parapsoriasis: one of a group of skin disorders that are characterized primarily by their resemblance to psoriasis (red, scaly lesions), rather than by their underlying etiology. Neoplasms can develop from parapsoriasis. For example, it can develop into cutaneous T-cell lymphoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
96 |
4. Check minimum number of eventsNone |
96 |
5. Include endpointsNone |
96 |
6. Filter based on genotype QC (FinnGen only) |
96 |
Control definitions (FinnGen only)
- Control exclude
- L12_PAPULOSQUAMOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Small plaque parapsoriasis
based on the number of shared cases.
Similar with more cases:
- Parapsoriasis
- Papulosquamous disorders
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 705 | 263 | 436 |
| Only index persons | 632 | 248 | 384 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 64.16 | 63.44 | 64.43 |
| Only index persons | 63.20 | 62.86 | 63.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 96 | 38 | 58 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 62.73 | 63.57 | 62.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 88
- Matched controls
- 881
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L41.3
ICD-10 Finland
Small plaque parapsoriasis
+∞
64.8
54
*
L41.4
ICD-10 Finland
Large plaque parapsoriasis
+∞
37.1
33
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
23.9
34.6
55
57
L41.9
ICD-10 Finland
Parapsoriasis, unspecified
+∞
22.9
21
*
E0000UV
ATC
NA
8.6
19.2
64
208
D07AC01
ATC
betamethasone; topical
7.6
17.4
60
194
L40.0
ICD-10 Finland
Psoriasis vulgaris
64.3
14.3
16
*
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
164.3
13.9
14
*
D07AB08
ATC
desonide; topical
9.0
13.7
31
50
L41.8
ICD-10 Finland
Other parapsoriasis
+∞
12.8
12
*
D07AB02
ATC
hydrocortisone butyrate; topical
5.4
12.2
48
159
L41.1
ICD-10 Finland
Pityriasis lichenoides chronica
+∞
11.7
11
*
D07AC13
ATC
mometasone; topical
5.1
11.6
49
173
E000001
ATC
NA
5.6
10.9
37
101
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.6
10.7
36
97
C84.0
ICD-10 Finland
Mycosis fungoides
124.2
10.7
11
*
D07AA02
ATC
hydrocortisone; topical
6.2
10.1
29
64
E000002
ATC
NA
6.6
9.3
25
50
D05BB02
ATC
acitretin; oral
37.1
8.3
10
*
D07AD01
ATC
clobetasol; topical
5.0
7.9
27
71
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
4.1
7.5
34
118
XQ848
NOMESCO Finland
Dermatological photography
15.5
7.1
11
8
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
6.3
6.6
17
32
D05AX02
ATC
calcipotriol; topical
12.4
6.5
11
10
Mortality – FinRegistry
↥Association
Association between endpoint L12_PARAPSO_PLAQUE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PARAPSO_PLAQUE | 0.861 [0.68, 1.09] | 0.211 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 367 males with L12_PARAPSO_PLAQUE died.
Mortality risk
Mortality risk for people of age
years, who have L12_PARAPSO_PLAQUE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.148% |
| 5 | No data | 0.872% |
| 10 | No data | 2.253% |
| 15 | No data | 4.263% |
| 20 | No data | 7.145% |
Relationships between endpoints
↥Index endpoint: L12_PARAPSO_PLAQUE – Small plaque parapsoriasis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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