Risteys · L12_LICHENRUBER

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L44.3 Cause of death: ICD-10 — L44.3 2 out of 7 registries used, show all original rules.	21
4. Check minimum number of events None	21
5. Include endpoints None	21
6. Filter based on genotype QC (FinnGen only)	21

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	160	92	66
Only index persons	134	83	51
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	68.66	68.52	68.91
Only index persons	67.70	68.14	66.99

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	21	12	9
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	65.30	63.90	67.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

6.87

2.35

2.6

1.4

4.4

4.3

pmol/l

—

(40768804) Tissue Pathology biopsy report

3.45

2.09

3.1

2.2

—

(3002256) Pathology report gross observation

4.49

2.00

1.2

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

2.79

1.48

2.2

103.7

106.2

pmol/l

—

(3019225) pH of Specimen

3.52

1.45

5.8

6.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

109

2.31

0.96

2.7

3.3

53.2

53.8

u/l

0.01

103

(3031040) Bacteria [#/volume] in Urine by Automated count

111

2.22

0.94

6.5

5.7

—

9286.8

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

2.16

0.92

1.4

2.3

52.6

54.3

u/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.41

0.81

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.41

0.81

1.2

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.05

0.80

2.1

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

2.12

0.80

3.5

2.8

120.3

129.8

ug/l

—

(40768797) Stomach Pathology biopsy report

2.20

0.76

1.8

1.2

—

(3009508) Creatinine [Moles/volume] in Urine

1.96

0.73

3.9

2.8

4.1

7.2

mmol/l

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.73

0.55

3.4

3.6

367.9

7900.4

umol/l

—

(3023368) Bacteria identified in Blood by Culture

1.60

0.37

6.3

3.8

—

(3026008) Bacteria identified in Urine by Culture

1.54

0.35

4.4

3.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.57

0.34

2.0

2.3

81.1

78.6

nmol/l

—

(3044889) 12 lead EKG panel

123

0.64

0.34

4.4

4.1

—

(3006315) Basophils [#/volume] in Blood

1.50

0.29

4.5

5.7

0.0

e9/l

0.17

(3001604) Monocytes [#/volume] in Blood

1.50

0.29

4.5

5.6

0.5

e9/l

0.11

(3019069) Monocytes/100 leukocytes in Blood

1.48

0.27

4.9

6.1

7.5

8.2

—

(3006504) Eosinophils/100 leukocytes in Blood

1.45

0.25

4.5

6.0

2.7

2.8

—

(36304419) Bacteria [Presence] in Urine

1.42

0.23

4.0

3.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.39

0.23

3.8

4.7

—

(3013115) Eosinophils [#/volume] in Blood

1.41

0.22

4.8

5.6

0.2

e9/l

0.10

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.22

0.0

2.6

—

51.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.22

0.0

1.9

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.22

0.0

1.9

—

24.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.9

—

(3019060) Gas panel - Arterial blood

0.00

0.22

0.0

3.0

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.22

0.0

1.8

—

131.9

—

(3000492) Spirometry study

0.00

0.21

0.0

1.5

—

(4010399)

0.00

0.21

0.0

1.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

0.67

0.21

2.2

3.7

635.8

1433.9

ng/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.34

0.16

2.2

4.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.31

0.14

2.1

2.6

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

1.29

0.12

6.8

5.9

1.3

1.2

mmol/l

—

(3000850) Epithelial cells [#/volume] in Urine

1.21

0.11

3.2

3.0

2.9

3.2

e6/l

—

(3033658) Prothrombin time (PT) actual/Normal

1.11

0.10

1.8

4.8

92.6

87.3

—

(1761868) Lipid panel - Serum or Plasma

1.21

0.10

2.3

3.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

158

0.82

0.10

5.9

4.1

1.4

1.2

mmol/l

0.77

146

(3021960) Folate [Moles/volume] in Serum or Plasma

1.15

0.10

1.8

15.8

24.4

nmol/l

—

(3013512) EKG study

0.78

0.10

6.4

4.6

—

(3044640) Blood type and Crossmatch panel - Blood

1.17

0.09

2.3

2.2

—

(3003338) MCHC [Mass/volume]

142

1.20

0.09

17.3

18.8

331.1

g/l

0.01

142

(3022096) Basophils/100 leukocytes in Blood

1.19

0.09

4.7

5.8

0.8

0.6

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

15.4

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

1.8

—

3.9

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

1.8

—

106.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

1.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

3.6

—

91.8

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

2.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

1.8

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(42870588) Differential panel, method unspecified - Blood

0.89

0.00

5.0

5.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

2.0

—

7.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

1.6

—

0.8

—

(3020891) Body temperature

0.00

0.0

2.9

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.0

1.0

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.0

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

2.0

—

1.7

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

2.5

—

1.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

2.0

—

55.3

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

5.1

—

2.9

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.0

—

(3036489) Thrombin time

0.00

0.0

4.3

—

21.8

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

1.6

—

0.5

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(4034850)

0.00

0.0

8.3

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.00

0.0

4.4

—

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

143

1.17

0.00

15.5

16.7

40.1

38.4

—

102

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.07

0.00

6.0

3.4

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

2.0

—

5.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.04

0.00

4.0

4.8

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

2.9

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.0

4.3

—

0.9

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

4.2

—

201.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_LICHENRUBER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_LICHENRUBER.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_LICHENRUBER – Lichen ruber moniliformis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	L12_LICHENRUBER
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L443
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L443
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Lichen ruber moniliformis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints