This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

N14_DRUGSANDHEAVYMETAL

Nephropathy induced by unspecified drug, medicament or biological substance

Endpoint Browser

NEPHROP_INDUCED_UNSPE_DRUG_MEDICAM_BIOLO_SUBST

No definition available.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — N14.2# 1 out of 7 registries used, show all original rules.	20
4. Check minimum number of events None	20
5. Include endpoints None	20
6. Filter based on genotype QC (FinnGen only)	20

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	NEPHROP_INDUCED_UNSPE_DRUG_MEDICAM_BIOLO_SUBST
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	N142
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Nephropathy induced by unspecified drug, medicament or biological substance based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	99	50	48
Only index persons	80	42	38
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	59.62	58.99	59.74
Only index persons	55.45	55.65	55.23

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	20	11	9
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	58.05	56.79	59.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40761536) Microorganisms panel - Urine sediment

17.18

8.86

8.7

4.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

7.25

3.66

5.4

3.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

5.94

3.57

4.3

6.8

—

(3013512) EKG study

5.67

3.45

3.6

4.6

—

(3022145) Colonoscopy Study observation

5.38

2.52

1.4

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

4.06

2.27

7.6

3.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

3.65

2.01

7.1

4.7

—

(42870588) Differential panel, method unspecified - Blood

3.37

1.76

5.3

6.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

3.10

1.61

5.8

2.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

3.08

1.54

3.4

5.3

17.3

53.6

ng/l

—

(40768797) Stomach Pathology biopsy report

3.34

1.37

1.4

—

(3015736) pH of Urine

2.71

1.35

3.6

4.2

—

(1761868) Lipid panel - Serum or Plasma

2.64

1.34

4.0

2.8

—

(3019225) pH of Specimen

3.15

1.30

11.2

5.3

—

(3021589) Normoblasts [#/volume] in Blood

2.49

1.24

17.9

8.9

0.0

e9/l

0.00

(36304419) Bacteria [Presence] in Urine

2.44

1.18

4.6

2.6

—

(3006315) Basophils [#/volume] in Blood

2.31

1.00

6.2

6.7

0.0

e9/l

0.17

(3001604) Monocytes [#/volume] in Blood

2.31

1.00

6.2

6.7

0.6

e9/l

0.11

(3019198) Lymphocytes [#/volume] in Blood

2.22

0.98

6.2

6.7

1.7

e9/l

0.03

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

0.00

0.86

0.0

2.3

—

0.8

—

(3022096) Basophils/100 leukocytes in Blood

2.11

0.81

6.7

6.0

0.7

0.07

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.96

0.69

1.8

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.64

0.0

1.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

1.83

0.62

6.7

6.0

24.5

26.3

0.23

(3026008) Bacteria identified in Urine by Culture

1.59

0.49

6.4

3.1

—

(3044889) 12 lead EKG panel

105

1.68

0.46

4.8

3.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.62

0.44

1.2

2.0

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.43

0.0

1.1

—

(3044640) Blood type and Crossmatch panel - Blood

0.62

0.33

2.4

2.2

—

(3022621) pH of Urine by Test strip

0.00

0.22

0.0

3.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.22

0.0

8.1

—

(3023368) Bacteria identified in Blood by Culture

1.25

0.22

3.5

4.5

—

(3003694) ABO and Rh group [Type] in Blood

1.15

0.11

1.6

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

0.89

0.09

3.1

3.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

3.4

—

1.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.0

—

152.6

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.0

1.8

—

3.9

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

0.0

1.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.0

7.6

—

24.7

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

2.2

—

1.5

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.4

—

202.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.06

0.00

4.3

4.1

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

4.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.6

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(40768804) Tissue Pathology biopsy report

0.94

0.00

2.1

2.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

2.2

—

8.1

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

5.0

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

3.4

—

0.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

134.6

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

5.2

—

(4094501)

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint NEPHROP_INDUCED_UNSPE_DRUG_MEDICAM_BIOLO_SUBST and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have NEPHROP_INDUCED_UNSPE_DRUG_MEDICAM_BIOLO_SUBST.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: NEPHROP_INDUCED_UNSPE_DRUG_MEDICAM_BIOLO_SUBST – Nephropathy induced by unspecified drug, medicament or biological substance

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Nephropathy induced by unspecified drug, medicament or biological substance

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints