This is a non-core endpoint: only basic statistics are computed.

Hypercementosis

K11_HYPERCEMENTOSIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K03.4 Hospital discharge: ICD-9 — 5215 Hospital discharge: ICD-8 — 5215 Cause of death: ICD-10 — K03.4 Cause of death: ICD-9 — 5215 Cause of death: ICD-8 — 5215 2 out of 7 registries used, show all original rules.	15
4. Check minimum number of events None	15
5. Include endpoints None	15
6. Filter based on genotype QC (FinnGen only)	15

Control definitions (FinnGen only)

Control exclude: K11_ORAL

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF5

NAME	K11_HYPERCEMENTOSIS
CONTROL_EXCLUDE	K11_ORAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K034
HD_ICD_9	5215
HD_ICD_8	5215
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K034
COD_ICD_9	5215
COD_ICD_8	5215
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Hypercementosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	117	83	33
Only index persons	111	79	32
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	43.53	45.20	38.34
Only index persons	42.21	44.85	35.69

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	15	8	7
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	31.11	34.71	27.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

4.44

1.67

9.0

2.7

—

(3013115) Eosinophils [#/volume] in Blood

3.53

1.58

9.1

6.0

0.2

0.1

e9/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

3.41

1.33

2.0

1.2

—

(42870588) Differential panel, method unspecified - Blood

2.76

1.04

12.8

5.7

—

(3044889) 12 lead EKG panel

2.67

0.99

3.6

3.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.47

0.89

2.6

3.3

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.88

0.0

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.37

0.79

1.8

1.4

0.7

1.4

mg/l

—

(40758558) Short blood count panel - Blood

2.26

0.76

12.6

6.9

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

2.12

0.74

11.4

9.3

3.1

3.7

e9/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

2.16

0.73

8.9

3.4

—

(3026008) Bacteria identified in Urine by Culture

2.08

0.71

4.6

2.7

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

2.08

0.71

3.2

1.6

1.8

2.9

mg/l

—

(3015736) pH of Urine

2.10

0.67

2.7

3.5

—

(40768804) Tissue Pathology biopsy report

2.10

0.62

1.7

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.08

0.58

2.8

3.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

2.06

0.56

6.6

4.7

6.7

6.2

mmol/l

—

(3003694) ABO and Rh group [Type] in Blood

1.99

0.50

1.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.70

0.46

1.8

2.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.43

0.0

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

0.22

0.0

3.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.22

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.22

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.22

0.0

1.3

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.22

0.0

1.8

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.22

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.22

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.22

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.22

0.0

1.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.21

0.0

1.7

—

(3021589) Normoblasts [#/volume] in Blood

1.17

0.11

18.8

11.2

0.0

e9/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

105

0.86

0.11

3.2

3.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.6

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

2.2

—

2.7

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3019060) Gas panel - Arterial blood

0.00

0.0

3.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

1.8

—

94.2

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.3

—

55.7

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.3

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.6

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.2

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.3

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.6

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.00

0.0

5.4

—

25.9

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint K11_HYPERCEMENTOSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_HYPERCEMENTOSIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: K11_HYPERCEMENTOSIS – Hypercementosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hypercementosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints