Arenaviral haemorrhagic fever

AB1_ARENAVIRAL_FEVER

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A96 Cause of death: ICD-10 — A96 2 out of 7 registries used, show all original rules.	7
4. Check minimum number of events None	7
5. Include endpoints None	7
6. Filter based on genotype QC (FinnGen only)	7

Control definitions (FinnGen only)

Control exclude: AB1_ARTHROPOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_ARENAVIRAL_FEVER
CONTROL_EXCLUDE	AB1_ARTHROPOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A96
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A96
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Arenaviral haemorrhagic fever based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Not enough data for upset table.

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	66	30	35
Only index persons	58	28	30
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	60.81	61.85	59.70
Only index persons	60.33	61.85	58.91

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	7	-	-
Unadjusted period prevalence (%)	0.00	-	-
Median age at first event (years)	60.49	-	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

+∞

0.23

6.0

5.2

mmol/l

4.8

4.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

+∞

0.23

6.6

5.9

mmol/l

3.1

2.8

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

+∞

0.23

5.4

5.1

mmol/l

1.2

1.4

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.00

0.23

0.0

3.7

—

11.2

—

(3022145) Colonoscopy Study observation

0.00

0.23

0.0

1.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

+∞

0.23

27.1

19.0

ml/min/173m2

66.3

77.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

+∞

0.23

5.0

4.7

mmol/l

1.2

1.3

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.0

1.2

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.00

0.0

4.2

—

2.6

—

(4010399)

0.00

0.0

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.0

1.6

—

(4035726)

0.00

0.0

1.4

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.2

—

22.6

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

2.0

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.0

2.4

—

25.1

—

(3019225) pH of Specimen

0.00

0.0

5.7

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

(40761511) CBC panel - Blood by Automated count

+∞

0.00

26.9

16.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.1

—

(3022313) Gas panel - Capillary blood

0.00

0.0

2.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.0

1.2

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

38.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_ARENAVIRAL_FEVER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_ARENAVIRAL_FEVER.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_ARENAVIRAL_FEVER – Arenaviral haemorrhagic fever

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Arenaviral haemorrhagic fever

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints