pityriasis rosea: a skin rash. It is benign but may inflict substantial discomfort in certain cases.Classically, it begins with a single "herald patch" lesion, followed in 1 or 2 weeks by a generalized body rash lasting up to 12 weeks, however usually around 6 - 8.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
284 |
4. Check minimum number of eventsNone |
284 |
5. Include endpointsNone |
284 |
6. Filter based on genotype QC (FinnGen only) |
284 |
Control definitions (FinnGen only)
- Control exclude
- L12_PAPULOSQUAMOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L40-L45
- Name in latin
- Pityriasis rosea
Similar endpoints
↥List of similar endpoints to
Pityriasis rosea
based on the number of shared cases.
Similar with more cases:
- Parapsoriasis
- Papulosquamous disorders
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2464 | 1398 | 1053 |
| Only index persons | 2221 | 1287 | 934 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 25.89 | 28.71 | 22.08 |
| Only index persons | 25.96 | 28.92 | 21.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 284 | 204 | 80 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | 32.40 | 31.72 | 34.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 255
- Matched controls
- 2548
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L42
ICD-10 Finland
Pityriasis rosea
1795.9
276.5
221
9
69630
ICD-8 Finland
Psoriasis and similar disorders, Pityriasis rosea
+∞
28.7
27
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.5
14.7
45
95
D07AC01
ATC
betamethasone; topical
2.8
12.2
101
482
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.0
8.8
54
209
E0000UV
ATC
NA
2.2
8.4
115
687
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.3
7.8
39
131
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.1
7.5
23
49
6963A
ICD-9 Finland
Psoriasis and similar disorders, Pityriasis rosea
+∞
7.3
7
*
D07AB08
ATC
desonide; topical
3.2
6.9
38
134
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.9
6.8
42
163
L43.8
ICD-10 Finland
Other lichen planus
+∞
6.3
6
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
12.9
6.1
10
8
H02AB06
ATC
prednisolone; systemic
2.0
6.1
115
755
Mortality – FinRegistry
↥Association
Association between endpoint L12_PITYROCHEA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PITYROCHEA | 1.391 [0.95, 2.03] | 0.087 |
| Birth year | 0.995 [0.99, 1.0] | 0.267 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 1019 females with L12_PITYROCHEA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PITYROCHEA | 1.467 [1.09, 1.98] | 0.013 |
| Birth year | 0.985 [0.97, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 650 males with L12_PITYROCHEA died.
Mortality risk
Mortality risk for people of age
years, who have L12_PITYROCHEA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.126% | 0.239% |
| 5 | 0.803% | 1.615% |
| 10 | 1.998% | 3.935% |
| 15 | 3.847% | 7.278% |
| 20 | 6.646% | 12.309% |
Relationships between endpoints
↥Index endpoint: L12_PITYROCHEA – Pityriasis rosea
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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