No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
84 |
4. Check minimum number of eventsNone |
84 |
5. Include endpointsNone |
84 |
6. Filter based on genotype QC (FinnGen only) |
84 |
Control definitions (FinnGen only)
- Control exclude
- L12_PAPULOSQUAMOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L44
- Name in latin
- Pityriasis rubra pilaris
Similar endpoints
↥List of similar endpoints to
Pityriasis rubra pilaris
based on the number of shared cases.
Similar with more cases:
- Other papulosquamous disorders
- Papulosquamous disorders
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 659 | 274 | 382 |
| Only index persons | 598 | 256 | 342 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 54.03 | 55.27 | 53.05 |
| Only index persons | 53.38 | 55.70 | 51.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 84 | 39 | 45 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 57.56 | 50.19 | 63.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 76
- Matched controls
- 758
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L44.0
ICD-10 Finland
Pityriasis rubra pilaris
+∞
96.9
71
*
D05BB02
ATC
acitretin; oral
+∞
44.1
38
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
18.8
21.1
34
31
L40.0
ICD-10 Finland
Psoriasis vulgaris
88.7
18.8
20
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
11.8
17.9
37
56
E0000UV
ATC
NA
9.0
17.1
57
190
D07XC01
ATC
betamethasone, combinations; topical
12.6
16.2
31
39
D07AC01
ATC
betamethasone; topical
8.0
15.8
50
147
D07AB08
ATC
desonide; topical
12.4
14.4
27
32
D05AX52
ATC
calcipotriol, combinations; topical
28.8
13.7
18
8
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
12.7
13.6
25
28
L26
ICD-10 Finland
Exfoliative dermatitis
+∞
12.9
12
*
D02AE01
ATC
carbamide; topical
17.6
12.3
19
14
E000001
ATC
NA
6.8
12.0
36
89
D07AC13
ATC
mometasone; topical
6.0
11.7
42
130
D07AD01
ATC
clobetasol; topical
8.3
11.4
27
47
E000003
ATC
NA
14.1
9.6
16
14
134
Kela drug reimbursment
General erythroderma
+∞
9.6
9
*
D07AB02
ATC
hydrocortisone butyrate; topical
4.8
8.9
37
126
TQW80
NOMESCO Finland
Local dermatologic skincare
17.1
8.6
13
9
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
8.4
7.8
17
25
E000002
ATC
NA
6.5
7.3
19
37
H02AB06
ATC
prednisolone; systemic
3.8
7.2
50
253
Mortality – FinRegistry
↥Association
Association between endpoint L12_PITYRIASISRUBRA and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_PITYRIASISRUBRA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_PITYRIASISRUBRA – Pityriasis rubra pilaris
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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