This is a non-core endpoint: only basic statistics are computed.

Testicular hyperfunction

E4_TESTICHYPER

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only males	226837
2. Check conditions None	226837
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E29.0 Hospital discharge: ICD-9 — 2570 Hospital discharge: ICD-8 — 2570 Cause of death: ICD-10 — E29.0 Cause of death: ICD-9 — 2570 Cause of death: ICD-8 — 2570 2 out of 7 registries used, show all original rules.	13
4. Check minimum number of events None	13
5. Include endpoints None	13
6. Filter based on genotype QC (FinnGen only)	13

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E29
Name in latin: Hyperfunctio testium

NAME	E4_TESTICHYPER
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	1
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E290
HD_ICD_9	2570
HD_ICD_8	2570
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E290
COD_ICD_9	2570
COD_ICD_8	2570
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Testicular hyperfunction based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	129	-	129
Only index persons	88	-	88
Unadjusted period prevalence (%)
Whole population	0.00	-	0.00
Only index persons	0.00	-	0.00
Median age at first event (years)
Whole population	-	-	49.07
Only index persons	-	-	42.09

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	13	-	13
Unadjusted period prevalence (%)	0.01	-	0.01
Median age at first event (years)	57.07	-	57.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

16.63

4.73

3.1

1.3

nmol/l

22.0

37.7

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

6.02

2.03

5.0

4.8

mmol/l

0.8

—

(42870588) Differential panel, method unspecified - Blood

4.64

2.00

5.3

9.4

—

(40768804) Tissue Pathology biopsy report

4.13

1.64

1.4

2.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

3.74

1.52

5.2

7.2

—

(40758558) Short blood count panel - Blood

3.84

1.43

14.0

7.1

—

(3023368) Bacteria identified in Blood by Culture

2.60

0.97

2.3

4.0

—

(3001604) Monocytes [#/volume] in Blood

2.80

0.88

6.8

9.1

e9/l

0.6

0.7

—

(3006315) Basophils [#/volume] in Blood

2.80

0.88

6.8

9.1

e9/l

0.0

—

(3019198) Lymphocytes [#/volume] in Blood

2.71

0.87

6.9

9.3

e9/l

2.3

1.8

—

(3013115) Eosinophils [#/volume] in Blood

2.71

0.87

6.9

11.1

e9/l

0.2

—

(3018418) pH of Serum or Plasma

2.07

0.51

3.4

4.5

—

7.4

—

(36304419) Bacteria [Presence] in Urine

1.83

0.48

3.0

2.2

—

(3030467) Casts [#/volume] in Urine by Automated count

1.76

0.47

3.2

2.2

e6/l

1.4

0.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

1.92

0.46

9.3

10.2

mmol/l

1.2

—

(3002582) Erythrocytes [#/volume] in Urine

1.63

0.28

3.2

2.5

e6/l

12.2

13.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.45

0.27

3.2

2.6

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

1.40

0.26

6.4

5.8

mmol/l

1.1

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

1.46

0.24

3.3

4.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.46

0.24

2.0

3.5

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.22

0.0

2.6

—

2.9

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

0.00

0.22

0.0

5.5

—

249.5

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.22

0.0

2.8

—

89.7

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.22

0.0

2.7

—

0.9

—

(3018095) Leukocytes [#/volume] in Urine

1.35

0.12

3.4

3.0

e6/l

39.9

21.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.31

0.12

3.2

4.5

—

(3019225) pH of Specimen

0.00

0.0

4.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.00

0.0

2.3

—

1.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.2

—

(40761535) Cells panel - Urine sediment

0.00

0.0

6.7

—

(3020891) Body temperature

0.00

0.0

2.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.0

10.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

2.1

—

1.3

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.3

—

(4010399)

0.00

0.0

2.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(4034850)

0.00

0.0

37.0

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.0

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.0

8.7

—

22.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_TESTICHYPER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_TESTICHYPER.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_TESTICHYPER – Testicular hyperfunction

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Testicular hyperfunction

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints