acute kidney tubular necrosis: Acute renal failure caused by the cell death of the renal tubules. Causes include nephrotoxins, cytotoxic drugs, and antibiotics.
Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
DOID EFO Endpoint Browser PheWeb
N14_DRUGSANDHEAVYMETAL
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
99 |
4. Check minimum number of eventsNone |
99 |
5. Include endpointsNone |
99 |
6. Filter based on genotype QC (FinnGen only) |
99 |
Control definitions (FinnGen only)
- Control exclude
- N14_RENALTUB
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N10-N16
- Name in latin
- Condiciones tubulo-interstitiales et tubulares ex medicamentis et metallis gravibus
Similar endpoints
↥List of similar endpoints to
Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
based on the number of shared cases.
Similar with more cases:
- Renal tubulo-interstitial diseases
- Genitourinary diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 684 | 289 | 389 |
| Only index persons | 549 | 241 | 308 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 64.13 | 65.48 | 62.95 |
| Only index persons | 62.02 | 64.29 | 60.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99 | 39 | 60 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 57.08 | 58.78 | 55.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 93
- Matched controls
- 929
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N14.1
ICD-10 Finland
Nephropathy induced by other drugs, medicaments and biological substances
+∞
62.8
53
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
700.0
44.0
40
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
+∞
32.2
29
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
62.2
23.9
27
6
N14.2
ICD-10 Finland
Nephropathy induced by unspecified drug, medicament or biological substance
+∞
20.6
19
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
39.7
19.5
24
8
N18.8
ICD-10 Finland
Other chronic renal failure
+∞
17.2
16
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
+∞
16.1
15
*
N19
ICD-10 Finland
Unspecified kidney failure
95.1
15.1
16
*
A11CC03
ATC
alfacalcidol; systemic
+∞
13.9
13
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
+∞
13.9
13
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.5
12.9
33
63
N14.0
ICD-10 Finland
Analgesic nephropathy
+∞
12.8
12
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
+∞
12.8
12
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
149.3
12.8
13
*
TK800
NOMESCO Finland
Hemodialysis
149.3
12.8
13
*
C03CA01
ATC
furosemide; systemic
5.4
12.3
46
142
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
136.2
11.7
12
*
L04AA06
ATC
mycophenolic acid; systemic
+∞
11.7
11
*
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
+∞
11.7
11
*
Z94.0
ICD-10 Finland
Kidney transplant status
+∞
10.6
10
*
N18.0
ICD-10 Finland
End-stage renal disease
+∞
10.6
10
*
N05AN01
ATC
lithium; oral
29.8
10.1
13
5
L04AX01
ATC
azathioprine; systemic
15.8
10.1
16
12
A12AA04
ATC
calcium carbonate; oral
110.8
9.6
10
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
+∞
9.5
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
9.3
59
282
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
14.6
9.2
15
12
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
9.4
8.9
18
23
B03XA02
ATC
darbepoetin alfa; parenteral
55.4
8.9
10
*
127
Kela drug reimbursment
Transplant complication
55.4
8.9
10
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
22.6
8.7
12
6
N05AA02
ATC
levomepromazine; systemic
16.5
8.5
13
9
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
8.5
8
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
8.5
8
*
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
+∞
8.5
8
*
N05CD07
ATC
temazepam; oral
6.0
8.4
24
51
L04AD01
ATC
ciclosporin; systemic
36.9
8.3
10
*
M04AA01
ATC
allopurinol; systemic
5.3
8.2
26
63
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.2
8.2
36
122
R50.9
ICD-10 Finland
Fever, unspecified
5.6
8.0
24
54
H02AB04
ATC
methylprednisolone; systemic
5.0
8.0
27
70
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.8
8.0
43
172
L04AA01
ATC
[U] ciclosporin; systemic
27.7
7.7
10
*
A41.9
ICD-10 Finland
Sepsis, unspecified
15.1
7.6
12
9
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
7.4
7
*
N05AH03
ATC
olanzapine; systemic
8.7
7.2
15
20
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
18.4
6.9
10
6
205
Kela drug reimbursment
Chronic hypertension
3.5
6.9
41
172
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.8
6.8
19
39
N05CF01
ATC
zopiclone; oral
3.3
6.7
41
177
3AC01
NOMESCO Finland
NA
74.8
6.5
7
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
19.7
6.4
9
5
N17.8
ICD-10 Finland
Other acute renal failure
+∞
6.3
6
*
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
+∞
6.3
6
*
N14.4
ICD-10 Finland
Toxic nephropathy, not elsewhere classified
+∞
6.3
6
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.2
6.2
16
30
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
43
11.52
26.93
8.2
1.3
143.7
59.8
ng/l
2.75
29
38
45
109
6.74
19.55
8.9
3.1
0.8
0.8
mmol/l
0.07
45
103
41
104
6.02
16.63
6.5
1.6
12.2
14.2
umol/l
1.10
41
91
76
359
5.81
14.00
23.8
4.8
1.2
1.2
mmol/l
0.50
58
292
70
334
4.74
12.07
20.1
4.3
1.2
1.2
mmol/l
0.61
65
300
51
201
4.17
11.27
4.1
2.4
407.6
9337.3
umol/l
1.23
45
169
14
18
8.89
10.42
4.1
2.2
16.5
16.3
%
—
8
10
31
89
4.62
10.37
5.8
3.5
—
—
—
0
0
54
242
3.71
9.53
8.2
3.9
30.4
11.4
mg/mmol
0.88
44
150
22
51
5.26
9.43
2.4
1.4
—
—
—
0
0
42
166
3.66
8.86
3.0
2.0
3.5
3.1
mg/l
0.33
34
142
12
16
8.40
8.61
1.9
1.3
—
—
—
0
0
58
287
3.47
8.50
3.4
1.9
77.2
76.9
nmol/l
0.03
53
246
49
221
3.41
8.30
6.9
2.6
0.3
0.3
e6/l
0.10
42
166
25
77
4.01
7.44
2.0
1.5
—
—
—
0
0
25
77
4.01
7.44
2.0
1.5
—
—
—
0
0
31
111
3.61
7.44
2.7
1.7
—
—
—
0
0
50
243
3.14
7.26
4.2
2.2
63.9
56.6
u/l
0.75
44
226
19
49
4.56
7.10
5.7
3.5
1.0
2.7
mmol/l
0.96
14
42
73
453
3.33
6.72
21.7
9.3
4.2
3.9
e9/l
0.56
67
399
38
171
2.98
6.13
1.7
1.5
15.7
21.9
nmol/l
2.34
32
135
11
20
6.06
5.95
1.6
1.5
—
—
—
0
0
19
56
3.96
5.94
4.8
3.8
35.9
61.1
ml/min/173m2
2.45
12
23
5
0
+∞
5.25
5.8
0.0
3.9
—
mmol/l
—
5
0
32
143
2.83
5.12
2.5
1.6
1236.5
1273.4
nmol/l
0.07
26
110
9
12
8.12
4.46
1.7
1.2
—
—
—
0
0
27
120
2.72
4.29
5.3
2.3
0.7
1.1
e6/l
0.34
18
68
9
13
7.49
4.26
1.7
1.1
—
—
—
0
0
25
108
2.76
4.19
6.0
2.4
0.9
1.6
e6/l
0.38
16
56
78
573
2.70
4.09
6.6
3.8
21.6
11.3
mm/h
3.60
71
526
9
14
6.95
4.08
1.7
1.6
—
—
—
0
0
59
384
2.33
4.04
8.9
4.2
0.0
0.0
estimate
0.00
19
86
69
484
2.40
3.92
15.7
4.0
6.7
6.7
mmol/l
0.02
64
445
15
51
3.29
3.76
26.7
6.7
1.0
1.8
mmol/l
1.26
15
51
39
219
2.29
3.72
7.5
3.4
0.0
0.0
estimate
0.00
16
82
14
46
3.38
3.70
11.1
2.4
119.8
127.7
g/l
0.59
14
46
6
6
10.53
3.54
15.5
16.2
1289.8
898.7
nmol/l
—
6
6
58
390
2.18
3.49
7.0
3.2
0.0
0.0
estimate
0.00
21
79
48
300
2.16
3.47
2.5
1.8
97.6
97.1
pmol/l
0.03
26
139
9
18
5.38
3.46
1.4
1.3
—
—
—
0
0
57
382
2.16
3.44
7.2
3.2
0.0
0.0
estimate
0.00
21
87
7
10
7.43
3.42
1.0
1.0
—
—
—
0
0
7
10
7.43
3.42
1.0
1.0
—
—
—
0
0
13
43
3.33
3.39
12.5
2.0
207.2
117.7
ng/l
0.48
13
37
15
55
3.04
3.33
3.1
2.1
39.5
28.2
u/l
0.70
15
44
12
39
3.36
3.21
16.4
2.9
24.5
24.6
mmol/l
0.05
12
39
9
20
4.84
3.20
1.7
1.5
—
—
—
0
0
8
16
5.34
3.12
1.1
1.3
—
—
—
0
0
11
35
3.41
3.03
7.2
2.7
0.0
0.1
e6/l
0.60
11
35
5
5
10.43
3.01
1.2
1.4
—
—
—
0
0
12
42
3.11
2.86
10.8
2.0
1.2
1.3
%
0.19
12
42
6
10
6.30
2.74
2.0
1.1
—
—
—
0
0
5
7
7.44
2.58
1.0
1.1
—
—
—
0
0
12
45
2.90
2.55
24.3
8.2
0.7
0.7
%
0.08
12
45
46
309
1.91
2.53
7.7
3.3
—
—
—
0
0
73
573
2.04
2.51
5.4
3.7
15.0
14.8
pmol/l
0.17
66
518
12
46
2.83
2.46
1.8
1.3
—
—
—
0
0
12
46
2.83
2.46
24.7
8.2
1.4
1.6
%
0.28
12
46
48
330
1.88
2.44
6.0
4.2
33.8
46.8
ng/l
0.46
37
246
30
182
1.93
2.19
5.0
2.1
—
—
—
0
0
5
10
5.20
2.09
1.0
1.2
—
—
—
0
0
6
15
4.18
2.07
1.3
1.3
—
—
—
0
0
50
364
1.75
2.00
4.8
3.8
—
—
—
0
0
8
28
3.02
1.91
2.3
2.6
—
—
—
0
0
10
40
2.67
1.90
11.2
3.4
51.1
48.6
%
—
10
40
6
18
3.48
1.77
1.3
1.2
—
—
—
0
0
10
42
2.54
1.74
1.3
1.7
—
—
—
0
0
5
14
3.70
1.63
1.6
1.2
—
—
—
0
0
7
26
2.82
1.61
1.9
1.4
2.9
2.9
g/l
—
7
21
7
27
2.71
1.54
1.9
1.4
—
—
—
0
0
7
27
2.71
1.54
1.9
1.4
7.7
7.9
g/l
—
7
22
7
27
2.71
1.54
1.9
1.4
4.0
3.8
g/l
—
7
21
5
16
3.23
1.45
1.6
1.2
—
—
—
0
0
5
17
3.04
1.37
1.6
1.2
—
—
—
0
0
5
19
2.71
1.23
1.6
1.2
—
—
—
0
0
6
26
2.39
1.20
3.2
1.8
—
—
—
0
0
84
758
1.71
1.10
43.6
11.8
57.5
81.3
ml/min/173m2
9.30
75
620
80
719
1.59
0.99
6.8
4.4
2.0
2.0
mu/l
0.04
75
641
6
27
2.30
0.95
3.2
2.2
—
—
—
0
0
6
27
2.30
0.95
1.8
1.9
0.0
0.9
g/l
—
6
22
6
28
2.21
0.93
1.3
2.4
—
—
—
0
0
61
525
1.42
0.90
4.3
3.0
56.9
55.4
u/l
0.07
53
494
6
30
2.06
0.88
1.7
1.4
—
0.1
—
0
7
86
794
1.63
0.85
47.3
12.1
21.8
21.8
mg/l
0.01
80
625
14
92
1.61
0.77
1.6
1.4
—
—
—
0
0
0
23
0.00
0.59
0.0
1.3
—
—
—
0
0
9
65
1.42
0.52
2.0
2.2
—
—
—
0
0
27
222
1.30
0.48
2.0
1.7
1.5
1.4
mmol/l
0.16
21
180
5
32
1.59
0.43
6.8
3.8
21.8
25.9
mmol/l
—
5
32
8
58
1.41
0.43
2.1
1.8
—
—
—
0
0
16
126
1.32
0.38
1.1
1.2
25.2
29.6
iu/ml
—
5
40
6
42
1.46
0.36
4.8
3.5
3.6
4.4
pmol/l
—
6
36
19
159
1.24
0.29
1.6
1.2
0.8
1.2
u/ml
—
9
44
32
284
1.19
0.28
4.7
4.2
25.1
21.5
%
0.64
18
130
50
462
1.17
0.27
3.9
3.0
—
—
—
0
0
39
355
1.16
0.25
5.4
4.8
2.7
2.9
ug/l
0.10
34
311
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.7
—
24.6
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
2.9
—
0
6
0
13
0.00
0.21
0.0
1.4
—
14.9
—
0
13
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
86
843
1.15
0.12
53.6
14.9
149.1
77.7
umol/l
6.38
86
843
78
796
0.91
0.10
5.7
4.5
1.3
1.5
mmol/l
2.01
70
718
80
784
1.11
0.09
6.5
4.4
6.3
6.0
mmol/l
1.12
73
705
11
97
1.15
0.09
18.5
8.1
—
—
—
0
0
13
117
1.13
0.08
1.8
1.6
—
—
—
0
0
80
814
0.91
0.08
6.4
5.0
2.4
2.7
mmol/l
2.56
73
736
79
803
0.92
0.07
5.8
4.5
4.3
4.6
mmol/l
2.46
72
735
77
759
1.07
0.05
8.2
5.7
41.2
40.0
mmol/mol
0.36
72
710
22
228
0.95
0.02
4.1
3.0
1.0
0.8
ug/l
0.58
16
145
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
13.1
—
0
7
77
770
1.00
0.00
5.1
4.0
1.5
1.3
mmol/l
1.23
69
691
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_DRUGSANDHEAVYMETAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_DRUGSANDHEAVYMETAL | 3.362 [2.25, 5.03] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.349 |
During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 233 females with N14_DRUGSANDHEAVYMETAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_DRUGSANDHEAVYMETAL | 3.426 [2.35, 4.99] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 306 males with N14_DRUGSANDHEAVYMETAL died.
Mortality risk
Mortality risk for people of age
years, who have N14_DRUGSANDHEAVYMETAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.39% | 0.579% |
| 5 | 1.968% | 3.236% |
| 10 | 4.881% | 8.516% |
| 15 | 9.146% | 16.055% |
| 20 | 15.779% | 26.508% |
Relationships between endpoints
↥Index endpoint: N14_DRUGSANDHEAVYMETAL – Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data