No definition available.
Viral haemorrhagic fevers, not elsewhere classified/unspecified
AB1_VIRAL_HEMOR_FEVER_NOS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3114 |
4. Check minimum number of eventsNone |
3114 |
5. Include endpointsNone |
3114 |
6. Filter based on genotype QC (FinnGen only) |
3114 |
Control definitions (FinnGen only)
- Control exclude
- AB1_ARTHROPOD
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Viral haemorrhagic fevers, not elsewhere classified/unspecified
based on the number of shared cases.
Similar with more cases:
- Arthropod-borne viral fevers and viral haemorrhagic fevers
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27199 | 10354 | 16781 |
| Only index persons | 26376 | 10098 | 16278 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.40 | 0.30 | 0.47 |
| Only index persons | 0.53 | 0.37 | 0.62 |
| Median age at first event (years) | |||
| Whole population | 48.48 | 50.96 | 46.94 |
| Only index persons | 48.19 | 50.75 | 46.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3114 | 1402 | 1712 |
| Unadjusted period prevalence (%) | 0.63 | 0.48 | 0.75 |
| Median age at first event (years) | 52.00 | 50.51 | 53.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2788
- Matched controls
- 27879
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A98.5
ICD-10 Finland
Haemorrhagic fever with renal syndrome
4503599627370496.0
323.0
2746
37
R50.9
ICD-10 Finland
Fever, unspecified
4.6
183.7
751
2073
N02BE01
ATC
paracetamol; systemic, rectal
2.0
43.0
2351
20283
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
38.5
1170
8263
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
38.1
329
1420
A03
ICPC
Fever
2.0
33.4
460
2458
B34.9
ICD-10 Finland
Viral infection, unspecified
4.5
29.9
109
250
B99
ICD-10 Finland
Other and unspecified infectious diseases
5.2
29.7
94
185
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
28.2
1034
7494
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
22.5
307
1622
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.2
22.0
119
384
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
21.7
550
3565
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
17.8
746
5443
A98.8
ICD-10 Finland
Other specified viral haemorrhagic fevers
+∞
17.7
17
*
SPAT1263
SPAT
Sampling
1.4
17.4
1047
8222
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
17.3
1024
8014
R51.80
ICD-10 Finland
Headache
1.7
17.0
356
2172
SPAT1301
SPAT
No procedures
1.5
16.7
760
5632
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
16.2
1016
8005
N02AX02
ATC
tramadol; systemic, rectal
1.4
16.1
1048
8312
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
16.1
390
2478
J01FA06
ATC
roxithromycin; oral
1.4
16.0
972
7607
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
15.3
329
2016
M54.5
ICD-10 Finland
Low back pain
1.4
15.3
781
5903
J01DB01
ATC
cefalexin; oral
1.4
14.9
2144
19453
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
14.4
827
6377
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
14.2
518
3637
M03BX02
ATC
tizanidine; oral
1.4
14.0
1578
13633
RD211
NOMESCO Finland
NA
2.3
13.8
124
545
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
13.7
205
1114
SPAT1153
SPAT
Removal of sutures
1.4
13.7
764
5849
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
13.4
354
2298
SPAT1324
SPAT
Screening procedure
1.6
12.7
362
2392
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
12.3
613
4582
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
12.1
381
2582
J01MA02
ATC
ciprofloxacin; systemic
1.4
12.0
913
7345
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
12.0
916
7373
R06.0
ICD-10 Finland
Dyspnoea
1.4
11.2
546
4054
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.8
10.9
194
1123
UJF32
NOMESCO Finland
Coloscopy
1.4
10.9
575
4332
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
10.8
1756
15721
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.1
10.7
120
586
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.8
10.7
189
1091
SPAT1193
SPAT
Pap smear
1.8
10.5
186
1075
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
10.4
1126
9499
AN1
HP
Coronary angiography
1.6
10.2
259
1662
S18
ICPC
Laceration/cut
1.3
10.1
976
8093
Z2221
NOMESCO Finland
Medical doctor
0.7
10.0
363
4947
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
9.9
360
2518
M01AC06
ATC
meloxicam; systemic, rectal
1.3
9.7
838
6826
J01AA02
ATC
doxycycline; systemic
1.3
9.7
1951
17834
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.8
9.6
156
877
SPAT1255
SPAT
Intravenous administration of medicine
1.8
9.5
159
903
J01CA04
ATC
amoxicillin; systemic
1.3
9.4
2030
18694
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
3.1
9.4
50
165
H02AB06
ATC
prednisolone; systemic
1.3
9.3
1064
8997
EBA00
NOMESCO Finland
Extraction of tooth
1.3
9.2
768
6209
N07BA03
ATC
varenicline; oral
1.9
9.2
133
718
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
9.1
533
4076
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.4
9.0
461
3438
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.9
8.9
133
727
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.6
8.9
203
1268
N03AX12
ATC
gabapentin; oral
1.5
8.4
340
2431
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
8.2
1267
11076
SPAT1310
SPAT
Counselling related to known health issue
1.3
8.1
702
5696
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
3.0
8.0
44
149
A02BC02
ATC
pantoprazole; systemic
1.3
7.9
1533
13750
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
7.7
1154
10031
AA1AD
NOMESCO Finland
CT of head and brain
1.3
7.6
501
3893
M25.5
ICD-10 Finland
Pain in joint
1.3
7.6
613
4913
WW200
SPAT
NA
1.5
7.6
244
1655
SPAT1312
SPAT
General health counselling
1.3
7.6
686
5590
SPAT1097
SPAT
Recording of ECG
1.4
7.5
320
2305
R50
ICD-10 Finland
Fever of other and unknown origin
7.1
7.5
17
24
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.5
7.3
279
1968
N28.9
ICD-10 Finland
Disorder of kidney and ureter, unspecified
6.8
7.3
17
25
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
7.3
448
3446
WZA90
NOMESCO Finland
Other doctors statement
1.3
7.2
497
3895
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.6
7.1
166
1045
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
1.9
7.1
105
575
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.3
7.1
954
8162
-1
NOMESCO Finland
NA
1.3
7.1
756
6288
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.3
7.1
456
3532
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.3
7.0
467
3633
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
7.0
1325
11775
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
2.7
7.0
45
168
KMAK
NOMESCO Finland
NA
1.2
6.9
1249
11049
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
1.8
6.7
107
600
ZYC01
SPAT
NA
1.7
6.7
123
724
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.7
608
4949
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.3
6.6
612
4985
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
2.4
6.6
54
232
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
2.2
6.6
62
285
C10AA07
ATC
rosuvastatin; oral
1.3
6.6
516
4115
ACC51
NOMESCO Finland
Release of median nerve
1.6
6.5
147
915
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.3
6.5
428
3321
J01MA14
ATC
moxifloxacin; systemic
1.5
6.5
187
1238
B01AA03
ATC
warfarin; systemic
1.4
6.5
369
2798
SPAT1059
SPAT
Spirometry at the office
1.8
6.4
112
648
R10.0
ICD-10 Finland
Acute abdomen
2.1
6.4
70
343
M01AE01
ATC
ibuprofen; systemic, rectal
1.3
6.4
2337
22264
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
4.7
6.4
20
43
WX720
NOMESCO Finland
Own respiration
1.9
6.3
89
481
K02.1
ICD-10 Finland
Caries of dentine
1.2
6.3
1354
12150
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
6.3
529
4258
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
1.8
6.2
92
506
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
6.2
1368
12296
M54.2
ICD-10 Finland
Cervicalgia
1.6
6.2
148
939
M77.1
ICD-10 Finland
Lateral epicondylitis
1.6
6.2
159
1028
SPAT1325
SPAT
Vaccination
1.3
6.1
706
5911
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.4
6.1
337
2544
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
6.1
627
5179
SPAT1058
SPAT
PEF monitoring instruction
1.6
6.1
158
1026
R09
ICPC
Sinus symptom/complaint
1.6
6.1
150
960
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
4.9
6.0
18
37
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.7
6.0
119
718
-
ICD-10 Finland
NA
2.3
6.0
53
238
Mortality – FinRegistry
↥Association
Association between endpoint AB1_VIRAL_HEMOR_FEVER_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_VIRAL_HEMOR_FEVER_NOS | 0.926 [0.82, 1.04] | 0.195 |
| Birth year | 0.994 [0.99, 1.0] | 0.201 |
During the follow-up period (1.1.1998 — 31.12.2019), 723 out of 9178 females with AB1_VIRAL_HEMOR_FEVER_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_VIRAL_HEMOR_FEVER_NOS | 0.821 [0.74, 0.91] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 1459 out of 14917 males with AB1_VIRAL_HEMOR_FEVER_NOS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_VIRAL_HEMOR_FEVER_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.086% | 0.206% |
| 5 | 0.518% | 1.017% |
| 10 | 1.374% | 2.399% |
| 15 | 2.556% | 4.582% |
| 20 | 4.55% | 7.826% |
Relationships between endpoints
↥Index endpoint: AB1_VIRAL_HEMOR_FEVER_NOS – Viral haemorrhagic fevers, not elsewhere classified/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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