This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Short stature, not elsewhere classified
E4_SHORT
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
894 |
4. Check minimum number of eventsNone |
894 |
5. Include endpointsNone |
894 |
6. Filter based on genotype QC (FinnGen only) |
894 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Short stature, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other endocrine disorders
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 894 | 509 | 385 |
| Unadjusted period prevalence (%) | 0.17 | 0.17 | 0.17 |
| Median age at first event (years) | 8.55 | 9.38 | 7.46 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 763
- Matched controls
- 7281
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E34.35
ICD-10 Finland
Abnormal growth retardation
2214.8
323.0
421
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
1777.5
270.8
251
*
H01AC01
ATC
somatropin; parenteral
1093.0
253.7
238
*
E34.30
ICD-10 Finland
Short stature NOS
+∞
212.6
197
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
25.5
194.3
287
168
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
149.7
141
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
137.6
130
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
1133.0
106.2
103
*
301
Kela drug reimbursment
Growth hormone
351.8
95.6
96
*
E34.31
ICD-10 Finland
Short stature, prenatal disorder
873.8
83.8
82
*
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
56.0
54
*
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
18.7
49.6
78
44
E34.3
ICD-10 Finland
Short stature, not elsewhere classified
+∞
44.5
43
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.0
39.1
179
517
E30.09
ICD-10 Finland
Delayed puberty NOS
+∞
36.1
35
*
E30.00
ICD-10 Finland
Familial delayed puberty
+∞
35.1
34
*
602
Kela drug reimbursment
Children's severe malnutrition
6.3
29.2
81
134
Z3226
NOMESCO Finland
Physiotherapist
2.5
22.8
230
1086
BF20A
NOMESCO Finland
NA
+∞
22.6
22
*
Z31.5
ICD-10 Finland
Genetic counselling
3.6
22.1
108
320
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
18.2
225
1157
Z3231
NOMESCO Finland
Registered nurse
2.0
17.4
304
1802
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
30.8
16.7
22
7
R62.0
ICD-10 Finland
Delayed milestone
3.4
16.7
84
254
E22.80
ICD-10 Finland
Central precocious puberty
165.7
16.2
17
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.5
15.6
56
125
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
15.4
15
*
E34.45
ICD-10 Finland
Abnormal growth increase
82.9
15.3
17
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
155.8
15.2
16
*
RD210
NOMESCO Finland
NA
3.3
14.5
77
242
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.2
14.2
163
799
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.7
13.7
101
394
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
13.2
158
786
H02AB09
ATC
hydrocortisone; systemic
3.5
13.1
61
174
ZXE00
NOMESCO Finland
One hour or less
1.8
13.0
322
2100
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
12.8
278
1732
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
4.4
12.8
46
104
L02AE02
ATC
leuprorelin; implant, parenteral
12.7
12.6
22
17
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
11.3
12.5
23
20
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
12.3
12
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.2
12.2
142
694
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
11.9
223
1316
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
11.8
160
838
127
Kela drug reimbursment
Transplant complication
5.2
11.7
36
69
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
29.2
11.4
15
5
Z2221
NOMESCO Finland
Medical doctor
1.8
11.1
218
1301
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.8
10.8
45
117
F82
ICD-10 Finland
Specific developmental disorder of motor function
3.6
10.7
48
133
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
10.4
81
325
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
6.5
10.3
26
39
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
10.3
208
1247
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
10.3
77
300
2594A
ICD-9 Finland
Other endocrine disorders, Dwarfism, not elsewhere classified
+∞
10.3
10
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.9
10.1
63
222
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
10.0
142
751
R4110
NOMESCO Finland
Physiotherapy
1.8
9.9
190
1119
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.8
9.8
62
221
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
9.8
9.7
19
19
XA800
NOMESCO Finland
Neuropsychological investigation
2.4
9.7
83
351
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
3.0
9.7
55
182
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
4.1
9.7
37
90
Z2445
NOMESCO Finland
Psychologist
2.1
9.6
116
573
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
9.6
124
631
L04AA06
ATC
mycophenolic acid; systemic
5.4
9.6
28
51
E30.1
ICD-10 Finland
Precocious puberty
96.6
9.3
10
*
E34.40
ICD-10 Finland
Constitutional tall stature
+∞
9.2
9
*
L04AA01
ATC
[U] ciclosporin; systemic
8.4
9.0
19
22
P05.1
ICD-10 Finland
Small for gestational age
6.3
8.9
23
36
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
8.9
60
223
ZXD05
NOMESCO Finland
Urgent procedure
1.8
8.8
193
1180
121
Kela drug reimbursment
Severe hypofunction of sexual glands
15.1
8.8
14
9
F83
ICD-10 Finland
Mixed specific developmental disorders
2.8
8.7
58
211
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.4
8.7
72
299
K03.66
ICD-10 Finland
Tooth plaque
2.0
8.6
115
592
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
8.5
218
1395
A11CC03
ATC
alfacalcidol; systemic
4.8
8.5
27
55
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.6
8.5
60
228
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
8.2
8
*
RL140
NOMESCO Finland
NA
4.4
8.1
28
62
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
8.3
8.1
17
20
F98.2
ICD-10 Finland
Feeding disorder of infancy and childhood
4.7
8.1
26
54
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.3
7.9
74
326
ZXA05
NOMESCO Finland
Left side
2.1
7.9
90
435
R4190
NOMESCO Finland
Nutritional therapy
2.0
7.8
105
544
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
4.0
7.6
29
71
ZXA10
NOMESCO Finland
Bilateral
1.9
7.6
123
678
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
7.5
113
608
Z3229
NOMESCO Finland
Other healthcare associate professional
2.0
7.4
94
473
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
3.1
7.3
39
126
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
7.3
135
780
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
2.8
7.2
43
150
BC00A
NOMESCO Finland
NA
9.1
7.1
14
15
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
7.0
110
600
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.2
7.0
68
307
TJD20
NOMESCO Finland
Change of gastrostomy tube
5.0
7.0
21
41
G03FB08
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
19.3
7.0
10
5
T10
ICPC
Growth delay
5.6
7.0
19
33
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
6.7
91
471
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
1.5
6.7
352
2654
XW000
NOMESCO Finland
Bone marrow biopsy
3.3
6.7
31
91
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.6
6.6
46
174
Q87.19
ICD-10 Finland
Congenital malformation syndromes predominantly associated with short stature
38.5
6.6
8
*
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
10.6
6.6
12
11
N91.0
ICD-10 Finland
Primary amenorrhoea
16.1
6.6
10
6
Z2446
NOMESCO Finland
Social worker
1.7
6.6
137
820
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
3.7
6.6
27
72
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.9
6.5
38
130
Q87.14
ICD-10 Finland
Noonan's syndrome
21.7
6.5
9
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.5
122
706
L04AD01
ATC
ciclosporin; systemic
3.5
6.5
28
78
F59
ICD-10 Finland
Unspecified behavioural syndromes associated with physiological disturbances and physical factors
4.6
6.4
21
45
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.0
6.4
85
437
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.9
6.3
24
60
H03AA01
ATC
levothyroxine sodium; systemic
2.0
6.2
76
379
E28.3
ICD-10 Finland
Primary ovarian failure
+∞
6.1
6
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
+∞
6.1
6
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
6.1
6
*
137
Kela drug reimbursment
Uraemia requiring dialysis
6.3
6.1
15
23
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.8
6.1
16
27
H52.0
ICD-10 Finland
Hypermetropia
2.5
6.0
43
167
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: E4_SHORT – Short stature, not elsewhere classified
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).