Pityriasis lichenoides et varioliformis acuta

L12_PARAPSO_PITYLICHETVARACUT

parapsoriasis: one of a group of skin disorders that are characterized primarily by their resemblance to psoriasis (red, scaly lesions), rather than by their underlying etiology. Neoplasms can develop from parapsoriasis. For example, it can develop into cutaneous T-cell lymphoma.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L41.0 Hospital discharge: ICD-9 — 6962A Cause of death: ICD-10 — L41.0 Cause of death: ICD-9 — 6962A 2 out of 7 registries used, show all original rules.	51
4. Check minimum number of events None	51
5. Include endpoints None	51
6. Filter based on genotype QC (FinnGen only)	51

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L41
Name in latin: Pityriasis lichenoides et varioliformis acuta

NAME	L12_PARAPSO_PITYLICHETVARACUT
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L410
HD_ICD_9	6962A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L410
COD_ICD_9	6962A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pityriasis lichenoides et varioliformis acuta based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	587	287	296
Only index persons	525	271	254
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	33.75	39.58	27.83
Only index persons	33.85	39.58	27.74

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	51	22	29
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	53.38	50.28	55.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

18.90

16.64

1.9

1.1

—

(42870588) Differential panel, method unspecified - Blood

118

3.19

3.97

8.8

6.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

13.33

3.86

1.8

1.4

—

(3007566) Smooth muscle Ab [Titer] in Serum

11.10

3.59

1.0

1.7

—

(3034770) Mitochondria Ab [Titer] in Serum

9.50

3.35

1.0

1.6

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

6.62

2.78

1.2

1.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.73

2.33

1.7

1.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

157

2.34

2.26

6.0

4.2

37.1

35.9

g/l

0.67

151

(3022948) Iron [Moles/volume] in Serum or Plasma

2.67

2.12

2.0

2.2

18.8

14.0

umol/l

1.10

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.91

1.99

1.0

1.1

1.0

1.2

g/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.60

1.91

1.8

2.1

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.60

1.91

2.0

2.2

2.3

g/l

0.02

(3009445) Proteinase 3 Ab [Units/volume] in Serum

3.85

1.90

2.0

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.79

1.89

1.8

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

100

2.24

1.83

4.2

5.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.34

1.83

1.4

2.1

—

(40761536) Microorganisms panel - Urine sediment

2.97

1.81

2.4

3.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

125

2.16

1.81

2.8

3.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.87

1.74

1.4

1.5

—

(3005322) IgE [Units/volume] in Serum or Plasma

3.43

1.71

2.3

1.3

194.1

67.6

u/ml

—

(3041096) Erythrocytes [Presence] in Urine by Automated

106

2.08

1.56

3.6

3.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.22

1.42

1.3

1.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.69

1.34

1.5

1.4

—

(3032080) INR in Blood by Coagulation assay

146

1.89

1.34

16.5

8.1

1.3

1.2

inr

—

(40768804) Tissue Pathology biopsy report

155

1.88

1.34

4.0

2.0

—

(3020961) Endomysium IgA Ab [Titer] in Serum

2.96

1.31

1.0

1.1

—

(3023368) Bacteria identified in Blood by Culture

1.97

1.29

5.3

4.6

—

(3023520) Reticulocytes [#/volume] in Blood

2.58

1.28

1.5

3.6

65.6

78.8

e9/l

—

(3013512) EKG study

114

1.89

1.25

4.0

3.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.18

1.18

1.9

1.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

236

1.80

1.17

4.0

3.7

—

66.5

—

(21494755) Public health laboratory ask at order entry panel

2.12

1.15

1.4

1.3

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.30

1.10

3.1

2.5

5.4

5.5

kpa

—

(3012544) pH of Venous blood

2.30

1.10

3.1

2.9

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.10

1.10

2.0

2.3

27.4

25.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

291

1.81

1.07

7.0

3.8

12.5

9.5

mm/h

0.59

266

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

138

1.74

1.03

5.3

4.5

14.1

48.9

ng/l

0.91

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.09

1.01

1.4

1.3

—

(3022145) Colonoscopy Study observation

2.09

1.01

1.6

—

(3018418) pH of Serum or Plasma

108

1.70

0.87

2.6

3.6

7.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

144

1.64

0.86

1.9

2.2

74.2

77.9

nmol/l

0.26

127

(3037467) Urinalysis macro (dipstick) panel - Urine

250

1.61

0.84

4.8

3.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.79

0.83

1.4

2.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.88

0.82

1.6

1.8

—

(3019225) pH of Specimen

1.92

0.82

6.0

7.8

—

(3022621) pH of Urine by Test strip

2.30

0.78

1.2

2.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.97

0.77

2.1

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

149

1.56

0.73

4.2

4.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.73

0.70

1.4

1.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

362

1.68

0.68

18.3

12.5

39.6

40.7

0.25

279

(3026008) Bacteria identified in Urine by Culture

106

1.59

0.67

2.3

2.5

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.86

0.61

5.3

4.0

—

0.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

101

1.53

0.57

4.9

3.6

12.6

8.0

mg/mmol

—

(3000492) Spirometry study

1.65

0.56

1.5

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

105

1.46

0.47

4.6

4.1

0.0

estimate

—

(1761868) Lipid panel - Serum or Plasma

180

1.39

0.47

2.0

2.8

—

(3042936) Bacteria identified in Isolate by Culture

1.51

0.45

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

260

1.37

0.45

3.6

3.1

—

(40768797) Stomach Pathology biopsy report

1.48

0.45

1.1

1.3

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.68

0.44

2.2

2.5

5.0

4.5

kpa

—

(3025159) Blasts/100 leukocytes in Blood

1.57

0.42

7.2

4.3

—

0.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.40

0.0

1.8

—

42.9

—

(3044889) 12 lead EKG panel

264

1.33

0.38

3.8

3.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

423

1.54

0.37

26.5

15.8

78.2

78.8

umol/l

0.07

423

(3019832) Treponema pallidum Ab [Presence] in Serum

1.41

0.36

1.3

1.6

—

(36304419) Bacteria [Presence] in Urine

1.38

0.34

2.5

—

(3012516) Albumin [Mass/volume] in Urine

1.38

0.34

3.3

2.8

105.1

68.7

mg/l

—

(3009261) Glucose [Presence] in Urine by Test strip

188

1.30

0.33

4.0

3.9

0.0

estimate

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.43

0.33

1.3

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.32

0.25

11.5

2.5

—

(40761511) CBC panel - Blood by Automated count

422

0.76

0.25

24.7

13.4

—

(3035350) Ketones [Presence] in Urine by Test strip

184

1.24

0.24

4.0

3.8

0.0

estimate

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.21

0.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.21

0.0

1.1

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

3.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

3.1

—

187.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.21

0.0

1.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

4.1

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.21

0.0

2.2

—

87.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

187

1.21

0.20

5.0

5.2

0.0

estimate

—

(3000494) Fungus identified in Specimen by Culture

1.17

0.20

1.2

1.3

—

(3002385) Erythrocyte distribution width [Ratio]

338

1.22

0.19

26.3

16.7

14.6

13.7

0.64

330

(40758558) Short blood count panel - Blood

1.23

0.16

15.3

7.2

—

(3015736) pH of Urine

148

0.84

0.15

3.5

3.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

370

1.11

0.05

21.3

13.6

82.7

84.3

ml/min/173m2

0.15

295

(3003694) ABO and Rh group [Type] in Blood

106

0.93

0.01

1.5

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

121

0.99

0.00

7.9

2.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

179

1.01

0.00

13.3

4.2

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

0.88

0.00

2.6

2.2

1.8

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(4094501)

0.00

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.4

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(44806118)

0.00

0.0

1.8

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

50.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

2.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.8

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(44790049)

0.00

0.0

1.8

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.0

—

2019.2

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

88.6

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.3

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.6

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

3.1

—

(4306422)

0.00

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(44790048)

0.00

0.0

1.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.7

—

19.9

—

(44790047)

0.00

0.0

1.8

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

3.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.3

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.1

—

101.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.0

—

(1616796) Gas panel - Central venous blood

0.00

0.0

4.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PARAPSO_PITYLICHETVARACUT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_PARAPSO_PITYLICHETVARACUT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_PARAPSO_PITYLICHETVARACUT – Pityriasis lichenoides et varioliformis acuta

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pityriasis lichenoides et varioliformis acuta

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints