Pityriasis rubra pilaris

L12_PITYRIASISRUBRA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L44.0 Hospital discharge: ICD-9 — 6964A Hospital discharge: ICD-8 — 6964 Cause of death: ICD-10 — L44.0 Cause of death: ICD-9 — 6964A Cause of death: ICD-8 — 6964 2 out of 7 registries used, show all original rules.	84
4. Check minimum number of events None	84
5. Include endpoints None	84
6. Filter based on genotype QC (FinnGen only)	84

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L44
Name in latin: Pityriasis rubra pilaris

NAME	L12_PITYRIASISRUBRA
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L440
HD_ICD_9	6964A
HD_ICD_8	6964
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L440
COD_ICD_9	6964A
COD_ICD_8	6964
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pityriasis rubra pilaris based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	659	274	382
Only index persons	598	256	342
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.03	55.27	53.05
Only index persons	53.38	55.70	51.65

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	84	39	45
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	57.56	50.19	63.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
76: Matched controls
758

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L44.0

ICD-10 Finland

Pityriasis rubra pilaris

+∞

96.9

D05BB02

ATC

acitretin; oral

+∞

44.1

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

18.8

21.1

L40.0

ICD-10 Finland

Psoriasis vulgaris

88.7

18.8

L30.9

ICD-10 Finland

Dermatitis, unspecified

11.8

17.9

E0000UV

ATC

9.0

17.1

190

D07XC01

ATC

betamethasone, combinations; topical

12.6

16.2

D07AC01

ATC

betamethasone; topical

8.0

15.8

147

D07AB08

ATC

desonide; topical

12.4

14.4

D05AX52

ATC

calcipotriol, combinations; topical

28.8

13.7

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

12.7

13.6

L26

ICD-10 Finland

Exfoliative dermatitis

+∞

12.9

D02AE01

ATC

carbamide; topical

17.6

12.3

E000001

ATC

6.8

12.0

D07AC13

ATC

mometasone; topical

6.0

11.7

130

D07AD01

ATC

clobetasol; topical

8.3

11.4

E000003

ATC

14.1

9.6

134

Kela drug reimbursment

General erythroderma

+∞

9.6

D07AB02

ATC

hydrocortisone butyrate; topical

4.8

8.9

126

TQW80

NOMESCO Finland

Local dermatologic skincare

17.1

8.6

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

8.4

7.8

E000002

ATC

6.5

7.3

H02AB06

ATC

prednisolone; systemic

3.8

7.2

253

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

18.31

27.49

2.2

1.0

—

(42870588) Differential panel, method unspecified - Blood

198

6.48

16.01

11.9

4.8

—

(3001604) Monocytes [#/volume] in Blood

319

6.44

12.50

13.1

5.3

0.6

e9/l

1.00

281

(3006315) Basophils [#/volume] in Blood

320

6.40

12.43

13.1

5.3

0.0

e9/l

1.40

284

(3019198) Lymphocytes [#/volume] in Blood

328

6.15

11.83

13.2

5.3

2.1

1.9

e9/l

0.25

297

(3013115) Eosinophils [#/volume] in Blood

332

6.03

11.54

13.6

5.3

0.3

0.2

e9/l

1.52

299

(3013650) Neutrophils [#/volume] in Blood by Automated count

379

5.17

9.11

14.5

9.8

4.3

4.2

e9/l

0.16

335

(3002179) Metamyelocytes/100 leukocytes in Blood

5.85

9.11

4.5

3.2

0.2

0.5

—

(3021440) Promyelocytes/100 leukocytes in Blood

5.29

8.18

5.2

3.0

0.7

0.2

—

(3021589) Normoblasts [#/volume] in Blood

280

3.79

7.98

17.4

8.5

0.0

e9/l

0.50

231

(3025159) Blasts/100 leukocytes in Blood

5.18

7.65

5.4

3.0

0.0

0.7

—

(3017181) Myelocytes/100 leukocytes in Blood

4.82

7.36

5.2

3.0

1.7

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

157

3.42

6.94

7.9

4.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.92

5.90

4.5

3.1

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

471

3.92

5.63

5.1

4.0

14.7

14.9

pmol/l

0.20

422

(3036481) Cortisol [Moles/volume] in Serum or Plasma

3.61

5.06

5.7

1.5

263.0

381.2

nmol/l

1.62

(3030905) Polymorphonuclear cells [#/volume] in Blood

9.91

4.92

3.3

2.9

4.6

3.2

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

9.91

4.92

3.6

3.0

58.0

56.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

143

2.85

4.76

2.1

1.8

2.9

3.0

mg/l

0.10

128

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

274

2.62

4.50

6.7

6.9

1.2

mmol/l

1.16

241

(3013707) Erythrocyte sedimentation rate by Westergren method

484

3.13

4.27

5.5

3.8

10.3

11.0

mm/h

0.20

442

(4035726)

3.59

4.17

2.0

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.71

4.12

1.6

2.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.59

4.01

1.5

1.8

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

7.90

3.95

1.6

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.10

3.86

2.3

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

136

2.59

3.79

1.2

1.0

u/ml

—

(3007164) IgA [Mass/volume] in Serum or Plasma

128

2.49

3.38

1.6

1.3

1.9

2.3

g/l

0.71

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.31

3.30

1.1

1.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

224

2.27

3.29

3.7

3.0

—

(3026493) Urate [Moles/volume] in Serum or Plasma

169

2.32

3.21

1.7

2.8

365.2

7029.3

umol/l

1.03

144

(3018418) pH of Serum or Plasma

165

2.27

3.02

4.5

3.5

7.4

—

(40758558) Short blood count panel - Blood

165

2.27

3.02

10.0

7.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

10.51

3.01

1.0

—

(3000494) Fungus identified in Specimen by Culture

2.71

2.96

2.1

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

176

2.21

2.87

3.2

2.7

0.2

0.3

e6/l

0.35

139

(3001122) Ferritin [Mass/volume] in Serum or Plasma

288

2.11

2.83

3.5

2.4

89.2

101.6

ug/l

0.30

263

(3028026) IgM [Mass/volume] in Serum or Plasma

3.41

2.74

1.8

1.6

0.9

1.1

g/l

—

(3018095) Leukocytes [#/volume] in Urine

230

2.09

2.69

4.9

3.1

62.0

42.5

e6/l

0.15

168

(36304419) Bacteria [Presence] in Urine

165

2.16

2.64

2.8

2.6

—

(3002582) Erythrocytes [#/volume] in Urine

200

2.07

2.54

4.2

2.7

10.0

342.9

e6/l

0.54

158

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.51

2.46

1.3

1.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

600

2.65

2.44

7.0

4.4

1.8

1.9

mu/l

0.16

537

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

4.39

2.41

1.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

4.39

2.41

1.0

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

4.39

2.41

1.0

1.1

—

(3002385) Erythrocyte distribution width [Ratio]

567

2.41

2.38

24.0

14.9

13.8

13.7

0.36

557

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

5.82

2.24

1.0

2.1

—

(3044290) Cell count panel - Cerebral spinal fluid

4.53

2.19

1.3

1.0

—

(3023410) Appearance of Cerebral spinal fluid

5.24

2.10

1.4

1.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.22

2.08

1.2

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

4.22

2.08

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

634

2.40

1.87

6.0

3.8

1.5

1.3

mmol/l

1.86

587

(40761536) Microorganisms panel - Urine sediment

2.54

1.86

6.4

3.2

—

(3012516) Albumin [Mass/volume] in Urine

160

1.91

1.85

4.8

3.1

99.5

59.2

mg/l

0.42

109

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.94

1.84

3.5

1.6

42.1

38.9

u/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

177

1.87

1.83

6.5

3.7

16.3

9.3

mg/mmol

0.42

116

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

106

2.02

1.77

1.7

1.3

1.2

5.4

u/ml

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

122

1.96

1.75

1.7

428.9

443.3

pmol/l

0.08

109

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

172

1.84

1.72

2.4

1.5

1.7

1.3

mmol/l

1.69

142

(3037467) Urinalysis macro (dipstick) panel - Urine

444

1.78

1.68

4.6

3.9

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

101

2.00

1.65

1.8

2.3

0.9

0.8

e6/l

0.04

(3003327) Ova and parasites identified in Stool by Light microscopy

3.15

1.61

2.2

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.73

1.55

1.9

1.1

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.73

1.55

1.1

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.46

1.48

1.7

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

2.11

1.48

2.8

2.4

93.4

114.3

ug/g

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

344

1.66

1.47

6.8

9.9

11.4

umol/l

0.92

325

(3000991) Gas panel - Venous blood

2.40

1.45

11.8

8.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

251

1.68

1.45

1.7

1.8

85.8

94.1

pmol/l

0.48

142

(3019550) Sodium [Moles/volume] in Serum or Plasma

682

2.20

1.44

22.8

13.9

139.5

139.8

mmol/l

0.45

662

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

594

1.91

1.44

6.9

5.5

40.2

39.2

mmol/mol

0.36

561

(3021601) Nitrite [Presence] in Urine by Test strip

317

1.65

1.43

7.3

5.0

0.0

estimate

—

(3044889) 12 lead EKG panel

445

1.68

1.42

4.3

3.7

—

(3035350) Ketones [Presence] in Urine by Test strip

318

1.64

1.40

4.9

3.5

0.0

estimate

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

671

2.10

1.38

20.6

12.7

17.9

23.8

mg/l

0.99

514

(3009261) Glucose [Presence] in Urine by Test strip

319

1.63

1.38

5.0

3.6

0.0

estimate

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

1.35

0.0

1.5

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.61

1.33

3.5

2.8

0.7

0.8

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.61

1.33

3.5

2.8

1.1

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

185

1.68

1.31

2.5

2.3

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

686

2.13

1.31

23.0

13.8

4.0

mmol/l

0.72

667

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.50

1.26

15.7

7.4

25.5

24.9

mmol/l

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

662

1.99

1.21

6.9

4.2

4.7

4.6

mmol/l

0.22

615

(3020564) Creatinine [Moles/volume] in Serum or Plasma

718

2.21

1.17

27.1

14.6

79.6

77.7

umol/l

0.16

718

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

458

1.58

1.15

3.1

2.9

63.3

42.1

u/l

1.26

434

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.29

1.11

1.0

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

175

1.61

1.10

3.9

3.5

0.0

estimate

—

(40768804) Tissue Pathology biopsy report

258

1.53

1.06

2.8

1.9

—

(3042936) Bacteria identified in Isolate by Culture

1.84

1.06

3.2

2.2

—

(3000330) Specific gravity of Urine by Test strip

2.09

1.02

3.4

4.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

233

1.52

1.00

4.1

3.4

80.1

29.5

ng/l

0.89

156

(3041096) Erythrocytes [Presence] in Urine by Automated

179

1.56

1.00

3.9

3.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

1.00

0.0

1.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.73

0.99

2.2

2.4

0.6

2.3

e6/l

—

(3003694) ABO and Rh group [Type] in Blood

171

1.56

0.98

1.5

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

662

1.78

0.97

5.6

4.2

1.3

1.4

mmol/l

1.39

612

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

103

1.68

0.96

1.4

1.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

676

1.80

0.92

6.7

4.6

2.8

mmol/l

0.01

623

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.90

0.89

3.6

3.4

1.2

mmol/l

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.07

0.89

3.3

3.5

24.4

25.3

mmol/l

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.86

0.87

1.0

1.3

—

32.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.01

0.86

3.5

3.2

122.0

128.8

g/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

115

1.60

0.85

1.6

1.3

10.9

40.9

iu/ml

—

(3023368) Bacteria identified in Blood by Culture

159

1.52

0.84

5.6

4.3

—

(3002032) Base excess in Venous blood by calculation

1.77

0.83

3.5

3.8

1.6

2.6

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

134

1.54

0.80

2.6

2.1

—

(3000492) Spirometry study

1.79

0.80

1.4

1.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

650

1.60

0.77

5.5

4.4

6.0

5.9

mmol/l

0.41

599

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

254

1.42

0.76

5.7

3.7

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

2.15

0.76

1.0

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.92

0.76

1.3

1.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.98

0.72

4.2

4.4

66.9

59.3

—

(3003338) MCHC [Mass/volume]

602

0.71

27.6

15.8

332.6

333.0

g/l

0.09

602

(3008898) HLA-B27 [Presence]

1.90

0.69

1.0

1.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

104

0.54

0.67

3.5

1.5

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.63

0.66

7.3

5.6

1.1

1.0

mmol/l

0.45

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.67

0.65

9.5

7.6

5.1

kpa

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.67

0.65

9.5

7.5

12.5

12.1

kpa

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.77

0.65

3.2

2.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.77

0.65

1.0

—

(36660697) Celiac disease serology panel - Serum

1.70

0.64

1.3

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

133

1.45

0.61

1.6

1.9

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.61

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.61

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.61

0.0

1.5

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.7

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.61

0.0

1.5

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.61

0.0

1.1

—

(1761868) Lipid panel - Serum or Plasma

263

1.35

0.60

4.1

2.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

627

1.44

0.60

20.7

12.6

39.7

40.1

0.10

480

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.59

0.0

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

286

1.32

0.54

3.6

3.9

—

(3012544) pH of Venous blood

1.50

0.48

3.0

3.8

—

(3022621) pH of Urine by Test strip

1.44

0.46

9.4

2.6

—

(3013512) EKG study

187

1.32

0.45

3.3

3.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

142

1.34

0.43

5.9

3.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.60

0.43

1.6

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.5

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.41

0.0

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.63

0.37

3.4

6.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.37

0.36

2.3

2.0

—

(3032080) INR in Blood by Coagulation assay

243

1.23

0.33

7.4

7.5

1.0

1.2

inr

2.15

(3022145) Colonoscopy Study observation

1.30

0.27

1.6

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

231

0.82

0.26

6.0

4.3

21.3

20.7

—

113

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.23

0.22

1.8

—

(3019060) Gas panel - Arterial blood

1.20

0.22

1.2

4.2

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

1.9

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

0.8

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.1

—

297.6

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.4

—

1.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.2

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

56.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.2

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

7.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.75

0.17

1.4

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

447

1.12

0.15

2.6

3.1

—

(40761511) CBC panel - Blood by Automated count

724

1.19

0.12

17.2

11.4

—

(4010399)

1.12

0.09

1.3

1.4

—

(3019225) pH of Specimen

1.12

0.09

3.5

6.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.04

0.08

1.2

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.08

0.08

1.6

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.05

0.08

1.6

1.9

—

(40768797) Stomach Pathology biopsy report

1.03

0.07

1.5

1.3

—

(3002256) Pathology report gross observation

1.03

0.07

1.9

1.2

—

(3026008) Bacteria identified in Urine by Culture

183

1.05

0.01

6.4

2.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

114

1.06

0.01

1.4

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.89

0.00

1.6

1.7

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.87

0.00

3.0

2.5

8.7

5.5

ug/l

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.8

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.0

—

12.4

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

1.6

—

5.8

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

9.0

—

0.6

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.4

—

197.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(4306422)

0.00

0.0

1.1

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.4

—

(4024509)

0.00

0.0

1.3

—

(40761535) Cells panel - Urine sediment

0.94

0.00

2.6

3.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

12.7

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.8

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

11.4

—

1013.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

13.4

—

1652.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.4

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

2.8

—

51.0

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3048402) Erythrocytes [#/area] in Urine sediment by Automated count

0.00

0.0

1.3

—

0.8

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.93

0.00

1.7

1.9

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.1

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

3.7

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.6

—

(44790048)

0.00

-0.00

0.0

1.8

—

(44790047)

0.00

-0.00

0.0

1.8

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

1.4

—

(44806118)

0.00

-0.00

0.0

1.8

—

(4268621)

0.00

-0.00

0.0

1.7

—

(44790049)

0.00

-0.00

0.0

1.8

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PITYRIASISRUBRA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_PITYRIASISRUBRA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_PITYRIASISRUBRA – Pityriasis rubra pilaris

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pityriasis rubra pilaris

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints