No definition available.
Nephropathy induced by other drugs, medicaments and biological substances
NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
59 |
4. Check minimum number of eventsNone |
59 |
5. Include endpointsNone |
59 |
6. Filter based on genotype QC (FinnGen only) |
59 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Nephropathy induced by other drugs, medicaments and biological substances
based on the number of shared cases.
Similar with more cases:
- Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
- Renal tubulo-interstitial diseases
- Genitourinary diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 334 | 136 | 196 |
| Only index persons | 289 | 121 | 168 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.01 |
| Only index persons | 0.01 | 0.00 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 63.70 | 64.51 | 62.94 |
| Only index persons | 62.17 | 64.29 | 60.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 59 | 22 | 37 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 57.07 | 59.32 | 55.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 53
- Matched controls
- 530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N14.1
ICD-10 Finland
Nephropathy induced by other drugs, medicaments and biological substances
+∞
75.9
53
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
32.3
18.9
25
14
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
135.8
10.8
11
*
A12AA04
ATC
calcium carbonate; oral
+∞
9.7
9
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
23.9
9.5
13
7
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
106.3
8.7
9
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
+∞
8.6
8
*
N03AG01
ATC
valproic acid; systemic, rectal
15.1
7.5
12
10
N05AH03
ATC
olanzapine; systemic
15.1
7.5
12
10
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
+∞
7.5
7
*
B03XA02
ATC
darbepoetin alfa; parenteral
+∞
7.5
7
*
N18.0
ICD-10 Finland
End-stage renal disease
+∞
7.5
7
*
N05AN01
ATC
lithium; oral
35.4
7.4
9
*
A11CC03
ATC
alfacalcidol; systemic
35.4
7.4
9
*
L04AX01
ATC
azathioprine; systemic
13.7
7.2
12
11
N17.9
ICD-10 Finland
Acute renal failure, unspecified
13.7
7.2
12
11
L04AA01
ATC
[U] ciclosporin; systemic
46.1
7.0
8
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
46.1
7.0
8
*
C03CA01
ATC
furosemide; systemic
5.2
6.8
25
78
N05CD07
ATC
temazepam; oral
7.9
6.6
15
25
Z49.0
ICD-10 Finland
Preparatory care for dialysis
79.0
6.6
7
*
L04AA06
ATC
mycophenolic acid; systemic
30.7
6.4
8
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
30.7
6.4
8
*
Z94.0
ICD-10 Finland
Kidney transplant status
+∞
6.4
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
183
8.71
12.56
10.1
4.9
34.3
35.9
g/l
1.27
47
171
26
70
5.85
9.95
8.0
2.3
12.5
15.6
umol/l
1.42
26
58
23
62
5.44
8.65
9.0
2.3
2.1
2.3
g/l
1.56
23
54
42
198
4.89
7.59
24.8
5.9
1.2
1.2
mmol/l
1.08
42
176
21
61
4.79
7.08
6.3
2.7
1.0
2.0
e6/l
0.30
14
32
15
33
5.75
6.91
1.8
1.4
—
—
—
0
0
21
68
4.24
6.08
5.9
2.5
0.4
1.6
e6/l
1.26
14
39
20
64
4.21
5.86
1.9
1.4
—
—
—
0
0
16
43
4.73
5.83
3.3
2.4
422.8
375.6
nmol/l
0.39
16
36
23
85
3.80
5.48
2.0
1.6
—
—
—
0
0
20
67
4.00
5.47
1.9
1.5
—
—
—
0
0
31
153
3.16
4.52
2.5
1.8
99.6
89.5
pmol/l
0.53
16
75
8
11
8.20
4.00
1.6
1.0
—
—
—
0
0
7
9
8.63
3.67
1.0
1.0
—
—
—
0
0
7
9
8.63
3.67
1.0
1.0
—
—
—
0
0
26
132
2.73
3.40
4.7
2.0
169.5
158.0
u/l
0.10
26
126
14
53
3.15
3.05
5.0
3.7
—
—
—
0
0
9
22
4.63
3.02
1.4
1.2
—
—
—
0
0
6
9
7.26
2.94
1.3
1.1
—
—
—
0
0
8
19
4.69
2.79
8.6
3.4
0.0
0.1
e6/l
—
8
19
6
10
6.53
2.77
1.7
1.3
—
—
—
0
0
10
33
3.44
2.67
27.7
6.7
23.5
25.4
mmol/l
—
10
33
5
8
6.70
2.42
1.4
1.3
—
—
—
0
0
10
36
3.14
2.33
2.5
2.8
38.9
31.1
u/l
—
10
31
6
14
4.64
2.21
1.2
1.3
—
—
—
0
0
5
10
5.34
2.11
1.4
1.1
—
—
—
0
0
5
11
4.85
1.98
1.4
1.5
—
—
—
0
0
8
28
3.14
1.94
14.8
2.3
0.9
1.4
%
—
8
28
18
100
2.15
1.78
6.6
2.1
—
—
—
0
0
7
26
2.91
1.64
14.6
2.5
49.3
49.6
%
—
7
26
7
27
2.80
1.57
25.3
4.5
24.6
23.8
mmol/l
—
7
27
34
247
1.89
1.55
10.0
4.5
0.0
0.0
estimate
—
9
53
28
191
1.89
1.55
6.4
4.4
31.1
29.9
ng/l
0.05
23
139
34
248
1.88
1.52
7.1
3.3
0.0
0.0
estimate
—
9
52
7
28
2.70
1.50
1.1
1.4
—
—
—
0
0
5
16
3.31
1.47
1.4
1.5
—
—
—
0
0
5
16
3.31
1.47
1.4
1.5
—
—
—
0
0
5
16
3.31
1.47
1.8
1.3
7.7
7.8
g/l
—
5
11
5
16
3.31
1.47
1.8
1.3
4.3
3.7
g/l
—
5
10
5
16
3.31
1.47
1.8
1.3
—
—
—
0
0
52
449
2.33
1.46
43.7
12.2
56.7
81.3
ml/min/173m2
5.63
45
370
34
252
1.82
1.41
7.1
3.4
0.0
0.0
estimate
—
9
46
0
40
0.00
1.39
0.0
1.9
—
—
—
0
0
29
210
1.75
1.26
4.7
4.0
—
—
—
0
0
21
140
1.78
1.20
6.7
3.5
0.0
0.0
estimate
—
8
50
26
193
1.62
0.97
7.5
3.4
—
—
—
0
0
53
480
2.02
0.95
62.7
15.5
140.0
139.6
mmol/l
0.30
53
467
10
58
1.87
0.86
1.5
1.2
—
—
—
0
0
53
482
1.98
0.82
64.0
15.6
4.1
4.0
mmol/l
0.97
53
470
0
19
0.00
0.61
0.0
1.3
—
—
—
0
0
21
165
1.42
0.56
4.0
4.3
24.0
21.4
%
—
9
73
11
80
1.46
0.42
1.8
1.8
437.4
413.8
pmol/l
0.09
11
70
53
501
1.57
0.36
56.5
15.6
163.1
81.6
umol/l
3.95
53
501
9
75
1.24
0.26
2.0
1.5
—
—
—
0
0
53
508
1.43
0.26
27.6
9.8
22.1
27.0
u/l
3.35
53
493
15
125
1.27
0.25
2.7
2.7
0.7
0.8
ug/l
—
9
76
32
292
1.21
0.24
3.8
3.3
—
—
—
0
0
5
41
1.24
0.22
2.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
6
47
1.31
0.21
1.8
2.2
—
—
—
0
0
7
58
1.23
0.19
20.3
9.1
—
—
—
0
0
10
86
1.20
0.12
1.5
1.2
0.8
1.4
u/ml
—
5
25
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
13.3
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
2.0
—
0
6
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
16.8
—
0
5
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST | 4.17 [2.8, 6.2] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 76 out of 162 males with NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST died.
Mortality risk
Mortality risk for people of age
years, who have NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.833% |
| 5 | No data | 4.413% |
| 10 | No data | 10.621% |
| 15 | No data | 18.911% |
| 20 | No data | 30.656% |
Relationships between endpoints
↥Index endpoint: NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST – Nephropathy induced by other drugs, medicaments and biological substances
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data