≡ Risteys
R13

Documentation Changelog GitHub Contact & Feedback

Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

DOID EFO Endpoint Browser PheWeb

N14_DRUGSANDHEAVYMETAL

acute kidney tubular necrosis: Acute renal failure caused by the cell death of the renal tubules. Causes include nephrotoxins, cytotoxic drugs, and antibiotics.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N14
  • Cause of death: ICD-10 — N14

2 out of 7 registries used, show all original rules.

106

4. Check minimum number of events

None

106

5. Include endpoints

None

106

6. Filter based on genotype QC (FinnGen only)

102

Control definitions (FinnGen only)

Control exclude
N14_RENALTUB

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N10-N16
Name in latin
Condiciones tubulo-interstitiales et tubulares ex medicamentis et metallis gravibus

Similar endpoints

↥

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 684 289 389
Only index persons 549 241 308
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 64.13 65.48 62.95
Only index persons 62.02 64.29 60.25

-FinnGen-

Key figures

All Female Male
Number of individuals 102 42 60
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 58.54 59.92 57.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
106
Matched controls
1060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N14.1
ICD-10 Finland
Nephropathy induced by other drugs, medicaments and biological substances
+∞
75.2
63
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
223.6
51.0
49
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
567.3
39.8
37
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
11.1
29.3
39
53
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
41.0
24.4
30
10
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
23.5
22.3
32
19
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
+∞
21.6
20
*
N14.2
ICD-10 Finland
Nephropathy induced by unspecified drug, medicament or biological substance
+∞
20.5
19
*
N19
ICD-10 Finland
Unspecified kidney failure
38.1
19.3
24
8
TK800
NOMESCO Finland
Hemodialysis
121.9
19.3
20
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
+∞
18.2
17
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
+∞
18.2
17
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
+∞
17.1
16
*
A11CC03
ATC
alfacalcidol; systemic
+∞
17.1
16
*
N14.0
ICD-10 Finland
Analgesic nephropathy
+∞
16.0
15
*
N18.8
ICD-10 Finland
Other chronic renal failure
66.7
15.3
17
*
N18.0
ICD-10 Finland
End-stage renal disease
+∞
13.8
13
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
159.6
13.8
14
*
B03XA02
ATC
darbepoetin alfa; parenteral
46.5
13.6
16
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
+∞
12.8
12
*
L04AA06
ATC
mycophenolic acid; systemic
43.1
12.6
15
*
N05AN01
ATC
lithium; oral
22.2
12.0
17
9
KA1AE
NOMESCO Finland
Kidney ultrasound examination
34.5
12.0
15
5
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
6.5
11.9
22
41
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
134.0
11.7
12
*
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
+∞
11.7
11
*
C03CA01
ATC
furosemide; systemic
4.0
11.3
51
199
127
Kela drug reimbursment
Transplant complication
48.9
11.2
13
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.6
11.2
20
36
N05CD07
ATC
temazepam; oral
4.9
10.7
28
72
A12AA04
ATC
calcium carbonate; oral
121.5
10.6
11
*
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
+∞
10.6
10
*
Z94.0
ICD-10 Finland
Kidney transplant status
+∞
10.6
10
*
205
Kela drug reimbursment
Chronic hypertension
3.9
10.4
47
181
L04AX01
ATC
azathioprine; systemic
14.2
10.3
17
14
L04AA01
ATC
[U] ciclosporin
60.7
9.8
11
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.3
9.8
31
92
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.2
9.7
23
54
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
9.5
9
*
V03AE01
ATC
polystyrene sulfonate; oral
+∞
9.5
9
*
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
+∞
9.5
9
*
M04AA01
ATC
allopurinol; systemic
4.4
9.5
29
84
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
9.3
68
352
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
11.0
9.2
17
18
N05AA02
ATC
levomepromazine; systemic
11.5
8.9
16
16
A41.9
ICD-10 Finland
Sepsis, unspecified
18.3
8.8
13
8
R33
ICD-10 Finland
Retention of urine
5.7
8.7
18
37
N03AG01
ATC
valproic acid; systemic, rectal
7.7
8.7
20
31
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
8.4
8
*
JN4AD
NOMESCO Finland
Body CT examination
4.7
8.4
22
56
N06AB04
ATC
citalopram; systemic
3.7
8.3
35
126
R50.9
ICD-10 Finland
Fever, unspecified
4.0
8.1
28
88
H02AB04
ATC
methylprednisolone; systemic
3.9
8.0
29
94
3AC01, ,
NOMESCO Finland
48.7
7.8
9
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.5
7.8
18
28
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
7.7
42
177
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.8
7.6
19
46
L04AD01
ATC
ciclosporin; systemic
17.3
7.4
11
7
ZXE10
NOMESCO Finland
More than one and less than three hours
3.1
7.4
52
254
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
+∞
7.4
7
*
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
+∞
7.4
7
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
7.4
7
*
N17.8
ICD-10 Finland
Other acute renal failure
+∞
7.4
7
*
J01MA02
ATC
ciprofloxacin; systemic
3.0
7.1
52
258
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
6.8
49
240
A03FA01
ATC
metoclopramide; systemic, rectal
3.3
6.7
31
117
N05AH03
ATC
olanzapine; systemic
5.8
6.6
18
36
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.2
6.5
19
52
F25.0
ICD-10 Finland
Schizoaffective disorder, manic type
74.1
6.5
7
*
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
12.1
6.5
11
10
ZXE00
NOMESCO Finland
One hour or less
2.8
6.4
54
286
N14.4
ICD-10 Finland
Toxic nephropathy, not elsewhere classified
+∞
6.3
6
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
6.3
6
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.8
6.3
50
256
N05CF01
ATC
zopiclone; oral
2.8
6.1
47
236
H02AB07
ATC
prednisone; oral
3.6
6.1
23
76

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
58
8.16
20.67
14.0
2.2
6.03
5.70
kpa
0.93
34
58
32
51
8.56
20.64
21.6
6.7
—
—
—
0
0
45
118
5.89
17.55
7.2
1.5
12.19
13.48
umol/l
0.66
45
105
82
387
5.94
15.17
25.0
4.8
1.22
1.22
mmol/l
0.15
63
323
62
247
4.64
13.91
14.8
3.0
7.38
7.40
ph
1.03
21
61
24
23
13.13
13.63
12.4
1.2
22.63
25.31
mmol/l
1.99
24
23
25
47
6.65
13.52
10.0
2.4
4.69
4.50
kpa
0.22
25
47
54
199
4.49
13.32
9.9
4.1
—
—
—
0
0
75
358
4.74
12.89
21.6
4.3
1.23
1.22
mmol/l
0.46
70
325
58
243
4.06
11.64
5.9
3.1
156.82
44.56
mg/l
1.16
47
157
54
216
4.06
11.57
4.0
2.4
407.38
10066.72
umol/l
1.44
48
180
59
254
3.98
11.30
7.2
2.8
41.04
277.97
e6/l
0.45
53
193
58
263
3.66
9.98
7.9
3.6
30.69
8.82
mg/mmol
1.24
48
164
45
177
3.68
9.55
3.1
2.0
3.37
3.14
mg/l
0.21
37
150
51
224
3.46
9.03
6.3
2.5
—
—
—
0
0
61
302
3.40
8.84
8.0
3.0
17.22
45.77
e6/l
1.06
53
210
52
234
3.40
8.81
7.1
2.6
0.25
0.33
e6/l
0.19
46
176
15
14
12.26
8.61
7.5
1.3
—
—
—
0
0
72
399
3.51
8.58
13.9
6.3
—
—
—
0
0
20
48
4.90
8.15
1.5
1.9
—
—
—
0
0
71
401
3.33
7.99
30.6
12.6
1.28
1.28
inr
0.01
29
125
54
263
3.15
7.80
4.0
2.3
65.67
56.27
u/l
1.06
48
243
48
220
3.16
7.67
4.7
2.5
—
—
—
0
0
23
65
4.24
7.65
6.6
2.4
69.00
72.58
e9/l
0.26
17
50
15
18
9.50
7.62
4.3
2.2
15.99
16.33
%
—
9
10
42
179
3.23
7.58
1.9
1.5
15.71
22.36
nmol/l
2.81
35
140
21
56
4.43
7.51
5.6
3.2
7.44
7.42
ph
—
7
7
79
487
3.44
7.45
20.7
9.2
4.35
3.83
e9/l
0.86
73
430
15
19
9.00
7.40
10.5
2.1
—
—
—
0
0
18
44
4.72
7.14
10.0
2.4
114.61
129.14
g/l
1.40
18
44
26
86
3.68
6.93
3.2
1.6
—
—
—
0
0
27
93
3.55
6.76
1.1
1.4
400.00
694.81
titre
—
6
27
69
412
2.93
6.53
13.2
5.5
23.94
27.84
%
2.31
69
390
13
17
8.54
6.34
5.4
2.4
—
—
—
0
0
67
398
2.86
6.33
13.4
5.4
3.11
2.76
%
0.50
67
375
6
0
+∞
6.31
3.0
0.0
—
—
—
0
0
6
0
+∞
6.31
8.3
0.0
4.22
—
mmol/l
—
6
0
67
399
2.85
6.29
13.8
5.7
9.04
8.84
%
0.20
67
380
35
149
3.01
6.17
2.5
1.6
1270.29
1258.69
nmol/l
0.02
28
117
10
9
12.11
5.93
11.4
1.0
—
—
—
0
0
65
390
2.72
5.87
13.6
5.4
0.62
0.70
%
0.73
65
368
26
97
3.23
5.69
19.1
6.0
104.35
103.64
mmol/l
0.24
26
97
18
54
3.81
5.45
25.6
6.6
1.02
1.72
mmol/l
1.33
18
54
32
139
2.87
5.36
2.9
1.9
—
—
—
0
0
11
15
8.04
5.29
2.5
1.5
1.33
1.56
mmol/l
0.69
11
15
18
57
3.60
5.04
1.6
1.6
—
—
—
0
0
9
10
9.70
4.89
2.6
1.3
87.16
90.52
%
—
9
10
64
406
2.45
4.80
8.8
4.2
0.00
0.00
estimate
-0.00
20
90
11
18
6.68
4.74
1.5
5.2
—
—
—
0
0
27
114
2.84
4.72
3.3
1.5
—
—
—
0
0
9
11
8.81
4.66
1.9
1.4
—
—
—
0
0
9
11
8.81
4.66
12.0
1.0
71.48
70.48
%
—
9
11
8
8
10.69
4.60
2.5
1.4
—
—
—
0
0
27
116
2.78
4.56
5.9
2.3
0.82
2.26
e6/l
0.68
17
61
21
79
3.07
4.48
9.3
3.9
—
—
—
0
0
11
20
6.00
4.42
12.5
1.8
8.36
8.57
kpa
0.10
11
20
11
20
6.00
4.42
12.5
1.7
5.06
4.93
kpa
0.19
11
20
39
206
2.41
4.30
11.8
5.6
—
—
—
0
0
60
382
2.32
4.30
29.4
9.7
0.00
0.01
e9/l
0.53
54
315
53
322
2.29
4.23
2.6
1.7
98.59
98.32
pmol/l
0.01
29
147
63
412
2.30
4.21
6.9
3.3
0.00
0.00
estimate
-0.00
22
83
19
70
3.09
4.19
6.6
5.9
0.20
0.63
%
—
10
27
74
520
2.40
4.15
16.3
4.0
6.65
6.62
mmol/l
0.04
69
479
62
406
2.27
4.09
7.0
3.2
0.00
0.01
estimate
0.50
22
97
14
37
4.20
4.08
14.2
3.0
25.09
24.97
mmol/l
0.05
14
37
79
575
2.47
4.03
9.6
3.7
—
—
—
0
0
14
39
3.98
3.88
9.9
2.0
0.66
0.66
%
0.00
14
39
82
612
2.50
3.88
6.5
3.9
21.47
11.26
mm/h
3.84
75
559
19
74
2.91
3.80
8.1
5.8
0.10
0.10
%
—
10
29
41
232
2.25
3.79
7.7
3.5
0.00
0.00
estimate
-0.00
17
86
14
40
3.87
3.78
10.8
2.0
1.23
1.36
%
0.15
14
40
33
171
2.35
3.74
4.4
2.9
—
—
—
0
0
18
70
2.89
3.60
7.9
5.9
0.00
0.35
%
—
9
26
8
13
6.55
3.57
1.5
2.7
—
—
—
0
0
6
6
10.49
3.54
15.5
16.2
1327.83
898.67
nmol/l
—
6
6
19
78
2.75
3.45
8.1
5.5
1.10
1.00
%
—
10
33
14
48
3.21
3.45
11.9
2.0
194.00
121.62
ng/l
0.40
14
42
19
79
2.71
3.37
2.1
1.5
—
—
—
0
0
25
120
2.42
3.32
2.2
1.6
—
—
—
0
0
10
25
4.30
3.18
1.6
1.3
—
—
—
0
0
6
8
7.86
3.09
1.0
1.1
—
—
—
0
0
6
8
7.86
3.09
1.7
1.4
—
—
—
0
0
13
46
3.08
3.04
25.4
8.5
0.70
0.74
%
0.16
13
46
5
5
10.40
3.01
1.0
2.0
—
—
—
0
0
13
47
3.01
2.94
25.8
8.4
1.52
1.64
%
0.16
13
47
7
13
5.68
2.92
1.3
1.3
—
—
—
0
0
7
13
5.68
2.92
3.0
4.5
59.43
55.92
%
—
7
13
79
615
2.12
2.86
5.4
3.8
14.83
14.83
pmol/l
0.00
72
554
12
41
3.17
2.73
6.1
3.1
—
—
—
0
0
51
347
1.91
2.68
6.3
4.1
34.65
44.73
ng/l
0.35
39
258
78
612
2.04
2.66
6.2
4.0
—
—
—
0
0
7
15
4.91
2.64
1.3
1.2
—
—
—
0
0
34
203
1.99
2.61
6.9
3.0
91.06
90.21
%
0.06
34
198
5
7
7.42
2.57
2.2
1.0
9.00
11.14
%
—
5
7
11
39
3.03
2.43
7.2
2.8
0.03
0.12
e6/l
0.87
11
39
6
13
4.82
2.30
3.3
3.2
4.59
4.54
e9/l
—
6
13
9
29
3.29
2.28
27.3
9.0
—
—
—
0
0
8
24
3.52
2.23
3.6
2.9
—
—
—
0
0
16
75
2.33
2.22
1.7
1.3
—
—
—
0
0
18
89
2.23
2.22
1.7
1.4
—
—
—
0
0
18
89
2.23
2.22
1.6
1.4
—
—
—
0
0
10
36
2.96
2.20
7.5
4.3
—
—
—
0
0
13
56
2.51
2.14
1.4
2.1
0.81
1.90
g/l
1.10
13
51
40
267
1.80
2.13
3.8
2.3
—
—
—
0
0
10
37
2.88
2.13
1.0
1.2
—
—
—
0
0
10
39
2.72
2.00
1.2
1.2
—
—
—
0
0
8
28
3.00
1.90
1.3
1.6
0.22
0.23
g/l
—
8
28
12
53
2.43
1.88
4.0
3.5
—
—
—
0
0
38
259
1.73
1.85
4.2
4.0
—
—
—
0
0
8
29
2.90
1.83
1.5
1.6
1.11
1.17
g/l
—
8
29
28
175
1.82
1.82
2.4
1.8
476.26
427.05
pmol/l
0.33
23
146
15
76
2.13
1.74
4.4
2.8
8.72
7.24
ug/l
0.10
15
71
5
13
3.98
1.73
1.8
1.8
32.80
34.23
pg
—
5
13
5
13
3.98
1.73
2.0
1.8
—
—
—
0
0
5
13
3.98
1.73
3.8
2.8
0.76
0.72
nmol/l
—
5
13
19
106
1.97
1.73
1.2
1.3
—
—
—
0
0
35
242
1.67
1.59
8.3
3.1
—
—
—
0
0
32
217
1.68
1.56
1.6
1.4
—
—
—
0
0
5
15
3.44
1.54
14.2
6.3
6.50
7.17
mmol/l
—
5
15
10
45
2.35
1.51
2.0
1.3
—
—
—
0
0
7
28
2.60
1.48
5.3
4.1
4.03
3.94
mmol/l
—
7
28
12
63
2.02
1.28
5.5
2.8
—
—
—
0
0
83
732
1.62
1.21
53.5
15.0
14.94
14.77
%
0.12
83
722
93
849
1.78
1.12
47.8
12.2
21.95
21.78
mg/l
0.02
85
665
41
322
1.45
1.00
2.3
2.1
—
—
—
0
0
0
31
0.00
0.98
0.0
1.0
—
—
—
0
0
86
779
1.55
0.96
6.8
4.5
1.99
2.00
mu/l
0.04
81
691
12
75
1.68
0.79
18.9
3.3
—
—
—
0
0
5
24
2.14
0.75
1.4
1.2
460.60
589.54
mg/l
—
5
24
6
35
1.76
0.59
6.5
3.5
22.18
25.72
mmol/l
—
6
35
10
68
1.52
0.49
1.4
1.8
—
—
—
0
0
29
246
1.25
0.40
2.0
1.7
1.48
1.41
mmol/l
0.16
23
201
42
375
1.20
0.35
5.5
4.8
2.73
2.82
ug/l
0.03
36
331
21
174
1.26
0.35
6.3
3.2
—
1.02
—
0
22
5
70
0.70
0.27
1.6
1.5
—
—
—
0
0
16
134
1.23
0.24
1.1
1.2
25.22
35.75
iu/ml
—
5
44
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
4.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
0.37
—
0
5
0
13
0.00
0.21
0.0
2.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.5
—
4.12
—
0
13
0
13
0.00
0.21
0.0
3.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
4.98
—
0
6
0
13
0.00
0.21
0.0
2.5
—
104.92
—
0
13
20
175
1.18
0.20
1.5
1.2
0.84
1.14
u/ml
—
9
48
93
907
1.21
0.19
53.8
14.8
155.24
76.97
umol/l
7.43
93
907
92
897
1.19
0.19
40.9
12.4
—
—
—
0
0
34
314
1.12
0.17
3.6
3.1
—
—
—
0
0
11
92
1.22
0.17
1.5
1.3
—
—
—
0
0
8
71
1.14
0.16
1.4
1.5
—
—
—
0
0
9
78
1.17
0.16
1.7
1.6
—
—
—
0
0
9
82
1.11
0.15
1.8
1.4
—
—
—
0
0
84
860
0.89
0.14
5.7
4.5
1.34
1.45
mmol/l
1.61
76
775
86
879
0.89
0.13
6.3
5.1
2.39
2.70
mmol/l
3.22
79
797
85
868
0.90
0.12
5.7
4.6
4.27
4.58
mmol/l
2.47
78
795
83
819
1.06
0.04
8.4
5.7
41.00
40.09
mmol/mol
0.28
78
767
85
847
1.02
0.00
6.6
4.4
6.29
5.98
mmol/l
1.11
78
763
83
834
0.98
0.00
5.0
4.0
1.46
1.29
mmol/l
1.11
75
748
24
236
1.02
0.00
4.2
3.0
0.99
0.75
ug/l
0.72
18
150
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
262.29
—
0
7
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
95
950
1.00
-0.00
71.3
18.9
38.24
40.77
%
4.11
90
894
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
2.68
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
24.28
—
0
5
0
6
0.00
-0.00
0.0
2.3
—
5.85
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint N14_DRUGSANDHEAVYMETAL and mortality.

Females

Parameter HR [95% CI] p-value
N14_DRUGSANDHEAVYMETAL 3.362 [2.25, 5.03] < 0.001
Birth year 0.996 [0.99, 1.0] 0.349

During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 233 females with N14_DRUGSANDHEAVYMETAL died.

Males

Parameter HR [95% CI] p-value
N14_DRUGSANDHEAVYMETAL 3.426 [2.35, 4.99] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 306 males with N14_DRUGSANDHEAVYMETAL died.

Mortality risk

Mortality risk for people of age

years, who have N14_DRUGSANDHEAVYMETAL.

N-year risk Females Males
1 0.39% 0.579%
5 1.968% 3.236%
10 4.881% 8.516%
15 9.146% 16.055%
20 15.779% 26.508%

Relationships between endpoints

↥

Index endpoint: N14_DRUGSANDHEAVYMETAL – Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data