No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
213 |
4. Check minimum number of eventsNone |
213 |
5. Include endpointsNone |
213 |
6. Filter based on genotype QC (FinnGen only) |
213 |
Control definitions (FinnGen only)
- Control exclude
- L12_PAPULOSQUAMOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified papulosquamous disorders
based on the number of shared cases.
Similar with more cases:
- Other papulosquamous disorders
- Papulosquamous disorders
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2302 | 1336 | 944 |
| Only index persons | 1746 | 1046 | 700 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.03 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 44.89 | 48.49 | 39.61 |
| Only index persons | 39.20 | 43.78 | 32.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 213 | 123 | 90 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 46.66 | 44.65 | 49.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 196
- Matched controls
- 1959
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L44.8
ICD-10 Finland
Other specified papulosquamous disorders
+∞
76.1
68
*
6970A
ICD-9 Finland
Lichen planus[LICHEN RUBER PLANUS]
+∞
53.6
49
*
L44.9
ICD-10 Finland
Papulosquamous disorder, unspecified
643.0
52.0
49
*
D07AC01
ATC
betamethasone; topical
5.3
26.0
111
387
L40.0
ICD-10 Finland
Psoriasis vulgaris
246.4
22.1
22
*
D07XC01
ATC
betamethasone, combinations; topical
7.8
21.8
54
91
D05AX52
ATC
calcipotriol, combinations; topical
18.9
16.6
25
15
E0000UV
ATC
NA
3.5
15.6
106
491
D05BB02
ATC
acitretin; oral
24.6
13.2
18
8
D07AB02
ATC
hydrocortisone butyrate; topical
3.4
13.0
81
339
D05AX02
ATC
calcipotriol; topical
13.7
12.5
21
17
E000001
ATC
NA
3.8
12.4
60
205
D07AA02
ATC
hydrocortisone; topical
4.5
12.0
46
126
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.8
11.9
56
186
D07AC13
ATC
mometasone; topical
3.1
10.7
73
318
E000002
ATC
NA
4.7
10.5
37
93
69619
ICD-8 Finland
Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)
+∞
9.4
9
*
D07AB08
ATC
desonide; topical
4.1
8.8
35
99
L40.5
ICD-10 Finland
Arthropathic psoriasis
+∞
8.4
8
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
+∞
8.4
8
*
L43.8
ICD-10 Finland
Other lichen planus
34.9
8.2
10
*
D07AD01
ATC
clobetasol; topical
3.4
8.2
41
141
R06AE07
ATC
cetirizine; oral
2.4
7.8
94
547
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.0
7.5
30
85
69698
ICD-8 Finland
Psoriasis and similar disorders, Other disorders
+∞
7.3
7
*
TQW80
NOMESCO Finland
Local dermatologic skincare
10.6
7.1
13
13
E000003
ATC
NA
6.9
6.8
16
25
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.6
6.7
54
249
D07AB01
ATC
clobetasone; topical
7.3
6.7
15
22
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.6
6.5
29
91
103
Kela drug reimbursment
Diabetes, insulin-treated
2.4
6.3
61
310
69699
ICD-8 Finland
NA
+∞
6.3
6
*
L40.8
ICD-10 Finland
Other psoriasis
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint L12_PAPULOSQUONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PAPULOSQUONAS | 1.667 [1.17, 2.38] | 0.005 |
| Birth year | 0.992 [0.98, 1.0] | 0.063 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 566 females with L12_PAPULOSQUONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PAPULOSQUONAS | 1.932 [1.32, 2.84] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 428 males with L12_PAPULOSQUONAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PAPULOSQUONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | 0.391% |
| 5 | 0.836% | 2.163% |
| 10 | 2.197% | 5.375% |
| 15 | 4.318% | 10.143% |
| 20 | 7.431% | 16.83% |
Relationships between endpoints
↥Index endpoint: L12_PAPULOSQUONAS – Other and unspecified papulosquamous disorders
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data