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Arthropod-borne viral fevers and viral haemorrhagic fevers

AB1_ARTHROPOD

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A90-A99
  • Hospital discharge: ICD-9 06[5-6]|078[6-7]
  • Hospital discharge: ICD-8 06[1|7-8]
  • Cause of death: ICD-10 A90-A99
  • Cause of death: ICD-9 06[5-6]|078[6-7]
  • Cause of death: ICD-8 06[1|7-8]

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

3858

6. Filter based on genotype QC (FinnGen only)

3858

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 3858 1687 2171
Unadjusted period prevalence (%) 0.79 0.58 0.96
Median age at first event (years) 50.15 49.15 50.92

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3462
Matched controls
34622
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A98.5
ICD-10 Finland
Haemorrhagic fever with renal syndrome
3371.9
323.0
2747
36
0786A
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Haemorrhagic nephrosonephritis[NEPHROPATHIA EPIDEMICA]
+∞
323.0
529
*
R50.9
ICD-10 Finland
Fever, unspecified
4.1
184.7
855
2586
A90
ICD-10 Finland
Dengue fever [classical dengue]
556.8
55.7
55
*
A92.8
ICD-10 Finland
Other specified mosquito-borne viral fevers
64.6
44.2
51
8
N02BE01
ATC
paracetamol; systemic, rectal
1.8
41.7
2884
25287
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
38.3
392
1829
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
37.3
1436
10581
A03
ICPC
Fever
1.9
33.8
529
2944
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
33.1
1281
9364
B34.9
ICD-10 Finland
Viral infection, unspecified
4.2
32.2
128
317
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.7
31.2
108
234
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
23.5
933
6734
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
21.2
681
4657
SPAT1301
SPAT
No procedures
1.5
20.9
941
6946
R51.80
ICD-10 Finland
Headache
1.7
20.3
425
2581
SPAT1263
SPAT
Sampling
1.4
19.6
1277
10112
M03BX02
ATC
tizanidine; oral
1.4
19.4
1962
16780
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
19.2
358
2094
SPAT1153
SPAT
Removal of sutures
1.4
18.4
963
7297
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.7
18.2
130
502
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
17.8
476
3095
A98.8
ICD-10 Finland
Other specified viral haemorrhagic fevers
+∞
17.7
17
*
J01DB01
ATC
cefalexin; oral
1.4
17.6
2644
24013
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
17.1
637
4485
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
17.1
1010
7808
RD211
NOMESCO Finland
NA
2.3
16.9
153
671
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
16.3
1255
10139
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
16.2
394
2492
N02AX02
ATC
tramadol; systemic, rectal
1.4
16.2
1297
10546
J01MA02
ATC
ciprofloxacin; systemic
1.4
15.6
1153
9233
H02AB06
ATC
prednisolone; systemic
1.3
14.8
1361
11256
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
14.8
1220
9926
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.8
14.7
252
1433
SPAT1255
SPAT
Intravenous administration of medicine
1.9
14.5
204
1082
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
14.2
442
2973
J01FA06
ATC
roxithromycin; oral
1.3
14.1
1175
9550
M54.5
ICD-10 Finland
Low back pain
1.4
14.0
950
7470
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
13.7
1116
9030
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.8
13.5
246
1428
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.4
13.3
607
4432
SPAT1193
SPAT
Pap smear
1.8
12.8
210
1180
J01CA04
ATC
amoxicillin; systemic
1.3
12.4
2501
22919
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
12.2
463
3252
SPAT1324
SPAT
Screening procedure
1.5
12.2
414
2838
R06.0
ICD-10 Finland
Dyspnoea
1.4
12.2
671
5071
S18
ICPC
Laceration/cut
1.3
12.2
1208
10029
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
12.1
752
5803
Z2221
NOMESCO Finland
Medical doctor
0.7
12.0
455
6169
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.0
11.7
150
770
UJF32
NOMESCO Finland
Coloscopy
1.4
11.4
715
5515
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.8
11.1
195
1118
M01AC06
ATC
meloxicam; systemic, rectal
1.3
11.1
1033
8474
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
10.5
2136
19325
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
10.5
602
4567
J01AA02
ATC
doxycycline; systemic
1.3
10.3
2417
22252
N03AX12
ATC
gabapentin; oral
1.5
10.1
414
2950
SPAT1097
SPAT
Recording of ECG
1.5
10.1
396
2799
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
10.0
1360
11685
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
9.8
674
5264
WW200
SPAT
NA
1.5
9.7
302
2029
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.5
9.5
347
2414
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.6
9.5
240
1532
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
9.4
214
1328
N07BA03
ATC
varenicline; oral
1.8
9.4
155
875
A02BC02
ATC
pantoprazole; systemic
1.2
9.3
1902
17099
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.3
9.2
743
5947
N28.9
ICD-10 Finland
Disorder of kidney and ureter, unspecified
10.0
9.0
17
17
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
9.0
1058
8893
EBA00
NOMESCO Finland
Extraction of tooth
1.3
8.8
916
7578
AN1
HP
Coronary angiography
1.5
8.8
315
2187
SPAT1310
SPAT
Counselling related to known health issue
1.3
8.7
872
7176
SPAT1325
SPAT
Vaccination
1.3
8.6
891
7360
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.6
8.5
216
1382
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
8.5
1399
12220
AA1AD
NOMESCO Finland
CT of head and brain
1.3
8.5
628
4954
R10.0
ICD-10 Finland
Acute abdomen
2.1
8.4
90
433
C09CA01
ATC
losartan; oral
1.3
8.3
629
4978
WX720
NOMESCO Finland
Own respiration
1.9
8.2
112
590
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.6
8.2
236
1558
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.4
8.1
424
3161
-1
NOMESCO Finland
NA
1.3
8.1
917
7655
A21.9
ICD-10 Finland
Tularaemia, unspecified
8.9
8.0
16
18
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.7
8.0
151
890
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
8.0
753
6141
M54.2
ICD-10 Finland
Cervicalgia
1.6
7.9
182
1140
R4110
NOMESCO Finland
Physiotherapy
0.8
7.8
468
5954
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
2.5
7.7
60
247
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
7.6
537
4204
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.2
7.6
1121
9644
SPAT1059
SPAT
Spirometry at the office
1.7
7.5
138
807
SPAT1104
SPAT
Monitoring of emergency patient
1.6
7.5
170
1058
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
7.5
1521
13528
-
ICD-10 Finland
NA
2.2
7.4
68
307
G43.9
ICD-10 Finland
Migraine, unspecified
1.8
7.4
126
723
A92.0
ICD-10 Finland
Chikungunya virus disease
+∞
7.3
7
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.4
7.2
339
2479
ZYC01
SPAT
NA
1.7
7.2
144
866
XX3DW
NOMESCO Finland
Time consuming IT work
1.5
7.2
270
1889
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
2.6
7.2
50
195
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.3
7.2
525
4128
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
1.7
7.1
129
752
A02BC01
ATC
omeprazole; systemic
1.3
7.1
724
5950
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.3
7.1
492
3833
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
2.2
7.1
68
314
M79.6
ICD-10 Finland
Pain in limb
1.2
7.0
939
7976
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
1.8
7.0
123
713
SPAT1254
SPAT
Administration of medicine
1.4
7.0
350
2592
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.6
7.0
155
960
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
6.9
640
5194
G44.2
ICD-10 Finland
Tension-type headache
1.4
6.9
316
2299
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.4
6.9
406
3088
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.3
6.9
581
4656
WZA90
NOMESCO Finland
Other doctors statement
1.3
6.9
594
4775
PAW37
NOMESCO Finland
Biopsy of temporal artery
4.1
6.9
25
62
J01DA01
ATC
[U] cefalexin; systemic
1.2
6.8
1836
16732
SFA00
NOMESCO Finland
Small filling
1.4
6.8
325
2387
B01AC04
ATC
clopidogrel; oral
1.4
6.7
389
2950
M13.9
ICD-10 Finland
Arthritis, unspecified
1.6
6.7
182
1192
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
6.6
1610
14524
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
1.7
6.6
117
681
SPAT1252
SPAT
Overall medication plan or its review
1.6
6.5
171
1110
K10.3
ICD-10 Finland
Alveolitis of jaws
1.8
6.5
109
622
A02BC03
ATC
lansoprazole; oral
1.3
6.5
760
6349
M01AE01
ATC
ibuprofen; systemic, rectal
1.3
6.5
2888
27636
B01AA03
ATC
warfarin; systemic
1.3
6.4
473
3720
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.3
6.4
422
3262
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
4.1
6.4
23
57
NH3EA
NOMESCO Finland
Feet X-ray examination with load
2.3
6.4
57
254
SPAT1130
SPAT
Esophagoscopy, gastroscopy and duodenoscopy
2.0
6.3
76
386
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.3
745
6223
45100
ICD-8 Finland
Phlebitis and thrombophlebitis, Of lower extremities
4.0
6.3
23
58
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
2.1
6.3
64
303
A95.9
ICD-10 Finland
Yellow fever, unspecified
+∞
6.2
6
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.5
6.2
211
1447
P01AB01
ATC
metronidazole; oral, rectal
1.2
6.2
1029
8917
D07AC01
ATC
betamethasone; topical
1.2
6.2
920
7887
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
6.2
492
3914
R05FB02
ATC
cough suppressants and expectorants
1.2
6.2
989
8544
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
2.1
6.2
66
321
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
2.0
6.1
77
398
J01FA15
ATC
telithromycin; oral
1.4
6.1
266
1921
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
4.7
6.1
19
41
SPAT1098
SPAT
Exercise ECG
2.2
6.1
58
268

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: AB1_ARTHROPOD – Arthropod-borne viral fevers and viral haemorrhagic fevers

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).