Parapsoriasis

L12_PARAPSORI

parapsoriasis: one of a group of skin disorders that are characterized primarily by their resemblance to psoriasis (red, scaly lesions), rather than by their underlying etiology. Neoplasms can develop from parapsoriasis. For example, it can develop into cutaneous T-cell lymphoma.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L41 Cause of death: ICD-10 — L41 2 out of 7 registries used, show all original rules.	381
4. Check minimum number of events None	381
5. Include endpoints L12_PARAPSO_PITYLICHETVARACUT L12_PARAPSO_PITYLICHCHRON L12_PARAPSO_PLAQUE L12_PARAPSO_RETIFORM L12_PITYROCHEA	702
6. Filter based on genotype QC (FinnGen only)	702

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L40-L45
Name in latin: Parapsoriasis

NAME	L12_PARAPSORI
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	L12_PARAPSO_PITYLICHETVARACUT\|L12_PARAPSO_PITYLICHCHRON\|L12_PARAPSO_PLAQUE\|L12_PARAPSO_RETIFORM\|L12_PITYROCHEA
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L41
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L41
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Parapsoriasis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	5761	2864	2860
Only index persons	5168	2640	2528
Unadjusted period prevalence (%)
Whole population	0.08	0.08	0.08
Only index persons	0.10	0.10	0.10
Median age at first event (years)
Whole population	41.07	38.49	43.65
Only index persons	39.87	37.84	41.99

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	702	379	323
Unadjusted period prevalence (%)	0.14	0.13	0.14
Median age at first event (years)	47.34	40.92	54.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
635: Matched controls
6348

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L42

ICD-10 Finland

Pityriasis rosea

485.9

236.2

222

L41.1

ICD-10 Finland

Pityriasis lichenoides chronica

+∞

132.0

122

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

13.4

123.9

237

269

L41.9

ICD-10 Finland

Parapsoriasis, unspecified

+∞

85.4

D07AC01

ATC

betamethasone; topical

4.4

64.0

334

1284

L30.9

ICD-10 Finland

Dermatitis, unspecified

5.4

63.0

227

593

E0000UV

ATC

4.2

62.5

374

1619

L41.3

ICD-10 Finland

Small plaque parapsoriasis

+∞

57.1

L41.8

ICD-10 Finland

Other parapsoriasis

+∞

56.1

L40.0

ICD-10 Finland

Psoriasis vulgaris

67.2

53.4

D07AB08

ATC

desonide; topical

6.2

51.9

156

318

L41.0

ICD-10 Finland

Pityriasis lichenoides et varioliformis acuta

+∞

47.5

D07AB02

ATC

hydrocortisone butyrate; topical

3.4

39.4

255

1054

L41.2

ICD-10 Finland

Lymphomatoid papulosis

+∞

37.9

E000001

ATC

3.6

37.4

205

738

D07AC13

ATC

mometasone; topical

3.2

36.2

246

1039

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

35.3

35.8

L41.4

ICD-10 Finland

Large plaque parapsoriasis

+∞

34.7

E000002

ATC

4.1

29.9

131

382

C84.0

ICD-10 Finland

Mycosis fungoides

305.1

29.0

69630

ICD-8 Finland

Psoriasis and similar disorders, Pityriasis rosea

+∞

28.3

D07AD01

ATC

clobetasol; topical

3.7

26.9

133

427

D05BB02

ATC

acitretin; oral

25.0

22.4

XQ848

NOMESCO Finland

Dermatological photography

9.4

22.2

D07AA02

ATC

hydrocortisone; topical

3.1

21.5

132

492

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

3.3

20.4

116

408

R21

ICD-10 Finland

Rash and other nonspecific skin eruption

5.7

19.7

110

L43.8

ICD-10 Finland

Other lichen planus

195.4

18.6

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

3.4

18.0

305

D05AX52

ATC

calcipotriol, combinations; topical

6.3

17.9

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

2.3

16.2

170

856

D07XC01

ATC

betamethasone, combinations; topical

3.1

16.1

334

H02AB06

ATC

prednisolone; systemic

2.0

14.7

306

2039

E000007

ATC

4.0

14.2

151

D02AX

ATC

Other emollients and protectives

6.1

14.0

D05AX02

ATC

calcipotriol; topical

6.2

13.2

69621

ICD-8 Finland

Psoriasis and similar disorders, Parapsoriasis guttata

+∞

12.5

E000006

ATC

3.5

12.1

179

L40.5

ICD-10 Finland

Arthropathic psoriasis

66.2

11.6

L41

ICD-10 Finland

Parapsoriasis

+∞

11.5

L20.0

ICD-10 Finland

Besnier prurigo

3.2

11.3

201

E000003

ATC

4.0

11.2

115

TQW80

NOMESCO Finland

Local dermatologic skincare

6.0

11.2

L43.9

ICD-10 Finland

Lichen planus, unspecified

18.2

10.8

D02AE01

ATC

carbamide; topical

3.2

10.7

180

L40.9

ICD-10 Finland

Psoriasis, unspecified

19.2

10.3

D07BA04

ATC

hydrocortisone and antiseptics; topical

2.5

9.9

340

WXQ12

NOMESCO Finland

Psoralen - Ultraviolet A therapy with local sensitivisation

55.8

9.7

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

2.8

9.5

236

9700/3-C44.5

ICD-O-3

Mycosis fungoides of skin of trunk

+∞

9.4

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

+∞

9.4

L30.0

ICD-10 Finland

Nummular dermatitis

4.6

9.3

R06AE07

ATC

cetirizine; oral

1.7

8.9

270

1935

L43.0

ICD-10 Finland

Hypertrophic lichen planus

91.2

8.4

L40.4

ICD-10 Finland

Guttate psoriasis

91.2

8.4

6961A

ICD-9 Finland

Psoriasis and similar disorders, Other psoriasis[PSORIASIS VULGARIS]

+∞

8.3

9700/3-C44.9

ICD-O-3

Mycosis fungoides of skin, NOS

+∞

8.3

L20.9

ICD-10 Finland

Atopic dermatitis, unspecified

3.6

7.9

ZXC50

NOMESCO Finland

Cryotherapy

4.5

7.8

M25.5

ICD-10 Finland

Pain in joint

1.7

7.5

168

1091

D01AC02

ATC

miconazole; topical

2.5

7.5

234

L30.3

ICD-10 Finland

Infective dermatitis

4.0

7.4

D09AB01

ATC

zinc bandage without supplements; topical

6.1

7.4

R06AX27

ATC

desloratadine; oral

1.7

7.3

166

1080

A06AC01

ATC

ispaghula (psylla seeds); oral

1.8

7.3

142

879

WXQ10

NOMESCO Finland

Psoralen - Ultraviolet A therapy with systemic sensitivisation

+∞

7.3

6963A

ICD-9 Finland

Psoriasis and similar disorders, Pityriasis rosea

+∞

7.3

69619

ICD-8 Finland

Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)

+∞

7.3

J01DA01

ATC

[U] cefalexin; systemic

1.6

7.2

375

3030

D07BC01

ATC

betamethasone and antiseptics; topical

2.1

6.9

368

J01MA02

ATC

ciprofloxacin; systemic

1.6

6.8

221

1586

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.7

6.7

162

1071

QBA25

NOMESCO Finland

Destruction of lesion of skin of trunk

7.0

6.5

134

Kela drug reimbursment

General erythroderma

70.5

6.4

L40.8

ICD-10 Finland

Other psoriasis

70.5

6.4

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.6

6.4

208

1486

H04.10

ICD-10 Finland

Dry eye syndrome

2.2

6.4

297

XQ800

NOMESCO Finland

Prick test

2.3

6.4

254

D05AX03

ATC

calcitriol; topical

11.2

6.3

QXA05

NOMESCO Finland

Skin division, unspecified location

18.2

6.3

L26

ICD-10 Finland

Exfoliative dermatitis

+∞

6.3

M07.0*L40.5

ICD-10 Finland

Distal interphalangeal psoriatic arthropathy

+∞

6.3

XQ802

NOMESCO Finland

Epicutan test

3.2

6.2

J01DB01

ATC

cefalexin; oral

1.6

6.2

493

4334

L23.0

ICD-10 Finland

Allergic contact dermatitis due to metals

8.7

6.1

Mortality – FinRegistry

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Association

Association between endpoint L12_PARAPSORI and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_PARAPSORI	1.115 [0.94, 1.32]	0.2
Birth year	0.997 [0.99, 1.01]	0.585

During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 2204 females with L12_PARAPSORI died.

Males

Parameter	HR [95% CI]	p-value
L12_PARAPSORI	0.996 [0.87, 1.14]	0.949
Birth year	0.988 [0.98, 1.0]	0.026

During the follow-up period (1.1.1998 — 31.12.2019), 354 out of 2069 males with L12_PARAPSORI died.

Mortality risk

Mortality risk for people of age

years, who have L12_PARAPSORI.

N-year risk	Females	Males
1	0.097%	0.203%
5	0.617%	1.12%
10	1.461%	2.943%
15	2.779%	5.843%
20	5.352%	10.016%

Relationships between endpoints

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Index endpoint: L12_PARAPSORI – Parapsoriasis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Parapsoriasis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints