2
1.39
1.48
mmol/l
3.59
314
2952
15
87
1.75
1.16
1.3
1.4
386.87
473.52
mg/l
0.72
15
82
17
103
1.68
1.14
1.1
1.2
—
—
—
0
0
22
143
1.57
1.14
3.6
2.8
0.60
0.67
%
0.73
22
143
386
3739
1.44
1.14
29.3
19.6
40.15
40.21
%
0.07
363
3516
7
31
2.28
1.11
1.7
1.0
—
—
—
0
0
7
31
2.28
1.11
3.1
2.5
—
—
—
0
0
344
3284
1.27
1.08
5.6
4.7
2.70
2.75
mmol/l
0.48
321
3027
10
52
1.95
1.07
1.3
1.1
0.87
2.21
u/ml
—
5
29
243
2244
1.20
1.04
3.9
3.8
—
—
—
0
0
19
122
1.58
1.04
2.4
2.7
22.26
21.70
s
0.10
19
110
26
366
0.69
1.03
1.6
1.7
—
—
—
0
0
30
214
1.43
1.03
1.2
1.3
—
38.66
—
0
13
12
68
1.79
1.01
1.4
1.4
—
—
—
0
0
102
870
1.23
1.01
1.9
1.6
1.51
1.34
mmol/l
1.27
86
737
48
375
1.32
0.97
2.2
3.0
4.90
7.62
umol/l
2.38
43
321
140
1238
1.20
0.95
3.7
3.7
36.41
40.14
ng/l
0.14
86
854
13
208
0.61
0.94
1.3
1.4
—
—
—
0
0
33
244
1.38
0.94
1.7
1.3
—
—
—
0
0
29
210
1.41
0.93
5.1
3.7
5.24
5.11
kpa
0.46
29
204
13
78
1.69
0.92
1.4
1.3
4.13
3.60
mmol/l
0.73
13
73
22
153
1.46
0.87
4.6
3.9
—
—
—
0
0
323
3085
1.21
0.87
4.7
3.8
1.37
1.25
mmol/l
2.20
299
2826
85
723
1.22
0.87
1.9
1.9
1.55
1.16
mg/l
0.72
65
556
6
31
1.95
0.84
1.0
1.1
—
—
—
0
0
8
45
1.79
0.84
1.1
1.2
—
—
—
0
0
10
57
1.77
0.84
1.0
1.2
—
—
—
0
0
32
241
1.36
0.83
2.2
2.4
—
19.76
—
0
16
30
225
1.36
0.80
2.6
2.7
82.80
190.21
ng/l
2.46
25
206
10
58
1.74
0.80
6.1
4.0
—
—
—
0
0
116
1030
1.17
0.75
3.0
2.3
—
—
—
0
0
10
60
1.68
0.72
6.1
4.0
—
—
—
0
0
17
119
1.45
0.68
1.6
1.6
—
—
—
0
0
103
916
1.17
0.65
3.4
3.4
—
—
—
0
0
7
44
1.60
0.65
2.3
1.9
—
—
—
0
0
13
87
1.51
0.64
1.2
1.3
—
—
—
0
0
5
30
1.67
0.61
2.8
1.7
9.90
4.04
mg/l
—
5
30
235
2222
1.13
0.60
3.6
3.1
55.40
44.11
u/l
1.28
219
2083
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
11
72
1.54
0.59
1.7
2.4
153.46
118.03
ug/min
—
5
38
8
54
1.49
0.57
1.8
1.5
—
—
—
0
0
21
159
1.34
0.56
12.5
9.3
—
—
—
0
0
113
1025
1.14
0.55
4.5
3.0
—
—
—
0
0
9
62
1.46
0.53
3.0
2.4
—
—
—
0
0
9
136
0.65
0.52
2.4
2.9
33.33
2128.60
u/ml
—
9
117
164
1529
1.12
0.51
2.7
2.6
—
—
—
0
0
37
307
1.23
0.51
2.6
2.4
31.33
31.01
u/l
0.03
30
259
10
67
1.50
0.50
1.2
1.6
2798.00
15628.02
e6/l
—
5
47
18
136
1.34
0.50
1.4
1.4
—
—
—
0
0
15
110
1.38
0.49
1.5
1.4
—
—
—
0
0
105
957
1.13
0.48
4.7
4.9
4.85
2.83
ug/l
0.43
94
839
7
48
1.47
0.47
1.1
1.2
—
—
—
0
0
7
49
1.44
0.46
1.0
1.6
—
—
—
0
0
5
83
0.60
0.46
1.2
1.3
—
—
—
0
0
19
147
1.31
0.46
1.4
1.4
—
—
—
0
0
19
147
1.31
0.46
1.4
1.4
—
—
—
0
0
18
139
1.31
0.44
1.1
1.1
—
—
—
0
0
19
149
1.29
0.42
1.4
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
5
35
1.43
0.39
1.2
1.2
—
—
—
0
0
5
35
1.43
0.39
2.2
2.9
—
—
—
0
0
5
36
1.39
0.38
1.2
1.4
—
—
—
0
0
9
69
1.31
0.37
3.7
2.4
136.78
130.39
g/l
—
9
51
6
44
1.37
0.34
1.3
1.5
—
—
—
0
0
24
200
1.21
0.34
2.5
3.9
—
—
—
0
0
17
136
1.26
0.34
1.9
1.8
—
—
—
0
0
6
45
1.34
0.34
2.5
2.7
3.87
4.00
mmol/l
—
6
45
6
45
1.34
0.34
2.5
2.7
104.33
106.60
mmol/l
—
6
45
24
201
1.21
0.33
1.5
1.2
—
—
—
0
0
7
52
1.35
0.31
3.4
2.3
68.81
60.15
%
—
7
52
7
52
1.35
0.31
7.0
3.8
—
—
—
0
0
18
148
1.23
0.29
1.4
1.4
—
—
—
0
0
87
934
0.91
0.29
4.3
3.8
—
—
—
0
0
13
161
0.80
0.27
1.4
1.9
—
—
—
0
0
19
161
1.19
0.24
3.4
3.9
—
—
—
0
0
9
77
1.17
0.24
1.1
1.1
—
—
—
0
0
9
77
1.17
0.24
1.0
1.1
—
—
—
0
0
5
38
1.32
0.23
1.2
1.4
—
—
—
0
0
5
39
1.29
0.23
11.2
5.0
—
—
—
0
0
11
88
1.26
0.22
3.1
4.8
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
0.56
0.53
nmol/l
—
5
34
5
40
1.25
0.22
1.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
12
98
1.23
0.21
1.8
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
2.0
2.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
5202.43
—
0
7
21
183
1.16
0.20
4.6
2.7
19.46
34.29
u/ml
1.15
21
173
16
136
1.18
0.20
5.1
4.3
24.31
24.92
mmol/l
0.41
16
129
5
66
0.75
0.17
1.8
1.5
—
—
—
0
0
5
66
0.75
0.17
1.8
1.5
—
—
—
0
0
5
69
0.72
0.17
1.8
1.6
—
—
—
0
0
14
120
1.17
0.16
2.2
2.6
—
—
—
0
0
8
72
1.11
0.16
7.5
4.4
14.70
25.43
mg/l
—
8
48
23
207
1.12
0.15
4.8
2.9
—
—
—
0
0
24
221
1.09
0.11
3.4
2.4
4.13
6.87
e9/l
0.81
19
185
30
281
1.07
0.10
4.7
3.8
—
—
—
0
0
5
45
1.11
0.10
2.8
2.7
—
—
—
0
0
5
45
1.11
0.10
1.2
1.9
88.06
90.20
%
—
5
45
55
573
0.95
0.09
3.3
3.0
0.66
0.76
ug/l
0.48
38
375
5
65
0.77
0.08
1.2
1.1
—
—
—
0
0
7
67
1.05
0.08
2.0
1.5
—
—
—
0
0
8
76
1.05
0.07
2.9
2.6
—
—
—
0
0
35
367
0.95
0.07
1.5
1.5
—
—
—
0
0
36
348
1.04
0.04
1.7
1.7
—
—
—
0
0
91
922
0.98
0.03
1.5
1.5
—
—
—
0
0
114
1152
0.99
0.02
3.3
2.8
—
—
—
0
0
16
168
0.95
0.02
2.4
2.4
—
—
—
0
0
10
94
1.07
0.01
1.3
1.2
—
—
—
0
0
40
402
0.99
0.00
1.5
1.2
—
—
—
0
0
32
325
0.98
0.00
3.9
4.2
17.91
21.46
ug/l
0.08
25
271
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
2.27
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
16.03
—
0
6
0
7
0.00
0.00
0.0
3.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
3695.60
—
0
5
31
310
1.00
-0.00
4.0
4.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
41.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PAPULOSQUAOTH and mortality.

Females

Parameter HR [95% CI] p-value
L12_PAPULOSQUAOTH 1.183 [0.96, 1.46] 0.119
Birth year 0.99 [0.98, 1.0] 0.027

During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 1235 females with L12_PAPULOSQUAOTH died.

Males

Parameter HR [95% CI] p-value
L12_PAPULOSQUAOTH 1.496 [1.14, 1.97] 0.004
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 1017 males with L12_PAPULOSQUAOTH died.

Mortality risk

Mortality risk for people of age

years, who have L12_PAPULOSQUAOTH.

N-year risk Females Males
1 0.083% 0.332%
5 0.566% 1.753%
10 1.522% 4.204%
15 2.952% 7.479%
20 5.118% 12.236%

Relationships between endpoints

↥

Index endpoint: L12_PAPULOSQUAOTH – Other papulosquamous disorders

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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