Small plaque parapsoriasis

L12_PARAPSO_PLAQUE

parapsoriasis: one of a group of skin disorders that are characterized primarily by their resemblance to psoriasis (red, scaly lesions), rather than by their underlying etiology. Neoplasms can develop from parapsoriasis. For example, it can develop into cutaneous T-cell lymphoma.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L41.3, L41.4, L41.5 Hospital discharge: ICD-9 — 6962C Cause of death: ICD-10 — L41.3, L41.4, L41.5 Cause of death: ICD-9 — 6962C 2 out of 7 registries used, show all original rules.	99
4. Check minimum number of events None	99
5. Include endpoints None	99
6. Filter based on genotype QC (FinnGen only)	95

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	L12_PARAPSO_PLAQUE
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L41[3-5]
HD_ICD_9	6962C
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L41[3-5]
COD_ICD_9	6962C
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Small plaque parapsoriasis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	705	263	436
Only index persons	632	248	384
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	64.16	63.44	64.43
Only index persons	63.20	62.86	63.43

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	95	39	56
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	63.10	63.70	62.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
99: Matched controls
990

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

32.3

71.7

L41.3

ICD-10 Finland

Small plaque parapsoriasis

+∞

70.4

L41.4

ICD-10 Finland

Large plaque parapsoriasis

+∞

45.3

D07AC01

ATC

betamethasone; topical

10.7

29.3

206

E0000UV, ,

ATC

10.0

25.3

257

L41.9

ICD-10 Finland

Parapsoriasis, unspecified

+∞

25.1

D07AB08

ATC

desonide; topical

8.8

22.0

D07AB02

ATC

hydrocortisone butyrate; topical

6.5

19.8

182

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

+∞

18.3

E000001, ,

ATC

6.4

18.2

106

L30.9

ICD-10 Finland

Dermatitis, unspecified

6.5

18.1

D07AC13

ATC

mometasone; topical

5.7

17.1

177

E000002, ,

ATC

7.6

16.5

L40.0

ICD-10 Finland

Psoriasis vulgaris

101.6

16.1

D07AD01

ATC

clobetasol; topical

6.3

15.7

L41.8

ICD-10 Finland

Other parapsoriasis

+∞

15.0

D07AA02

ATC

hydrocortisone; topical

5.7

13.8

L41.1

ICD-10 Finland

Pityriasis lichenoides chronica

+∞

12.8

C84.0

ICD-10 Finland

Mycosis fungoides

135.1

11.7

D05BB02

ATC

acitretin; oral

61.2

9.9

D05AX02

ATC

calcipotriol; topical

30.6

8.7

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

3.7

8.6

137

ZXC50

NOMESCO Finland

Cryotherapy

10.7

7.6

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

4.8

7.5

XQ848

NOMESCO Finland

Dermatological photography

11.3

7.3

S18

ICPC

Laceration/cut

2.9

6.4

331

L40.9

ICD-10 Finland

Psoriasis, unspecified

+∞

6.3

9700/3-C44.9

ICD-O-3

Mycosis fungoides of skin, NOS

+∞

6.3

QAA25

NOMESCO Finland

Destruction of lesion of head or neck

13.7

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

19.92

20.34

1.5

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

343

5.03

12.64

7.6

6.2

—

(3017962) TCRG gene rearrangements [Presence] in Blood or Tissue by Molecular genetics method

+∞

6.31

2.0

0.0

—

(3021589) Normoblasts [#/volume] in Blood

344

2.89

6.17

9.6

10.6

0.00

0.01

e9/l

0.21

283

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

3.78

4.84

2.4

—

(3052851) Hemolysis interference index of Serum or Plasma

5.54

4.49

2.1

3.0

—

(3051651) Icteric interference index of Serum or Plasma

12.64

3.81

1.7

2.8

—

(3048689) Calprotectin [Mass/mass] in Stool

2.90

3.73

2.0

1.7

62.54

171.01

ug/g

0.94

(3051611) Lipemic interference index of Serum or Plasma

8.26

3.62

1.7

2.4

—

(3044941) Cell count panel - Synovial fluid

7.43

3.42

1.7

1.5

—

(40758558) Short blood count panel - Blood

204

2.20

3.30

6.8

—

(3044889) 12 lead EKG panel

535

2.27

3.27

4.2

—

(4035726) Immunohistochemistry procedure

2.67

3.23

1.6

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.53

2.81

1.6

1.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.11

2.66

3.7

7.3

—

(3008898) HLA-B27 [Presence]

3.85

2.65

1.0

1.1

—

(3018418) pH of Serum or Plasma

239

1.96

2.54

3.4

4.1

7.40

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.40

2.54

1.7

1.9

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

5.24

2.44

1.8

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.34

2.40

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.34

2.40

1.4

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

5.78

2.24

7.8

2.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.25

2.23

1.3

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

4.49

2.18

1.3

1.2

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

5.20

2.09

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

510

1.80

2.01

4.4

4.2

—

(3000494) Fungus identified in Specimen by Culture

2.18

1.99

1.5

1.4

—

(3023368) Bacteria identified in Blood by Culture

213

1.82

1.97

4.3

4.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.92

1.96

1.7

1.2

—

(3022217) INR in Platelet poor plasma by Coagulation assay

387

1.72

1.89

21.7

15.9

1.44

1.33

inr

0.24

120

(3003396) Base excess in Arterial blood by calculation

103

2.05

1.88

2.8

6.3

2.55

1.10

mmol/l

0.72

(3020564) Creatinine [Moles/volume] in Serum or Plasma

804

2.31

1.87

23.6

18.3

76.12

81.77

umol/l

1.86

804

(3000012) Reticulocyte production index

4.33

1.84

1.2

2.0

—

(3037522) Nuclear Ab [Titer] in Serum

2.10

1.83

1.3

—

298.82

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.19

1.83

1.3

1.2

—

(3042936) Bacteria identified in Isolate by Culture

104

2.02

1.83

2.1

1.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.05

1.73

1.3

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.99

1.73

1.8

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.29

1.69

1.7

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.93

1.68

2.7

2.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.53

1.67

1.2

1.6

—

(3026782) Osmolality of Urine

182

1.75

1.61

1.8

2.9

498.53

547.56

mosm/kgh2o

0.72

151

(3009542) Hematocrit [Volume Fraction] of Blood

836

2.42

1.61

30.6

22.0

40.03

40.33

0.12

789

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

3.12

1.60

3.0

2.4

532.50

319.76

ug/l

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

3.12

1.60

2.5

1.6

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.12

1.60

1.5

—

(3002256) Pathology report gross observation

2.06

1.59

1.7

1.2

—

(40768797) Stomach Pathology biopsy report

103

1.91

1.53

1.1

1.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

384

1.61

1.51

6.0

6.5

1.21

mmol/l

0.30

325

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

113

1.84

1.45

1.6

2.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

205

1.66

1.43

2.1

1.6

1.55

1.30

mmol/l

0.68

168

(3013512) EKG study

245

0.54

1.35

3.6

4.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

165

1.69

1.35

2.0

1.7

0.68

1.16

mg/l

1.33

137

(40761511) CBC panel - Blood by Automated count

794

1.97

1.31

16.2

14.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.71

1.23

2.2

2.7

197.00

223.89

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.83

1.19

3.1

3.8

—

(40768804) Tissue Pathology biopsy report

287

1.53

1.17

3.1

2.1

—

(3035350) Ketones [Presence] in Urine by Test strip

382

1.50

1.16

3.8

4.1

0.00

estimate

-0.00

(3031040) Bacteria [#/volume] in Urine by Automated count

491

1.50

1.14

5.0

4.6

—

397.69

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

106

1.73

1.12

3.4

6.5

100.18

103.19

mmol/l

1.38

106

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.03

1.11

1.0

1.7

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.84

1.09

2.8

2.1

1.84

1.56

0.33

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.20

1.08

1.6

2.3

3.19

3.27

g/l

—

(3009261) Glucose [Presence] in Urine by Test strip

387

1.47

1.06

3.8

4.1

0.00

estimate

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.87

1.06

1.3

1.5

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

238

1.51

1.05

2.8

2.9

36.66

31.32

u/l

0.56

225

(3022145) Colonoscopy Study observation

1.74

1.04

1.4

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

719

1.59

0.99

5.0

4.9

5.84

6.08

mmol/l

1.35

651

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.01

0.99

1.6

2.2

11.74

9.64

g/l

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

259

1.48

0.99

4.4

4.7

26.24

20.31

1.15

125

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.97

0.0

1.5

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.96

0.96

1.6

2.2

7.43

7.76

g/l

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.96

0.96

1.6

2.2

4.33

3.81

g/l

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.96

0.96

1.6

1.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.96

0.96

1.6

2.2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.80

0.95

1.6

3.7

9.90

9.06

g/l

—

(3019309) Folate [Moles/volume] in Red Blood Cells

145

1.57

0.95

1.7

1069.58

1330.27

nmol/l

0.97

113

(3021601) Nitrite [Presence] in Urine by Test strip

385

1.42

0.92

5.7

5.2

0.00

estimate

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

757

1.60

0.91

22.0

15.3

26.07

24.16

mg/l

0.22

612

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

339

1.41

0.89

2.8

2.5

—

(3022621) pH of Urine by Test strip

1.89

0.88

4.0

1.8

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

256

1.43

0.86

1.8

3.6

1526.85

1274.84

ng/l

0.20

213

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

1.99

0.86

1.7

2.4

38.08

36.52

g/l

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

727

1.52

0.85

5.0

4.7

4.53

mmol/l

0.01

667

(3011397) Hemoglobin [Presence] in Urine by Test strip

175

1.49

0.85

3.8

4.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

115

1.58

0.84

2.6

2.9

0.67

2.39

e6/l

1.10

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.93

0.83

3.0

2.1

—

(4200892) Spirometry reversibility

1.72

0.81

1.0

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.87

0.80

1.7

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.72

0.79

3.7

2.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

678

1.44

0.78

5.3

4.4

1.94

2.02

mu/l

0.16

602

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

318

1.37

0.76

3.9

4.3

21.86

37.22

ng/l

0.81

242

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.14

0.75

1.2

1.0

—

(3019060) Gas panel - Arterial blood

1.74

0.75

1.8

3.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

120

1.50

0.70

2.6

2.7

0.38

0.87

e6/l

—

(3018095) Leukocytes [#/volume] in Urine

294

1.35

0.68

3.9

3.8

41.82

54.91

e6/l

0.16

217

(3041096) Erythrocytes [Presence] in Urine by Automated

211

1.38

0.67

3.3

3.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.63

0.66

1.1

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

553

1.32

0.63

4.4

3.7

15.46

15.01

pmol/l

0.72

494

(36660697) Celiac disease serology panel - Serum

1.65

0.63

1.6

1.2

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.61

0.0

5.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.61

0.0

2.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

2.0

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

711

1.37

0.60

19.8

15.2

80.12

77.30

ml/min/173m2

0.66

586

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.71

0.58

1.0

1.5

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.66

0.56

1.2

3.8

0.77

0.76

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.66

0.56

1.2

3.8

1.20

1.11

—

(3026008) Bacteria identified in Urine by Culture

245

1.32

0.56

3.3

3.1

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.62

0.55

4.8

3.4

4.57

4.35

pmol/l

—

(3000850) Epithelial cells [#/volume] in Urine

190

1.35

0.55

2.0

2.7

2.89

3.95

e6/l

0.49

167

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

726

1.35

0.54

4.9

4.7

1.38

1.43

mmol/l

0.42

660

(3020630) Protein [Mass/volume] in Serum or Plasma

1.52

0.53

3.9

2.8

68.99

66.36

g/l

0.61

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

191

1.34

0.53

3.2

3.1

0.67

0.69

ug/l

0.04

119

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

295

1.29

0.52

3.7

4.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.50

0.50

1.2

1.6

—

(3026493) Urate [Moles/volume] in Serum or Plasma

204

1.30

0.47

4.8

3.2

14989.16

5741.00

umol/l

0.27

172

(36304419) Bacteria [Presence] in Urine

223

1.29

0.46

3.3

2.8

—

(3044640) Blood type and Crossmatch panel - Blood

243

1.27

0.45

2.3

—

(3049717) Cytology report of Urine Cyto stain

1.64

0.43

2.6

3.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.39

0.42

1.3

1.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.41

0.0

2.8

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.45

0.41

1.2

1.6

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.0

—

(40768793) Breast Pathology biopsy report

0.00

0.40

0.0

1.3

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.9

—

(1616796) Gas panel - Central venous blood

0.00

0.39

0.0

3.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

295

1.23

0.39

3.1

3.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

707

1.25

0.37

4.3

4.2

1.30

1.29

mmol/l

0.04

638

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

173

1.27

0.37

2.3

2.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

307

1.22

0.36

3.0

1.9

95.58

95.39

pmol/l

0.01

159

(3028026) IgM [Mass/volume] in Serum or Plasma

1.42

0.36

1.5

2.0

1.25

1.24

g/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.65

0.34

4.7

9.6

—

(3002582) Erythrocytes [#/volume] in Urine

261

1.21

0.33

3.0

3.1

12.95

278.89

e6/l

0.58

207

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.40

0.32

5.9

6.0

24.89

24.71

mmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.32

0.31

1.6

1.2

—

(3030467) Casts [#/volume] in Urine by Automated count

236

1.20

0.28

3.1

2.8

0.35

0.31

e6/l

0.07

183

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

747

1.21

0.27

6.0

5.3

2.77

2.66

mmol/l

0.52

678

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.30

0.23

2.8

3.2

144.60

275.76

u/ml

—

(3029937) Albumin [Presence] in Urine by Test strip

212

1.17

0.22

3.9

4.9

0.00

0.01

estimate

—

(3012516) Albumin [Mass/volume] in Urine

222

1.17

0.22

3.0

37.63

55.57

mg/l

—

146

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.3

—

1.20

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.21

0.0

1.9

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

5.8

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

0.21

0.0

1.8

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

18.50

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.6

—

4.04

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.6

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

4.3

—

16.69

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.1

—

(3025941) Bacteria identified in Stool by Culture

1.27

0.20

1.0

1.2

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.7

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.26

0.19

1.9

1.4

—

(3019150) Specific gravity of Urine by Refractometry

168

1.16

0.17

3.1

4.7

1.01

1.02

kg/l

—

(3009508) Creatinine [Moles/volume] in Urine

236

1.14

0.17

4.0

3.0

5.49

8.19

mmol/l

3.75

194

(3000991) Gas panel - Venous blood

1.19

0.16

4.7

6.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

425

0.90

0.15

3.8

2.7

—

(3003694) ABO and Rh group [Type] in Blood

191

1.13

0.13

1.4

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

241

1.11

0.12

3.6

3.7

11.93

8.15

mg/mmol

—

150

(21494755) Public health laboratory ask at order entry panel

1.14

0.09

1.5

1.4

—

(40761536) Microorganisms panel - Urine sediment

1.12

0.08

5.9

4.3

—

(3000492) Spirometry study

1.07

0.07

1.1

1.5

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

119

1.11

0.06

2.2

2.53

2.42

g/l

0.22

106

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

101

1.10

0.04

1.5

1.3

—

(1761868) Lipid panel - Serum or Plasma

280

1.05

0.03

2.7

3.1

—

(3022948) Iron [Moles/volume] in Serum or Plasma

128

1.02

0.00

2.2

13.43

14.47

umol/l

0.16

116

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.5

—

83.46

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.9

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

1.7

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.3

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.1

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.1

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.94

-0.00

1.0

1.2

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.6

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.6

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.4

—

5.64

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.5

—

63.67

—

(3009343) pH of Capillary blood

1.02

-0.00

5.0

3.6

—

7.44

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

2.5

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

4.86

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

3.2

—

13.74

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.6

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

1.8

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.92

-0.00

3.0

1.8

188.00

364.26

nmol/l

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PARAPSO_PLAQUE and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
L12_PARAPSO_PLAQUE	0.861 [0.68, 1.09]	0.211
Birth year	0.982 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 367 males with L12_PARAPSO_PLAQUE died.

Mortality risk

Mortality risk for people of age

years, who have L12_PARAPSO_PLAQUE.

N-year risk	Females	Males
1	No data	0.148%
5	No data	0.872%
10	No data	2.253%
15	No data	4.263%
20	No data	7.145%

Relationships between endpoints

↥

Index endpoint: L12_PARAPSO_PLAQUE – Small plaque parapsoriasis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Small plaque parapsoriasis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints